Utp18

Functionⁱ

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Biological processⁱ

rRNA processing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	rRNA processing

Biological process

rRNA processing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U3 small nucleolar RNA-associated protein 18 homolog Alternative name(s): WD repeat-containing protein 50
Gene namesⁱ	Name:Utp18 Synonyms:Wdr50
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1923402 Utp18

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051406	1 – 552	U3 small nucleolar RNA-associated protein 18 homologAdd BLAST		552

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	78	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	114	PhosphoserineCombined sources	1
Modified residueⁱ	115	PhosphoserineCombined sources	1
Modified residueⁱ	118	PhosphoserineCombined sources	1
Cross-linkⁱ	178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	197	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	200	PhosphothreonineBy similarity	1
Modified residueⁱ	201	PhosphoserineCombined sources	1
Modified residueⁱ	202	PhosphoserineCombined sources	1
Modified residueⁱ	206	PhosphoserineCombined sources	1
Modified residueⁱ	217	PhosphothreonineBy similarity	1
Cross-linkⁱ	513	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q5SSI6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5SSI6
PaxDbⁱ	Q5SSI6
PRIDEⁱ	Q5SSI6

PTM databases

iPTMnetⁱ	Q5SSI6
PhosphoSitePlusⁱ	Q5SSI6
SwissPalmⁱ	Q5SSI6

Miscellaneous databases

PMAP-CutDBⁱ	Q5SSI6

PMAP-CutDBⁱ

Q5SSI6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000054079 Expressed in 279 organ(s), highest expression level in primary oocyte
ExpressionAtlasⁱ	Q5SSI6 baseline and differential
Genevisibleⁱ	Q5SSI6 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	229843, 2 interactors
STRINGⁱ	10090.ENSMUSP00000068103

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5SSI6
SMRⁱ	Q5SSI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	245 – 284	WD 1Add BLAST	40
Repeatⁱ	289 – 329	WD 2Add BLAST	41
Repeatⁱ	376 – 415	WD 3Add BLAST	40
Repeatⁱ	417 – 458	WD 4Add BLAST	42
Repeatⁱ	467 – 508	WD 5Add BLAST	42
Repeatⁱ	515 – 551	WD 6Add BLAST	37

Sequence similaritiesⁱ

Belongs to the WD repeat UTP18 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG2055 Eukaryota ENOG410YBWP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033919
HOGENOMⁱ	HOG000242429
HOVERGENⁱ	HBG082494
InParanoidⁱ	Q5SSI6
KEGG Orthology (KO) More...KOⁱ	K14553
OMAⁱ	QFHPTST
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BJP
PhylomeDBⁱ	Q5SSI6
TreeFamⁱ	TF313426

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
SMARTⁱ	View protein in SMART SM00320 WD40, 6 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5SSI6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPPERKSRTR RDRRAGATPG RKARPGSGST PAKAARSSQR TQPAEPRAAP 
        60         70         80         90        100
SAGSAAAAAE EEESRLRQRN RLTLEDDKPA AERCLEQLVF GDVEDDEDAL 
       110        120        130        140        150
LQRLRSSRGQ LHGSSDESEV ENEAKDIFSQ KKKQPVWVDE DDEDEEIVDM 
       160        170        180        190        200
SNNRFRKDIM KNASESKLSK DKLQKRLKEE FQHAMGGVPD WAEAGSKRRT 
       210        220        230        240        250
SSDDESEEDE DDLLQRTGNF ISTSTSLPRG ILKMKNCRPA NAERPTTARI 
       260        270        280        290        300
SSVQFHPGAQ VVMVSGVDNA ISLFQVDGKT NPKIQSIYLE KFPIFKACFS 
       310        320        330        340        350
ANGEEVLATS MHSKVLYVYD MLAGKLIPVH QVRGLKEKTV KQFEVSPDGS 
       360        370        380        390        400
FLLISGIAGF SHLLSMKTKE LIGSMKINGR IAASTFSSDS KRIYTYSENG 
       410        420        430        440        450
EVYVWDVNSR KCMNRFLDEG SLCGLSIAAS KNGQYVACGS KSGVVNIYNQ 
       460        470        480        490        500
DSCLQQTNPK PIKAIMNLVT GVTSLAFNPT TEILAVASRK MKEAVRLVHL 
       510        520        530        540        550
PSCTVFSNFP VFKKSTLSRV QTMDFSPRGG YFALGNEKGR ALMYRLHHYS 

