Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q5SRE5 (NU188_HUMAN)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nucleoporin NUP188 homolog

Gene

NUP188

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a component of the nuclear pore complex (NPC).

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP188 homolog
Short name:
hNup188
Gene namesi
Name:NUP188
Synonyms:KIAA0169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000095319.14
HGNCiHGNC:17859 NUP188
MIMi615587 gene
neXtProtiNX_Q5SRE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Involvement in diseasei

Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.1 Publication

Organism-specific databases

OpenTargetsiENSG00000095319
PharmGKBiPA134908952

Polymorphism and mutation databases

DMDMi74743623

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002991722 – 1749Nucleoporin NUP188 homologAdd BLAST1748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei1523PhosphoserineCombined sources1
Modified residuei1709PhosphoserineCombined sources1
Modified residuei1712PhosphothreonineCombined sources1
Modified residuei1717PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5SRE5
MaxQBiQ5SRE5
PaxDbiQ5SRE5
PeptideAtlasiQ5SRE5
PRIDEiQ5SRE5
ProteomicsDBi63844
63845 [Q5SRE5-2]

PTM databases

iPTMnetiQ5SRE5
PhosphoSitePlusiQ5SRE5

Expressioni

Gene expression databases

BgeeiENSG00000095319
CleanExiHS_NUP188
GenevisibleiQ5SRE5 HS

Organism-specific databases

HPAiHPA061750
HPA063942

Interactioni

Protein-protein interaction databases

BioGridi117058, 50 interactors
IntActiQ5SRE5, 33 interactors
STRINGi9606.ENSP00000361658

Structurei

3D structure databases

ProteinModelPortaliQ5SRE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4833 Eukaryota
ENOG410Z045 LUCA
GeneTreeiENSGT00390000005742
HOGENOMiHOG000113876
HOVERGENiHBG055598
InParanoidiQ5SRE5
KOiK14311
OMAiTFGDIPH
OrthoDBiEOG091G02FQ
PhylomeDBiQ5SRE5
TreeFamiTF101106

