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Entry version 130 (16 Oct 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Glycoprotein endo-alpha-1,2-mannosidase

Gene

MANEA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 6.2.1 Publication

Temperature dependencei

Optimum temperature is 37 degrees Celsius.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS16090-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.130 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH99 Glycoside Hydrolase Family 99

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycoprotein endo-alpha-1,2-mannosidase (EC:3.2.1.1302 Publications)
Short name:
Endo-alpha mannosidase
Short name:
Endomannosidase
Short name:
hEndo
Alternative name(s):
Mandaselin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MANEA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21072 MANEA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612327 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SRI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 462LumenalSequence analysisAdd BLAST433

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79694

Open Targets

More...
OpenTargetsi
ENSG00000172469

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134891001

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5SRI9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MANEA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743637

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002823151 – 462Glycoprotein endo-alpha-1,2-mannosidaseAdd BLAST462

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic cleavage in the C-terminal region.

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SRI9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SRI9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5SRI9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SRI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SRI9

PeptideAtlas

More...
PeptideAtlasi
Q5SRI9

PRoteomics IDEntifications database

More...
PRIDEi
Q5SRI9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63853

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SRI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SRI9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5SRI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172469 Expressed in 198 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SRI9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SRI9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011046
HPA011069

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122815, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q5SRI9, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351669

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SRI9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 462CatalyticCuratedAdd BLAST403

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 99 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG22 Eukaryota
ENOG410XT8Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016054

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SRI9

KEGG Orthology (KO)

More...
KOi
K15538

Identification of Orthologs from Complete Genome Data

More...
OMAi
ASYNNWP

Database of Orthologous Groups

More...
OrthoDBi
975667at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SRI9

TreeFam database of animal gene trees

More...
TreeFami
TF324051

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11574 GH99, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026071 Glyco_Hydrolase_99
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

More...
PANTHERi
PTHR13572 PTHR13572, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16317 Glyco_hydro_99, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SRI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKFRRRTCI ILALFILFIF SLMMGLKMLR PNTATFGAPF GLDLLPELHQ
60 70 80 90 100
RTIHLGKNFD FQKSDRINSE TNTKNLKSVE ITMKPSKASE LNLDELPPLN
110 120 130 140 150
NYLHVFYYSW YGNPQFDGKY IHWNHPVLEH WDPRIAKNYP QGRHNPPDDI
160 170 180 190 200
GSSFYPELGS YSSRDPSVIE THMRQMRSAS IGVLALSWYP PDVNDENGEP
210 220 230 240 250
TDNLVPTILD KAHKYNLKVT FHIEPYSNRD DQNMYKNVKY IIDKYGNHPA
260 270 280 290 300
FYRYKTKTGN ALPMFYVYDS YITKPEKWAN LLTTSGSRSI RNSPYDGLFI
310 320 330 340 350
ALLVEEKHKY DILQSGFDGI YTYFATNGFT YGSSHQNWAS LKLFCDKYNL
360 370 380 390 400
IFIPSVGPGY IDTSIRPWNT QNTRNRINGK YYEIGLSAAL QTRPSLISIT
410 420 430 440 450
SFNEWHEGTQ IEKAVPKRTS NTVYLDYRPH KPGLYLELTR KWSEKYSKER
460
ATYALDRQLP VS
Length:462
Mass (Da):53,671
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB593CB9B3DAA056
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R7A2X6R7A2_HUMAN
Glycoprotein endo-alpha-1,2-mannosi...
MANEA
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL07306 differs from that shown. Reason: Frameshift.Curated
The sequence CAD97640 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129E → G in CAD97640 (PubMed:17974005).Curated1
Sequence conflicti237N → S in CAE12165 (PubMed:15760709).Curated1
Sequence conflicti344F → I in AAQ75077 (PubMed:15677381).Curated1
Sequence conflicti344F → I in BAB14298 (PubMed:14702039).Curated1
Sequence conflicti344F → I in CAE45927 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036242331Y → C in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780723017Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ577574 mRNA Translation: CAE12165.1
AY372528 mRNA Translation: AAQ75077.1
AK022900 mRNA Translation: BAB14298.1
AK291940 mRNA Translation: BAF84629.1
BX537398 mRNA Translation: CAD97640.1 Different initiation.
BX640869 mRNA Translation: CAE45927.1
AL671884 Genomic DNA No translation available.
BC137014 mRNA Translation: AAI37015.1
BC137016 mRNA Translation: AAI37017.1
BC146671 mRNA Translation: AAI46672.1
BC150199 mRNA Translation: AAI50200.1
AY048774 mRNA Translation: AAL07306.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5032.1

