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Entry version 135 (17 Jun 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Tetratricopeptide repeat protein 39A

Gene

TTC39A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 39A
Short name:
TPR repeat protein 39A
Alternative name(s):
Differentially expressed in MCF7 with estradiol protein 6
Short name:
DEME-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC39A
Synonyms:C1orf34, KIAA0452
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000085831.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18657 TTC39A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SRH9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22996

Open Targets

More...
OpenTargetsi
ENSG00000085831

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162407260

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5SRH9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC39A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743633

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002919961 – 613Tetratricopeptide repeat protein 39AAdd BLAST613

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5SRH9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5SRH9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SRH9

PeptideAtlas

More...
PeptideAtlasi
Q5SRH9

PRoteomics IDEntifications database

More...
PRIDEi
Q5SRH9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17678
33736
63849 [Q5SRH9-1]
63850 [Q5SRH9-2]
63851 [Q5SRH9-3]
63852 [Q5SRH9-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q5SRH9-1 [Q5SRH9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SRH9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SRH9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085831 Expressed in testis and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SRH9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SRH9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000085831 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116643, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q5SRH9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393952

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5SRH9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5SRH9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati315 – 348TPR 1Add BLAST34
Repeati505 – 538TPR 2Add BLAST34
Repeati546 – 579TPR 3Add BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC39 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182917

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_108974_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SRH9

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELGYNEF

Database of Orthologous Groups

More...
OrthoDBi
754120at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SRH9

TreeFam database of animal gene trees

More...
TreeFami
TF313761

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019412 Iml2/TPR_39
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR030416 TTC39A

The PANTHER Classification System

More...
PANTHERi
PTHR31859 PTHR31859, 1 hit
PTHR31859:SF3 PTHR31859:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10300 DUF3808, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SRH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQKGHKDSL YPCGGTPESS LHEALDQCMT ALDLFLTNQF SEALSYLKPR
60 70 80 90 100
TKESMYHSLT YATILEMQAM MTFDPQDILL AGNMMKEAQM LCQRHRRKSS
110 120 130 140 150
VTDSFSSLVN RPTLGQFTEE EIHAEVCYAE CLLQRAALTF LQGSSHGGAV
160 170 180 190 200
RPRALHDPSH ACSCPPGPGR QHLFLLQDEN MVSFIKGGIK VRNSYQTYKE
210 220 230 240 250
LDSLVQSSQY CKGENHPHFE GGVKLGVGAF NLTLSMLPTR ILRLLEFVGF
260 270 280 290 300
SGNKDYGLLQ LEEGASGHSF RSVLCVMLLL CYHTFLTFVL GTGNVNIEEA
310 320 330 340 350
EKLLKPYLNR YPKGAIFLFF AGRIEVIKGN IDAAIRRFEE CCEAQQHWKQ
360 370 380 390 400
FHHMCYWELM WCFTYKGQWK MSYFYADLLS KENCWSKATY IYMKAAYLSM
410 420 430 440 450
FGKEDHKPFG DDEVELFRAV PGLKLKIAGK SLPTEKFAIR KSRRYFSSNP
460 470 480 490 500
ISLPVPALEM MYIWNGYAVI GKQPKLTDGI LEIITKAEEM LEKGPENEYS
510 520 530 540 550
VDDECLVKLL KGLCLKYLGR VQEAEENFRS ISANEKKIKY DHYLIPNALL
560 570 580 590 600
ELALLLMEQD RNEEAIKLLE SAKQNYKNYS MESRTHFRIQ AATLQAKSSL
610
ENSSRSMVSS VSL
Length:613
Mass (Da):69,778
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23B898B6016F7E6F
GO
Isoform 2 (identifier: Q5SRH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Show »
Length:221
Mass (Da):25,147
Checksum:i7CFC06CC98B35CAE
GO
Isoform 3 (identifier: Q5SRH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGQKGHKDSLYPCGG → MDSSPSLPLIR
     334-424: AIRRFEECCE...ELFRAVPGLK → VSDGGPGRGW...LQWREVEGGA
     425-613: Missing.

