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Protein

TOM1-like protein 2

Gene

Tom1l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable role in protein transport. May regulate growth factor-induced mitogenic signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 2
Alternative name(s):
Target of Myb-like protein 2
Gene namesi
Name:Tom1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443306 Tom1l2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002787911 – 507TOM1-like protein 2Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineCombined sources1
Modified residuei164PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SRX1
PeptideAtlasiQ5SRX1
PRIDEiQ5SRX1

PTM databases

iPTMnetiQ5SRX1
PhosphoSitePlusiQ5SRX1

Expressioni

Tissue specificityi

Ubiquitously expressed. Splicing pattern displays tissue specific variation.1 Publication

Gene expression databases

BgeeiENSMUSG00000000538 Expressed in 247 organ(s), highest expression level in ear
CleanExiMM_TOM1L2
ExpressionAtlasiQ5SRX1 baseline and differential
GenevisibleiQ5SRX1 MM

Interactioni

Subunit structurei

Interacts with clathrin, SRC and TOLLIP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229791, 1 interactor
IntActiQ5SRX1, 1 interactor
MINTiQ5SRX1
STRINGi10090.ENSMUSP00000099744

Structurei

3D structure databases

ProteinModelPortaliQ5SRX1
SMRiQ5SRX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 152VHSPROSITE-ProRule annotationAdd BLAST133
Domaini219 – 307GATPROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 334Clathrin-binding6

Domaini

The GAT domain mediates interaction with TOLLIP.By similarity

Sequence similaritiesi

Belongs to the TOM1 family.Curated

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOVERGENiHBG025068
InParanoidiQ5SRX1
OMAiQRKNVKY
OrthoDBiEOG091G08M1
PhylomeDBiQ5SRX1
TreeFamiTF314105

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027429 TOM1L2
IPR002014 VHS_dom
PANTHERiPTHR13856:SF31 PTHR13856:SF31, 1 hit
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SRX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA
60 70 80 90 100
IRALKKRLSG NRNYREVMLA LTVLETCVKN CGHRFHLLVA NRDFIDSVLV
110 120 130 140 150
KIISPKNNPP TIVQDKVLAL IQAWADAFRS SPDLTGVVHI YEELKRRGIE
160 170 180 190 200
FPMADLDALS PIHTPQRSVP EMDPAATIPR SQTQPRTTAG TYSSPPPASY
210 220 230 240 250
STLQAPALSV TGPITANSEQ IARLRSELDI VRGNTKVMSE MLTEMVPGQE
260 270 280 290 300
DSSDLELLQE LNRTCRAMQH RIVELISRVS NEEVTEELLH VNDDLNNVFL
310 320 330 340 350
RYERFERYRS GRSVQNASNG VLSEVTEDNL IDLGPGSPAV VSPMVGSTAP
360 370 380 390 400
PSSLSSQLAG LDLGTESVSG TLSSLQQCKP QDGFDMFAQT RGNSLAEQRK
410 420 430 440 450
TVTYEDPQAV GGLASALDNR KQNSEMIPVA QPSVMDDIEV WLRTDLKGDD
460 470 480 490 500
LEEGVTSEEF DKFLEERAKA AETVPDLPSP PTEAPAPASN TSTRKKPERS

DDALFAL
Length:507
Mass (Da):55,663
Last modified:December 21, 2004 - v1
Checksum:iBE1A56C6EFEE7F25
GO
Isoform 2 (identifier: Q5SRX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-446: Missing.

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):53,383
Checksum:iEACD6C5C8352BBC0
GO
Isoform 3 (identifier: Q5SRX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-440: IPVAQPSVMDDIEV → VGLHTCVLPTVFWR
     441-507: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):48,408
Checksum:iED86C2E36FCC05B8
GO
Isoform 4 (identifier: Q5SRX1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-450: IPVAQPSVMDDIEVWLRTDLKGDD → EMYGNACLSAWQGRRRLPGPPGLE
     451-507: Missing.

Note: No experimental confirmation available.
Show »
Length:450
Mass (Da):49,439
Checksum:i6EA7604813A26D88
GO
Isoform 5 (identifier: Q5SRX1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-286: ELNRTCRAMQHRIVELISRVSNEEVTE → VFQVCPSTAHESNRETCELLVWRFLEK
     287-507: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:286
Mass (Da):31,789
Checksum:i8AA0424F6A7107A8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SXA5Q5SXA5_MOUSE
TOM1-like protein 2
Tom1l2
457Annotation score:
Q5SXA4Q5SXA4_MOUSE
TOM1-like protein 2
Tom1l2
462Annotation score:
F6ZDJ1F6ZDJ1_MOUSE
TOM1-like protein 2
Tom1l2
199Annotation score:
F6RBX1F6RBX1_MOUSE
TOM1-like protein 2
Tom1l2
179Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42E → K in AAH62947 (PubMed:15489334).Curated1
Sequence conflicti131S → G in BAC29576 (PubMed:16141072).Curated1
Sequence conflicti414A → T in AAL77033 (PubMed:11997338).Curated1
Sequence conflicti418D → G in BAC31458 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023393260 – 286ELNRT…EEVTE → VFQVCPSTAHESNRETCELL VWRFLEK in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_023394287 – 507Missing in isoform 5. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_023395427 – 450IPVAQ…LKGDD → EMYGNACLSAWQGRRRLPGP PGLE in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_023396427 – 446Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_023397427 – 440IPVAQ…DDIEV → VGLHTCVLPTVFWR in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_023398441 – 507Missing in isoform 3. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_023399451 – 507Missing in isoform 4. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467887 mRNA Translation: AAL77033.1
AK036788 mRNA Translation: BAC29576.1
AK043095 mRNA Translation: BAC31458.1
AK054531 mRNA Translation: BAC35813.1
AK166040 mRNA Translation: BAE38537.1
AL596090, AL669954 Genomic DNA Translation: CAI24070.1
AL596090, AL669954 Genomic DNA Translation: CAI24071.1
AL596090, AL669954 Genomic DNA Translation: CAI24072.1
AL669954, AL596090 Genomic DNA Translation: CAI25761.1
AL669954, AL596090 Genomic DNA Translation: CAI25762.1
AL669954, AL596090 Genomic DNA Translation: CAI25763.1
BC062947 mRNA Translation: AAH62947.2
BC127266 mRNA Translation: AAI27267.1
CCDSiCCDS24786.1 [Q5SRX1-1]
CCDS24787.1 [Q5SRX1-3]
CCDS36171.1 [Q5SRX1-2]
RefSeqiNP_001034181.1, NM_001039092.3 [Q5SRX1-2]
NP_001034182.1, NM_001039093.1 [Q5SRX1-3]
NP_694720.2, NM_153080.2 [Q5SRX1-1]
XP_006532930.1, XM_006532867.3
UniGeneiMm.218875

