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UniProtKB - Q5SQI0 (ATAT_HUMAN)

Entry version 123 (05 Jun 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Alpha-tubulin N-acetyltransferase 1

Gene

ATAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.UniRule annotation4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 2.2 h(-1) for the acetylation of polymerized tubulin (microtubules), 0.35 h(-1) for the acetylation of free tubulin, and 1.47 h(-1)with acetyl-CoA as substrate.
  1. KM=2.0 µM for free alpha-tubulin2 Publications
  2. KM=1.6 µM for polymerized tubulin (microtubules)2 Publications
  3. KM=2.2 µM for acetyl-CoA2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei58Crucial for catalytic activityUniRule annotation1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-5617833 Cilium Assembly

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Alpha-tubulin N-acetyltransferase 1UniRule annotation (EC:2.3.1.108UniRule annotation3 Publications)
    Short name:
    Alpha-TATUniRule annotation
    Short name:
    Alpha-TAT1UniRule annotation
    Short name:
    TATUniRule annotation
    Alternative name(s):
    Acetyltransferase mec-17 homologUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ATAT1UniRule annotation
    Synonyms:C6orf134, MEC17UniRule annotation
    ORF Names:Nbla00487
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:21186 ATAT1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		615556 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q5SQI0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell junction, Cell projection, Coated pit, Cytoplasm, Cytoskeleton, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58Q → A: Loss of acetyltransferase activity. 1 Publication1
    Mutagenesisi61S → A: No effect on catalytic activity. 1 Publication1
    Mutagenesisi64I → A: Strong reduction in acetyltransferase activity. 3 Publications1
    Mutagenesisi69R → A: Strong reduction in acetyltransferase activity. 1 Publication1
    Mutagenesisi102K → A: Strong reduction in acetyltransferase activity. 1 Publication1
    Mutagenesisi105F → A: Reduced activity. 1 Publication1
    Mutagenesisi106V → A: Reduced activity. 1 Publication1
    Mutagenesisi107L → A: Reduced activity. 1 Publication1
    Mutagenesisi108D → A: Reduced activity. 1 Publication1
    Mutagenesisi109D → A: Slight increase in activity. 1 Publication1
    Mutagenesisi109D → R: Marginal increase in activity. 1 Publication1
    Mutagenesisi111E → A: 2-fold increase in activity. 1 Publication1
    Mutagenesisi111E → R: No effect on catalytic activity. 1 Publication1
    Mutagenesisi115E → A: Reduced activity. 1 Publication1
    Mutagenesisi117E → A: Reduced activity. 1 Publication1
    Mutagenesisi120C → A or S: Strong reduction in microtubule acetylation. 1 Publication1
    Mutagenesisi157D → E or N: Strong reduction in microtubule acetylation. 2 Publications1
    Mutagenesisi158R → A: 20% of wild-type acetyltransferase activity. 2 Publications1
    Mutagenesisi182N → A: Strong reduction in activity. 1 Publication1
    Mutagenesisi183F → A: Strong reduction in activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		79969

    Open Targets

    More...    OpenTargetsi    		ENSG00000137343

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA134948212

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		ATAT1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		74743537

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003480661 – 421Alpha-tubulin N-acetyltransferase 1Add BLAST421

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei146N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei233N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei244N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei272PhosphoserineBy similarity1
    Modified residuei276PhosphoserineCombined sources1
    Modified residuei305Asymmetric dimethylarginineBy similarity1
    Modified residuei315PhosphoserineCombined sources1
    Modified residuei323Omega-N-methylarginineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Autoacetylation strongly increases tubulin acetylation.UniRule annotation

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q5SQI0

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q5SQI0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q5SQI0

    PeptideAtlas

    More...    PeptideAtlasi    		Q5SQI0

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q5SQI0

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		63801
    63802 [Q5SQI0-2]
    63803 [Q5SQI0-3]
    63804 [Q5SQI0-4]
    63805 [Q5SQI0-5]
    63806 [Q5SQI0-6]
    63807 [Q5SQI0-7]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q5SQI0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q5SQI0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000137343 Expressed in 165 organ(s), highest expression level in brain

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q5SQI0 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q5SQI0 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA046816
    HPA050999

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Component of the BBSome complex.

    Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.

    UniRule annotation4 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		123036, 9 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q5SQI0, 2 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000327832

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1421
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q5SQI0

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 190N-acetyltransferaseUniRule annotationAdd BLAST190

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 137Acetyl-CoA bindingUniRule annotation3 PublicationsAdd BLAST14
    Regioni160 – 169Acetyl-CoA bindingUniRule annotation3 Publications10

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the acetyltransferase ATAT1 family.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG4601 Eukaryota
    ENOG4111Q8H LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000008276

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q5SQI0

    KEGG Orthology (KO)

    More...    KOi    		K19573

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		WVGTCST

    Database of Orthologous Groups

    More...    OrthoDBi    		729490at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q5SQI0

    TreeFam database of animal gene trees

    More...    TreeFami    		TF315643

    Family and domain databases

    HAMAP database of protein families

    More...    HAMAPi    		MF_03130 mec17, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR038746 Atat
    IPR007965 GNAT_ATAT

    The PANTHER Classification System

    More...    PANTHERi    		PTHR12327 PTHR12327, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF05301 Acetyltransf_16, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS51730 GNAT_ATAT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 11 Publication (identifier: Q5SQI0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL 
            60         70         80         90        100
    GKASAKAQNL SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG 
           110        120        130        140        150
    YKKLFVLDDR EAHNEVEPLC ILDFYIHESV QRHGHGRELF QYMLQKERVE 
           160        170        180        190        200
    PHQLAIDRPS QKLLKFLNKH YNLETTVPQV NNFVIFEGFF AHQHRPPAPS 
           210        220        230        240        250
    LRATRHSRAA AVDPTPAAPA RKLPPKRAEG DIKPYSSSDR EFLKVAVEPP 
           260        270        280        290        300
    WPLNRAPRRA TPPAHPPPRS SSLGNSPERG PLRPFVPEQE LLRSLRLCPP 
           310        320        330        340        350
    HPTARLLLAA DPGGSPAQRR RTRGTPPGLV AQSCCYSRHG GVNSSSPNTG 
           360        370        380        390        400
    NQDSKQGEQE TKNRSASEEQ ALSQDGSGEK PMHTAPPQAP APPAQSWTVG 
           410        420 
    GDILNARFIR NLQERRSTRP W
    Length:421
    Mass (Da):46,810
    Last modified:December 21, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CC9B4B844930842
    GO
    Isoform 22 Publications (identifier: Q5SQI0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: Missing.
         13-36: ERITVLDQHLRPPARRPGTTTPAR → MWLTWPFCFLTITLREEGVCHLES

    Show »
    Length:409
    Mass (Da):45,574
    Checksum:iD2D140F7FADEDEEA
    GO
    Isoform 31 Publication (identifier: Q5SQI0-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-218: RPPAPSLRATRHSRAAAVDPTPAA → P

    Show »
    Length:398
    Mass (Da):44,458
    Checksum:i4E53964B391B8C4F
    GO
    Isoform 42 Publications (identifier: Q5SQI0-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         323-333: RGTPPGLVAQS → SSLPRSEESRY
         334-421: Missing.

    Show »
    Length:333
    Mass (Da):37,478
    Checksum:i9AF89C8C2FF122FC
    GO
    Isoform 52 Publications (identifier: Q5SQI0-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         324-421: Missing.

    Show »
    Length:323
    Mass (Da):36,342
    Checksum:iE3D8C0B120A640FB
    GO
    Isoform 61 Publication (identifier: Q5SQI0-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
         323-333: RGTPPGLVAQS → SSLPRSEESRY
         334-421: Missing.

