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UniProtKB - Q5SQ80 (A20A2_HUMAN)

Entry version 120 (10 Feb 2021)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

Putative ankyrin repeat domain-containing protein 20A2

Gene

ANKRD20A2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Could be the product of a pseudogene.Curated

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5SQ80

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative ankyrin repeat domain-containing protein 20A2
Alternative name(s):
Ankyrin repeat domain-containing protein 20A2 pseudogeneImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD20A2PImported
Synonyms:ANKRD20A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:31979, ANKRD20A2P

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5SQ80

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183148.6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672619

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5SQ80, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANKRD20A2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74743522

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002408371 – 823Putative ankyrin repeat domain-containing protein 20A2Add BLAST823

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5SQ80

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5SQ80

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5SQ80

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5SQ80

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5SQ80

PeptideAtlas

More...PeptideAtlasi		Q5SQ80

PRoteomics IDEntifications database

More...PRIDEi		Q5SQ80

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63791

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5SQ80

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5SQ80

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183148, Expressed in sural nerve and 90 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5SQ80, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5SQ80, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183148, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366826

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5SQ80, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5SQ80

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati66 – 95ANK 1Add BLAST30
Repeati99 – 128ANK 2Add BLAST30
Repeati132 – 161ANK 3Add BLAST30
Repeati165 – 194ANK 4Add BLAST30
Repeati198 – 227ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili431 – 480Sequence analysisAdd BLAST50
Coiled coili565 – 724Sequence analysisAdd BLAST160
Coiled coili776 – 805Sequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0504, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163801

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001111_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5SQ80

Identification of Orthologs from Complete Genome Data

More...OMAi		TQDISEQ

Database of Orthologous Groups

More...OrthoDBi		294605at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5SQ80

TreeFam database of animal gene trees

More...TreeFami		TF333496

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF14915, CCDC144C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SQ80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE 
        60         70         80         90        100
RCLARRSGDL DALDKQHRTA LHLACASGHV QVVTLLVNRK CQIDVCDKEN 
       110        120        130        140        150
RTPLIQAVHC QEEACAVILL EHGANPNLKD IYGNTALHYA VYSESTSLAE 
       160        170        180        190        200
KLLSHGAHIE ALDKDNNTPL LFAIICKKEK MVEFLLKRKA SSHAVDRLRR 
       210        220        230        240        250
SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI SHHLTKIQQQ 
       260        270        280        290        300
ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC 
       310        320        330        340        350
VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV 
       360        370        380        390        400
QRKNVQTLRA EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS 
       410        420        430        440        450
ENICDSTSSA AAGRLTQQRK IGKTYPQQFP KKLKEEHDRC TLKQENEEKT 
       460        470        480        490        500
NVNMLYKKNR EELERKEKQY KKEVEAKQLE PTVQSLEMKS KTARNTPNRD 
       510        520        530        540        550
FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN KYLKDIKIVK 
       560        570        580        590        600
ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK 
       610        620        630        640        650
RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI 
       660        670        680        690        700
SKVKDENEFL TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS 
       710        720        730        740        750
QTQQQTQEMK EMYQNAEAKV NNSTGKWNCV EERICHLQRE NAWLVQQLDD 
       760        770        780        790        800
VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE KSKKLMNECD HLKESLFQYE 
       810        820 
REKTEGVVSI KEDKYFQTSR KKI
Length:823
Mass (Da):94,087
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C1C478C3EE9B67F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1P9A0A087X1P9_HUMAN
Putative ankyrin repeat domain-cont...
ANKRD20A2P
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL773545 Genomic DNA No translation available.
BX664727 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001012421.1, NM_001012421.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377601; ENSP00000366826; ENSG00000183148

UCSC genome browser

More...UCSCi		uc004acd.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773545 Genomic DNA No translation available.
BX664727 Genomic DNA No translation available.
RefSeqiNP_001012421.1, NM_001012421.1

3D structure databases

SMRiQ5SQ80
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366826

PTM databases

iPTMnetiQ5SQ80
PhosphoSitePlusiQ5SQ80

Genetic variation databases

BioMutaiANKRD20A2
DMDMi74743522

Proteomic databases

EPDiQ5SQ80
jPOSTiQ5SQ80
MassIVEiQ5SQ80
MaxQBiQ5SQ80
PaxDbiQ5SQ80
PeptideAtlasiQ5SQ80
PRIDEiQ5SQ80
ProteomicsDBi63791

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		71388, 3 antibodies

Genome annotation databases

EnsembliENST00000377601; ENSP00000366826; ENSG00000183148
UCSCiuc004acd.4, human

Organism-specific databases

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANKRD20A2P
HGNCiHGNC:31979, ANKRD20A2P
HPAiENSG00000183148, Tissue enriched (testis)
neXtProtiNX_Q5SQ80
PharmGKBiPA142672619
VEuPathDBiHostDB:ENSG00000183148.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
GeneTreeiENSGT00940000163801
HOGENOMiCLU_001111_3_0_1
InParanoidiQ5SQ80
OMAiTQDISEQ
OrthoDBi294605at2759
PhylomeDBiQ5SQ80
TreeFamiTF333496

Enzyme and pathway databases

PathwayCommonsiQ5SQ80

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		441430, 347 hits in 448 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		441430
PharosiQ5SQ80, Tdark

Protein Ontology

More...PROi		PR:Q5SQ80
RNActiQ5SQ80, protein

Gene expression databases

BgeeiENSG00000183148, Expressed in sural nerve and 90 other tissues
ExpressionAtlasiQ5SQ80, baseline and differential
GenevisibleiQ5SQ80, HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF14915, CCDC144C, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA20A2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SQ80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: February 10, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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