DF

Length:552

Mass (Da):61,218

Last modified:December 21, 2004 - v1

Checksum:ⁱ770648B0A19103E1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL663078 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25245.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001013393.1, NM_001013375.1
UniGeneⁱ	Mm.379350

Genome annotation databases

Ensemblⁱ	ENSMUST00000066888; ENSMUSP00000068103; ENSMUSG00000054079
GeneIDⁱ	217109
KEGGⁱ	mmu:217109
UCSC genome browser More...UCSCⁱ	uc007kxk.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5SSI6	UTP18, small subunit (SSU) processome component, homolog (Yeast)		MOUSE		552	UniRef100_Q5SSI6
Uncharacterized protein		MOUSE		439

Protein	Similar proteins		Species	Score	Length	Source
Q5SSI6	UTP18, small subunit (SSU) processome component, homolog (Yeast)		MOUSE		552	UniRef90_Q5SSI6
U3 small nucleolar RNA-associated protein 18 homolog isoform X1		MESAU		570
UTP18 small subunit processome component		RAT		546
UPI000B4F6C40		MERUN		574
UPI000A3141A1		MUSPA		554
+8

Protein	Similar proteins		Species	Score	Length	Source
Q5SSI6	U3 small nucleolar RNA-associated protein 18 homolog		HUMAN		556	UniRef50_Q9Y5J1
Uncharacterized protein		RHIRO		596
Uncharacterized protein		RHIBE		585
UTP18 isoform 6 (Fragment)		PONAB		42
UTP18 isoform 6 (Fragment)		PANTR		42
+298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL663078 Genomic DNA No translation available.
CCDSⁱ	CCDS25245.1
RefSeqⁱ	NP_001013393.1, NM_001013375.1
UniGeneⁱ	Mm.379350

3D structure databases

ProteinModelPortalⁱ	Q5SSI6
SMRⁱ	Q5SSI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229843, 2 interactors
STRINGⁱ	10090.ENSMUSP00000068103

PTM databases

iPTMnetⁱ	Q5SSI6
PhosphoSitePlusⁱ	Q5SSI6
SwissPalmⁱ	Q5SSI6

Proteomic databases

EPDⁱ	Q5SSI6
MaxQBⁱ	Q5SSI6
PaxDbⁱ	Q5SSI6
PRIDEⁱ	Q5SSI6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000066888; ENSMUSP00000068103; ENSMUSG00000054079
GeneIDⁱ	217109
KEGGⁱ	mmu:217109
UCSCⁱ	uc007kxk.1 mouse

Organism-specific databases

CTDⁱ	51096
MGIⁱ	MGI:1923402 Utp18

Phylogenomic databases

eggNOGⁱ	KOG2055 Eukaryota ENOG410YBWP LUCA
GeneTreeⁱ	ENSGT00440000033919
HOGENOMⁱ	HOG000242429
HOVERGENⁱ	HBG082494
InParanoidⁱ	Q5SSI6
KOⁱ	K14553
OMAⁱ	QFHPTST
OrthoDBⁱ	EOG091G0BJP
PhylomeDBⁱ	Q5SSI6
TreeFamⁱ	TF313426

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	Utp18 mouse
PMAP-CutDBⁱ	Q5SSI6
Protein Ontology More...PROⁱ	PR:Q5SSI6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000054079 Expressed in 279 organ(s), highest expression level in primary oocyte
ExpressionAtlasⁱ	Q5SSI6 baseline and differential
Genevisibleⁱ	Q5SSI6 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
SMARTⁱ	View protein in SMART SM00320 WD40, 6 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UTP18_MOUSE
Accessionⁱ	Q5SSI6Primary (citable) accession number: Q5SSI6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5SSI6 (UTP18_MOUSE)

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U3 small nucleolar RNA-associated protein 18 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