UniProtKB - Q5SQ64 (LY66F_HUMAN)
Protein
Lymphocyte antigen 6 complex locus protein G6f
Gene
LY6G6F
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.1 Publication
GO - Biological processi
- platelet degranulation Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q5SQ64 |
Reactomei | R-HSA-114608, Platelet degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Lymphocyte antigen 6 complex locus protein G6f |
Gene namesi | Name:LY6G6F Synonyms:C6orf21, G6F, LY6G6D, NG32 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204424.9 |
HGNCi | HGNC:13933, LY6G6F |
MIMi | 611404, gene |
neXtProti | NX_Q5SQ64 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- platelet alpha granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 235 | ExtracellularSequence analysisAdd BLAST | 219 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 297 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 281 | Y → F: No phosphorylation. No interaction with GRB2 and GRB7. No phosphorylation increase of p42/44 MAP kinase. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 259215 |
OpenTargetsi | ENSG00000204424 ENSG00000250641 |
PharmGKBi | PA38371 |
Miscellaneous databases
Pharosi | Q5SQ64, Tdark |
Polymorphism and mutation databases
BioMutai | LY6G6F |
DMDMi | 172045922 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000318923 | 17 – 297 | Lymphocyte antigen 6 complex locus protein G6fAdd BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 106 | PROSITE-ProRule annotation | ||
Glycosylationi | 88 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 281 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q5SQ64 |
PaxDbi | Q5SQ64 |
PeptideAtlasi | Q5SQ64 |
PRIDEi | Q5SQ64 |
ProteomicsDBi | 63788 [Q5SQ64-1] 83413 |
PTM databases
GlyGeni | Q5SQ64, 1 site |
iPTMneti | Q5SQ64 |
PhosphoSitePlusi | Q5SQ64 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204424, Expressed in monocyte and 40 other tissues |
ExpressionAtlasi | Q5SQ64, baseline and differential |
Genevisiblei | Q5SQ64, HS |
Organism-specific databases
HPAi | ENSG00000204424, Tissue enhanced (blood, bone marrow, lung, lymphoid tissue) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with GRB2 and GRB7 in a phosphorylation-dependent manner.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 129225, 5 interactors |
IntActi | Q5SQ64, 2 interactors |
MINTi | Q5SQ64 |
STRINGi | 9606.ENSP00000364992 |
Miscellaneous databases
RNActi | Q5SQ64, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 122 | Ig-like V-typeAdd BLAST | 106 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SNF5, Eukaryota |
GeneTreei | ENSGT00390000015960 |
HOGENOMi | CLU_071209_0_0_1 |
InParanoidi | Q5SQ64 |
OMAi | PRTICCL |
PhylomeDBi | Q5SQ64 |
TreeFami | TF337100 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR026524, LY6G6d/LY6G6f |
PANTHERi | PTHR32286, PTHR32286, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5SQ64-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVLFLLLFL CGTPQAADNM QAIYVALGEA VELPCPSPPT LHGDEHLSWF
60 70 80 90 100
CSPAAGSFTT LVAQVQVGRP APDPGKPGRE SRLRLLGNYS LWLEGSKEED
110 120 130 140 150
AGRYWCAVLG QHHNYQNWRV YDVLVLKGSQ LSARAADGSP CNVLLCSVVP
160 170 180 190 200
SRRMDSVTWQ EGKGPVRGRV QSFWGSEAAL LLVCPGEGLS EPRSRRPRII
210 220 230 240 250
RCLMTHNKGV SFSLAASIDA SPALCAPSTG WDMPWILMLL LTMGQGVVIL
260 270 280 290
ALSIVLWRQR VRGAPGRDAS IPQFKPEIQV YENIHLARLG PPAHKPR
Sequence cautioni
The sequence AAD18078 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB63382 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038908 | 34 | P → Q. Corresponds to variant dbSNP:rs17200983EnsemblClinVar. | 1 | |
