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Protein

Dihydrolipoyl dehydrogenase

Gene

TTHA0233

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12FADCombined sources1
Binding sitei48FADCombined sources1
Binding sitei53FADCombined sources1
Binding sitei138FAD; via carbonyl oxygenCombined sources1
Binding sitei272FADCombined sources1
Binding sitei309FADCombined sources1
Binding sitei440FAD; via carbonyl oxygenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 17FADCombined sources2
Nucleotide bindingi36 – 37FADCombined sources2
Nucleotide bindingi43 – 44FADCombined sources2
Nucleotide bindingi114 – 115FADCombined sources2
Nucleotide bindingi315 – 317FADCombined sources3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotationCombined sources, Flavoprotein, NADUniRule annotation, Nucleotide-bindingCombined sources, PyruvateImported

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-241-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0233Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 49Combined sources

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0233

Structurei

3D structure databases

ProteinModelPortaliQ5SLR0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLR0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 324FAD/NAD-binding_domInterPro annotationAdd BLAST318
Domaini342 – 450Pyr_redox_dimInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2 Bacteria
COG1249 LUCA
HOGENOMiHOG000276708
KOiK00382
OMAiRFEKQGI
PhylomeDBiQ5SLR0

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SLR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPMKTYDLI VIGTGPGGYH AAIRAAQLGL KVLAVEAGEV GGVCLNVGCI
60 70 80 90 100
PTKALLHAAE TLHHLKVAEG FGLKAKPELD LKKLGGWRDQ VVKKLTGGVG
110 120 130 140 150
TLLKGNGVEL LRGFARLVGP KEVEVGGERY GAKSLILATG SEPLELKGFP
160 170 180 190 200
FGEDVWDSTR ALKVEEGLPK RLLVIGGGAV GLELGQVYRR LGAEVTLIEY
210 220 230 240 250
MPEILPQGDP ETAALLRRAL EKEGIRVRTK TKAVGYEKKK DGLHVRLEPA
260 270 280 290 300
EGGEGEEVVV DKVLVAVGRK PRTEGLGLEK AGVKVDERGF IRVNARMETS
310 320 330 340 350
VPGVYAIGDA ARPPLLAHKA MREGLIAAEN AAGKDSAFDY QVPSVVYTSP
360 370 380 390 400
EWAGVGLTEE EAKRAGYKVK VGKFPLAASG RALTLGGAEG MVKVVGDEET
410 420 430 440 450
DLLLGVFIVG PQAGELIAEA ALALEMGATL TDLALTVHPH PTLSESLMEA
460
AEAFHKQAIH ILNR
Length:464
Mass (Da):49,084
Last modified:December 21, 2004 - v1
Checksum:iE4B03C80109B5E9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70056.1
RefSeqiWP_011227797.1, NC_006461.1
YP_143499.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD70056; BAD70056; BAD70056
GeneIDi3169717
KEGGittj:TTHA0233
PATRICifig|300852.9.peg.232

Similar proteinsi

Entry informationi

Entry nameiQ5SLR0_THET8
AccessioniPrimary (citable) accession number: Q5SLR0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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