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Entry version 119 (16 Oct 2019)
Sequence version 2 (01 Feb 2005)
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Protein

Cytoplasmic FMR1-interacting protein 2

Gene

Cyfip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic FMR1-interacting protein 2
Alternative name(s):
p53-inducible protein 121
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cyfip2Imported
Synonyms:Kiaa1168Imported, Pir121Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924134 Cyfip2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus, Synapse, Synaptosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002797101 – 1253Cytoplasmic FMR1-interacting protein 2Add BLAST1253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1037N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SQX6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SQX6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SQX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SQX6

PeptideAtlas

More...
PeptideAtlasi
Q5SQX6

PRoteomics IDEntifications database

More...
PRIDEi
Q5SQX6

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2249

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SQX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SQX6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5SQX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hippocampus (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020340 Expressed in 278 organ(s), highest expression level in prefrontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SQX6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SQX6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1.

Interacts with FMR1, FXR1 and FXR2 (PubMed:11438699).

Interacts with FMR1; the interaction occurs in a RNA-dependent manner (By similarity).

Interacts with RAC1 (activated form) which causes the complex to dissociate, releasing activated WASF1 (By similarity). The complex can also be activated by NCK1 (By similarity).

Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex (PubMed:24153177).

Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (PubMed:27605705).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Shank3Q4ACU63EBI-773783,EBI-771450

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
218375, 43 interactors

Database of interacting proteins

More...
DIPi
DIP-32111N

Protein interaction database and analysis system

More...
IntActi
Q5SQX6, 63 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000090854

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SQX6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CYFIP family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3534 Eukaryota
ENOG410XPKW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044831

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SQX6

KEGG Orthology (KO)

More...
KOi
K05749

Identification of Orthologs from Complete Genome Data

More...
OMAi
ATNRFVK

Database of Orthologous Groups

More...
OrthoDBi
108507at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SQX6

TreeFam database of animal gene trees

More...
TreeFami
TF312925

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008081 Cytoplasmic_FMR1-int
IPR009828 DUF1394

The PANTHER Classification System

More...
PANTHERi
PTHR12195 PTHR12195, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07159 DUF1394, 1 hit
PF05994 FragX_IP, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF008153 FMR1_interacting, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01698 CYTOFMRPINTP

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5SQX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN
60 70 80 90 100
AFVTGIARYI EQATVHSSMN EMLEEGHDYA VMLYTWRSCS RAIPQVKCNE
110 120 130 140 150
QPNRVEIYEK TVEVLEPEVT KLMKFMYFQR KAIERFCSEV KRLCHAERRK
160 170 180 190 200
DFVSEAYLLT LGKFINMFAV LDELKNMKCS VKNDHSAYKR AAQFLRKMAD
210 220 230 240 250
PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD IVNICVDYYE
260 270 280 290 300
NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK
310 320 330 340 350
QLQVVPLFGD MQIELARYIK TSAHYEENKS KWTCTQSSIS PQYNICEQMV
360 370 380 390 400
QIRDDHIRFI SELARYSNSE VVTGSGLDSQ KSDEEYRELF DLALRGLQLL
410 420 430 440 450
SKWSAHVMEV YSWKLVHPTD KFCNKDCPGT AEEYERATRY NYTSEEKFAF
460 470 480 490 500
VEVIAMIKGL QVLMGRMESV FNQAIRNTIY AALQDFAQVT LREPLRQAVR
510 520 530 540 550
KKKNVLISVL QAIRKTICDW EGGREPPNDP CLRGEKDPKG GFDIKVPRRA
560 570 580 590 600
VGPSSTQLYM VRTMLESLIA DKSGSKKTLR SSLDGPIVLA IEDFHKQSFF
610 620 630 640 650
FTHLLNISEA LQQCCDLSQL WFREFFLELT MGRRIQFPIE MSMPWILTDH
660 670 680 690 700
ILETKEPSMM EYVLYPLDLY NDSAYYALTK FKKQFLYDEI EAEVNLCFDQ
710 720 730 740 750
FVYKLADQIF AYYKAMAGSV LLDKRFRAEC KNYGVIIPYP PSNRYETLLK
760 770 780 790 800
QRHVQLLGRS IDLNRLITQR ISAAMYKSLD QAISRFESED LTSIVELEWL
810 820 830 840 850
LEINRLTHRL LCKHMTLDSF DAMFREANHN VSAPYGRITL HVFWELNFDF
860 870 880 890 900
LPNYCYNGST NRFVRTAIPF TQEPQRDKPA NVQPYYLYGS KPLNIAYSHI
910 920 930 940 950
YSSYRNFVGP PHFKTICRLL GYQGIAVVME ELLKIVKSLL QGTILQYVKT
960 970 980 990 1000
LIEVMPKICR LPRHEYGSPG ILEFFHHQLK DIIEYAELKT DVFQSLREVG
1010 1020 1030 1040 1050
NAILFCLLIE QALSQEEVCD LLHAAPFQNI LPRVYIKEGE RLEVRMKRLE
1060 1070 1080 1090 1100
AKYAPLHLVP LIERLGTPQQ IAIAREGDLL TKERLCCGLS MFEVILTRIR
1110 1120 1130 1140 1150
SYLQDPIWRG PPPTNGVMHV DECVEFHRLW SAMQFVYCIP VGTNEFTAEQ
1160 1170 1180 1190 1200
CFGDGLNWAG CSIIVLLGQQ RRFDLFDFCY HLLKVQRQDG KDEIIKNVPL
1210 1220 1230 1240 1250
KKMADRIRKY QILNNEVFAI LNKYMKSVET DSSTVEHVRC FQPPIHQSLA

