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Protein

U3 small nucleolar RNA-associated protein 18 homolog

Gene

Utp18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Biological processi

Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 18 homolog
Alternative name(s):
WD repeat-containing protein 50
Gene namesi
Name:Utp18
Synonyms:Wdr50
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923402 Utp18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514061 – 552U3 small nucleolar RNA-associated protein 18 homologAdd BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei114PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei200PhosphothreonineBy similarity1
Modified residuei201PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei217PhosphothreonineBy similarity1
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5SSI6
MaxQBiQ5SSI6
PaxDbiQ5SSI6
PRIDEiQ5SSI6

PTM databases

iPTMnetiQ5SSI6
PhosphoSitePlusiQ5SSI6
SwissPalmiQ5SSI6

Miscellaneous databases

PMAP-CutDBiQ5SSI6

Expressioni

Gene expression databases

BgeeiENSMUSG00000054079 Expressed in 279 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ5SSI6 baseline and differential
GenevisibleiQ5SSI6 MM

Interactioni

Protein-protein interaction databases

BioGridi229843, 2 interactors
STRINGi10090.ENSMUSP00000068103

Structurei

3D structure databases

ProteinModelPortaliQ5SSI6
SMRiQ5SSI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati245 – 284WD 1Add BLAST40
Repeati289 – 329WD 2Add BLAST41
Repeati376 – 415WD 3Add BLAST40
Repeati417 – 458WD 4Add BLAST42
Repeati467 – 508WD 5Add BLAST42
Repeati515 – 551WD 6Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat UTP18 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2055 Eukaryota
ENOG410YBWP LUCA
GeneTreeiENSGT00440000033919
HOGENOMiHOG000242429
HOVERGENiHBG082494
InParanoidiQ5SSI6
KOiK14553
OMAiQFHPTST
OrthoDBiEOG091G0BJP
PhylomeDBiQ5SSI6
TreeFamiTF313426

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SSI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPERKSRTR RDRRAGATPG RKARPGSGST PAKAARSSQR TQPAEPRAAP
60 70 80 90 100
SAGSAAAAAE EEESRLRQRN RLTLEDDKPA AERCLEQLVF GDVEDDEDAL
110 120 130 140 150
LQRLRSSRGQ LHGSSDESEV ENEAKDIFSQ KKKQPVWVDE DDEDEEIVDM
160 170 180 190 200
SNNRFRKDIM KNASESKLSK DKLQKRLKEE FQHAMGGVPD WAEAGSKRRT
210 220 230 240 250
SSDDESEEDE DDLLQRTGNF ISTSTSLPRG ILKMKNCRPA NAERPTTARI
260 270 280 290 300
SSVQFHPGAQ VVMVSGVDNA ISLFQVDGKT NPKIQSIYLE KFPIFKACFS
310 320 330 340 350
ANGEEVLATS MHSKVLYVYD MLAGKLIPVH QVRGLKEKTV KQFEVSPDGS
360 370 380 390 400
FLLISGIAGF SHLLSMKTKE LIGSMKINGR IAASTFSSDS KRIYTYSENG
410 420 430 440 450
EVYVWDVNSR KCMNRFLDEG SLCGLSIAAS KNGQYVACGS KSGVVNIYNQ
460 470 480 490 500
DSCLQQTNPK PIKAIMNLVT GVTSLAFNPT TEILAVASRK MKEAVRLVHL
510 520 530 540 550
PSCTVFSNFP VFKKSTLSRV QTMDFSPRGG YFALGNEKGR ALMYRLHHYS

DF
Length:552
Mass (Da):61,218
Last modified:December 21, 2004 - v1
Checksum:i770648B0A19103E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663078 Genomic DNA No translation available.
CCDSiCCDS25245.1
RefSeqiNP_001013393.1, NM_001013375.1
UniGeneiMm.379350

Genome annotation databases

EnsembliENSMUST00000066888; ENSMUSP00000068103; ENSMUSG00000054079
GeneIDi217109
KEGGimmu:217109
UCSCiuc007kxk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663078 Genomic DNA No translation available.
CCDSiCCDS25245.1
RefSeqiNP_001013393.1, NM_001013375.1
UniGeneiMm.379350

3D structure databases

ProteinModelPortaliQ5SSI6
SMRiQ5SSI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229843, 2 interactors
STRINGi10090.ENSMUSP00000068103

PTM databases

iPTMnetiQ5SSI6
PhosphoSitePlusiQ5SSI6
SwissPalmiQ5SSI6

Proteomic databases

EPDiQ5SSI6
MaxQBiQ5SSI6
PaxDbiQ5SSI6
PRIDEiQ5SSI6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066888; ENSMUSP00000068103; ENSMUSG00000054079
GeneIDi217109
KEGGimmu:217109
UCSCiuc007kxk.1 mouse

Organism-specific databases

CTDi51096
MGIiMGI:1923402 Utp18

Phylogenomic databases

eggNOGiKOG2055 Eukaryota
ENOG410YBWP LUCA
GeneTreeiENSGT00440000033919
HOGENOMiHOG000242429
HOVERGENiHBG082494
InParanoidiQ5SSI6
KOiK14553
OMAiQFHPTST
OrthoDBiEOG091G0BJP
PhylomeDBiQ5SSI6
TreeFamiTF313426

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiUtp18 mouse
PMAP-CutDBiQ5SSI6
PROiPR:Q5SSI6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054079 Expressed in 279 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ5SSI6 baseline and differential
GenevisibleiQ5SSI6 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUTP18_MOUSE
AccessioniPrimary (citable) accession number: Q5SSI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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