Natural variantiVAR_038909 | 39 | P → S1 PublicationCorresponds to variant dbSNP:rs805295Ensembl. | 1 | |
Natural variantiVAR_038910 | 107 | A → T1 PublicationCorresponds to variant dbSNP:rs9267547Ensembl. | 1 | |
Natural variantiVAR_038911 | 167 | R → K. Corresponds to variant dbSNP:rs2242653Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055597 | 268 – 297 | DASIP…AHKPR → GNRMRCYNCGGSPSSSCKEA VTTCGEGRPQPGLEQIKLPG NPPVTLIHQHPACVAAHHCN QVETESVGDVTYPAHRDCYL GDLCNSAVASHVAPAGILAA AATALTCLLPGLWSG in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ496460 mRNA Translation: CAD42968.1 AF129756 Genomic DNA Translation: AAD18078.1 Sequence problems. BA000025 Genomic DNA Translation: BAB63382.1 Sequence problems. AF195764 mRNA Translation: AAF35181.1 AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX248244 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759787 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03485.1 CH471081 Genomic DNA Translation: EAX03487.1 BC137212 mRNA Translation: AAI37213.1 BC137213 mRNA Translation: AAI37214.1 |
CCDSi | CCDS34403.1 [Q5SQ64-1] |
RefSeqi | NP_001003693.1, NM_001003693.1 [Q5SQ64-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ496460 mRNA Translation: CAD42968.1 AF129756 Genomic DNA Translation: AAD18078.1 Sequence problems. BA000025 Genomic DNA Translation: BAB63382.1 Sequence problems. AF195764 mRNA Translation: AAF35181.1 AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX248244 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759787 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03485.1 CH471081 Genomic DNA Translation: EAX03487.1 BC137212 mRNA Translation: AAI37213.1 BC137213 mRNA Translation: AAI37214.1 |
CCDSi | CCDS34403.1 [Q5SQ64-1] |
RefSeqi | NP_001003693.1, NM_001003693.1 [Q5SQ64-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129225, 5 interactors |
IntActi | Q5SQ64, 2 interactors |
MINTi | Q5SQ64 |
STRINGi | 9606.ENSP00000364992 |
PTM databases
GlyGeni | Q5SQ64, 1 site |
iPTMneti | Q5SQ64 |
PhosphoSitePlusi | Q5SQ64 |
Polymorphism and mutation databases
BioMutai | LY6G6F |
DMDMi | 172045922 |
Proteomic databases
MassIVEi | Q5SQ64 |
PaxDbi | Q5SQ64 |
PeptideAtlasi | Q5SQ64 |
PRIDEi | Q5SQ64 |
ProteomicsDBi | 63788 [Q5SQ64-1] 83413 |
Protocols and materials databases
Antibodypediai | 34899, 138 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 259215 |
DisGeNETi | 259215 |
EuPathDBi | HostDB:ENSG00000204424.9 |
GeneCardsi | LY6G6F |
HGNCi | HGNC:13933, LY6G6F |
HPAi | ENSG00000204424, Tissue enhanced (blood, bone marrow, lung, lymphoid tissue) |
MIMi | 611404, gene |
neXtProti | NX_Q5SQ64 |
OpenTargetsi | ENSG00000204424 ENSG00000250641 |
PharmGKBi | PA38371 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SNF5, Eukaryota |
GeneTreei | ENSGT00390000015960 |
HOGENOMi | CLU_071209_0_0_1 |
InParanoidi | Q5SQ64 |
OMAi | PRTICCL |
PhylomeDBi | Q5SQ64 |
TreeFami | TF337100 |
Enzyme and pathway databases
PathwayCommonsi | Q5SQ64 |
Reactomei | R-HSA-114608, Platelet degranulation |
Miscellaneous databases
BioGRID-ORCSi | 259215, 2 hits in 839 CRISPR screens |
GenomeRNAii | 259215 |
Pharosi | Q5SQ64, Tdark |
PROi | PR:Q5SQ64 |
RNActi | Q5SQ64, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204424, Expressed in monocyte and 40 other tissues |
ExpressionAtlasi | Q5SQ64, baseline and differential |
Genevisiblei | Q5SQ64, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR026524, LY6G6d/LY6G6f |
PANTHERi | PTHR32286, PTHR32286, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LY66F_HUMAN | |
Accessioni | Q5SQ64Primary (citable) accession number: Q5SQ64 Secondary accession number(s): B0UXB7 Q9NZJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations