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Entry version 145 (13 Feb 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Heterochromatin protein 1-binding protein 3

Gene

HP1BP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • nucleosome binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterochromatin protein 1-binding protein 3
Alternative name(s):
Protein HP1-BP741 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HP1BP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127483.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24973 HP1BP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616072 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SSJ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50809

Open Targets

More...
OpenTargetsi
ENSG00000127483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671673

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HP1BP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743691

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003396422 – 553Heterochromatin protein 1-binding protein 3Add BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei85PhosphothreonineBy similarity1
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei142PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei190N6-acetyllysineBy similarity1
Modified residuei248PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei441PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SSJ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SSJ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SSJ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SSJ5

PeptideAtlas

More...
PeptideAtlasi
Q5SSJ5

PRoteomics IDEntifications database

More...
PRIDEi
Q5SSJ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63880
63881 [Q5SSJ5-2]
63882 [Q5SSJ5-3]
63883 [Q5SSJ5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SSJ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SSJ5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5SSJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127483 Expressed in 228 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SSJ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SSJ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028215
HPA054295

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PxVxL motif) with CBX5 (via Trp-174).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-2880687,EBI-748397

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119128, 122 interactors

Protein interaction database and analysis system

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IntActi
Q5SSJ5, 38 interactors

Molecular INTeraction database

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MINTi
Q5SSJ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312625

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1553
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQPNMR-A153-237[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5SSJ5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5SSJ5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5SSJ5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini157 – 232H15 1PROSITE-ProRule annotationAdd BLAST76
Domaini255 – 330H15 2PROSITE-ProRule annotationAdd BLAST76
Domaini337 – 413H15 3PROSITE-ProRule annotationAdd BLAST77

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi255 – 259PxVxL motif1 Publication5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi454 – 553Lys-richAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4012 Eukaryota
ENOG4112541 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155314

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG097678

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SSJ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRCEKNG

Database of Orthologous Groups

More...
OrthoDBi
903215at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SSJ5

TreeFam database of animal gene trees

More...
TreeFami
TF106395

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00073 H15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR033061 HP1BP3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15832:SF1 PTHR15832:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00538 Linker_histone, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00526 H15, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51504 H15, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SSJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDTSQGEL VHPKALPLIV GAQLIHADKL GEKVEDSTMP IRRTVNSTRE
60 70 80 90 100
TPPKSKLAEG EEEKPEPDIS SEESVSTVEE QENETPPATS SEAEQPKGEP
110 120 130 140 150
ENEEKEENKS SEETKKDEKD QSKEKEKKVK KTIPSWATLS ASQLARAQKQ
160 170 180 190 200
TPMASSPRPK MDAILTEAIK ACFQKSGASV VAIRKYIIHK YPSLELERRG
210 220 230 240 250
YLLKQALKRE LNRGVIKQVK GKGASGSFVV VQKSRKTPQK SRNRKNRSSA
260 270 280 290 300
VDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL
310 320 330 340 350
LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI
360 370 380 390 400
AAMNEPKTCS TTALKKYVLE NHPGTNSNYQ MHLLKKTLQK CEKNGWMEQI
410 420 430 440 450
SGKGFSGTFQ LCFPYYPSPG VLFPKKEPDD SRDEDEDEDE SSEEDSEDEE
460 470 480 490 500
PPPKRRLQKK TPAKSPGKAA SVKQRGSKPA PKVSAAQRGK ARPLPKKAPP
510 520 530 540 550
KAKTPAKKTR PSSTVIKKPS GGSSKKPATS ARKEVKLPGK GKSTMKKSFR

VKK
Length:553
Mass (Da):61,207
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD18B28EE0156F09B
GO
Isoform 2 (identifier: Q5SSJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:515
Mass (Da):57,211
Checksum:i130AD6B3FFD97525
GO
Isoform 3 (identifier: Q5SSJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Show »
Length:401
Mass (Da):44,435
Checksum:i31A31A118D2508B7
GO
Isoform 4 (identifier: Q5SSJ5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-133: DEKDQSKEKEKKVKKTI → ERADSIHSTLFIIGQNS
     134-553: Missing.

Show »
Length:133
Mass (Da):14,594
Checksum:i87E1DE4A3A8FB907
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SWC8Q5SWC8_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
278Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RGJ2X6RGJ2_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
327Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QZK4B0QZK4_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QZK8B0QZK8_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QZK6B0QZK6_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QZK5B0QZK5_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QZK9B0QZK9_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QZK7B0QZK7_HUMAN
Heterochromatin protein 1-binding p...
HP1BP3
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF14871 differs from that shown. Reason: Frameshift at positions 226, 237 and 243.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti262V → G in AAF14871 (PubMed:10931946).Curated1
Sequence conflicti267F → S in BAF83941 (PubMed:14702039).Curated1
Sequence conflicti499P → S in BAG64972 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0341681 – 152Missing in isoform 3. 2 PublicationsAdd BLAST152
Alternative sequenceiVSP_0341691 – 38Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_034170117 – 133DEKDQ…VKKTI → ERADSIHSTLFIIGQNS in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_034171134 – 553Missing in isoform 4. 1 PublicationAdd BLAST420

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF113534 mRNA Translation: AAF14871.1 Frameshift.
AK023129 mRNA Translation: BAG51160.1
AK291252 mRNA Translation: BAF83941.1
AK304065 mRNA Translation: BAG64972.1
AL833978 mRNA Translation: CAD38822.1
AL606477 Genomic DNA No translation available.
AL663074 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94953.1
BC032139 mRNA Translation: AAH32139.1
BC045660 mRNA Translation: AAH45660.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30621.1 [Q5SSJ5-1]

