UniProtKB - Q5SRY7 (FBW1B_MOUSE)
F-box/WD repeat-containing protein 11
Fbxw11
Functioni
GO - Molecular functioni
- dynein complex binding Source: GO_Central
- microtubule plus-end binding Source: GO_Central
- protein dimerization activity Source: InterPro
- ubiquitin-protein transferase activity Source: UniProtKB
GO - Biological processi
- brain morphogenesis Source: GO_Central
- establishment of mitotic spindle orientation Source: GO_Central
- germ cell development Source: GO_Central
- microtubule organizing center organization Source: GO_Central
- negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: MGI
- nuclear migration Source: GO_Central
- positive regulation of circadian rhythm Source: UniProtKB
- positive regulation of proteolysis Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein dephosphorylation Source: UniProtKB
- protein destabilization Source: UniProtKB
- protein polyubiquitination Source: UniProtKB
- protein ubiquitination Source: MGI
- regulation of circadian rhythm Source: UniProtKB
- regulation of microtubule motor activity Source: GO_Central
- retrograde axonal transport Source: GO_Central
- rhythmic process Source: UniProtKB-KW
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- vesicle transport along microtubule Source: GO_Central
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Biological rhythms, Cell cycle, Ubl conjugation pathway, Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-202424, Downstream TCR signaling R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: F-box/WD repeat-containing protein 11Alternative name(s): F-box and WD repeats protein beta-TrCP2 F-box/WD repeat-containing protein 1B Homologous to Slimb protein Short name: HOS |
Gene namesi | Name:Fbxw11 Synonyms:Btrcp2, Fbw1b, Fbxw1b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2144023, Fbxw11 |
Subcellular locationi
Cytoskeleton
- centrosome Source: MGI
- cytoplasmic microtubule Source: GO_Central
- microtubule associated complex Source: GO_Central
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nuclear envelope Source: GO_Central
- nucleus Source: UniProtKB
Other locations
- axon cytoplasm Source: GOC
- cytoplasm Source: UniProtKB
- kinetochore Source: GO_Central
- neuron projection Source: GO_Central
- neuronal cell body Source: GO_Central
- SCF ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000396126 | 1 – 542 | F-box/WD repeat-containing protein 11Add BLAST | 542 |
Proteomic databases
EPDi | Q5SRY7 |
PaxDbi | Q5SRY7 |
PeptideAtlasi | Q5SRY7 |
PRIDEi | Q5SRY7 |
PTM databases
iPTMneti | Q5SRY7 |
PhosphoSitePlusi | Q5SRY7 |
SwissPalmi | Q5SRY7 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000020271, Expressed in cumulus cell and 309 other tissues |
ExpressionAtlasi | Q5SRY7, baseline and differential |
Genevisiblei | Q5SRY7, MM |
Interactioni
Subunit structurei
Self-associates.
Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer.
Interacts with BTRC, BST2, PER1, RCAN1 and USP47.
Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1, PER1 and PER2; the interaction requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S.
Interacts with TRIM21.
Interacts with PER3.
Interacts with phosphorylated ubiquitination substrate CEP68 (By similarity).
Interacts with INAVA (By similarity).
Interacts with REST (By similarity).
