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Entry version 94 (12 Aug 2020)
Sequence version 2 (13 Nov 2013)
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Protein
Submitted name:

Family with sequence similarity 184 member A

Gene

fam184a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Family with sequence similarity 184 member AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fam184aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041014-214, fam184a

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SPS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000014081, Expressed in brain and 15 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SPS1, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000122466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 271FAM184InterPro annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1052 – 1135DisorderedSequence analysisAdd BLAST84

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili62 – 104Sequence analysisAdd BLAST43
Coiled coili108 – 142Sequence analysisAdd BLAST35
Coiled coili191 – 222Sequence analysisAdd BLAST32
Coiled coili227 – 276Sequence analysisAdd BLAST50
Coiled coili295 – 364Sequence analysisAdd BLAST70
Coiled coili400 – 441Sequence analysisAdd BLAST42
Coiled coili450 – 470Sequence analysisAdd BLAST21
Coiled coili486 – 506Sequence analysisAdd BLAST21
Coiled coili516 – 568Sequence analysisAdd BLAST53
Coiled coili576 – 617Sequence analysisAdd BLAST42
Coiled coili645 – 680Sequence analysisAdd BLAST36
Coiled coili686 – 742Sequence analysisAdd BLAST57
Coiled coili781 – 819Sequence analysisAdd BLAST39
Coiled coili840 – 906Sequence analysisAdd BLAST67
Coiled coili926 – 953Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1059 – 1085PolarSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R5KC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063669

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008886_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SPS1

Database of Orthologous Groups

More...
OrthoDBi
170922at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316006

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029605, FAM184
IPR029607, FAM184A
IPR039478, FAM184A/B_N

The PANTHER Classification System

More...
PANTHERi
PTHR18870, PTHR18870, 1 hit
PTHR18870:SF7, PTHR18870:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15665, FAM184, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5SPS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATGAGWQHY YNPAGSASTG KYNSTSTSTS TSTSFPSGLT LEYTQDLHLK
60 70 80 90 100
MSKKIAQLTK VIYALNTKND EHEAAIQTLK EAHEEEVQQI LSETREKIMQ
110 120 130 140 150
YKSKISDEMD LKRRIQSLEE SMELHERMKR QALDEFETYR QRVEDMQLCT
160 170 180 190 200
EAQHTQRVVS MSREVEEMRR SFEEKLRSFA QLQSQFEQEK RQALEELRSG
210 220 230 240 250
HRQEVQELLR SHQSQNANYS KDQEKLGQLH KAEVDSLNER VEELKQDKKR
260 270 280 290 300
LVEEYEAKLN KAQAFYEREL EAMKRTQQMT AENLLAWKKT EAELRKEFQA
310 320 330 340 350
QEAALQKTLG KLRSELQRVQ DEARESREKS HKLQASLMTA ENNIKELHKQ
360 370 380 390 400
LEEVTKDAEI VEIRQREGEC ELEASRDRVQ QQATEILLKA SQIGSLQATQ
410 420 430 440 450
MTHEAVIRDL ESEKSRLKDK VLRLEEERGA LQNKCQTLDD RQRQQIVTLE
460 470 480 490 500
KSLREEKQIY EKELMNLRAK YEDDTAHFKE SHSRALEELS RKHRASLENI
510 520 530 540 550
QSLSEKEKNR LLSDMEDQFN KERTSLEEQK RILREELDSL REELTAKLNM
560 570 580 590 600
ANNEVSRLQE LVKQGEQTLG SSEGHISNLK DAQKKLLEEL DATRARLRET
610 620 630 640 650
SNLLTALQGE METQKQQHDA KLISIKEEEK LKMDKMALEL ELKWTETLRQ
660 670 680 690 700
ECKKLREELR EDHEEDKRSA LTQLAQNKDQ ELCSARESWQ RKVEDLLEQI
710 720 730 740 750
SLLKQSLEMQ LSQSQHSLQQ LQAQFSQERE HLGQQLEEME MEHQHRQQRL
760 770 780 790 800
QEAHCCAIQD MQEARKHDLK ALEERLRQQH HMELQTLREA HRQNIETLKQ
810 820 830 840 850
QSEQELQTLR FELEDEGKAM LASLRSELNH LHASAIEHMR QTHQQETAAA
860 870 880 890 900
KQELENALEQ SRVQERELLS RISDLQEEVS RRKKHIADLD HEIHTLNENI
910 920 930 940 950
STLTKELELK GKEVLKIRSE ANQQIRAHEQ DLCKKHEREM AELNALHHRE
960 970 980 990 1000
TQNMLSDFNK AQELLKDKIS ALQILLEGTE DKFRNRESRP EDLQTIAELK
1010 1020 1030 1040 1050
DMVAEREALV KKLVDDKKFY QLELVNRETS FNKIFNANPN VGVINPLVKQ
1060 1070 1080 1090 1100
KRKNDKSATR FSSSANLRAN VEASGTGSGQ PQPNRLEPLP NSPIHQLEPN
1110 1120 1130 1140
ASKPLSLPTP LTEPKKVTSP PEGEESALTS PDPQRQEWFA QYFSF
Length:1,145
Mass (Da):133,841
Last modified:November 13, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4113D86BC7CBBD1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SPS2Q5SPS2_DANRE
Family with sequence similarity 184...
fam184a
1,036Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QI95A0A2R8QI95_DANRE
Family with sequence similarity 184...
fam184a
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PX74A0A2R8PX74_DANRE
Family with sequence similarity 184...
fam184a
552Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RM27A0A2R8RM27_DANRE
Family with sequence similarity 184...
fam184a
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL845301 Genomic DNA No translation available.
AL845322 Genomic DNA No translation available.
AL928827 Genomic DNA No translation available.
BX649543 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_683302.2, XM_678210.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000135715; ENSDARP00000122466; ENSDARG00000014081

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
555640

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845301 Genomic DNA No translation available.
AL845322 Genomic DNA No translation available.
AL928827 Genomic DNA No translation available.
BX649543 Genomic DNA No translation available.
RefSeqiXP_683302.2, XM_678210.7

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122466

Proteomic databases

PaxDbiQ5SPS1

Genome annotation databases

EnsembliENSDART00000135715; ENSDARP00000122466; ENSDARG00000014081
GeneIDi555640

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79632
ZFINiZDB-GENE-041014-214, fam184a

Phylogenomic databases

eggNOGiENOG502R5KC, Eukaryota
GeneTreeiENSGT00530000063669
HOGENOMiCLU_008886_0_0_1
InParanoidiQ5SPS1
OrthoDBi170922at2759
TreeFamiTF316006

Gene expression databases

BgeeiENSDARG00000014081, Expressed in brain and 15 other tissues
ExpressionAtlasiQ5SPS1, baseline

Family and domain databases

InterProiView protein in InterPro
IPR029605, FAM184
IPR029607, FAM184A
IPR039478, FAM184A/B_N
PANTHERiPTHR18870, PTHR18870, 1 hit
PTHR18870:SF7, PTHR18870:SF7, 1 hit
PfamiView protein in Pfam
PF15665, FAM184, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5SPS1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SPS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: November 13, 2013
Last modified: August 12, 2020
This is version 94 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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