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Entry version 119 (07 Apr 2021)
Sequence version 2 (15 Jan 2008)
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Protein

Phytanoyl-CoA dioxygenase domain-containing protein 1

Gene

PHYHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA. Isoform 2 and isoform 3 probably lack enzyme activity.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe cation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is increased by ascorbate. Inhibited by myristoyl-CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei102Alpha-ketoglutarateBy similarity1
Binding sitei141Alpha-ketoglutarateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi156IronBy similarity1
Metal bindingi158IronBy similarity1
Binding sitei174Alpha-ketoglutarateBy similarity1
Metal bindingi246IronBy similarity1
Binding sitei248Alpha-ketoglutarateBy similarity1
Binding sitei257Alpha-ketoglutarateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5SRE7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC:1.-.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHYHD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23396, PHYHD1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SRE7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000175287.18

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
254295

Open Targets

More...
OpenTargetsi
ENSG00000175287

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134959674

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5SRE7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHYHD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166220781

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003136331 – 291Phytanoyl-CoA dioxygenase domain-containing protein 1Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SRE7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SRE7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5SRE7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SRE7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SRE7

PeptideAtlas

More...
PeptideAtlasi
Q5SRE7

PRoteomics IDEntifications database

More...
PRIDEi
Q5SRE7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63846 [Q5SRE7-1]
63847 [Q5SRE7-2]
63848 [Q5SRE7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SRE7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SRE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175287, Expressed in muscle tissue and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SRE7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SRE7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175287, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
129029, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5SRE7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309515

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5SRE7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1291
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SRE7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5SRE7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni156 – 158Alpha-ketoglutarate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PhyH family. PHYHD1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3290, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_048953_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SRE7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTRSRWA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SRE7

TreeFam database of animal gene trees

More...
TreeFami
TF300011

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008775, Phytyl_CoA_dOase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05721, PhyH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SRE7-1) [UniParc]FASTAAdd to basket
Also known as: A, PHYHD1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACLSPSQLQ KFQQDGFLVL EGFLSAEECV AMQQRIGEIV AEMDVPLHCR
60 70 80 90 100
TEFSTQEEEQ LRAQGSTDYF LSSGDKIRFF FEKGVFDEKG NFLVPPEKSI
110 120 130 140 150
NKIGHALHAH DPVFKSITHS FKVQTLARSL GLQMPVVVQS MYIFKQPHFG
160 170 180 190 200
GEVSPHQDAS FLYTEPLGRV LGVWIAVEDA TLENGCLWFI PGSHTSGVSR
210 220 230 240 250
RMVRAPVGSA PGTSFLGSEP ARDNSLFVPT PVQRGALVLI HGEVVHKSKQ
260 270 280 290
NLSDRSRQAY TFHLMEASGT TWSPENWLQP TAELPFPQLY T
Length:291
Mass (Da):32,411
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7796A6C35A2E97DD
GO
Isoform 2 (identifier: Q5SRE7-2) [UniParc]FASTAAdd to basket
Also known as: C, PHYHD1C

The sequence of this isoform differs from the canonical sequence as follows:
     125-145: Missing.

Show »
Length:270
Mass (Da):30,047
Checksum:iF28E4D75E929904E
GO
Isoform 3 (identifier: Q5SRE7-3) [UniParc]FASTAAdd to basket
Also known as: B, PHYHD1B

The sequence of this isoform differs from the canonical sequence as follows:
     146-291: QPHFGGEVSP...AELPFPQLYT → SPLIRTPPSC...RRAGALAPPG

Show »
Length:297
Mass (Da):32,668
Checksum:i806C69D3A9D997A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2Q0H7C2Q0_HUMAN
Phytanoyl-CoA dioxygenase domain-co...
PHYHD1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9M0G5E9M0_HUMAN
Phytanoyl-CoA dioxygenase domain co...
PHYHD1 hCG_30598
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I7HJS6I7HJS6_HUMAN
Phytanoyl-CoA dioxygenase domain-co...
PHYHD1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RJK6X6RJK6_HUMAN
Phytanoyl-CoA dioxygenase domain-co...
PHYHD1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3M4H7C3M4_HUMAN
Phytanoyl-CoA dioxygenase domain-co...
PHYHD1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RCI6X6RCI6_HUMAN
Phytanoyl-CoA dioxygenase domain-co...
PHYHD1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RFQ9X6RFQ9_HUMAN
Phytanoyl-CoA dioxygenase domain-co...
PHYHD1
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCG7F8WCG7_HUMAN
Phytanoyl-CoA dioxygenase domain-co...
PHYHD1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q5SRE7-3)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti193E → G in AAH09373 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050529222R → W. Corresponds to variant dbSNP:rs10988159Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030077125 – 145Missing in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_030078146 – 291QPHFG…PQLYT → SPLIRTPPSCTRSPWAGCWA CGSQWRMPRWRTAVSGSSLA PTPVVCQEGWSGPLLAQRLV PASLGQSQPGITASLCPPQC REGPWSSSMEKWYTRASRTS LTARARPTLSTSWRPLAPPG ARRTGSSQQLNCPFPNCTPK GSRRAGALAPPG in isoform 3. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095000 mRNA Translation: BAG52969.1
AL672142 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87844.1
CH471090 Genomic DNA Translation: EAW87845.1
CH471090 Genomic DNA Translation: EAW87847.1
BC009373 mRNA Translation: AAH09373.1
BC051300 mRNA Translation: AAH51300.1
BC053853 mRNA Translation: AAH53853.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43885.1 [Q5SRE7-1]
CCDS43886.1 [Q5SRE7-2]
CCDS6914.1 [Q5SRE7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001094346.1, NM_001100876.1 [Q5SRE7-1]
NP_001094347.1, NM_001100877.1 [Q5SRE7-2]
NP_777593.2, NM_174933.3 [Q5SRE7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308941; ENSP00000309515; ENSG00000175287 [Q5SRE7-3]
ENST00000353176; ENSP00000340945; ENSG00000175287 [Q5SRE7-2]
ENST00000372592; ENSP00000361673; ENSG00000175287 [Q5SRE7-1]
ENST00000421063; ENSP00000409928; ENSG00000175287 [Q5SRE7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
254295