By similarity3 PublicationsGO - Molecular functioni
- microtubule plus-end binding Source: GO_Central
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 222123, 34 interactors |
DIPi | DIP-59921N |
IntActi | Q5SRY7, 21 interactors |
STRINGi | 10090.ENSMUSP00000075721 |
Miscellaneous databases
RNActi | Q5SRY7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 167 | F-boxPROSITE-ProRule annotationAdd BLAST | 47 | |
Repeati | 238 – 275 | WD 1Add BLAST | 38 | |
Repeati | 278 – 315 | WD 2Add BLAST | 38 | |
Repeati | 318 – 355 | WD 3Add BLAST | 38 | |
Repeati | 361 – 398 | WD 4Add BLAST | 38 | |
Repeati | 401 – 440 | WD 5Add BLAST | 40 | |
Repeati | 442 – 478 | WD 6Add BLAST | 37 | |
Repeati | 490 – 527 | WD 7Add BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 116 | Homodimerization domain DBy similarityAdd BLAST | 50 |
Domaini
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0281, Eukaryota |
GeneTreei | ENSGT00940000155898 |
HOGENOMi | CLU_000288_103_6_1 |
InParanoidi | Q5SRY7 |
OMAi | AHNFDVF |
OrthoDBi | 666965at2759 |
TreeFami | TF105679 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR021977, Beta-TrCP_D IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12125, Beta-TrCP_D, 1 hit PF12937, F-box-like, 1 hit PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM01028, Beta-TrCP_D, 1 hit SM00256, FBOX, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS00678, WD_REPEATS_1, 5 hits PS50082, WD_REPEATS_2, 7 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI
60 70 80 90 100
SNGTSSVIVS RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC
110 120 130 140 150
HYQHGHINSY LKPMLQRDFI TALPEQGLDH IAENILSYLD ARSLCAAELV
160 170 180 190 200
CKEWQRVISE GMLWKKLIER MVRTDPLWKG LSERRGWDQY LFKNRPTDGP
210 220 230 240 250
PNSFYRSLYP KIIQDIETIE SNWRCGRHNL QRIQCRSENS KGVYCLQYDD
260 270 280 290 300
DKIISGLRDN SIKIWDKSSL ECLKVLTGHT GSVLCLQYDE RVIVTGSSDS
310 320 330 340 350
TVRVWDVNTG EVLNTLIHHN EAVLHLRFSN GLMVTCSKDR SIAVWDMASA
360 370 380 390 400
TDITLRRVLV GHRAAVNVVD FDDKYIVSAS GDRTIKVWST STCEFVRTLN
410 420 430 440 450
GHKRGIACLQ YRDRLVVSGS SDNTIRLWDI ECGACLRVLE GHEELVRCIR
460 470 480 490 500
FDNKRIVSGA YDGKIKVWDL QAALDPRAPA STLCLRTLVE HSGRVFRLQF
510 520 530 540
DEFQIISSSH DDTILIWDFL NVPPSAQNET RSPSRTYTYI SR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF7BGU3 | F7BGU3_MOUSE | F-box/WD repeat-containing protein ... | Fbxw11 | 43 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 219 | I → V in BAE38644 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 534 | S → F in AAK72095 (PubMed:11896578).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039579 | 16 – 49 | Missing in isoform 4. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_039580 | 16 – 48 | CSVPR…SVRCL → NTSVMEDQNEDESPKKSALW in isoform 3. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_039581 | 49 | Q → QNTSVMEDQNEDESPKKSAL WQ in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY038079 mRNA Translation: AAK72095.1 Frameshift. AK041532 mRNA Translation: BAC30975.1 AK149139 mRNA Translation: BAE28749.1 AK152181 mRNA Translation: BAE31012.1 AK160086 mRNA Translation: BAE35617.1 AK166226 mRNA Translation: BAE38644.1 AK168667 mRNA Translation: BAE40519.1 AL669844 Genomic DNA No translation available. AL669951 Genomic DNA No translation available. BC034261 mRNA Translation: AAH34261.1 |
CCDSi | CCDS36125.1 [Q5SRY7-2] CCDS70157.1 [Q5SRY7-1] CCDS70158.1 [Q5SRY7-3] |
