Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 89 (11 Dec 2019)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein translocase subunit SecDF

Gene

secDF

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Conducts protons, which can be regulated by a proton gradient or by binding of an unfolded protein. Proton conduction requires the large periplasmic domain of the SecD.
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
TTHE300852:G1GKC-714-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.4.3 the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocase subunit SecDF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secDF
Ordered Locus Names:TTHA0697
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri300852 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000532 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 24Helical; Name=1CuratedAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 268PeriplasmicCuratedAdd BLAST244
Transmembranei269 – 293Helical; Name=2CuratedAdd BLAST25
Transmembranei294 – 315Helical; Name=3CuratedAdd BLAST22
Topological domaini316 – 324PeriplasmicCurated9
Transmembranei325 – 347Helical; Name=4CuratedAdd BLAST23
Topological domaini348 – 360CytoplasmicCuratedAdd BLAST13
Transmembranei361 – 390Helical; Name=5CuratedAdd BLAST30
Topological domaini391 – 396PeriplasmicCurated6
Transmembranei397 – 425Helical; Name=6CuratedAdd BLAST29
Topological domaini426 – 444CytoplasmicCuratedAdd BLAST19
Transmembranei445 – 468Helical; Name=7CuratedAdd BLAST24
Topological domaini469 – 565PeriplasmicCuratedAdd BLAST97
Transmembranei566 – 589Helical; Name=8CuratedAdd BLAST24
Transmembranei590 – 615Helical; Name=9CuratedAdd BLAST26
Topological domaini616 – 620PeriplasmicCurated5
Transmembranei621 – 646Helical; Name=10CuratedAdd BLAST26
Topological domaini647 – 660CytoplasmicCuratedAdd BLAST14
Transmembranei661 – 688Helical; Name=11CuratedAdd BLAST28
Topological domaini689 – 692PeriplasmicCurated4
Transmembranei693 – 723Helical; Name=12CuratedAdd BLAST31
Topological domaini724 – 735CytoplasmicCuratedAdd BLAST12

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi340D → N: Abolishes ion channel activity. 1 Publication1
Mutagenesisi637D → N: No effect on ion channel activity. 1 Publication1
Mutagenesisi671R → M: Abolishes ion channel activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004127131 – 735Protein translocase subunit SecDFAdd BLAST735

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary protein SecDF. Other proteins may also be involved (By similarity). Monomer.

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
300852.55772079

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1735
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SKE6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 434SecDAdd BLAST434
Regioni112 – 248Required for proton transportAdd BLAST137
Regioni435 – 735SecFAdd BLAST301

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the SecD/SecF family. SecD subfamily.Curated
In the C-terminal section; belongs to the SecD/SecF family. SecF subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C3D Bacteria
COG0341 LUCA
COG0342 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000018636

KEGG Orthology (KO)

More...
KOi
K12257

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTVNTGM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SKE6

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01463_B SecD_B, 1 hit
MF_01464_B SecF_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005791 SecD
IPR022813 SecD/SecF_arch_bac
IPR022645 SecD/SecF_bac
IPR022646 SecD/SecF_CS
IPR005665 SecF_bac
IPR000731 SSD

The PANTHER Classification System

More...
PANTHERi
PTHR30081 PTHR30081, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07549 Sec_GG, 2 hits
PF02355 SecD_SecF, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01755 SECFTRNLCASE

