UniProtKB - Q5SP67 (WDR26_DANRE)
WD repeat-containing protein 26
wdr26
Functioni
G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity).
Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
By similarityGO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 26 |
Gene namesi | Name:wdr26 ORF Names:si:ch211-153j24.6 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-041014-277, wdr26b |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
- Mitochondrion By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- GID complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280737 | 1 – 576 | WD repeat-containing protein 26Add BLAST | 576 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q5SP67 |
PTM databases
iPTMneti | Q5SP67 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000006812, Expressed in mature ovarian follicle and 32 other tissues |
Interactioni
Subunit structurei
Forms homooligomers. Identified in the CTLH complex that contains at least MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10.
Interacts with DDB1-CUL4A/B E3 ligase complexes.
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000036145 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 83 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 84 – 143 | CTLHPROSITE-ProRule annotationAdd BLAST | 60 | |
Repeati | 265 – 304 | WD 1Add BLAST | 40 | |
Repeati | 311 – 350 | WD 2Add BLAST | 40 | |
Repeati | 356 – 396 | WD 3Add BLAST | 41 | |
Repeati | 436 – 475 | WD 4Add BLAST | 40 | |
Repeati | 478 – 520 | WD 5Add BLAST | 43 | |
Repeati | 523 – 563 | WD 6Add BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 44 | Polar residuesSequence analysisAdd BLAST | 44 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0293, Eukaryota |
GeneTreei | ENSGT00940000153634 |
InParanoidi | Q5SP67 |
OMAi | YCKFSPD |
OrthoDBi | 349428at2759 |
PhylomeDBi | Q5SP67 |
TreeFami | TF314869 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR006595, CTLH_C IPR020472, G-protein_beta_WD-40_rep IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MQSNGTGQEQ NHPANTQNGD ANGLQSNAGS ASGASGTGSG SLKKKKRLSQ
60 70 80 90 100
AEEDVIRLIG QHLHGLGLNQ TVDLLMQESG CRLEHSSATK FRNHVMEGEW
110 120 130 140 150
DKAENDLNEL KALMHSPNAI VRMKFLLLQQ KYLEYLEDGK VLEALQVLRG
160 170 180 190 200
ELTPLKYNTD RIHVLSGYLM CSHAEDLKAK AEWEGKGAGS RCRLLDKLQT
210 220 230 240 250
YLPPSVMLPP RRLQTLLRQA VELQRDRCLY HNTKLDSSLD SVSLLLDHVC
260 270 280 290 300
SRKQFPCYTQ QILTEHCNEV WFCKFSNDGT KLATGSKDTT VIIWQVEPDT
310 320 330 340 350
HQLKLLRTLE GHAYGVSYLA WSPDDVYLIA CGPDDCSELW LWNVQTGELR
360 370 380 390 400
TKMSQSHEDS LTSVAWNPDG KRFVTGGQRG QFYQCDLDGN LLESWEGVRV
410 420 430 440 450
QCLWCMGDGR TVLASDTHQR IRGYSFEDLT DRNIVQEDHP IMSFTVSKNG
460 470 480 490 500
RLALLNVATQ GVHLWDLQDR VLVRKYQGVT QGFYTIHSCF GGHNEDFIAS
510 520 530 540 550
GSEDHKVYIW HKRSELPIVE LTGHTRTVNC VSWNPCIPSL MASASDDGTV
560 570
RIWGPAPFLD AQELDGLTES CSSMDS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL929435, BX004824 Genomic DNA Translation: CAI11628.1 BX004824, AL929435 Genomic DNA Translation: CAI12019.1 |
RefSeqi | NP_001189371.1, NM_001202442.1 XP_009293240.1, XM_009294965.2 |
Genome annotation databases
Ensembli | ENSDART00000029894; ENSDARP00000036145; ENSDARG00000006812 ENSDART00000167398; ENSDARP00000132796; ENSDARG00000006812 |
GeneIDi | 564794 |
KEGGi | dre:564794 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL929435, BX004824 Genomic DNA Translation: CAI11628.1 BX004824, AL929435 Genomic DNA Translation: CAI12019.1 |
RefSeqi | NP_001189371.1, NM_001202442.1 XP_009293240.1, XM_009294965.2 |
3D structure databases
SMRi | Q5SP67 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000036145 |
PTM databases
iPTMneti | Q5SP67 |
Proteomic databases
PaxDbi | Q5SP67 |
Genome annotation databases
Ensembli | ENSDART00000029894; ENSDARP00000036145; ENSDARG00000006812 ENSDART00000167398; ENSDARP00000132796; ENSDARG00000006812 |
GeneIDi | 564794 |
KEGGi | dre:564794 |
Organism-specific databases
CTDi | 564794 |
ZFINi | ZDB-GENE-041014-277, wdr26b |
Phylogenomic databases
eggNOGi | KOG0293, Eukaryota |
GeneTreei | ENSGT00940000153634 |
InParanoidi | Q5SP67 |
OMAi | YCKFSPD |
OrthoDBi | 349428at2759 |
PhylomeDBi | Q5SP67 |
TreeFami | TF314869 |
Miscellaneous databases
PROi | PR:Q5SP67 |
Gene expression databases
Bgeei | ENSDARG00000006812, Expressed in mature ovarian follicle and 32 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR006595, CTLH_C IPR020472, G-protein_beta_WD-40_rep IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR26_DANRE | |
Accessioni | Q5SP67Primary (citable) accession number: Q5SP67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |