UniProtKB - Q5SHP3 (RL22_THET8)
50S ribosomal protein L22
rplV
Functioni
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
By similarityThe globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome. This extension seems to form part of the wall of the exit tunnel.
GO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L22 |
Gene namesi | Name:rplV Ordered Locus Names:TTHA1687 |
Organismi | Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) |
Taxonomic identifieri | 300852 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125249 | 1 – 113 | 50S ribosomal protein L22Add BLAST | 113 |
Proteomic databases
PRIDEi | Q5SHP3 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
Protein-protein interaction databases
IntActi | Q5SHP3, 8 interactors |
STRINGi | 300852.55773069 |
Structurei
Secondary structure
3D structure databases
SMRi | Q5SHP3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5SHP3 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0091, Bacteria |
HOGENOMi | CLU_083987_3_1_0 |
OMAi | KRIQPRA |
PhylomeDBi | Q5SHP3 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MEAKAIARYV RISPRKVRLV VDLIRGKSLE EARNILRYTN KRGAYFVAKV
60 70 80 90 100
LESAAANAVN NHDMLEDRLY VKAAYVDEGP ALKRVLPRAR GRADIIKKRT
110
SHITVILGEK HGK
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP008226 Genomic DNA Translation: BAD71510.1 |
RefSeqi | WP_011173710.1, NC_006461.1 YP_144953.1, NC_006461.1 |
Genome annotation databases
EnsemblBacteriai | BAD71510; BAD71510; BAD71510 |
GeneIDi | 3169835 |
KEGGi | ttj:TTHA1687 |
PATRICi | fig|300852.9.peg.1657 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP008226 Genomic DNA Translation: BAD71510.1 |
RefSeqi | WP_011173710.1, NC_006461.1 YP_144953.1, NC_006461.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ML5 | electron microscopy | 14.00 | s | 1-113 | [»] | |
1VVJ | X-ray | 3.44 | RW/YW | 1-113 | [»] | |
1VY4 | X-ray | 2.60 | BW/DW | 1-113 | [»] | |
1VY5 | X-ray | 2.55 | BW/DW | 1-113 | [»] | |
1VY6 | X-ray | 2.90 | BW/DW | 1-113 | [»] | |
1VY7 | X-ray | 2.80 | BW/DW | 1-113 | [»] | |
4L47 | X-ray | 3.22 | RW/YW | 1-113 | [»] | |
4L71 | X-ray | 3.90 | RW/YW | 1-113 | [»] | |
4LEL | X-ray | 3.90 | RW/YW | 1-113 | [»] | |
4LFZ | X-ray | 3.92 | RW/YW | 1-113 | [»] | |
4LNT | X-ray | 2.94 | RW/YW | 1-113 | [»] | |
4LSK | X-ray | 3.48 | RW/YW | 1-113 | [»] | |
4LT8 | X-ray | 3.14 | RW/YW | 1-113 | [»] | |
4P6F | X-ray | 3.60 | RW/YW | 1-113 | [»] | |
4P70 | X-ray | 3.68 | RW/YW | 1-113 | [»] | |
4TUA | X-ray | 3.60 | RW/YW | 1-113 | [»] | |
4TUB | X-ray | 3.60 | RW/YW | 1-113 | [»] | |
4TUC | X-ray | 3.60 | RW/YW | 1-113 | [»] | |
4TUD | X-ray | 3.60 | RW/YW | 1-113 | [»] | |
4TUE | X-ray | 3.50 | RW/YW | 1-113 | [»] | |
4V42 | X-ray | 5.50 | BS | 1-113 | [»] | |
4V4P | X-ray | 5.50 | AS | 1-113 | [»] | |
4V4R | X-ray | 5.90 | BW | 1-113 | [»] | |
4V4S | X-ray | 6.76 | BW | 1-113 | [»] | |
4V4T | X-ray | 6.46 | BW | 1-113 | [»] | |
4V4X | X-ray | 5.00 | BV | 1-113 | [»] | |
4V4Y | X-ray | 5.50 | BV | 1-113 | [»] | |
4V4Z | X-ray | 4.51 | BV | 1-113 | [»] | |
4V51 | X-ray | 2.80 | BW/DW | 1-113 | [»] | |