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00916 2A0604s01, 2 hits
TIGR00966 3a0501s07, 1 hit
TIGR01129 secD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5SKE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRKNLTSLF LLGVFLLALL FVWKPWAPEE PKVRLGLDLK GGLRIVLEAD
60 70 80 90 100
VENPTLDDLE KARTVLENRI NALGVAEPLI QIQGQKRIVV ELPGLSQADQ
110 120 130 140 150
DRALKLIGQR AVLEFRIVKE GATGTTVAQI NQALRENPRL NREELEKDLI
160 170 180 190 200
KPEDLGPPLL TGADLADARA VFDQFGRPQV SLTFTPEGAK KFEEVTRQNI
210 220 230 240 250
GKRLAIVLDG RVYTAPVIRQ AITGGQAVIE GLSSVEEASE IALVLRSGSL
260 270 280 290 300
PVPLKVAEIR AIGPTLGQDA IQAGIRSALI GTLAIFLLIF AYYGPHLGLV
310 320 330 340 350
ASLGLLYTSA LILGLLSGLG ATLTLPGIAG LVLTLGAAVD GNVLSFERIK
360 370 380 390 400
EELRAGKKLR QAIPEGFRHS TLTIMDVNIA HLLAAAALYQ YATGPVRGFA
410 420 430 440 450
VILAIGVVAS VFSNLVFSRH LLERLADRGE IRPPMWLVDP RFNFMGPARY
460 470 480 490 500
VTAATLLLAA LAAGVVFAKG FNYSIDFTGG TAYTLRAEPN VEVETLRRFL
510 520 530 540 550
EEKGFPGKEA VITQVQAPTA AYREFLVKLP PLSDERRLEL ERLFASELKA
560 570 580 590 600
TVLASETVGP AIGEELRRNA VMAVLVGLGL ILLYVAFRFD WTFGVASILA
610 620 630 640 650
VAHDVAIVAG MYSLLGLEFS IPTIAALLTI VGYSINDSIV VSDRIRENQK
660 670 680 690 700
LLRHLPYAEL VNRSINQTLS RTVMTSLTTL LPILALLFLG GSVLRDFALA
710 720 730
IFVGIFVGTY SSIYVVSALV VAWKNRRKAQ EASKA
Length:735
Mass (Da):79,678
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6283A10A1163539D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70520.1

NCBI Reference Sequences

More...
RefSeqi
WP_011172795.1, NC_006461.1
YP_143963.1, NC_006461.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAD70520; BAD70520; BAD70520

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3168575

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ttj:TTHA0697

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|300852.9.peg.691

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70520.1
RefSeqiWP_011172795.1, NC_006461.1
YP_143963.1, NC_006461.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RRNNMR-A470-559[»]
3AQOX-ray2.60A/B/C/D35-263[»]
3AQPX-ray3.30A/B1-735[»]
5YHFX-ray2.80A1-735[»]
SMRiQ5SKE6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi300852.55772079

Protein family/group databases

TCDBi2.A.6.4.3 the resistance-nodulation-cell division (rnd) superfamily

Genome annotation databases

EnsemblBacteriaiBAD70520; BAD70520; BAD70520
GeneIDi3168575
KEGGittj:TTHA0697
PATRICifig|300852.9.peg.691

Phylogenomic databases

eggNOGiENOG4105C3D Bacteria
COG0341 LUCA
COG0342 LUCA
HOGENOMiHOG000018636
KOiK12257
OMAiRTVNTGM
PhylomeDBiQ5SKE6

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-714-MONOMER

Family and domain databases

HAMAPiMF_01463_B SecD_B, 1 hit
MF_01464_B SecF_B, 1 hit
InterProiView protein in InterPro
IPR005791 SecD
IPR022813 SecD/SecF_arch_bac
IPR022645 SecD/SecF_bac
IPR022646 SecD/SecF_CS
IPR005665 SecF_bac
IPR000731 SSD
PANTHERiPTHR30081 PTHR30081, 2 hits
PfamiView protein in Pfam
PF07549 Sec_GG, 2 hits
PF02355 SecD_SecF, 2 hits
PRINTSiPR01755 SECFTRNLCASE
TIGRFAMsiTIGR00916 2A0604s01, 2 hits
TIGR00966 3a0501s07, 1 hit
TIGR01129 secD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECDF_THET8
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SKE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: December 21, 2004
Last modified: December 11, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again