    Show »
    Length:310
    Mass (Da):35,126
    Checksum:i1F8BD442CF9A9797
    GO
    Isoform 72 Publications (identifier: Q5SQI0-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
         324-421: Missing.

    Show »
    Length:300
    Mass (Da):33,990
    Checksum:i359BE466FD5562B1
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0528991 – 12Missing in isoform 2. 2 PublicationsAdd BLAST12
    Alternative sequenceiVSP_05290013 – 36ERITV…TTPAR → MWLTWPFCFLTITLREEGVC HLES in isoform 2. 2 PublicationsAdd BLAST24
    Alternative sequenceiVSP_052901195 – 218RPPAP…PTPAA → P in isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST24
    Alternative sequenceiVSP_052902323 – 333RGTPPGLVAQS → SSLPRSEESRY in isoform 4 and isoform 6. 3 PublicationsAdd BLAST11
    Alternative sequenceiVSP_052903324 – 421Missing in isoform 5 and isoform 7. 3 PublicationsAdd BLAST98
    Alternative sequenceiVSP_052904334 – 421Missing in isoform 4 and isoform 6. 3 PublicationsAdd BLAST88

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AB075512 mRNA Translation: BAE45758.1
    AK023220 mRNA Translation: BAB14472.1
    AL662800 Genomic DNA No translation available.
    AL732442 Genomic DNA No translation available.
    AL845353 Genomic DNA No translation available.
    BX119957 Genomic DNA No translation available.
    BX908728 Genomic DNA No translation available.
    CR753328 Genomic DNA No translation available.
    CR759778 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX03306.1
    CH471081 Genomic DNA Translation: EAX03307.1
    BC006105 mRNA Translation: AAH06105.1
    BC047303 mRNA Translation: AAH47303.1
    AL833858 mRNA Translation: CAD38717.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS4683.2 [Q5SQI0-4]
    CCDS54978.1 [Q5SQI0-2]
    CCDS59002.1 [Q5SQI0-6]
    CCDS83072.1 [Q5SQI0-5]
    CCDS83073.1 [Q5SQI0-7]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001026892.1, NM_001031722.3 [Q5SQI0-2]
    NP_001177653.1, NM_001190724.2
    NP_001241881.1, NM_001254952.2 [Q5SQI0-6]
    NP_001305691.1, NM_001318762.1 [Q5SQI0-7]
    NP_001305692.1, NM_001318763.1 [Q5SQI0-5]
    NP_079185.2, NM_024909.3 [Q5SQI0-4]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000318999; ENSP00000324222; ENSG00000137343 [Q5SQI0-7]
    ENST00000319027; ENSP00000324459; ENSG00000137343 [Q5SQI0-6]
    ENST00000329992; ENSP00000332374; ENSG00000137343 [Q5SQI0-4]
    ENST00000330083; ENSP00000327832; ENSG00000137343 [Q5SQI0-2]
    ENST00000376483; ENSP00000365666; ENSG00000137343 [Q5SQI0-5]
    ENST00000376485; ENSP00000365668; ENSG00000137343 [Q5SQI0-1]
    ENST00000383582; ENSP00000373076; ENSG00000206488 [Q5SQI0-2]
    ENST00000383583; ENSP00000373077; ENSG00000206488 [Q5SQI0-4]
    ENST00000383584; ENSP00000373078; ENSG00000206488 [Q5SQI0-7]
    ENST00000383585; ENSP00000373079; ENSG00000206488 [Q5SQI0-1]
    ENST00000400575; ENSP00000383419; ENSG00000206488 [Q5SQI0-5]
    ENST00000400576; ENSP00000383420; ENSG00000206488 [Q5SQI0-6]
    ENST00000411724; ENSP00000388617; ENSG00000234549 [Q5SQI0-5]
    ENST00000416435; ENSP00000412993; ENSG00000235658 [Q5SQI0-2]
    ENST00000416917; ENSP00000402998; ENSG00000234549 [Q5SQI0-7]
    ENST00000417183; ENSP00000393868; ENSG00000231257 [Q5SQI0-7]
    ENST00000418248; ENSP00000411362; ENSG00000231257 [Q5SQI0-5]
    ENST00000420586; ENSP00000411050; ENSG00000231257 [Q5SQI0-1]
    ENST00000423338; ENSP00000415000; ENSG00000223752 [Q5SQI0-7]
    ENST00000423654; ENSP00000403142; ENSG00000235658 [Q5SQI0-5]
    ENST00000424121; ENSP00000412198; ENSG00000223752 [Q5SQI0-6]
    ENST00000425448; ENSP00000391244; ENSG00000223752 [Q5SQI0-2]
    ENST00000428764; ENSP00000399509; ENSG00000235658 [Q5SQI0-4]
    ENST00000430611; ENSP00000409296; ENSG00000235658 [Q5SQI0-6]
    ENST00000432356; ENSP00000416994; ENSG00000234549 [Q5SQI0-1]
    ENST00000432643; ENSP00000416925; ENSG00000231257 [Q5SQI0-2]
    ENST00000442844; ENSP00000394914; ENSG00000235658 [Q5SQI0-1]
    ENST00000443114; ENSP00000405656; ENSG00000229061 [Q5SQI0-7]
    ENST00000443391; ENSP00000406071; ENSG00000229061 [Q5SQI0-6]
    ENST00000445486; ENSP00000398422; ENSG00000223752 [Q5SQI0-1]
    ENST00000445973; ENSP00000415408; ENSG00000231257 [Q5SQI0-6]
    ENST00000446100; ENSP00000393269; ENSG00000229061 [Q5SQI0-5]
    ENST00000448670; ENSP00000389129; ENSG00000229061 [Q5SQI0-2]
    ENST00000449905; ENSP00000399529; ENSG00000235658 [Q5SQI0-7]
    ENST00000450003; ENSP00000406421; ENSG00000223752 [Q5SQI0-4]
    ENST00000450220; ENSP00000405036; ENSG00000231257 [Q5SQI0-4]
    ENST00000454794; ENSP00000409067; ENSG00000229061 [Q5SQI0-1]
    ENST00000454987; ENSP00000410415; ENSG00000234549 [Q5SQI0-6]
    ENST00000456215; ENSP00000399452; ENSG00000234549 [Q5SQI0-4]
    ENST00000456704; ENSP00000394357; ENSG00000229061 [Q5SQI0-4]
    ENST00000457161; ENSP00000388171; ENSG00000223752 [Q5SQI0-5]
    ENST00000457334; ENSP00000398374; ENSG00000234549 [Q5SQI0-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		79969

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:79969

    UCSC genome browser

    More...    UCSCi    		uc003nqr.5 human [Q5SQI0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AB075512 mRNA Translation: BAE45758.1
    AK023220 mRNA Translation: BAB14472.1
    AL662800 Genomic DNA No translation available.
    AL732442 Genomic DNA No translation available.
    AL845353 Genomic DNA No translation available.
    BX119957 Genomic DNA No translation available.
    BX908728 Genomic DNA No translation available.
    CR753328 Genomic DNA No translation available.
    CR759778 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX03306.1
    CH471081 Genomic DNA Translation: EAX03307.1
    BC006105 mRNA Translation: AAH06105.1
    BC047303 mRNA Translation: AAH47303.1
    AL833858 mRNA Translation: CAD38717.1
    CCDSiCCDS4683.2 [Q5SQI0-4]
    CCDS54978.1 [Q5SQI0-2]
    CCDS59002.1 [Q5SQI0-6]
    CCDS83072.1 [Q5SQI0-5]
    CCDS83073.1 [Q5SQI0-7]
    RefSeqiNP_001026892.1, NM_001031722.3 [Q5SQI0-2]
    NP_001177653.1, NM_001190724.2
    NP_001241881.1, NM_001254952.2 [Q5SQI0-6]
    NP_001305691.1, NM_001318762.1 [Q5SQI0-7]
    NP_001305692.1, NM_001318763.1 [Q5SQI0-5]
    NP_079185.2, NM_024909.3 [Q5SQI0-4]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3VWDX-ray1.25A1-194[»]
    3VWEX-ray1.96A1-194[»]
    4B5OX-ray1.05A1-196[»]
    4B5PX-ray1.60A/B1-196[»]
    4GS4X-ray2.11A2-236[»]
    4IF5X-ray1.70A1-193[»]
    4PK2X-ray1.35A1-194[»]
    4PK3X-ray1.35A1-194[»]
    4U9YX-ray2.20A1-194[»]
    4U9ZX-ray1.80A1-194[»]
    SMRiQ5SQI0
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi123036, 9 interactors
    IntActiQ5SQI0, 2 interactors
    STRINGi9606.ENSP00000327832

    PTM databases

    iPTMnetiQ5SQI0
    PhosphoSitePlusiQ5SQI0

    Polymorphism and mutation databases

    BioMutaiATAT1
    DMDMi74743537

    Proteomic databases

    EPDiQ5SQI0
    jPOSTiQ5SQI0
    PaxDbiQ5SQI0
    PeptideAtlasiQ5SQI0
    PRIDEiQ5SQI0
    ProteomicsDBi63801
    63802 [Q5SQI0-2]
    63803 [Q5SQI0-3]
    63804 [Q5SQI0-4]
    63805 [Q5SQI0-5]
    63806 [Q5SQI0-6]
    63807 [Q5SQI0-7]

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		79969
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000318999; ENSP00000324222; ENSG00000137343 [Q5SQI0-7]
    ENST00000319027; ENSP00000324459; ENSG00000137343 [Q5SQI0-6]
    ENST00000329992; ENSP00000332374; ENSG00000137343 [Q5SQI0-4]
    ENST00000330083; ENSP00000327832; ENSG00000137343 [Q5SQI0-2]
    ENST00000376483; ENSP00000365666; ENSG00000137343 [Q5SQI0-5]
    ENST00000376485; ENSP00000365668; ENSG00000137343 [Q5SQI0-1]
    ENST00000383582; ENSP00000373076; ENSG00000206488 [Q5SQI0-2]
    ENST00000383583; ENSP00000373077; ENSG00000206488 [Q5SQI0-4]
    ENST00000383584; ENSP00000373078; ENSG00000206488 [Q5SQI0-7]
    ENST00000383585; ENSP00000373079; ENSG00000206488 [Q5SQI0-1]
    ENST00000400575; ENSP00000383419; ENSG00000206488 [Q5SQI0-5]
    ENST00000400576; ENSP00000383420; ENSG00000206488 [Q5SQI0-6]
    ENST00000411724; ENSP00000388617; ENSG00000234549 [Q5SQI0-5]
    ENST00000416435; ENSP00000412993; ENSG00000235658 [Q5SQI0-2]
    ENST00000416917; ENSP00000402998; ENSG00000234549 [Q5SQI0-7]
    ENST00000417183; ENSP00000393868; ENSG00000231257 [Q5SQI0-7]
    ENST00000418248; ENSP00000411362; ENSG00000231257 [Q5SQI0-5]
    ENST00000420586; ENSP00000411050; ENSG00000231257 [Q5SQI0-1]
    ENST00000423338; ENSP00000415000; ENSG00000223752 [Q5SQI0-7]
    ENST00000423654; ENSP00000403142; ENSG00000235658 [Q5SQI0-5]
    ENST00000424121; ENSP00000412198; ENSG00000223752 [Q5SQI0-6]
    ENST00000425448; ENSP00000391244; ENSG00000223752 [Q5SQI0-2]
    ENST00000428764; ENSP00000399509; ENSG00000235658 [Q5SQI0-4]
    ENST00000430611; ENSP00000409296; ENSG00000235658 [Q5SQI0-6]
    ENST00000432356; ENSP00000416994; ENSG00000234549 [Q5SQI0-1]
    ENST00000432643; ENSP00000416925; ENSG00000231257 [Q5SQI0-2]
    ENST00000442844; ENSP00000394914; ENSG00000235658 [Q5SQI0-1]
    ENST00000443114; ENSP00000405656; ENSG00000229061 [Q5SQI0-7]
    ENST00000443391; ENSP00000406071; ENSG00000229061 [Q5SQI0-6]
    ENST00000445486; ENSP00000398422; ENSG00000223752 [Q5SQI0-1]
    ENST00000445973; ENSP00000415408; ENSG00000231257 [Q5SQI0-6]
    ENST00000446100; ENSP00000393269; ENSG00000229061 [Q5SQI0-5]
    ENST00000448670; ENSP00000389129; ENSG00000229061 [Q5SQI0-2]
    ENST00000449905; ENSP00000399529; ENSG00000235658 [Q5SQI0-7]
    ENST00000450003; ENSP00000406421; ENSG00000223752 [Q5SQI0-4]
    ENST00000450220; ENSP00000405036; ENSG00000231257 [Q5SQI0-4]
    ENST00000454794; ENSP00000409067; ENSG00000229061 [Q5SQI0-1]
    ENST00000454987; ENSP00000410415; ENSG00000234549 [Q5SQI0-6]
    ENST00000456215; ENSP00000399452; ENSG00000234549 [Q5SQI0-4]
    ENST00000456704; ENSP00000394357; ENSG00000229061 [Q5SQI0-4]
    ENST00000457161; ENSP00000388171; ENSG00000223752 [Q5SQI0-5]
    ENST00000457334; ENSP00000398374; ENSG00000234549 [Q5SQI0-2]
    GeneIDi79969
    KEGGihsa:79969
    UCSCiuc003nqr.5 human [Q5SQI0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		79969
    DisGeNETi79969