4V5A | X-ray | 3.50 | BW/DW | 1-113 | [»] | |
4V5C | X-ray | 3.30 | BW/DW | 1-113 | [»] | |
4V5D | X-ray | 3.50 | BW/DW | 1-113 | [»] | |
4V5E | X-ray | 3.45 | BW/DW | 1-113 | [»] | |
4V5F | X-ray | 3.60 | BW/DW | 1-113 | [»] | |
4V5G | X-ray | 3.60 | BW/DW | 1-113 | [»] | |
4V5J | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V5K | X-ray | 3.20 | BW/DW | 1-113 | [»] | |
4V5L | X-ray | 3.10 | BW | 1-113 | [»] | |
4V5M | electron microscopy | 7.80 | BW | 1-113 | [»] | |
4V5N | electron microscopy | 7.60 | BW | 1-113 | [»] | |
4V5P | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V5Q | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V5R | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V5S | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V68 | electron microscopy | 6.40 | BW | 1-113 | [»] | |
4V6A | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V6F | X-ray | 3.10 | AS/DS | 1-113 | [»] | |
4V6G | X-ray | 3.50 | BS/DS | 1-113 | [»] | |
4V7J | X-ray | 3.30 | AW/BW | 1-113 | [»] | |
4V7K | X-ray | 3.60 | AW/BW | 1-113 | [»] | |
4V7L | X-ray | 3.00 | BW/DW | 1-113 | [»] | |
4V7M | X-ray | 3.45 | BW/DW | 1-113 | [»] | |
4V7W | X-ray | 3.00 | BW/DW | 1-113 | [»] | |
4V7X | X-ray | 3.00 | BW/DW | 1-113 | [»] | |
4V7Y | X-ray | 3.00 | BW/DW | 1-113 | [»] | |
4V7Z | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V87 | X-ray | 3.10 | AS/DS | 1-113 | [»] | |
4V8A | X-ray | 3.20 | AW/BW | 1-113 | [»] | |
4V8B | X-ray | 3.00 | BS/DS | 1-113 | [»] | |
4V8C | X-ray | 3.30 | AS/BS | 1-113 | [»] | |
4V8D | X-ray | 3.00 | BS/DS | 1-113 | [»] | |
4V8E | X-ray | 3.30 | AS/CS | 1-113 | [»] | |
4V8F | X-ray | 3.30 | AS/DS | 1-113 | [»] | |
4V8G | X-ray | 3.00 | BW/DW | 1-113 | [»] | |
4V8H | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V8I | X-ray | 2.70 | BW/DW | 1-113 | [»] | |
4V8J | X-ray | 3.90 | BW/DW | 1-113 | [»] | |
4V8N | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4V8O | X-ray | 3.80 | BW | 1-113 | [»] | |
4V8Q | X-ray | 3.10 | AW | 1-113 | [»] | |
4V8U | X-ray | 3.70 | BW/DW | 1-113 | [»] | |
4V8X | X-ray | 3.35 | BW/DW | 1-113 | [»] | |
4V90 | X-ray | 2.95 | BW | 1-113 | [»] | |
4V95 | X-ray | 3.20 | BW/DW | 1-113 | [»] | |
4V97 | X-ray | 3.52 | BW/DW | 1-113 | [»] | |
4V9A | X-ray | 3.30 | BS/DS | 1-113 | [»] | |
4V9B | X-ray | 3.10 | BS/DS | 1-113 | [»] | |
4V9H | X-ray | 2.86 | BW | 1-113 | [»] | |
4V9I | X-ray | 3.30 | BW/DW | 1-112 | [»] | |
4V9R | X-ray | 3.00 | BW/DW | 1-113 | [»] | |
4V9S | X-ray | 3.10 | BW/DW | 1-113 | [»] | |
4W2E | X-ray | 2.90 | W | 1-113 | [»] | |
4W2F | X-ray | 2.40 | BW/DW | 1-113 | [»] | |
4W2G | X-ray | 2.55 | BW/DW | 1-113 | [»] | |
4W2H | X-ray | 2.70 | BW/DW | 1-113 | [»] | |
4W2I | X-ray | 2.70 | BW/DW | 1-113 | [»] | |
4W4G | X-ray | 3.30 | RW/YW | 1-113 | [»] | |
4WPO | X-ray | 2.80 | AW/CW | 1-113 | [»] | |
4WQ1 | X-ray | 3.10 | A5/E8 | 1-113 | [»] | |
4WQF | X-ray | 2.80 | AW/CW | 1-113 | [»] | |
4WQR | X-ray | 3.15 | A5/E8 | 1-113 | [»] | |
4WQU | X-ray | 2.80 | AW/CW | 1-113 | [»] | |
4WQY | X-ray | 2.80 | AW/CW | 1-113 | [»] | |
