UniProtKB - Q5SRQ6 (Q5SRQ6_HUMAN)
Protein
Casein kinase II subunit beta
Gene
CSNK2B
Organism
Homo sapiens (Human)
Status
Functioni
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.UniRule annotation
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- protein kinase regulator activity Source: InterPro
- ribonucleoprotein complex binding Source: Ensembl
GO - Biological processi
- liver regeneration Source: Ensembl
- response to testosterone Source: Ensembl
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | KinaseImported, Transferase |
Biological process | Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase II subunit betaUniRule annotationARBA annotationShort name: CK II betaUniRule annotation |
Gene namesi | Name:CSNK2BImported ORF Names:hCG_43725Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2460, CSNK2B |
VEuPathDBi | HostDB:ENSG00000204435.13 |
Subcellular locationi
Nucleus
- nuclear matrix Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- chromatin Source: Ensembl
- cilium Source: Ensembl
- cytoplasm Source: Ensembl
- protein kinase CK2 complex Source: UniProtKB-UniRule
Expressioni
Gene expression databases
Bgeei | ENSG00000204435, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | Q5SRQ6, baseline and differential |
Interactioni
Subunit structurei
Tetramer of two alpha and two beta subunits.
UniRule annotationProtein-protein interaction databases
IntActi | Q5SRQ6, 3 interactors |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000003781 |
OMAi | QVPYYRE |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q5SRQ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKCKGTSRM AGTTSADVKM SSSEEVSWIS WFCGLRGNEF FCEVDEDYIQ
60 70 80 90 100
DKFNLTGLNE QVPHYRQALD MILDLEPDEE LEDNPNQSDL IEQAAEMLYG
110 120 130 140 150
LIHARYILTN RGIAQMLEKY QQGDFGYCPR VYCENQPMLP IGLSDIPGEA
160 170 180 190 200
MVKLYCPKCM DVYTPKSSRH HHTDGAYFGT GFPHMLFMVH PEYRPKRPAN
210 220 230
QFVPRLYGFK IHPMAYQLQL QAASNFKSPV KTIR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP67870 | CSK2B_HUMAN | Casein kinase II subunit beta | CSNK2B CK2N, G5A | 215 | Annotation score: | ||
Q5SRQ3 | Q5SRQ3_HUMAN | Casein kinase II subunit beta | CSNK2B CSNK2B-LY6G5B-1181 | 228 | Annotation score: | ||
N0E644 | N0E644_HUMAN | Casein kinase II subunit beta | CSNK2B CSNK2B-LY6G5B-562 | 161 | Annotation score: | ||
A0A0G2JM58 | A0A0G2JM58_HUMAN | Casein kinase II subunit beta | CSNK2B | 161 | Annotation score: | ||
N0E472 | N0E472_HUMAN | Casein kinase II subunit beta | CSNK2B CSNK2B-LY6G5B--991 | 304 | Annotation score: | ||
A0A0G2JM12 | A0A0G2JM12_HUMAN | Casein kinase II subunit beta | CSNK2B | 304 | Annotation score: | ||
H0Y6P8 | H0Y6P8_HUMAN | Uncharacterized protein | 212 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03475.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03475.1 |
3D structure databases
SMRi | Q5SRQ6 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q5SRQ6, 3 interactors |
Proteomic databases
MaxQBi | Q5SRQ6 |
PRIDEi | Q5SRQ6 |
ProteomicsDBi | 63864 |
Protocols and materials databases
Antibodypediai | 1045, 586 antibodies |
Genome annotation databases
Organism-specific databases
HGNCi | HGNC:2460, CSNK2B |
OpenTargetsi | ENSG00000204435 |
VEuPathDBi | HostDB:ENSG00000204435.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000003781 |
OMAi | QVPYYRE |
Miscellaneous databases
ChiTaRSi | CSNK2B, human |
Gene expression databases
Bgeei | ENSG00000204435, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | Q5SRQ6, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SRQ6_HUMAN | |
Accessioni | Q5SRQ6Primary (citable) accession number: Q5SRQ6 Secondary accession number(s): Q5SQ53 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |