UniProtKB - Q5SSK0 (Q5SSK0_HUMAN)

BLAST

>tr|Q5SSK0|Q5SSK0_HUMAN Sodium-dependent lysophosphatidylcholine symporter 1 (Fragment) OS=Homo sapiens OX=9606 GN=MFSD2A PE=1 SV=1
MAKGEGAESGSAAGLLPTSILQSTERPAQKEPKKKKQQLSVCNKLCYALGGAPYQVTGCA
LGFFLQIYLLDVAQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFS
TPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSA
TAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQKAY
LLAAGVIVCIYIICAVILILGVREQR

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History
Entry version 85 (12 Sep 2018)
Sequence version 1 (21 Dec 2004)
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Protein

Submitted name:

Sodium-dependent lysophosphatidylcholine symporter 1

Gene

MFSD2A

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Sodium-dependent lysophosphatidylcholine symporter 1Imported
Gene namesⁱ	Name:MFSD2AImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168389.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25897 MFSD2A

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	113 – 134	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	146 – 170	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	239 – 262	HelicalSequence analysisAdd BLAST	24

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000168389

OpenTargetsⁱ

ENSG00000168389

PTM / Processingⁱ

Proteomic databases

EPDⁱ	Q5SSK0
PeptideAtlas More...PeptideAtlasⁱ	Q5SSK0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168389 Expressed in 171 organ(s), highest expression level in placenta
ExpressionAtlasⁱ	Q5SSK0 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5SSK0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005318
HOGENOMⁱ	HOG000294186
HOVERGENⁱ	HBG080097

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf
SUPFAMⁱ	SSF103473 SSF103473, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q5SSK0-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAKGEGAESG SAAGLLPTSI LQSTERPAQK EPKKKKQQLS VCNKLCYALG 
        60         70         80         90        100
GAPYQVTGCA LGFFLQIYLL DVAQVGPFSA SIILFVGRAW DAITDPLVGL 
       110        120        130        140        150
CISKSPWTCL GRLMPWIIFS TPLAVIAYFL IWFVPDFPHG QTYWYLLFYC 
       160        170        180        190        200
LFETMVTCFH VPYSALTMFI STEQTERDSA TAYRMTVEVL GTVLGTAIQG 
       210        220        230        240        250
QIVGQADTPC FQDLNSSTVA SQSANHTHGT TSHRETQKAY LLAAGVIVCI 
       260 
YIICAVILIL GVREQR

Length:266

Mass (Da):29,097

Last modified:December 21, 2004 - v1

Checksum:ⁱBB8E3D8FC541CA1E

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8NA29	NLS1_HUMAN	Sodium-dependent lysophosphatidylch... Sodium-dependent lysophosphatidylcholine symporter 1, NLS1, Sodium-dependent LPC symporter 1 (Major facilitator superfamily domain-containing protein 2A)	MFSD2A MFSD2, NLS1, HMFN0656, PP9177, UNQ300/PRO341	543	Annotation score:
E7EPI8	E7EPI8_HUMAN	Sodium-dependent lysophosphatidylch... Sodium-dependent lysophosphatidylcholine symporter 1	MFSD2A	374	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	266	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL663070 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL663070 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000434861; ENSP00000407606; ENSG00000168389
UCSC genome browser More...UCSCⁱ	uc057fdl.1 human

Protein	Similar proteins		Species	Score	Length	Source
Q5SSK0	MFSD2A isoform 3 (Fragment)		PANTR		266	UniRef100_Q5SSK0
UPI000387AE71		HUMAN		528

Protein	Similar proteins		Species	Score	Length	Source
Q5SSK0	Sodium-dependent lysophosphatidylcholine symporter 1		HUMAN		543	UniRef90_Q8NA29
Uncharacterized protein		COLAP		543
Uncharacterized protein		Cebus capucinus imitator		543
MFSD2A isoform 4		PONAB		543
MFSD2A isoform 4		PANTR		543
+57

Protein	Similar proteins		Species	Score	Length	Source
Q5SSK0	Sodium-dependent lysophosphatidylcholine symporter 1		HUMAN		543	UniRef50_Q8NA29
MFSD2A isoform 4		PANTR		543
MFSD2A isoform 4		PONAB		543
Uncharacterized protein		MANLE		543
Uncharacterized protein		AOTNA		543
+224

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL663070 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL663070 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	Q5SSK0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	Q5SSK0
PeptideAtlasⁱ	Q5SSK0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000434861; ENSP00000407606; ENSG00000168389
UCSCⁱ	uc057fdl.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168389.17
HGNCⁱ	HGNC:25897 MFSD2A
OpenTargetsⁱ	ENSG00000168389
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000005318
HOGENOMⁱ	HOG000294186
HOVERGENⁱ	HBG080097

Miscellaneous databases

ChiTaRSⁱ	MFSD2A human

ChiTaRSⁱ

MFSD2A human

Gene expression databases

Bgeeⁱ	ENSG00000168389 Expressed in 171 organ(s), highest expression level in placenta
ExpressionAtlasⁱ	Q5SSK0 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5SSK0_HUMAN
Accessionⁱ	Q5SSK0Primary (citable) accession number: Q5SSK0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	September 12, 2018
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q5SSK0 (Q5SSK0_HUMAN)

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Sodium-dependent lysophosphatidylcholine symporter 1

MFSD2A

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