NCBI Reference Sequences

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RefSeqi
NP_057371.2, NM_016287.3 [Q5SSJ5-1]
XP_005245932.1, XM_005245875.4 [Q5SSJ5-1]
XP_005245933.1, XM_005245876.3 [Q5SSJ5-1]
XP_005245934.1, XM_005245877.4 [Q5SSJ5-1]
XP_005245935.1, XM_005245878.4 [Q5SSJ5-1]
XP_005245936.1, XM_005245879.4 [Q5SSJ5-2]
XP_011539834.1, XM_011541532.1 [Q5SSJ5-2]
XP_011539835.1, XM_011541533.1 [Q5SSJ5-2]
XP_011539836.1, XM_011541534.2 [Q5SSJ5-2]
XP_016856882.1, XM_017001393.1 [Q5SSJ5-1]
XP_016856883.1, XM_017001394.1 [Q5SSJ5-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.142442

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000312239; ENSP00000312625; ENSG00000127483 [Q5SSJ5-1]
ENST00000375000; ENSP00000364139; ENSG00000127483 [Q5SSJ5-5]
ENST00000375003; ENSP00000364142; ENSG00000127483 [Q5SSJ5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
50809

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:50809

UCSC genome browser

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UCSCi
uc001bdw.2 human [Q5SSJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113534 mRNA Translation: AAF14871.1 Frameshift.
AK023129 mRNA Translation: BAG51160.1
AK291252 mRNA Translation: BAF83941.1
AK304065 mRNA Translation: BAG64972.1
AL833978 mRNA Translation: CAD38822.1
AL606477 Genomic DNA No translation available.
AL663074 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94953.1
BC032139 mRNA Translation: AAH32139.1
BC045660 mRNA Translation: AAH45660.1
CCDSiCCDS30621.1 [Q5SSJ5-1]
RefSeqiNP_057371.2, NM_016287.3 [Q5SSJ5-1]
XP_005245932.1, XM_005245875.4 [Q5SSJ5-1]
XP_005245933.1, XM_005245876.3 [Q5SSJ5-1]
XP_005245934.1, XM_005245877.4 [Q5SSJ5-1]
XP_005245935.1, XM_005245878.4 [Q5SSJ5-1]
XP_005245936.1, XM_005245879.4 [Q5SSJ5-2]
XP_011539834.1, XM_011541532.1 [Q5SSJ5-2]
XP_011539835.1, XM_011541533.1 [Q5SSJ5-2]
XP_011539836.1, XM_011541534.2 [Q5SSJ5-2]
XP_016856882.1, XM_017001393.1 [Q5SSJ5-1]
XP_016856883.1, XM_017001394.1 [Q5SSJ5-2]
UniGeneiHs.142442

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQPNMR-A153-237[»]
ProteinModelPortaliQ5SSJ5
SMRiQ5SSJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119128, 122 interactors
IntActiQ5SSJ5, 38 interactors
MINTiQ5SSJ5
STRINGi9606.ENSP00000312625

PTM databases

iPTMnetiQ5SSJ5
PhosphoSitePlusiQ5SSJ5
SwissPalmiQ5SSJ5

Polymorphism and mutation databases

BioMutaiHP1BP3
DMDMi74743691

Proteomic databases

EPDiQ5SSJ5
jPOSTiQ5SSJ5
MaxQBiQ5SSJ5
PaxDbiQ5SSJ5
PeptideAtlasiQ5SSJ5
PRIDEiQ5SSJ5
ProteomicsDBi63880
63881 [Q5SSJ5-2]
63882 [Q5SSJ5-3]
63883 [Q5SSJ5-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
50809
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312239; ENSP00000312625; ENSG00000127483 [Q5SSJ5-1]
ENST00000375000; ENSP00000364139; ENSG00000127483 [Q5SSJ5-5]
ENST00000375003; ENSP00000364142; ENSG00000127483 [Q5SSJ5-3]
GeneIDi50809
KEGGihsa:50809
UCSCiuc001bdw.2 human [Q5SSJ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
50809
DisGeNETi50809
EuPathDBiHostDB:ENSG00000127483.17

GeneCards: human genes, protein and diseases

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GeneCardsi
HP1BP3
HGNCiHGNC:24973 HP1BP3
HPAiHPA028215
HPA054295
MIMi616072 gene
neXtProtiNX_Q5SSJ5
OpenTargetsiENSG00000127483
PharmGKBiPA142671673

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00940000155314
HOVERGENiHBG097678
InParanoidiQ5SSJ5
OMAiQRCEKNG
OrthoDBi903215at2759
PhylomeDBiQ5SSJ5
TreeFamiTF106395

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HP1BP3 human
EvolutionaryTraceiQ5SSJ5

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HP1BP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
50809

Protein Ontology

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PROi
PR:Q5SSJ5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127483 Expressed in 228 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ5SSJ5 baseline and differential
GenevisibleiQ5SSJ5 HS

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 3 hits
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR033061 HP1BP3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR15832:SF1 PTHR15832:SF1, 1 hit
PfamiView protein in Pfam
PF00538 Linker_histone, 3 hits
SMARTiView protein in SMART
SM00526 H15, 3 hits
SUPFAMiSSF46785 SSF46785, 3 hits
PROSITEiView protein in PROSITE
PS51504 H15, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHP1B3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SSJ5
Secondary accession number(s): A6NI71
, A8K5D7, B3KMZ8, B4E210, Q05BI0, Q5SSJ6, Q5SWC6, Q6PIM9, Q8NDF0, Q9UHY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 21, 2004
Last modified: February 13, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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