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Protein

SUN domain-containing protein 3

Gene

Sun3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 3
Alternative name(s):
Sad1/unc-84 domain-containing protein 1
Gene namesi
Name:Sun3
Synonyms:Sunc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3041199 Sun3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6NuclearCurated6
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23
Topological domaini30 – 320Perinuclear spaceCuratedAdd BLAST291

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122221 – 320SUN domain-containing protein 3Add BLAST320

Proteomic databases

PaxDbiQ5SS91
PRIDEiQ5SS91

PTM databases

PhosphoSitePlusiQ5SS91

Expressioni

Tissue specificityi

Specifically expressed in testis (at protein level).1 Publication

Developmental stagei

Exclusively expressed in postmeiotic stages of male germ cell development. First detected at day 25 p.p. when spermatids are most frequent within seminiferous tubules.1 Publication

Gene expression databases

BgeeiENSMUSG00000040985 Expressed in 27 organ(s), highest expression level in testis
CleanExiMM_SUNC1
ExpressionAtlasiQ5SS91 baseline and differential
GenevisibleiQ5SS91 MM

Interactioni

Subunit structurei

Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1. Can interact with SYNE3; the interaction is questioned by missing colocalization in spermatids.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5SS91, 3 interactors
STRINGi10090.ENSMUSP00000099973

Structurei

3D structure databases

ProteinModelPortaliQ5SS91
SMRiQ5SS91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 317SUNPROSITE-ProRule annotationAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 102Sequence analysisAdd BLAST40

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687 Eukaryota
ENOG410YM6S LUCA
GeneTreeiENSGT00390000011587
HOGENOMiHOG000007503
HOVERGENiHBG108520
InParanoidiQ5SS91
KOiK21874
OMAiEYGSRLY
OrthoDBiEOG091G0AZ8
PhylomeDBiQ5SS91
TreeFamiTF323915

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR030274 SUN3
IPR012919 SUN_dom
PANTHERiPTHR12911:SF24 PTHR12911:SF24, 1 hit
PfamiView protein in Pfam
PF07738 Sad1_UNC, 1 hit
PROSITEiView protein in PROSITE
PS51469 SUN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SS91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTRSWKIIL STVFISTFLL VGLLNHQWLK ETEFPQKPRQ LYTVIAEYGS
60 70 80 90 100
RLYNYQARLR MPKEQQELLK KESQTLENNF REILFLIEQI DVLKALLKDM
110 120 130 140 150
KDGVHNHSLP VHRDAVQDQA TTDVLDEEMS NLVHYVLKKF RGDQIQLADY
160 170 180 190 200
ALKSAGASVI EAGTSESYKN NKAKLYWHGI GFLNYEMPPD MILQPDVHPG
210 220 230 240 250
KCWAFPGSQG HILIKLARKI IPTAVTMEHI SEKVSPSGNI SSAPKEFSVY
260 270 280 290 300
GVMKKCEGEE IFLGQFIYNK MEATIQTFEL QNEASESLLC VKLQILSNWG
310 320
HPKYTCLYRF RVHGIPSDYT
Length:320
Mass (Da):36,758
Last modified:December 21, 2004 - v1
Checksum:i8DEC1E6B0D0BC1FB
GO
Isoform 2 (identifier: Q5SS91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Show »
Length:260
Mass (Da):29,544
Checksum:iABF66504F0D13B7F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297501 – 60Missing in isoform 2. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052771 mRNA Translation: BAC35140.1
AK132922 mRNA Translation: BAE21423.1
AL669837 Genomic DNA No translation available.
BC109334 mRNA Translation: AAI09335.1
CCDSiCCDS24430.1 [Q5SS91-2]
CCDS70140.1 [Q5SS91-1]
RefSeqiNP_001277448.1, NM_001290519.1 [Q5SS91-1]
NP_001277449.1, NM_001290520.1 [Q5SS91-2]
NP_808244.1, NM_177576.3 [Q5SS91-2]
UniGeneiMm.79210

Genome annotation databases

EnsembliENSMUST00000043377; ENSMUSP00000045199; ENSMUSG00000040985 [Q5SS91-1]
ENSMUST00000102909; ENSMUSP00000099973; ENSMUSG00000040985 [Q5SS91-2]
GeneIDi194974
KEGGimmu:194974
UCSCiuc007hzt.1 mouse [Q5SS91-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSUN3_MOUSE
AccessioniPrimary (citable) accession number: Q5SS91
Secondary accession number(s): Q8BHY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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