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR018864 Nucleoporin_Nup188
PfamiView protein in Pfam
PF10487 Nup188, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SRE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY 
        60         70         80         90        100
KPPSPSSAEK VKANKDVASP LKELGLRISK FLGLDEEQSV QLLQCYLQED 
       110        120        130        140        150
YRGTRDSVKT VLQDERQSQA LILKIADYYY EERTCILRCV LHLLTYFQDE 
       160        170        180        190        200
RHPYRVEYAD CVDKLEKELV SKYRQQFEEL YKTEAPTWET HGNLMTERQV 
       210        220        230        240        250
SRWFVQCLRE QSMLLEIIFL YYAYFEMAPS DLLVLTKMFK EQGFGSRQTN 
       260        270        280        290        300
RHLVDETMDP FVDRIGYFSA LILVEGMDIE SLHKCALDDR RELHQFAQDG 
       310        320        330        340        350
LICQDMDCLM LTFGDIPHHA PVLLAWALLR HTLNPEETSS VVRKIGGTAI 
       360        370        380        390        400
QLNVFQYLTR LLQSLASGGN DCTTSTACMC VYGLLSFVLT SLELHTLGNQ 
       410        420        430        440        450
QDIIDTACEV LADPSLPELF WGTEPTSGLG IILDSVCGMF PHLLSPLLQL 
       460        470        480        490        500
LRALVSGKST AKKVYSFLDK MSFYNELYKH KPHDVISHED GTLWRRQTPK 
       510        520        530        540        550
LLYPLGGQTN LRIPQGTVGQ VMLDDRAYLV RWEYSYSSWT LFTCEIEMLL 
       560        570        580        590        600
HVVSTADVIQ HCQRVKPIID LVHKVISTDL SIADCLLPIT SRIYMLLQRL 
       610        620        630        640        650
TTVISPPVDV IASCVNCLTV LAARNPAKVW TDLRHTGFLP FVAHPVSSLS 
       660        670        680        690        700
QMISAEGMNA GGYGNLLMNS EQPQGEYGVT IAFLRLITTL VKGQLGSTQS 
       710        720        730        740        750
QGLVPCVMFV LKEMLPSYHK WRYNSHGVRE QIGCLILELI HAILNLCHET 
       760        770        780        790        800
DLHSSHTPSL QFLCICSLAY TEAGQTVINI MGIGVDTIDM VMAAQPRSDG 
       810        820        830        840        850
AEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA LSQHGAHGNN 
       860        870        880        890        900
LIAVLAKYIY HKHDPALPRL AIQLLKRLAT VAPMSVYACL GNDAAAIRDA 
       910        920        930        940        950
FLTRLQSKIE DMRIKVMILE FLTVAVETQP GLIELFLNLE VKDGSDGSKE 
       960        970        980        990       1000
FSLGMWSCLH AVLELIDSQQ QDRYWCPPLL HRAAIAFLHA LWQDRRDSAM 
      1010       1020       1030       1040       1050
LVLRTKPKFW ENLTSPLFGT LSPPSETSEP SILETCALIM KIICLEIYYV 
      1060       1070       1080       1090       1100
VKGSLDQSLK DTLKKFSIEK RFAYWSGYVK SLAVHVAETE GSSCTSLLEY 
      1110       1120       1130       1140       1150
QMLVSAWRML LIIATTHADI MHLTDSVVRR QLFLDVLDGT KALLLVPASV 
      1160       1170       1180       1190       1200
NCLRLGSMKC TLLLILLRQW KRELGSVDEI LGPLTEILEG VLQADQQLME 
      1210       1220       1230       1240       1250
KTKAKVFSAF ITVLQMKEMK VSDIPQYSQL VLNVCETLQE EVIALFDQTR 
      1260       1270       1280       1290       1300
HSLALGSATE DKDSMETDDC SRSRHRDQRD GVCVLGLHLA KELCEVDEDG 
      1310       1320       1330       1340       1350
DSWLQVTRRL PILPTLLTTL EVSLRMKQNL HFTEATLHLL LTLARTQQGA 
      1360       1370       1380       1390       1400
TAVAGAGITQ SICLPLLSVY QLSTNGTAQT PSASRKSLDA PSWPGVYRLS 
      1410       1420       1430       1440       1450
MSLMEQLLKT LRYNFLPEAL DFVGVHQERT LQCLNAVRTV QSLACLEEAD 
      1460       1470       1480       1490       1500
HTVGFILQLS NFMKEWHFHL PQLMRDIQVN LGYLCQACTS LLHSRKMLQH 
      1510       1520       1530       1540       1550
YLQNKNGDGL PSAVAQRVQR PPSAASAAPS SSKQPAADTE ASEQQALHTV 
      1560       1570       1580       1590       1600
QYGLLKILSK TLAALRHFTP DVCQILLDQS LDLAEYNFLF ALSFTTPTFD 
      1610       1620       1630       1640       1650
SEVAPSFGTL LATVNVALNM LGELDKKKEP LTQAVGLSTQ AEGTRTLKSL 
      1660       1670       1680       1690       1700
LMFTMENCFY LLISQAMRYL RDPAVHPRDK QRMKQELSSE LSTLLSSLSR 
      1710       1720       1730       1740 
YFRRGAPSSP ATGVLPSPQG KSTSLSKASP ESQEPLIQLV QAFVRHMQR
Length:1,749
Mass (Da):196,043
Last modified:December 21, 2004 - v1
Checksum:iE7856A552698F542
GO
Isoform 2 (identifier: Q5SRE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-226: Missing.

Show »
Length:1,638
Mass (Da):182,293
Checksum:i14E227EADB7DEAE7
GO

Sequence cautioni

The sequence CAD97835 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti773A → T in CAD97835 (PubMed:17974005).Curated1
Sequence conflicti995R → W in AAH40352 (PubMed:15489334).Curated1
Sequence conflicti1196Q → R in CAD97835 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0347921419A → V. Corresponds to variant dbSNP:rs17433024Ensembl.1
Natural variantiVAR_0347931587N → K. Corresponds to variant dbSNP:rs12350674Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027585116 – 226Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537774 mRNA Translation: CAD97835.1 Different initiation.
AL592211 Genomic DNA No translation available.
AL672142 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87850.1
D79991 mRNA Translation: BAA11486.1
BC040352 mRNA Translation: AAH40352.1
BC111045 mRNA Translation: AAI11046.1
CCDSiCCDS35156.1 [Q5SRE5-1]
RefSeqiNP_056169.1, NM_015354.2 [Q5SRE5-1]
UniGeneiHs.308340

Genome annotation databases

EnsembliENST00000372577; ENSP00000361658; ENSG00000095319 [Q5SRE5-1]
GeneIDi23511
KEGGihsa:23511
UCSCiuc004bws.3 human [Q5SRE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNU188_HUMAN
AccessioniPrimary (citable) accession number: Q5SRE5
Secondary accession number(s): Q14675
, Q2TA87, Q7Z3K8, Q8IWF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health