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:254295

UCSC genome browser

More...
UCSCi
uc004bwn.3, human [Q5SRE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095000 mRNA Translation: BAG52969.1
AL672142 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87844.1
CH471090 Genomic DNA Translation: EAW87845.1
CH471090 Genomic DNA Translation: EAW87847.1
BC009373 mRNA Translation: AAH09373.1
BC051300 mRNA Translation: AAH51300.1
BC053853 mRNA Translation: AAH53853.1
CCDSiCCDS43885.1 [Q5SRE7-1]
CCDS43886.1 [Q5SRE7-2]
CCDS6914.1 [Q5SRE7-3]
RefSeqiNP_001094346.1, NM_001100876.1 [Q5SRE7-1]
NP_001094347.1, NM_001100877.1 [Q5SRE7-2]
NP_777593.2, NM_174933.3 [Q5SRE7-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OPWX-ray1.90A1-291[»]
3OBZX-ray2.15A1-291[»]
SMRiQ5SRE7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi129029, 3 interactors
IntActiQ5SRE7, 3 interactors
STRINGi9606.ENSP00000309515

PTM databases

iPTMnetiQ5SRE7
PhosphoSitePlusiQ5SRE7

Genetic variation databases

BioMutaiPHYHD1
DMDMi166220781

Proteomic databases

EPDiQ5SRE7
jPOSTiQ5SRE7
MassIVEiQ5SRE7
MaxQBiQ5SRE7
PaxDbiQ5SRE7
PeptideAtlasiQ5SRE7
PRIDEiQ5SRE7
ProteomicsDBi63846 [Q5SRE7-1]
63847 [Q5SRE7-2]
63848 [Q5SRE7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2006, 137 antibodies

The DNASU plasmid repository

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DNASUi
254295

Genome annotation databases

EnsembliENST00000308941; ENSP00000309515; ENSG00000175287 [Q5SRE7-3]
ENST00000353176; ENSP00000340945; ENSG00000175287 [Q5SRE7-2]
ENST00000372592; ENSP00000361673; ENSG00000175287 [Q5SRE7-1]
ENST00000421063; ENSP00000409928; ENSG00000175287 [Q5SRE7-2]
GeneIDi254295
KEGGihsa:254295
UCSCiuc004bwn.3, human [Q5SRE7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
254295
DisGeNETi254295

GeneCards: human genes, protein and diseases

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GeneCardsi
PHYHD1
HGNCiHGNC:23396, PHYHD1
HPAiENSG00000175287, Low tissue specificity
neXtProtiNX_Q5SRE7
OpenTargetsiENSG00000175287
PharmGKBiPA134959674
VEuPathDBiHostDB:ENSG00000175287.18

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3290, Eukaryota
GeneTreeiENSGT00390000006287
HOGENOMiCLU_048953_0_0_1
InParanoidiQ5SRE7
OMAiCTRSRWA
PhylomeDBiQ5SRE7
TreeFamiTF300011

Enzyme and pathway databases

PathwayCommonsiQ5SRE7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
254295, 7 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PHYHD1, human
EvolutionaryTraceiQ5SRE7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
254295
PharosiQ5SRE7, Tdark

Protein Ontology

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PROi
PR:Q5SRE7
RNActiQ5SRE7, protein

Gene expression databases

BgeeiENSG00000175287, Expressed in muscle tissue and 196 other tissues
ExpressionAtlasiQ5SRE7, baseline and differential
GenevisibleiQ5SRE7, HS

Family and domain databases

InterProiView protein in InterPro
IPR008775, Phytyl_CoA_dOase
PfamiView protein in Pfam
PF05721, PhyH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHYD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SRE7
Secondary accession number(s): A6PWN9
, A6PWP0, B3KT57, B4E3X8, Q5SRE9, Q5SRF0, Q7Z623, Q7Z7P9, Q96GM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 7, 2021
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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