Genome annotation databases

EnsembliENSMUST00000064019; ENSMUSP00000063414; ENSMUSG00000000538 [Q5SRX1-4]
ENSMUST00000095254; ENSMUSP00000092884; ENSMUSG00000000538 [Q5SRX1-2]
ENSMUST00000102682; ENSMUSP00000099743; ENSMUSG00000000538 [Q5SRX1-3]
ENSMUST00000102683; ENSMUSP00000099744; ENSMUSG00000000538 [Q5SRX1-1]
GeneIDi216810
KEGGimmu:216810
UCSCiuc007jfq.1 mouse [Q5SRX1-1]
uc007jfr.1 mouse [Q5SRX1-2]
uc007jft.1 mouse [Q5SRX1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467887 mRNA Translation: AAL77033.1
AK036788 mRNA Translation: BAC29576.1
AK043095 mRNA Translation: BAC31458.1
AK054531 mRNA Translation: BAC35813.1
AK166040 mRNA Translation: BAE38537.1
AL596090, AL669954 Genomic DNA Translation: CAI24070.1
AL596090, AL669954 Genomic DNA Translation: CAI24071.1
AL596090, AL669954 Genomic DNA Translation: CAI24072.1
AL669954, AL596090 Genomic DNA Translation: CAI25761.1
AL669954, AL596090 Genomic DNA Translation: CAI25762.1
AL669954, AL596090 Genomic DNA Translation: CAI25763.1
BC062947 mRNA Translation: AAH62947.2
BC127266 mRNA Translation: AAI27267.1
CCDSiCCDS24786.1 [Q5SRX1-1]
CCDS24787.1 [Q5SRX1-3]
CCDS36171.1 [Q5SRX1-2]
RefSeqiNP_001034181.1, NM_001039092.3 [Q5SRX1-2]
NP_001034182.1, NM_001039093.1 [Q5SRX1-3]
NP_694720.2, NM_153080.2 [Q5SRX1-1]
XP_006532930.1, XM_006532867.3
UniGeneiMm.218875

3D structure databases

ProteinModelPortaliQ5SRX1
SMRiQ5SRX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229791, 1 interactor
IntActiQ5SRX1, 1 interactor
MINTiQ5SRX1
STRINGi10090.ENSMUSP00000099744

PTM databases

iPTMnetiQ5SRX1
PhosphoSitePlusiQ5SRX1

Proteomic databases

PaxDbiQ5SRX1
PeptideAtlasiQ5SRX1
PRIDEiQ5SRX1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064019; ENSMUSP00000063414; ENSMUSG00000000538 [Q5SRX1-4]
ENSMUST00000095254; ENSMUSP00000092884; ENSMUSG00000000538 [Q5SRX1-2]
ENSMUST00000102682; ENSMUSP00000099743; ENSMUSG00000000538 [Q5SRX1-3]
ENSMUST00000102683; ENSMUSP00000099744; ENSMUSG00000000538 [Q5SRX1-1]
GeneIDi216810
KEGGimmu:216810
UCSCiuc007jfq.1 mouse [Q5SRX1-1]
uc007jfr.1 mouse [Q5SRX1-2]
uc007jft.1 mouse [Q5SRX1-3]

Organism-specific databases

CTDi146691
MGIiMGI:2443306 Tom1l2

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOVERGENiHBG025068
InParanoidiQ5SRX1
OMAiQRKNVKY
OrthoDBiEOG091G08M1
PhylomeDBiQ5SRX1
TreeFamiTF314105

Miscellaneous databases

PROiPR:Q5SRX1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000538 Expressed in 247 organ(s), highest expression level in ear
CleanExiMM_TOM1L2
ExpressionAtlasiQ5SRX1 baseline and differential
GenevisibleiQ5SRX1 MM

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027429 TOM1L2
IPR002014 VHS_dom
PANTHERiPTHR13856:SF31 PTHR13856:SF31, 1 hit
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM1L2_MOUSE
AccessioniPrimary (citable) accession number: Q5SRX1
Secondary accession number(s): A0JP66
, Q5SRX7, Q5SRY0, Q6P5D7, Q8C6J0, Q8C935, Q8CB51, Q8R4H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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