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UniProtKB - Q5SRE5 (NU188_HUMAN)

Entry version 148 (02 Jun 2021)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

Nucleoporin NUP188

Gene

NUP188

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884).

1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5SRE5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1169408, ISG15 antiviral mechanism
R-HSA-159227, Transport of the SLBP independent Mature mRNA
R-HSA-159230, Transport of the SLBP Dependant Mature mRNA
R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276, NS1 Mediated Effects on Host Pathways
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746, Nuclear import of Rev protein
R-HSA-180910, Vpr-mediated nuclear import of PICs
R-HSA-191859, snRNP Assembly
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-4085377, SUMOylation of SUMOylation proteins
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4615885, SUMOylation of DNA replication proteins
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q5SRE5

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin NUP188Curated
Short name:
hNup188
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP188
Synonyms:KIAA0169
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17859, NUP188

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615587, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5SRE5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000095319.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.1 Publication
Sandestig-Stefanova syndrome (SANDSTEF)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by pre- and postnatal microcephaly, trigonocephaly, congenital bilateral cataract, microphthalmia, cleft lip and palate or high-arched palate, camptodactyly, rocker-bottom feet, heart anomalies, specific brain changes such as loss of periventricular white matter, thin corpus callosum, and delayed myelinization.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083845113 – 1749Missing in SANDSTEF. 1 PublicationAdd BLAST1637
Natural variantiVAR_083846630 – 1749Missing in SANDSTEF. 1 PublicationAdd BLAST1120
Natural variantiVAR_0838471048 – 1749Missing in SANDSTEF; undetectable protein expression; loss of nuclear localization. 1 PublicationAdd BLAST702
Natural variantiVAR_0838481360 – 1749Missing in SANDSTEF. 1 PublicationAdd BLAST390

Keywords - Diseasei

Cataract, Disease variant, Microphthalmia

Organism-specific databases

DisGeNET

More...DisGeNETi		23511

MalaCards human disease database

More...MalaCardsi		NUP188
MIMi618804, phenotype

Open Targets

More...OpenTargetsi		ENSG00000095319

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134908952

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5SRE5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NUP188

Domain mapping of disease mutations (DMDM)

More...DMDMi		74743623

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991722 – 1749Nucleoporin NUP188Add BLAST1748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei1523PhosphoserineCombined sources1
Modified residuei1709PhosphoserineCombined sources1
Modified residuei1712PhosphothreonineCombined sources1
Modified residuei1717PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5SRE5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5SRE5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5SRE5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5SRE5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5SRE5

PeptideAtlas

More...PeptideAtlasi		Q5SRE5

PRoteomics IDEntifications database

More...PRIDEi		Q5SRE5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63844 [Q5SRE5-1]
63845 [Q5SRE5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5SRE5

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q5SRE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5SRE5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q5SRE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000095319, Expressed in testis and 195 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5SRE5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000095319, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (NPC).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117058, 90 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-873, Nuclear pore complex

Protein interaction database and analysis system

More...IntActi		Q5SRE5, 41 interactors

Molecular INTeraction database

More...MINTi		Q5SRE5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361658

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5SRE5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5SRE5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1514 – 1542DisorderedSequence analysisAdd BLAST29
Regioni1707 – 1733DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1523 – 1542Polar residuesSequence analysisAdd BLAST20
Compositional biasi1712 – 1733Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nup188 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4833, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002623_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5SRE5

Identification of Orthologs from Complete Genome Data

More...OMAi		MENCFYV

Database of Orthologous Groups

More...OrthoDBi		79804at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5SRE5