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		ATAT1

    H-Invitational Database, human transcriptome db

    More...    H-InvDBi    		HIX0166068
    HIX0166337
    HIX0166615
    HIX0166865
    HIX0167123
    HIX0167356
    HIX0184148
    HGNCiHGNC:21186 ATAT1
    HPAiHPA046816
    HPA050999
    MIMi615556 gene
    neXtProtiNX_Q5SQI0
    OpenTargetsiENSG00000137343
    PharmGKBiPA134948212

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG4601 Eukaryota
    ENOG4111Q8H LUCA
    GeneTreeiENSGT00390000008276
    InParanoidiQ5SQI0
    KOiK19573
    OMAiWVGTCST
    OrthoDBi729490at2759
    PhylomeDBiQ5SQI0
    TreeFamiTF315643

    Enzyme and pathway databases

    ReactomeiR-HSA-5617833 Cilium Assembly

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		79969

    Protein Ontology

    More...    PROi    		PR:Q5SQI0

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000137343 Expressed in 165 organ(s), highest expression level in brain
    ExpressionAtlasiQ5SQI0 baseline and differential
    GenevisibleiQ5SQI0 HS

    Family and domain databases

    HAMAPiMF_03130 mec17, 1 hit
    InterProiView protein in InterPro
    IPR038746 Atat
    IPR007965 GNAT_ATAT
    PANTHERiPTHR12327 PTHR12327, 1 hit
    PfamiView protein in Pfam
    PF05301 Acetyltransf_16, 1 hit
    PROSITEiView protein in PROSITE
    PS51730 GNAT_ATAT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATAT_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SQI0
    Secondary accession number(s): A2AB28
    , Q3LIB0, Q5JP39, Q5JP40, Q5JP42, Q5SQI1, Q5SU03, Q86X42, Q8NDK9, Q9BRS1, Q9H8X5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: December 21, 2004
    Last modified: June 5, 2019
    This is version 123 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries
    5. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
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