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Protein

HORMA domain-containing protein 2

Gene

Hormad2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.2 Publications

GO - Biological processi

  • meiotic cell cycle Source: UniProtKB
  • meiotic sister chromatid cohesion Source: UniProtKB

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
HORMA domain-containing protein 2
Gene namesi
Name:Hormad2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923078 Hormad2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice are infertile due to spermatocyte loss as a result of characteristic impairment of sex body formation. Spermatocyte apoptosis is confined to the stage IV seminiferous tubules. In contrast to males, female mice are fertile.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846701 – 306HORMA domain-containing protein 2Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in a SPO11-dependent manner.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SQP1
PRIDEiQ5SQP1

PTM databases

iPTMnetiQ5SQP1
PhosphoSitePlusiQ5SQP1

Expressioni

Tissue specificityi

Specifically expressed in meiotic germ cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000020419 Expressed in 24 organ(s), highest expression level in testis
CleanExiMM_HORMAD2
ExpressionAtlasiQ5SQP1 baseline and differential
GenevisibleiQ5SQP1 MM

Interactioni

Subunit structurei

Interacts with HORMAD1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105574

Structurei

3D structure databases

ProteinModelPortaliQ5SQP1
SMRiQ5SQP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 232HORMAPROSITE-ProRule annotationAdd BLAST204

Phylogenomic databases

eggNOGiKOG4652 Eukaryota
ENOG410XT4N LUCA
GeneTreeiENSGT00390000018130
HOGENOMiHOG000293366
HOVERGENiHBG074209
InParanoidiQ5SQP1
OMAiKRYLHMA
OrthoDBiEOG091G0F8O
PhylomeDBiQ5SQP1
TreeFamiTF313989

Family and domain databases

Gene3Di3.30.900.10, 1 hit
InterProiView protein in InterPro
IPR003511 HORMA_dom
IPR036570 HORMA_dom_sf
PfamiView protein in Pfam
PF02301 HORMA, 1 hit
SUPFAMiSSF56019 SSF56019, 1 hit
PROSITEiView protein in PROSITE
PS50815 HORMA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SQP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAQLSHNT RTLKASKNTI FPSQVTNEHE SLVVVKKLFA TCISCITYLR
60 70 80 90 100
GLFPESSYRD RRLDDLSLKI LREDKKCPGS LHIIKWIQGC FDALEKRYLH
110 120 130 140 150
MAVLTLYTNP KEPEKVTEIY QFRFKYTKKG TTMDFDSSST SFESGTDSED
160 170 180 190 200
IKKACSLLIR QLYILMQNLG PLPNDVILTM KLHYYNSVTP HDYQPPGFKE
210 220 230 240 250
AVNSHFLLFE GEPVSLRMGS VSSGFHSMKV KVTTEATRML DGENSVSQDD
260 270 280 290 300
GTTEIAHQGL DCDEEEEACG SQVQRMNFVH IEPSFESSRK KKKVSEPVTV

FIPNRK
Length:306
Mass (Da):34,812
Last modified:December 21, 2004 - v1
Checksum:iA0E41A74BA7E3A63
GO
Isoform 2 (identifier: Q5SQP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
     60-65: DRRLDD → MRRDPN

Show »
Length:247
Mass (Da):28,196
Checksum:iE3865E18FE343DA6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ATD3B1ATD3_MOUSE
HORMA domain-containing protein 2
Hormad2
105Annotation score:
H7BWX7H7BWX7_MOUSE
HORMA domain-containing protein 2
Hormad2
65Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246051 – 59Missing in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_02460660 – 65DRRLDD → MRRDPN in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015939 mRNA Translation: BAB30043.1
AL731658, AL645910 Genomic DNA Translation: CAI25202.1
AL731658, AL645910 Genomic DNA Translation: CAI25203.1
AL645910, AL731658 Genomic DNA Translation: CAI35181.1
AL645910, AL731658 Genomic DNA Translation: CAI35183.1
BC120781 mRNA Translation: AAI20782.1
BC120783 mRNA Translation: AAI20784.1
BC144842 mRNA Translation: AAI44843.1
CCDSiCCDS36096.1 [Q5SQP1-1]
RefSeqiNP_083734.1, NM_029458.1 [Q5SQP1-1]
XP_011242079.1, XM_011243777.2 [Q5SQP1-1]
XP_011242081.1, XM_011243779.2 [Q5SQP1-1]
XP_011242082.1, XM_011243780.2 [Q5SQP1-1]
XP_011242083.1, XM_011243781.1 [Q5SQP1-1]
UniGeneiMm.159592