TTC
Length:1,253
Mass (Da):145,659
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i321011BF830F424E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QD74F6QD74_MOUSE
Cytoplasmic FMR1-interacting protei...
Cyfip2
948Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C3H9F7C3H9_MOUSE
Cytoplasmic FMR1-interacting protei...
Cyfip2
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC41472 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76G → V in BAC26942 (PubMed:16141072).Curated1
Sequence conflicti229E → G in BAE27779 (PubMed:16141072).Curated1
Sequence conflicti242V → A in BAE27779 (PubMed:16141072).Curated1
Sequence conflicti678L → P in BAC26942 (PubMed:16141072).Curated1
Sequence conflicti1080L → P in BAC26942 (PubMed:16141072).Curated1

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at position 320.1 Publication
Partially edited. Editing appears to be brain-specific.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti320K → E in RNA edited version. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF334144 mRNA Translation: AAK81821.1
AB093288 mRNA Translation: BAC41472.2 Different initiation.
AK030397 mRNA Translation: BAC26942.1
AK147224 mRNA Translation: BAE27779.1
AK147586 mRNA Translation: BAE28010.1
AK147632 mRNA Translation: BAE28036.1
AL662806 Genomic DNA No translation available.
AL713958 Genomic DNA No translation available.
AF162472 mRNA Translation: AAD45803.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24573.1

NCBI Reference Sequences

More...
RefSeqi
NP_001239388.1, NM_001252459.1
NP_001239389.1, NM_001252460.1
NP_598530.2, NM_133769.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093165; ENSMUSP00000090853; ENSMUSG00000020340
ENSMUST00000093166; ENSMUSP00000090854; ENSMUSG00000020340
ENSMUST00000165599; ENSMUSP00000127586; ENSMUSG00000020340

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76884

UCSC genome browser

More...
UCSCi
uc007iob.2 mouse

Keywords - Coding sequence diversityi

RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334144 mRNA Translation: AAK81821.1
AB093288 mRNA Translation: BAC41472.2 Different initiation.
AK030397 mRNA Translation: BAC26942.1
AK147224 mRNA Translation: BAE27779.1
AK147586 mRNA Translation: BAE28010.1
AK147632 mRNA Translation: BAE28036.1
AL662806 Genomic DNA No translation available.
AL713958 Genomic DNA No translation available.
AF162472 mRNA Translation: AAD45803.1
CCDSiCCDS24573.1
RefSeqiNP_001239388.1, NM_001252459.1
NP_001239389.1, NM_001252460.1
NP_598530.2, NM_133769.3

3D structure databases

SMRiQ5SQX6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi218375, 43 interactors
DIPiDIP-32111N
IntActiQ5SQX6, 63 interactors
STRINGi10090.ENSMUSP00000090854

PTM databases

GlyConnecti2249
iPTMnetiQ5SQX6
PhosphoSitePlusiQ5SQX6
SwissPalmiQ5SQX6

Proteomic databases

EPDiQ5SQX6
jPOSTiQ5SQX6
MaxQBiQ5SQX6
PaxDbiQ5SQX6
PeptideAtlasiQ5SQX6
PRIDEiQ5SQX6

Genome annotation databases

EnsembliENSMUST00000093165; ENSMUSP00000090853; ENSMUSG00000020340
ENSMUST00000093166; ENSMUSP00000090854; ENSMUSG00000020340
ENSMUST00000165599; ENSMUSP00000127586; ENSMUSG00000020340
GeneIDi76884
KEGGimmu:76884
UCSCiuc007iob.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26999
MGIiMGI:1924134 Cyfip2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3534 Eukaryota
ENOG410XPKW LUCA
GeneTreeiENSGT00500000044831
InParanoidiQ5SQX6
KOiK05749
OMAiATNRFVK
OrthoDBi108507at2759
PhylomeDBiQ5SQX6
TreeFamiTF312925

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cyfip2 mouse

Protein Ontology

More...
PROi
PR:Q5SQX6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSMUSG00000020340 Expressed in 278 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiQ5SQX6 baseline and differential
GenevisibleiQ5SQX6 MM

Family and domain databases

InterProiView protein in InterPro
IPR008081 Cytoplasmic_FMR1-int
IPR009828 DUF1394
PANTHERiPTHR12195 PTHR12195, 1 hit
PfamiView protein in Pfam
PF07159 DUF1394, 1 hit
PF05994 FragX_IP, 1 hit
PIRSFiPIRSF008153 FMR1_interacting, 1 hit
PRINTSiPR01698 CYTOFMRPINTP

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYFP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SQX6
Secondary accession number(s): Q3UH21
, Q3UHS8, Q8BSW0, Q8CHA9, Q924D3, Q9R181
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 1, 2005
Last modified: October 16, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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