4WR6 | X-ray | 3.05 | A5/E8 | 1-113 | [»] | |
4WRA | X-ray | 3.05 | A5/E8 | 1-113 | [»] | |
4WRO | X-ray | 3.05 | E8 | 1-113 | [»] | |
4WSD | X-ray | 2.95 | A5/E8 | 1-113 | [»] | |
4WSM | X-ray | 3.30 | A5/E8 | 1-113 | [»] | |
4WT1 | X-ray | 3.05 | A5/E8 | 1-113 | [»] | |
4WT8 | X-ray | 3.40 | CW | 1-113 | [»] | |
DW | 1-112 | [»] | ||||
4WU1 | X-ray | 3.20 | A5/E8 | 1-113 | [»] | |
4WZD | X-ray | 3.10 | A5/E8 | 1-113 | [»] | |
4WZO | X-ray | 3.30 | A5/E8 | 1-113 | [»] | |
4Y4O | X-ray | 2.30 | 1W/2W | 1-113 | [»] | |
4Y4P | X-ray | 2.50 | 1W/2W | 1-113 | [»] | |
4YPB | X-ray | 3.40 | RW/YW | 1-113 | [»] | |
4YZV | X-ray | 3.10 | RW/YW | 1-113 | [»] | |
4Z3S | X-ray | 2.65 | 1W/2W | 1-113 | [»] | |
4Z8C | X-ray | 2.90 | 1W/2W | 1-113 | [»] | |
4ZER | X-ray | 3.10 | 1W/2W | 1-112 | [»] | |
4ZSN | X-ray | 3.60 | RW/YW | 1-113 | [»] | |
5A9Z | electron microscopy | 4.70 | AT | 1-110 | [»] | |
5AA0 | electron microscopy | 5.00 | AT | 1-110 | [»] | |
5CZP | X-ray | 3.30 | RW/YW | 1-113 | [»] | |
5D8B | X-ray | 3.63 | MB/Q | 1-113 | [»] | |
5DFE | X-ray | 3.10 | RW/YW | 1-113 | [»] | |
5DOX | X-ray | 3.10 | 1W/2W | 1-113 | [»] | |
5DOY | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
5E7K | X-ray | 3.20 | A5/E8 | 1-113 | [»] | |
5E81 | X-ray | 2.95 | A5/E8 | 1-113 | [»] | |
5EL4 | X-ray | 3.15 | A5/E8 | 1-113 | [»] | |
5EL5 | X-ray | 3.15 | A5/E8 | 1-113 | [»] | |
5EL6 | X-ray | 3.10 | A5/E8 | 1-113 | [»] | |
5EL7 | X-ray | 3.15 | A5/E8 | 1-113 | [»] | |
5F8K | X-ray | 2.80 | 1W/2W | 1-112 | [»] | |
5FDU | X-ray | 2.90 | 1W/2W | 1-112 | [»] | |
5FDV | X-ray | 2.80 | 1W/2W | 1-112 | [»] | |
5HAU | X-ray | 3.00 | 1U/2U | 1-113 | [»] | |
5HCP | X-ray | 2.89 | 1W/2W | 1-113 | [»] | |
5HCQ | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
5HCR | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
5HD1 | X-ray | 2.70 | 1W/2W | 1-113 | [»] | |
5IB7 | X-ray | 2.99 | A5/E8 | 1-113 | [»] | |
5IB8 | X-ray | 3.13 | A5/E8 | 1-113 | [»] | |
5IBB | X-ray | 2.96 | A5/E8 | 1-113 | [»] | |
5IMQ | electron microscopy | 3.80 | o | 1-113 | [»] | |
5IMR | electron microscopy | - | o | 1-113 | [»] | |
5J30 | X-ray | 3.20 | RW/YW | 1-113 | [»] | |
5J3C | X-ray | 3.04 | RW/YW | 1-113 | [»] | |
5J4B | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
5J4C | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
5J8B | X-ray | 2.60 | W | 1-113 | [»] | |
5NDJ | X-ray | 3.15 | A5/E8 | 1-113 | [»] | |
5NDK | X-ray | 2.95 | A5/E8 | 1-113 | [»] | |
5OT7 | electron microscopy | 3.80 | x | 1-113 | [»] | |
5UQ7 | electron microscopy | 3.50 | W | 1-112 | [»] | |
5UQ8 | electron microscopy | 3.20 | W | 1-112 | [»] | |
5VP2 | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
5VPO | X-ray | 3.34 | RW/YW | 1-113 | [»] | |
5VPP | X-ray | 3.90 | RW/YW | 1-113 | [»] | |
5W4K | X-ray | 2.70 | 1W/2W | 1-113 | [»] | |
5WIS | X-ray | 2.70 | 1W/2W | 1-113 | [»] | |
5WIT | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
5ZLU | electron microscopy | 3.60 | p | 1-113 | [»] | |
6BUW | X-ray | 3.50 | RW/YW | 1-113 | [»] | |
6BZ6 | X-ray | 3.18 | RW/YW | 1-113 | [»] | |
6BZ7 | X-ray | 3.68 | RW/YW | 1-113 | [»] | |
