Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Connexin 28.8

Gene

cx28.8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.SAAS annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Connexin 28.8Imported
Submitted name:
Novel protein similar to connexin familyImported
Submitted name:
Similar to gap junction membrane channel protein beta 4Imported
Gene namesi
Name:cx28.8Imported
Synonyms:LOC566668Imported
ORF Names:BUSM1-189A20.5-001Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-050616-1 cx28.8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei118 – 146HelicalSequence analysisAdd BLAST29
Transmembranei178 – 203HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000071042 Expressed in 4 organ(s), highest expression level in pharyngeal gill

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.SAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 75CNXInterPro annotationAdd BLAST34
Domaini134 – 201Connexin_CCCInterPro annotationAdd BLAST68

Sequence similaritiesi

Belongs to the connexin family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IHN0 Eukaryota
ENOG410YZ0T LUCA
GeneTreeiENSGT00910000144026
HOVERGENiHBG009576
KOiK07626
OMAiDLKPCPN
OrthoDBiEOG091G0FKH
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 2 hits
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SNV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWGFLENVL SGVNRYSTVV GRVWLSILFI FRILVFVAAA EQVWKDEFKD
60 70 80 90 100
FVCNTQQPGC EQVCFDHFFP ISQVRLWALQ LIMVSTPSLL VALHVAYREH
110 120 130 140 150
RERKHKRRLY QDKGSIDGGL LFTYITSLVL KTSFEVGTLL AFYLLYSGFH
160 170 180 190 200
VPRLLRCAES PCPNSVDCYI ARATEKKIFL YIMGCTSILC IALNLLEMGY
210 220 230 240 250
IVSKQCWKSF SKRYTPVRDG ATRPPSTFTL GPPQPSCTAK EEGDQSAPAG

QETA
Length:254
Mass (Da):28,801
Last modified:December 21, 2004 - v1
Checksum:i8426AE945F6ADF60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511077 Genomic DNA No translation available.
BC163824 mRNA Translation: AAI63824.1
BC163854 mRNA Translation: AAI63854.1
AL954305 Genomic DNA Translation: CAI11514.1
RefSeqiNP_001020715.1, NM_001025544.2
NP_001038704.2, NM_001045239.2
XP_009292760.1, XM_009294485.1
UniGeneiDr.91612

Genome annotation databases

EnsembliENSDART00000130003; ENSDARP00000104801; ENSDARG00000071042
ENSDART00000189117; ENSDARP00000153762; ENSDARG00000071042
ENSDART00000189675; ENSDARP00000150825; ENSDARG00000071042
GeneIDi566668
KEGGidre:566668

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511077 Genomic DNA No translation available.
BC163824 mRNA Translation: AAI63824.1
BC163854 mRNA Translation: AAI63854.1
AL954305 Genomic DNA Translation: CAI11514.1
RefSeqiNP_001020715.1, NM_001025544.2
NP_001038704.2, NM_001045239.2
XP_009292760.1, XM_009294485.1
UniGeneiDr.91612

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000130003; ENSDARP00000104801; ENSDARG00000071042
ENSDART00000189117; ENSDARP00000153762; ENSDARG00000071042
ENSDART00000189675; ENSDARP00000150825; ENSDARG00000071042
GeneIDi566668
KEGGidre:566668

Organism-specific databases

CTDi566668
ZFINiZDB-GENE-050616-1 cx28.8

Phylogenomic databases

eggNOGiENOG410IHN0 Eukaryota
ENOG410YZ0T LUCA
GeneTreeiENSGT00910000144026
HOVERGENiHBG009576
KOiK07626
OMAiDLKPCPN
OrthoDBiEOG091G0FKH
TreeFamiTF329606

Gene expression databases

BgeeiENSDARG00000071042 Expressed in 4 organ(s), highest expression level in pharyngeal gill

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 2 hits
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SNV2_DANRE
AccessioniPrimary (citable) accession number: Q5SNV2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again