Genome annotation databases

EnsembliENSMUST00000109948; ENSMUSP00000105574; ENSMUSG00000020419 [Q5SQP1-1]
ENSMUST00000109949; ENSMUSP00000105575; ENSMUSG00000020419 [Q5SQP1-1]
GeneIDi75828
KEGGimmu:75828
UCSCiuc007huv.1 mouse [Q5SQP1-1]
uc011xqw.1 mouse [Q5SQP1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015939 mRNA Translation: BAB30043.1
AL731658, AL645910 Genomic DNA Translation: CAI25202.1
AL731658, AL645910 Genomic DNA Translation: CAI25203.1
AL645910, AL731658 Genomic DNA Translation: CAI35181.1
AL645910, AL731658 Genomic DNA Translation: CAI35183.1
BC120781 mRNA Translation: AAI20782.1
BC120783 mRNA Translation: AAI20784.1
BC144842 mRNA Translation: AAI44843.1
CCDSiCCDS36096.1 [Q5SQP1-1]
RefSeqiNP_083734.1, NM_029458.1 [Q5SQP1-1]
XP_011242079.1, XM_011243777.2 [Q5SQP1-1]
XP_011242081.1, XM_011243779.2 [Q5SQP1-1]
XP_011242082.1, XM_011243780.2 [Q5SQP1-1]
XP_011242083.1, XM_011243781.1 [Q5SQP1-1]
UniGeneiMm.159592

3D structure databases

ProteinModelPortaliQ5SQP1
SMRiQ5SQP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105574

PTM databases

iPTMnetiQ5SQP1
PhosphoSitePlusiQ5SQP1

Proteomic databases

PaxDbiQ5SQP1
PRIDEiQ5SQP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109948; ENSMUSP00000105574; ENSMUSG00000020419 [Q5SQP1-1]
ENSMUST00000109949; ENSMUSP00000105575; ENSMUSG00000020419 [Q5SQP1-1]
GeneIDi75828
KEGGimmu:75828
UCSCiuc007huv.1 mouse [Q5SQP1-1]
uc011xqw.1 mouse [Q5SQP1-2]

Organism-specific databases

CTDi150280
MGIiMGI:1923078 Hormad2

Phylogenomic databases

eggNOGiKOG4652 Eukaryota
ENOG410XT4N LUCA
GeneTreeiENSGT00390000018130
HOGENOMiHOG000293366
HOVERGENiHBG074209
InParanoidiQ5SQP1
OMAiKRYLHMA
OrthoDBiEOG091G0F8O
PhylomeDBiQ5SQP1
TreeFamiTF313989

Miscellaneous databases

PROiPR:Q5SQP1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020419 Expressed in 24 organ(s), highest expression level in testis
CleanExiMM_HORMAD2
ExpressionAtlasiQ5SQP1 baseline and differential
GenevisibleiQ5SQP1 MM

Family and domain databases

Gene3Di3.30.900.10, 1 hit
InterProiView protein in InterPro
IPR003511 HORMA_dom
IPR036570 HORMA_dom_sf
PfamiView protein in Pfam
PF02301 HORMA, 1 hit
SUPFAMiSSF56019 SSF56019, 1 hit
PROSITEiView protein in PROSITE
PS50815 HORMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHORM2_MOUSE
AccessioniPrimary (citable) accession number: Q5SQP1
Secondary accession number(s): B7ZMW2, Q9D507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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