TreeFam database of animal gene trees

More...TreeFami		TF101106

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR018864, Nucleoporin_Nup188

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10487, Nup188, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SRE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY 
        60         70         80         90        100
KPPSPSSAEK VKANKDVASP LKELGLRISK FLGLDEEQSV QLLQCYLQED 
       110        120        130        140        150
YRGTRDSVKT VLQDERQSQA LILKIADYYY EERTCILRCV LHLLTYFQDE 
       160        170        180        190        200
RHPYRVEYAD CVDKLEKELV SKYRQQFEEL YKTEAPTWET HGNLMTERQV 
       210        220        230        240        250
SRWFVQCLRE QSMLLEIIFL YYAYFEMAPS DLLVLTKMFK EQGFGSRQTN 
       260        270        280        290        300
RHLVDETMDP FVDRIGYFSA LILVEGMDIE SLHKCALDDR RELHQFAQDG 
       310        320        330        340        350
LICQDMDCLM LTFGDIPHHA PVLLAWALLR HTLNPEETSS VVRKIGGTAI 
       360        370        380        390        400
QLNVFQYLTR LLQSLASGGN DCTTSTACMC VYGLLSFVLT SLELHTLGNQ 
       410        420        430        440        450
QDIIDTACEV LADPSLPELF WGTEPTSGLG IILDSVCGMF PHLLSPLLQL 
       460        470        480        490        500
LRALVSGKST AKKVYSFLDK MSFYNELYKH KPHDVISHED GTLWRRQTPK 
       510        520        530        540        550
LLYPLGGQTN LRIPQGTVGQ VMLDDRAYLV RWEYSYSSWT LFTCEIEMLL 
       560        570        580        590        600
HVVSTADVIQ HCQRVKPIID LVHKVISTDL SIADCLLPIT SRIYMLLQRL 
       610        620        630        640        650
TTVISPPVDV IASCVNCLTV LAARNPAKVW TDLRHTGFLP FVAHPVSSLS 
       660        670        680        690        700
QMISAEGMNA GGYGNLLMNS EQPQGEYGVT IAFLRLITTL VKGQLGSTQS 
       710        720        730        740        750
QGLVPCVMFV LKEMLPSYHK WRYNSHGVRE QIGCLILELI HAILNLCHET 
       760        770        780        790        800
DLHSSHTPSL QFLCICSLAY TEAGQTVINI MGIGVDTIDM VMAAQPRSDG 
       810        820        830        840        850
AEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA LSQHGAHGNN 
       860        870        880        890        900
LIAVLAKYIY HKHDPALPRL AIQLLKRLAT VAPMSVYACL GNDAAAIRDA 
       910        920        930        940        950
FLTRLQSKIE DMRIKVMILE FLTVAVETQP GLIELFLNLE VKDGSDGSKE 
       960        970        980        990       1000
FSLGMWSCLH AVLELIDSQQ QDRYWCPPLL HRAAIAFLHA LWQDRRDSAM 
      1010       1020       1030       1040       1050
LVLRTKPKFW ENLTSPLFGT LSPPSETSEP SILETCALIM KIICLEIYYV 
      1060       1070       1080       1090       1100
VKGSLDQSLK DTLKKFSIEK RFAYWSGYVK SLAVHVAETE GSSCTSLLEY 
      1110       1120       1130       1140       1150
QMLVSAWRML LIIATTHADI MHLTDSVVRR QLFLDVLDGT KALLLVPASV 
      1160       1170       1180       1190       1200
NCLRLGSMKC TLLLILLRQW KRELGSVDEI LGPLTEILEG VLQADQQLME 
      1210       1220       1230       1240       1250
KTKAKVFSAF ITVLQMKEMK VSDIPQYSQL VLNVCETLQE EVIALFDQTR 
      1260       1270       1280       1290       1300
HSLALGSATE DKDSMETDDC SRSRHRDQRD GVCVLGLHLA KELCEVDEDG 
      1310       1320       1330       1340       1350
DSWLQVTRRL PILPTLLTTL EVSLRMKQNL HFTEATLHLL LTLARTQQGA 
      1360       1370       1380       1390       1400
TAVAGAGITQ SICLPLLSVY QLSTNGTAQT PSASRKSLDA PSWPGVYRLS 
      1410       1420       1430       1440       1450
MSLMEQLLKT LRYNFLPEAL DFVGVHQERT LQCLNAVRTV QSLACLEEAD 
      1460       1470       1480       1490       1500
HTVGFILQLS NFMKEWHFHL PQLMRDIQVN LGYLCQACTS LLHSRKMLQH 
      1510       1520       1530       1540       1550
YLQNKNGDGL PSAVAQRVQR PPSAASAAPS SSKQPAADTE ASEQQALHTV 
      1560       1570       1580       1590       1600
QYGLLKILSK TLAALRHFTP DVCQILLDQS LDLAEYNFLF ALSFTTPTFD 
      1610       1620       1630       1640       1650
SEVAPSFGTL LATVNVALNM LGELDKKKEP LTQAVGLSTQ AEGTRTLKSL 
      1660       1670       1680       1690       1700
LMFTMENCFY LLISQAMRYL RDPAVHPRDK QRMKQELSSE LSTLLSSLSR 
      1710       1720       1730       1740 
YFRRGAPSSP ATGVLPSPQG KSTSLSKASP ESQEPLIQLV QAFVRHMQR
Length:1,749
Mass (Da):196,043
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7856A552698F542
GO
Isoform 2 (identifier: Q5SRE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-226: Missing.