RefSeqi | NP_001258276.1, NM_001271347.1 [Q5SRY7-1] NP_001258277.1, NM_001271348.1 [Q5SRY7-3] NP_001258278.1, NM_001271349.1 [Q5SRY7-4] NP_598776.1, NM_134015.3 [Q5SRY7-2] |
Genome annotation databases
Ensembli | ENSMUST00000076383; ENSMUSP00000075721; ENSMUSG00000020271 [Q5SRY7-2] ENSMUST00000093205; ENSMUSP00000090893; ENSMUSG00000020271 [Q5SRY7-1] ENSMUST00000109366; ENSMUSP00000104991; ENSMUSG00000020271 [Q5SRY7-3] |
GeneIDi | 103583 |
KEGGi | mmu:103583 |
UCSCi | uc007ijx.2, mouse [Q5SRY7-2] uc007ijy.2, mouse [Q5SRY7-3] uc007ijz.2, mouse [Q5SRY7-1] uc007ika.2, mouse [Q5SRY7-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY038079 mRNA Translation: AAK72095.1 Frameshift. AK041532 mRNA Translation: BAC30975.1 AK149139 mRNA Translation: BAE28749.1 AK152181 mRNA Translation: BAE31012.1 AK160086 mRNA Translation: BAE35617.1 AK166226 mRNA Translation: BAE38644.1 AK168667 mRNA Translation: BAE40519.1 AL669844 Genomic DNA No translation available. AL669951 Genomic DNA No translation available. BC034261 mRNA Translation: AAH34261.1 |
CCDSi | CCDS36125.1 [Q5SRY7-2] CCDS70157.1 [Q5SRY7-1] CCDS70158.1 [Q5SRY7-3] |
RefSeqi | NP_001258276.1, NM_001271347.1 [Q5SRY7-1] NP_001258277.1, NM_001271348.1 [Q5SRY7-3] NP_001258278.1, NM_001271349.1 [Q5SRY7-4] NP_598776.1, NM_134015.3 [Q5SRY7-2] |
3D structure databases
SMRi | Q5SRY7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 222123, 34 interactors |
DIPi | DIP-59921N |
IntActi | Q5SRY7, 21 interactors |
STRINGi | 10090.ENSMUSP00000075721 |
PTM databases
iPTMneti | Q5SRY7 |
PhosphoSitePlusi | Q5SRY7 |
SwissPalmi | Q5SRY7 |
Proteomic databases
EPDi | Q5SRY7 |
PaxDbi | Q5SRY7 |
PeptideAtlasi | Q5SRY7 |
PRIDEi | Q5SRY7 |
Protocols and materials databases
Antibodypediai | 28871, 235 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000076383; ENSMUSP00000075721; ENSMUSG00000020271 [Q5SRY7-2] ENSMUST00000093205; ENSMUSP00000090893; ENSMUSG00000020271 [Q5SRY7-1] ENSMUST00000109366; ENSMUSP00000104991; ENSMUSG00000020271 [Q5SRY7-3] |
GeneIDi | 103583 |
KEGGi | mmu:103583 |
UCSCi | uc007ijx.2, mouse [Q5SRY7-2] uc007ijy.2, mouse [Q5SRY7-3] uc007ijz.2, mouse [Q5SRY7-1] uc007ika.2, mouse [Q5SRY7-4] |
Organism-specific databases
CTDi | 23291 |
MGIi | MGI:2144023, Fbxw11 |
Phylogenomic databases
eggNOGi | KOG0281, Eukaryota |
GeneTreei | ENSGT00940000155898 |
HOGENOMi | CLU_000288_103_6_1 |
InParanoidi | Q5SRY7 |
OMAi | AHNFDVF |
OrthoDBi | 666965at2759 |
TreeFami | TF105679 |
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-202424, Downstream TCR signaling R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 103583, 9 hits in 19 CRISPR screens |
ChiTaRSi | Fbxw11, mouse |
PROi | PR:Q5SRY7 |
RNActi | Q5SRY7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020271, Expressed in cumulus cell and 309 other tissues |
ExpressionAtlasi | Q5SRY7, baseline and differential |
Genevisiblei | Q5SRY7, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR021977, Beta-TrCP_D IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12125, Beta-TrCP_D, 1 hit PF12937, F-box-like, 1 hit PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM01028, Beta-TrCP_D, 1 hit SM00256, FBOX, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS00678, WD_REPEATS_1, 5 hits PS50082, WD_REPEATS_2, 7 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBW1B_MOUSE | |
Accessioni | Q5SRY7Primary (citable) accession number: Q5SRY7 Secondary accession number(s): Q3TGM9 Q923H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot