UniProtKB - Q5SSI6 (UTP18_MOUSE)
Protein
U3 small nucleolar RNA-associated protein 18 homolog
Gene
Utp18
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity
GO - Biological processi
- rRNA processing Source: UniProtKB-KW
Keywordsi
Biological process | rRNA processing |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 18 homologAlternative name(s): WD repeat-containing protein 50 |
Gene namesi | Name:Utp18 Synonyms:Wdr50 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923402, Utp18 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- nuclear membrane Source: MGI
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
- Pwp2p-containing subcomplex of 90S preribosome Source: GO_Central
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051406 | 1 – 552 | U3 small nucleolar RNA-associated protein 18 homologAdd BLAST | 552 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 78 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 114 | PhosphoserineCombined sources | 1 | |
Modified residuei | 115 | PhosphoserineCombined sources | 1 | |
Modified residuei | 118 | PhosphoserineCombined sources | 1 | |
Cross-linki | 178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 197 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 200 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 201 | PhosphoserineCombined sources | 1 | |
Modified residuei | 202 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 217 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 513 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q5SSI6 |
jPOSTi | Q5SSI6 |
MaxQBi | Q5SSI6 |
PaxDbi | Q5SSI6 |
PRIDEi | Q5SSI6 |
PTM databases
iPTMneti | Q5SSI6 |
PhosphoSitePlusi | Q5SSI6 |
SwissPalmi | Q5SSI6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000054079, Expressed in primary oocyte and 295 other tissues |
ExpressionAtlasi | Q5SSI6, baseline and differential |
Genevisiblei | Q5SSI6, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229843, 24 interactors |
STRINGi | 10090.ENSMUSP00000068103 |
Miscellaneous databases
RNActi | Q5SSI6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 245 – 284 | WD 1Add BLAST | 40 | |
Repeati | 289 – 329 | WD 2Add BLAST | 41 | |
Repeati | 376 – 415 | WD 3Add BLAST | 40 | |
Repeati | 417 – 458 | WD 4Add BLAST | 42 | |
Repeati | 467 – 508 | WD 5Add BLAST | 42 | |
Repeati | 515 – 551 | WD 6Add BLAST | 37 |
Sequence similaritiesi
Belongs to the WD repeat UTP18 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG2055, Eukaryota |
GeneTreei | ENSGT00440000033919 |
HOGENOMi | CLU_011055_3_1_1 |
InParanoidi | Q5SSI6 |
OMAi | QFHPTST |
OrthoDBi | 462558at2759 |
PhylomeDBi | Q5SSI6 |
TreeFami | TF313426 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5SSI6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPERKSRTR RDRRAGATPG RKARPGSGST PAKAARSSQR TQPAEPRAAP
60 70 80 90 100
SAGSAAAAAE EEESRLRQRN RLTLEDDKPA AERCLEQLVF GDVEDDEDAL
110 120 130 140 150
LQRLRSSRGQ LHGSSDESEV ENEAKDIFSQ KKKQPVWVDE DDEDEEIVDM
160 170 180 190 200
SNNRFRKDIM KNASESKLSK DKLQKRLKEE FQHAMGGVPD WAEAGSKRRT
210 220 230 240 250
SSDDESEEDE DDLLQRTGNF ISTSTSLPRG ILKMKNCRPA NAERPTTARI
260 270 280 290 300
SSVQFHPGAQ VVMVSGVDNA ISLFQVDGKT NPKIQSIYLE KFPIFKACFS
310 320 330 340 350
ANGEEVLATS MHSKVLYVYD MLAGKLIPVH QVRGLKEKTV KQFEVSPDGS
360 370 380 390 400
FLLISGIAGF SHLLSMKTKE LIGSMKINGR IAASTFSSDS KRIYTYSENG
410 420 430 440 450
EVYVWDVNSR KCMNRFLDEG SLCGLSIAAS KNGQYVACGS KSGVVNIYNQ
460 470 480 490 500
DSCLQQTNPK PIKAIMNLVT GVTSLAFNPT TEILAVASRK MKEAVRLVHL
510 520 530 540 550
PSCTVFSNFP VFKKSTLSRV QTMDFSPRGG YFALGNEKGR ALMYRLHHYS
DF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL663078 Genomic DNA No translation available. |
CCDSi | CCDS25245.1 |
RefSeqi | NP_001013393.1, NM_001013375.1 |
Genome annotation databases
Ensembli | ENSMUST00000066888; ENSMUSP00000068103; ENSMUSG00000054079 |
GeneIDi | 217109 |
KEGGi | mmu:217109 |
UCSCi | uc007kxk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL663078 Genomic DNA No translation available. |
CCDSi | CCDS25245.1 |
RefSeqi | NP_001013393.1, NM_001013375.1 |
3D structure databases
SMRi | Q5SSI6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229843, 24 interactors |
STRINGi | 10090.ENSMUSP00000068103 |
PTM databases
iPTMneti | Q5SSI6 |
PhosphoSitePlusi | Q5SSI6 |
SwissPalmi | Q5SSI6 |
Proteomic databases
EPDi | Q5SSI6 |
jPOSTi | Q5SSI6 |
MaxQBi | Q5SSI6 |
PaxDbi | Q5SSI6 |
PRIDEi | Q5SSI6 |
Protocols and materials databases
Antibodypediai | 30799, 65 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000066888; ENSMUSP00000068103; ENSMUSG00000054079 |
GeneIDi | 217109 |
KEGGi | mmu:217109 |
UCSCi | uc007kxk.1, mouse |
Organism-specific databases
CTDi | 51096 |
MGIi | MGI:1923402, Utp18 |
Phylogenomic databases
eggNOGi | KOG2055, Eukaryota |
GeneTreei | ENSGT00440000033919 |
HOGENOMi | CLU_011055_3_1_1 |
InParanoidi | Q5SSI6 |
OMAi | QFHPTST |
OrthoDBi | 462558at2759 |
PhylomeDBi | Q5SSI6 |
TreeFami | TF313426 |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 217109, 8 hits in 17 CRISPR screens |
ChiTaRSi | Utp18, mouse |
PROi | PR:Q5SSI6 |
RNActi | Q5SSI6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000054079, Expressed in primary oocyte and 295 other tissues |
ExpressionAtlasi | Q5SSI6, baseline and differential |
Genevisiblei | Q5SSI6, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UTP18_MOUSE | |
Accessioni | Q5SSI6Primary (citable) accession number: Q5SSI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families