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UniProtKB - Q5SQS8 (CJ120_HUMAN)

Entry version 101 (02 Dec 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Uncharacterized protein C10orf120

Gene

C10orf120

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5SQS8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C10orf120
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C10orf120
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000183559.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:25707, C10orf120

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5SQS8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000183559

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134871711

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5SQS8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C10orf120

Domain mapping of disease mutations (DMDM)

More...DMDMi		74743566

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002439401 – 335Uncharacterized protein C10orf120Add BLAST335

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5SQS8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5SQS8

PeptideAtlas

More...PeptideAtlasi		Q5SQS8

PRoteomics IDEntifications database

More...PRIDEi		Q5SQS8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63822

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5SQS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5SQS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183559, Expressed in right testis and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5SQS8, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183559, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		134419, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q5SQS8, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000331012

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5SQS8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5SQS8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RNK6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005511

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_071615_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5SQS8

Identification of Orthologs from Complete Genome Data

More...OMAi		MNVVFKS

Database of Orthologous Groups

More...OrthoDBi		1334048at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5SQS8

TreeFam database of animal gene trees

More...TreeFami		TF337245

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040721, DUF5520

The PANTHER Classification System

More...PANTHERi		PTHR47509, PTHR47509, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17658, DUF5520, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SQS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIREWKNDCQ RIEKQRASDT MVQERKNEKP VRIFNTNSSF QDQAPTCCQE 
        60         70         80         90        100
DLSSASPLRI WSKFYRSDPR IALGKYSPLE KEILRLGGIH TIAARRLLAY 
       110        120        130        140        150
KQEEECRMLK ELQLLSPDYK QAMEYKKKHS SPCAICVPLE KIWTAKVIAP 
       160        170        180        190        200
LEAFKMPQRE QVNVSKHIER MRLARALGNH QPLPYIERFT RSSFLSGVGL 
       210        220        230        240        250
GPMAKNKARR KEDNYDTHNC DDANQDKKEE AEGKNTKRRE IKMNVVFKSK 
       260        270        280        290        300
EPKKCLTYHG NDRKSFLPAK KPERSIAGLT NRNLFCISEF PGDLMLMNQD 
       310        320        330 
FISRRDHFSD LVKTYSLEEE SIWKERMRKA TPYHY
Length:335
Mass (Da):39,268
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5325092A9DF7A5C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y758H0Y758_HUMAN
Uncharacterized protein C10orf120
C10orf120
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05085920T → K. Corresponds to variant dbSNP:rs41448048Ensembl.1
Natural variantiVAR_050860269A → T2 PublicationsCorresponds to variant dbSNP:rs2947594Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL731543 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49307.1
BC140922 mRNA Translation: AAI40923.1
BC065903 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31302.1

NCBI Reference Sequences

More...RefSeqi		NP_001010912.1, NM_001010912.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329446; ENSP00000331012; ENSG00000183559

Database of genes from NCBI RefSeq genomes

More...GeneIDi		399814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:399814

UCSC genome browser

More...UCSCi		uc001lgn.3, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731543 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49307.1
BC140922 mRNA Translation: AAI40923.1
BC065903 mRNA No translation available.
CCDSiCCDS31302.1
RefSeqiNP_001010912.1, NM_001010912.2

3D structure databases

SMRiQ5SQS8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi134419, 2 interactors
IntActiQ5SQS8, 2 interactors
STRINGi9606.ENSP00000331012

PTM databases

iPTMnetiQ5SQS8
PhosphoSitePlusiQ5SQS8

Polymorphism and mutation databases

BioMutaiC10orf120
DMDMi74743566

Proteomic databases

MassIVEiQ5SQS8
PaxDbiQ5SQS8
PeptideAtlasiQ5SQS8
PRIDEiQ5SQS8
ProteomicsDBi63822

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49180, 23 antibodies

Genome annotation databases

EnsembliENST00000329446; ENSP00000331012; ENSG00000183559
GeneIDi399814
KEGGihsa:399814
UCSCiuc001lgn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		399814
EuPathDBiHostDB:ENSG00000183559.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		C10orf120
HGNCiHGNC:25707, C10orf120
HPAiENSG00000183559, Tissue enriched (testis)
neXtProtiNX_Q5SQS8
OpenTargetsiENSG00000183559
PharmGKBiPA134871711

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RNK6, Eukaryota
GeneTreeiENSGT00390000005511
HOGENOMiCLU_071615_0_0_1
InParanoidiQ5SQS8
OMAiMNVVFKS
OrthoDBi1334048at2759
PhylomeDBiQ5SQS8
TreeFamiTF337245

Enzyme and pathway databases

PathwayCommonsiQ5SQS8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		399814, 1 hit in 830 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		399814
PharosiQ5SQS8, Tdark

Protein Ontology

More...PROi		PR:Q5SQS8
RNActiQ5SQS8, protein

Gene expression databases

BgeeiENSG00000183559, Expressed in right testis and 26 other tissues
ExpressionAtlasiQ5SQS8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR040721, DUF5520
PANTHERiPTHR47509, PTHR47509, 1 hit
PfamiView protein in Pfam
PF17658, DUF5520, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCJ120_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SQS8
Secondary accession number(s): B2RU17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: December 2, 2020
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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