Show »
Length:420
Mass (Da):46,394
Checksum:iF015AB6661598C91
GO
Isoform 4 (identifier: Q5SRH9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGQKGHKDSLYPCGG → MAFLTTWKEAASGKSDRR
     143-177: Missing.

Show »
Length:581
Mass (Da):66,630
Checksum:i18D58CC091644EA4
GO
Isoform 5 (identifier: Q5SRH9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGQKGHKDSLYPCG → MTSAGGAPGALPA
     143-177: Missing.

Show »
Length:577
Mass (Da):65,732
Checksum:iF975764F4EF63FD7
GO
Isoform 6 (identifier: Q5SRH9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-177: Missing.

Show »
Length:578
Mass (Da):66,152
Checksum:i84D3025AFABC23D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WE04F6WE04_HUMAN
HCG40295, isoform CRA_d
TTC39A hCG_40295
550Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRQ0A0A0A0MRQ0_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHX9E9PHX9_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PAZ4E9PAZ4_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ33E9PQ33_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W961F8W961_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSH8A0A0A0MSH8_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQX3E9PQX3_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U5GXS1U5GXS1_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSW9A0A0A0MSW9_HUMAN
Tetratricopeptide repeat protein 39...
TTC39A
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH28374 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA32297 differs from that shown. Reason: Frameshift.Curated
The sequence BAA32297 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti175L → V in AAH28374 (PubMed:15489334).Curated1
Sequence conflicti338F → L in BAH13518 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0263481 – 392Missing in isoform 2. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_0263491 – 15MGQKG…YPCGG → MDSSPSLPLIR in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0263501 – 15MGQKG…YPCGG → MAFLTTWKEAASGKSDRR in isoform 4. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0471981 – 14MGQKG…LYPCG → MTSAGGAPGALPA in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_026351143 – 177Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_026352334 – 424AIRRF…VPGLK → VSDGGPGRGWGSLGVSQTSR KSGTCDILRDRIDWGRGGGQ ERTNQRAGAGEALLAEQPGK TREEEAFVVPGILTGRYRTA ALQWREVEGGA in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_026353425 – 613Missing in isoform 3. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007921 mRNA Translation: BAA32297.1 Sequence problems.
AK301587 mRNA Translation: BAH13518.1
AL162430 Genomic DNA No translation available.
AL671986 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06826.1
BC004399 mRNA Translation: AAH04399.1
BC028374 mRNA Translation: AAH28374.1 Different initiation.
CX788693 mRNA No translation available.
AF007170 mRNA Translation: AAC39582.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44143.1 [Q5SRH9-4]
CCDS44144.1 [Q5SRH9-6]
CCDS72790.1 [Q5SRH9-1]
CCDS76162.1 [Q5SRH9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001073963.1, NM_001080494.3 [Q5SRH9-6]
NP_001138304.1, NM_001144832.2 [Q5SRH9-4]
NP_001284592.1, NM_001297663.1 [Q5SRH9-5]
NP_001284593.1, NM_001297664.1
NP_001284594.1, NM_001297665.1 [Q5SRH9-1]
NP_001284595.1, NM_001297666.1 [Q5SRH9-2]
NP_001284596.1, NM_001297667.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262676; ENSP00000262676; ENSG00000085831 [Q5SRH9-3]
ENST00000371750; ENSP00000360815; ENSG00000085831 [Q5SRH9-6]
ENST00000413473; ENSP00000406144; ENSG00000085831 [Q5SRH9-4]
ENST00000447632; ENSP00000393952; ENSG00000085831 [Q5SRH9-1]
ENST00000530004; ENSP00000431228; ENSG00000085831 [Q5SRH9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22996