Show »
Length:1,638
Mass (Da):182,293
Checksum:i14E227EADB7DEAE7
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD97835 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti773A → T in CAD97835 (PubMed:17974005).Curated1
Sequence conflicti995R → W in AAH40352 (PubMed:15489334).Curated1
Sequence conflicti1196Q → R in CAD97835 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083845113 – 1749Missing in SANDSTEF. 1 PublicationAdd BLAST1637
Natural variantiVAR_083846630 – 1749Missing in SANDSTEF. 1 PublicationAdd BLAST1120
Natural variantiVAR_0838471048 – 1749Missing in SANDSTEF; undetectable protein expression; loss of nuclear localization. 1 PublicationAdd BLAST702
Natural variantiVAR_0838481360 – 1749Missing in SANDSTEF. 1 PublicationAdd BLAST390
Natural variantiVAR_0347921419A → V. Corresponds to variant dbSNP:rs17433024Ensembl.1
Natural variantiVAR_0347931587N → K. Corresponds to variant dbSNP:rs12350674Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027585116 – 226Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX537774 mRNA Translation: CAD97835.1 Different initiation.
AL592211 Genomic DNA No translation available.
AL672142 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87850.1
D79991 mRNA Translation: BAA11486.1
BC040352 mRNA Translation: AAH40352.1
BC111045 mRNA Translation: AAI11046.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35156.1 [Q5SRE5-1]

NCBI Reference Sequences

More...RefSeqi		NP_056169.1, NM_015354.2 [Q5SRE5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372577; ENSP00000361658; ENSG00000095319 [Q5SRE5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23511

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23511

UCSC genome browser

More...UCSCi		uc004bws.3, human [Q5SRE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537774 mRNA Translation: CAD97835.1 Different initiation.
AL592211 Genomic DNA No translation available.
AL672142 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87850.1
D79991 mRNA Translation: BAA11486.1
BC040352 mRNA Translation: AAH40352.1
BC111045 mRNA Translation: AAI11046.1
CCDSiCCDS35156.1 [Q5SRE5-1]
RefSeqiNP_056169.1, NM_015354.2 [Q5SRE5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJOelectron microscopy21.40J/V1-1749[»]
SMRiQ5SRE5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117058, 90 interactors
ComplexPortaliCPX-873, Nuclear pore complex
IntActiQ5SRE5, 41 interactors
MINTiQ5SRE5
STRINGi9606.ENSP00000361658

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

iPTMnetiQ5SRE5
MetOSiteiQ5SRE5
PhosphoSitePlusiQ5SRE5
SwissPalmiQ5SRE5

Genetic variation databases

BioMutaiNUP188
DMDMi74743623

Proteomic databases

EPDiQ5SRE5
jPOSTiQ5SRE5
MassIVEiQ5SRE5
MaxQBiQ5SRE5
PaxDbiQ5SRE5
PeptideAtlasiQ5SRE5
PRIDEiQ5SRE5
ProteomicsDBi63844 [Q5SRE5-1]
63845 [Q5SRE5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34836, 84 antibodies

The DNASU plasmid repository

More...DNASUi		23511

Genome annotation databases

EnsembliENST00000372577; ENSP00000361658; ENSG00000095319 [Q5SRE5-1]
GeneIDi23511
KEGGihsa:23511
UCSCiuc004bws.3, human [Q5SRE5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23511
DisGeNETi23511

GeneCards: human genes, protein and diseases

More...GeneCardsi		NUP188
HGNCiHGNC:17859, NUP188
HPAiENSG00000095319, Tissue enhanced (testis)
MalaCardsiNUP188
MIMi615587, gene
618804, phenotype
neXtProtiNX_Q5SRE5
OpenTargetsiENSG00000095319
PharmGKBiPA134908952
VEuPathDBiHostDB:ENSG00000095319.14

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4833, Eukaryota
GeneTreeiENSGT00390000005742
HOGENOMiCLU_002623_1_0_1
InParanoidiQ5SRE5
OMAiMENCFYV
OrthoDBi79804at2759
PhylomeDBiQ5SRE5
TreeFamiTF101106

Enzyme and pathway databases

PathwayCommonsiQ5SRE5
ReactomeiR-HSA-1169408, ISG15 antiviral mechanism
R-HSA-159227, Transport of the SLBP independent Mature mRNA
R-HSA-159230, Transport of the SLBP Dependant Mature mRNA
R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276, NS1 Mediated Effects on Host Pathways
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746, Nuclear import of Rev protein
R-HSA-180910, Vpr-mediated nuclear import of PICs
R-HSA-191859, snRNP Assembly
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-4085377, SUMOylation of SUMOylation proteins
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4615885, SUMOylation of DNA replication proteins
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation
SIGNORiQ5SRE5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23511, 64 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NUP188, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23511
PharosiQ5SRE5, Tbio

Protein Ontology

More...PROi		PR:Q5SRE5
RNActiQ5SRE5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000095319, Expressed in testis and 195 other tissues
GenevisibleiQ5SRE5, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR018864, Nucleoporin_Nup188
PfamiView protein in Pfam
PF10487, Nup188, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU188_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SRE5
Secondary accession number(s): Q14675
, Q2TA87, Q7Z3K8, Q8IWF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: June 2, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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