NCBI Reference Sequences

More...
RefSeqi
NP_078917.2, NM_024641.3
XP_005267204.1, XM_005267147.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358812; ENSP00000351669; ENSG00000172469

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79694

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79694

UCSC genome browser

More...
UCSCi
uc003poo.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577574 mRNA Translation: CAE12165.1
AY372528 mRNA Translation: AAQ75077.1
AK022900 mRNA Translation: BAB14298.1
AK291940 mRNA Translation: BAF84629.1
BX537398 mRNA Translation: CAD97640.1 Different initiation.
BX640869 mRNA Translation: CAE45927.1
AL671884 Genomic DNA No translation available.
BC137014 mRNA Translation: AAI37015.1
BC137016 mRNA Translation: AAI37017.1
BC146671 mRNA Translation: AAI46672.1
BC150199 mRNA Translation: AAI50200.1
AY048774 mRNA Translation: AAL07306.1 Frameshift.
CCDSiCCDS5032.1
RefSeqiNP_078917.2, NM_024641.3
XP_005267204.1, XM_005267147.3

3D structure databases

SMRiQ5SRI9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122815, 26 interactors
IntActiQ5SRI9, 16 interactors
STRINGi9606.ENSP00000351669

Protein family/group databases

CAZyiGH99 Glycoside Hydrolase Family 99

PTM databases

iPTMnetiQ5SRI9
PhosphoSitePlusiQ5SRI9
SwissPalmiQ5SRI9

Polymorphism and mutation databases

BioMutaiMANEA
DMDMi74743637

Proteomic databases

EPDiQ5SRI9
jPOSTiQ5SRI9
MassIVEiQ5SRI9
MaxQBiQ5SRI9
PaxDbiQ5SRI9
PeptideAtlasiQ5SRI9
PRIDEiQ5SRI9
ProteomicsDBi63853

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79694

Genome annotation databases

EnsembliENST00000358812; ENSP00000351669; ENSG00000172469
GeneIDi79694
KEGGihsa:79694
UCSCiuc003poo.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79694
DisGeNETi79694

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MANEA
HGNCiHGNC:21072 MANEA
HPAiHPA011046
HPA011069
MIMi612327 gene
neXtProtiNX_Q5SRI9
OpenTargetsiENSG00000172469
PharmGKBiPA134891001

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG22 Eukaryota
ENOG410XT8Q LUCA
GeneTreeiENSGT00390000016054
InParanoidiQ5SRI9
KOiK15538
OMAiASYNNWP
OrthoDBi975667at2759
PhylomeDBiQ5SRI9
TreeFamiTF324051

Enzyme and pathway databases

BioCyciMetaCyc:HS16090-MONOMER
BRENDAi3.2.1.130 2681
ReactomeiR-HSA-964739 N-glycan trimming and elongation in the cis-Golgi

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MANEA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79694
PharosiQ5SRI9

Protein Ontology

More...
PROi
PR:Q5SRI9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172469 Expressed in 198 organ(s), highest expression level in kidney
ExpressionAtlasiQ5SRI9 baseline and differential
GenevisibleiQ5SRI9 HS

Family and domain databases

CDDicd11574 GH99, 1 hit
InterProiView protein in InterPro
IPR026071 Glyco_Hydrolase_99
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR13572 PTHR13572, 1 hit
PfamiView protein in Pfam
PF16317 Glyco_hydro_99, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMANEA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SRI9
Secondary accession number(s): A6H8M6
, Q5SRJ0, Q6MZV0, Q70JE9, Q7Z3V7, Q8WWX5, Q9H9D2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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