6BZ8 | X-ray | 3.74 | RW/YW | 1-113 | [»] | |
6C5L | X-ray | 3.20 | BW/DW | 1-113 | [»] | |
6CAE | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
6CFJ | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
6CFK | X-ray | 2.70 | 1W/2W | 1-113 | [»] | |
6CFL | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
6CZR | X-ray | 3.14 | 1W/2W | 1-112 | [»] | |
6FKR | X-ray | 3.20 | 1W/2W | 1-112 | [»] | |
6GSJ | X-ray | 2.96 | A5/E8 | 1-113 | [»] | |
6GSK | X-ray | 3.36 | A5/E8 | 1-113 | [»] | |
6GSL | X-ray | 3.16 | A5/E8 | 1-113 | [»] | |
6GZQ | electron microscopy | 3.28 | R1 | 1-113 | [»] | |
6GZX | electron microscopy | 4.57 | R1/R2 | 1-113 | [»] | |
6GZZ | electron microscopy | 4.13 | R1/R2 | 1-113 | [»] | |
6ND5 | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
6ND6 | X-ray | 2.85 | 1W/2W | 1-113 | [»] | |
6NDK | X-ray | 3.64 | RW/YW | 1-113 | [»] | |
6NSH | X-ray | 3.40 | RW/YW | 1-113 | [»] | |
6NTA | X-ray | 3.10 | RW/YW | 1-113 | [»] | |
6NUO | X-ray | 3.20 | RW/YW | 1-113 | [»] | |
6NWY | X-ray | 3.50 | RW/YW | 1-113 | [»] | |
6O3M | X-ray | 3.97 | RW/YW | 1-113 | [»] | |
6O97 | X-ray | 2.75 | 1W/2W | 1-113 | [»] | |
6OF1 | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
6OF6 | X-ray | 3.20 | RW/YW | 1-113 | [»] | |
6OJ2 | X-ray | 3.20 | RW/YW | 1-113 | [»] | |
6OPE | X-ray | 3.10 | RW/YW | 1-113 | [»] | |
6ORD | X-ray | 3.10 | RW/YW | 1-113 | [»] | |
6OSI | X-ray | 4.14 | RW/YW | 1-113 | [»] | |
6OTR | X-ray | 3.12 | RW/YW | 1-113 | [»] | |
6OXA | X-ray | 3.25 | RW/YW | 1-113 | [»] | |
6OXI | X-ray | 3.50 | RW/YW | 1-113 | [»] | |
6Q95 | electron microscopy | 3.70 | S | 1-113 | [»] | |
6QNQ | X-ray | 3.50 | A5/E8 | 1-113 | [»] | |
6QNR | X-ray | 3.10 | A5/E8 | 1-113 | [»] | |
6UCQ | X-ray | 3.50 | 1W/2W | 1-113 | [»] | |
6UO1 | X-ray | 2.95 | 1W/2W | 1-113 | [»] | |
6XHV | X-ray | 2.40 | 1W/2W | 1-113 | [»] | |
6XHW | X-ray | 2.50 | 1W/2W | 1-113 | [»] | |
6XHX | X-ray | 2.55 | 1W/2W | 1-113 | [»] | |
6XHY | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
6XQD | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
6XQE | X-ray | 3.00 | 1W/2W | 1-113 | [»] | |
7JQL | X-ray | 3.00 | 1W/2W | 1-113 | [»] | |
7JQM | X-ray | 3.05 | 1W/2W | 1-113 | [»] | |
7LH5 | X-ray | 3.27 | BW/DW | 1-113 | [»] | |
7MD7 | X-ray | 2.80 | 1W/2W | 1-113 | [»] | |
7RQ8 | X-ray | 2.50 | 1W/2W | 1-113 | [»] | |
7RQ9 | X-ray | 2.60 | 1W/2W | 1-113 | [»] | |
SMRi | Q5SHP3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q5SHP3, 8 interactors |
STRINGi | 300852.55773069 |
Proteomic databases
PRIDEi | Q5SHP3 |
Genome annotation databases
EnsemblBacteriai | BAD71510; BAD71510; BAD71510 |
GeneIDi | 3169835 |
KEGGi | ttj:TTHA1687 |
PATRICi | fig|300852.9.peg.1657 |
Phylogenomic databases
eggNOGi | COG0091, Bacteria |
HOGENOMi | CLU_083987_3_1_0 |
OMAi | KRIQPRA |
PhylomeDBi | Q5SHP3 |
Miscellaneous databases
EvolutionaryTracei | Q5SHP3 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL22_THET8 | |
Accessioni | Q5SHP3Primary (citable) accession number: Q5SHP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families