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22996

UCSC genome browser

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UCSCi
uc001csj.4 human [Q5SRH9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007921 mRNA Translation: BAA32297.1 Sequence problems.
AK301587 mRNA Translation: BAH13518.1
AL162430 Genomic DNA No translation available.
AL671986 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06826.1
BC004399 mRNA Translation: AAH04399.1
BC028374 mRNA Translation: AAH28374.1 Different initiation.
CX788693 mRNA No translation available.
AF007170 mRNA Translation: AAC39582.1
CCDSiCCDS44143.1 [Q5SRH9-4]
CCDS44144.1 [Q5SRH9-6]
CCDS72790.1 [Q5SRH9-1]
CCDS76162.1 [Q5SRH9-2]
RefSeqiNP_001073963.1, NM_001080494.3 [Q5SRH9-6]
NP_001138304.1, NM_001144832.2 [Q5SRH9-4]
NP_001284592.1, NM_001297663.1 [Q5SRH9-5]
NP_001284593.1, NM_001297664.1
NP_001284594.1, NM_001297665.1 [Q5SRH9-1]
NP_001284595.1, NM_001297666.1 [Q5SRH9-2]
NP_001284596.1, NM_001297667.1

3D structure databases

SMRiQ5SRH9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116643, 2 interactors
IntActiQ5SRH9, 2 interactors
STRINGi9606.ENSP00000393952

PTM databases

iPTMnetiQ5SRH9
PhosphoSitePlusiQ5SRH9

Polymorphism and mutation databases

BioMutaiTTC39A
DMDMi74743633

Proteomic databases

jPOSTiQ5SRH9
MassIVEiQ5SRH9
MaxQBiQ5SRH9
PeptideAtlasiQ5SRH9
PRIDEiQ5SRH9
ProteomicsDBi17678
33736
63849 [Q5SRH9-1]
63850 [Q5SRH9-2]
63851 [Q5SRH9-3]
63852 [Q5SRH9-4]
TopDownProteomicsiQ5SRH9-1 [Q5SRH9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32939 27 antibodies

The DNASU plasmid repository

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DNASUi
22996

Genome annotation databases

EnsembliENST00000262676; ENSP00000262676; ENSG00000085831 [Q5SRH9-3]
ENST00000371750; ENSP00000360815; ENSG00000085831 [Q5SRH9-6]
ENST00000413473; ENSP00000406144; ENSG00000085831 [Q5SRH9-4]
ENST00000447632; ENSP00000393952; ENSG00000085831 [Q5SRH9-1]
ENST00000530004; ENSP00000431228; ENSG00000085831 [Q5SRH9-2]
GeneIDi22996
KEGGihsa:22996
UCSCiuc001csj.4 human [Q5SRH9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22996
DisGeNETi22996
EuPathDBiHostDB:ENSG00000085831.15

GeneCards: human genes, protein and diseases

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GeneCardsi
TTC39A
HGNCiHGNC:18657 TTC39A
HPAiENSG00000085831 Low tissue specificity
neXtProtiNX_Q5SRH9
OpenTargetsiENSG00000085831
PharmGKBiPA162407260

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00950000182917
HOGENOMiCLU_108974_0_0_1
InParanoidiQ5SRH9
OMAiELGYNEF
OrthoDBi754120at2759
PhylomeDBiQ5SRH9
TreeFamiTF313761

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22996 3 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTC39A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Tetratricopeptide_Repeat_39A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22996
PharosiQ5SRH9 Tdark

Protein Ontology

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PROi
PR:Q5SRH9
RNActiQ5SRH9 protein

Gene expression databases

BgeeiENSG00000085831 Expressed in testis and 180 other tissues
ExpressionAtlasiQ5SRH9 baseline and differential
GenevisibleiQ5SRH9 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR019412 Iml2/TPR_39
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR030416 TTC39A
PANTHERiPTHR31859 PTHR31859, 1 hit
PTHR31859:SF3 PTHR31859:SF3, 1 hit
PfamiView protein in Pfam
PF10300 DUF3808, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTT39A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SRH9
Secondary accession number(s): B7Z782
, E7EQY9, G3XAF8, O43417, O75040, Q5SRH5, Q5SRH6, Q5SRH7, Q5SRH8, Q5SRI0, Q5SRI1, Q5SRI2, Q5T7S1, Q6PIU8, Q9BT24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: June 17, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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