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UniProtKB - Q5SPS2 (Q5SPS2_DANRE)

Entry version 83 (07 Oct 2020)
Sequence version 1 (21 Dec 2004)
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Protein
Submitted name:

Family with sequence similarity 184 member A

Gene

fam184a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Family with sequence similarity 184 member AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fam184aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-041014-214, fam184a

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000014081, Expressed in brain and 15 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5SPS2, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 211FAM184InterPro annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni939 – 1027DisorderedSequence analysisAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2 – 44Sequence analysisAdd BLAST43
Coiled coili48 – 82Sequence analysisAdd BLAST35
Coiled coili131 – 162Sequence analysisAdd BLAST32
Coiled coili167 – 216Sequence analysisAdd BLAST50
Coiled coili235 – 304Sequence analysisAdd BLAST70
Coiled coili340 – 381Sequence analysisAdd BLAST42
Coiled coili390 – 410Sequence analysisAdd BLAST21
Coiled coili426 – 446Sequence analysisAdd BLAST21
Coiled coili456 – 508Sequence analysisAdd BLAST53
Coiled coili516 – 557Sequence analysisAdd BLAST42
Coiled coili585 – 620Sequence analysisAdd BLAST36
Coiled coili626 – 682Sequence analysisAdd BLAST57
Coiled coili721 – 759Sequence analysisAdd BLAST39
Coiled coili780 – 846Sequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi950 – 976PolarSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063669

Identification of Orthologs from Complete Genome Data

More...OMAi		MCKKVAQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029605, FAM184
IPR029607, FAM184A
IPR039478, FAM184A/B_N

The PANTHER Classification System

More...PANTHERi		PTHR18870, PTHR18870, 2 hits
PTHR18870:SF7, PTHR18870:SF7, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15665, FAM184, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5SPS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VIYALNTKND EHEAAIQTLK EAHEEEVQQI LSETREKIMQ YKSKISDEMD 
        60         70         80         90        100
LKRRIQSLEE SMELHERMKR QALDEFETYR QRVEDMQLCT EAQHTQRVVS 
       110        120        130        140        150
MSREVEEMRR SFEEKLRSFA QLQSQFEQEK RQALEELRSG HRQEVQELLR 
       160        170        180        190        200
SHQSQNANYS KDQEKLGQLH KAEVDSLNER VEELKQDKKR LVEEYEAKLN 
       210        220        230        240        250
KAQAFYEREL EAMKRTQQMT AENLLAWKKT EAELRKEFQA QEAALQKTLG 
       260        270        280        290        300
KLRSELQRVQ DEARESREKS HKLQASLMTA ENNIKELHKQ LEEVTKDAEI 
       310        320        330        340        350
VEIRQREGEC ELEASRDRVQ QQATEILLKA SQIGSLQATQ MTHEAVIRDL 
       360        370        380        390        400
ESEKSRLKDK VLRLEEERGA LQNKCQTLDD RQRQQIVTLE KSLREEKQIY 
       410        420        430        440        450
EKELMNLRAK YEDDTAHFKE SHSRALEELS RKHRASLENI QSLSEKEKNR 
       460        470        480        490        500
LLSDMEDQFN KERTSLEEQK RILREELDSL REELTAKLNM ANNEVSRLQE 
       510        520        530        540        550
LVKQGEQTLG SSEGHISNLK DAQKKLLEEL DATRARLRET SNLLTALQGE 
       560        570        580        590        600
METQKQQHDA KLISIKEEEK LKMDKMALEL ELKWTETLRQ ECKKLREELR 
       610        620        630        640        650
EDHEEDKRSA LTQLAQNKDQ ELCSARESWQ RKVEDLLEQI SLLKQSLEMQ 
       660        670        680        690        700
LSQSQHSLQQ LQAQFSQERE HLGQQLEEME MEHQHRQQRL QEAHCCAIQD 
       710        720        730        740        750
MQEARKHDLK ALEERLRQQH HMELQTLREA HRQNIETLKQ QSEQELQTLR 
       760        770        780        790        800
FELEDEGKAM LASLRSELNH LHASAIEHMR QTHQQETAAA KQELENALEQ 
       810        820        830        840        850
SRVQERELLS RISDLQEEVS RRKKHIADLD HEIHTLNENI STLTKELELK 
       860        870        880        890        900
GKEVLKIRSE ANQQIRLEGT EDKFRNRESR PEDLQTIAEL KDMVAEREAL 
       910        920        930        940        950
VKKLVDDKKF YQLELVNRET SFNKIFNANP NVGVINPLVK QKRKNDKSAT 
       960        970        980        990       1000
RFSSSANLRA NVEASGTGSG QPQPNRLEPL PNSPIHQLEP NASKPLSLPT 
      1010       1020       1030 
PLTEPKKVTS PPEGEESALT SPDPQRQEWF AQYFSF
Length:1,036
Mass (Da):121,673
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i690F73AD08BC335A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SPS1Q5SPS1_DANRE
Family with sequence similarity 184...
fam184a
1,145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QI95A0A2R8QI95_DANRE
Family with sequence similarity 184...
fam184a
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PX74A0A2R8PX74_DANRE
Family with sequence similarity 184...
fam184a
552Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RM27A0A2R8RM27_DANRE
Family with sequence similarity 184...
fam184a
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL845301 Genomic DNA No translation available.
AL845322 Genomic DNA No translation available.
AL928827 Genomic DNA No translation available.
BX649543 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000138686; ENSDARP00000116098; ENSDARG00000014081

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845301 Genomic DNA No translation available.
AL845322 Genomic DNA No translation available.
AL928827 Genomic DNA No translation available.
BX649543 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000138686; ENSDARP00000116098; ENSDARG00000014081

Organism-specific databases

ZFINiZDB-GENE-041014-214, fam184a

Phylogenomic databases

GeneTreeiENSGT00530000063669
OMAiMCKKVAQ

Gene expression databases

BgeeiENSDARG00000014081, Expressed in brain and 15 other tissues
ExpressionAtlasiQ5SPS2, baseline

Family and domain databases

InterProiView protein in InterPro
IPR029605, FAM184
IPR029607, FAM184A
IPR039478, FAM184A/B_N
PANTHERiPTHR18870, PTHR18870, 2 hits
PTHR18870:SF7, PTHR18870:SF7, 2 hits
PfamiView protein in Pfam
PF15665, FAM184, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5SPS2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SPS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 7, 2020
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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