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Protein

Ribosomal RNA small subunit methyltransferase E

Gene

TTHA0657

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(1498) in 16S rRNA = S-adenosyl-L-homocysteine + N3-methyluracil(1498) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1
Binding sitei181S-adenosyl-L-methionine; via amide nitrogenCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase
Biological processrRNA processingUniRule annotation
LigandS-adenosyl-L-methionineUniRule annotationCombined sources

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-676-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase EUniRule annotation (EC:2.1.1.193UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0657Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0657

Structurei

3D structure databases

ProteinModelPortaliQ5SKI6
SMRiQ5SKI6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SKI6

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni158 – 159S-adenosyl-L-homocysteine bindingCombined sources2
Regioni181 – 184S-adenosyl-L-homocysteine bindingCombined sources4
Regioni204 – 209S-adenosyl-L-homocysteine bindingCombined sources6
Regioni204 – 209S-adenosyl-L-methionine bindingCombined sources6

Sequence similaritiesi

Belongs to the RNA methyltransferase RsmE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105QF0 Bacteria
COG1385 LUCA
HOGENOMiHOG000015266
KOiK09761
OMAiERMEFTI
PhylomeDBiQ5SKI6

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR015947 PUA-like_sf
IPR006700 rRNA_ssu_MeTrfase-E
IPR029026 tRNA_m1G_MTases_N
PANTHERiPTHR30027 PTHR30027, 1 hit
PfamiView protein in Pfam
PF04452 Methyltrans_RNA, 1 hit
PIRSFiPIRSF015601 MTase_slr0722, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00046 TIGR00046, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SKI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPHRAFSPG LTGVLPLRET RHLVEVLRAR VGDRFTVFDG EREALAEVVD
60 70 80 90 100
LGPPLRYRVL EERRPEREVG VEVVLYVALL KGDKLAEVVR AATELGATRI
110 120 130 140 150
QPLVTRHSVP KEMGEGKLRR LRAVALEAAK QSGRVVVPEV LPPIPLKAVP
160 170 180 190 200
QVAQGLVAHV GATARVREVL DPEKPLALAV GPEGGFAEEE VALLEARGFT
210 220
PVSLGRRILR AETAALALLA LCTAGEGR
Length:228
Mass (Da):24,671
Last modified:December 21, 2004 - v1
Checksum:i3533C109242B3190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70480.1
RefSeqiWP_011228101.1, NC_006461.1
YP_143923.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD70480; BAD70480; BAD70480
GeneIDi3169973
KEGGittj:TTHA0657
PATRICifig|300852.9.peg.651

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70480.1
RefSeqiWP_011228101.1, NC_006461.1
YP_143923.1, NC_006461.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V6ZX-ray2.00A/B1-228[»]
2CX8X-ray2.53A/B1-228[»]
2Z0YX-ray2.80A/B1-228[»]
ProteinModelPortaliQ5SKI6
SMRiQ5SKI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0657

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70480; BAD70480; BAD70480
GeneIDi3169973
KEGGittj:TTHA0657
PATRICifig|300852.9.peg.651

Phylogenomic databases

eggNOGiENOG4105QF0 Bacteria
COG1385 LUCA
HOGENOMiHOG000015266
KOiK09761
OMAiERMEFTI
PhylomeDBiQ5SKI6

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-676-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ5SKI6

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR015947 PUA-like_sf
IPR006700 rRNA_ssu_MeTrfase-E
IPR029026 tRNA_m1G_MTases_N
PANTHERiPTHR30027 PTHR30027, 1 hit
PfamiView protein in Pfam
PF04452 Methyltrans_RNA, 1 hit
PIRSFiPIRSF015601 MTase_slr0722, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00046 TIGR00046, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SKI6_THET8
AccessioniPrimary (citable) accession number: Q5SKI6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 10, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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