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UniProtKB - Q5SHB0 (Q5SHB0_THET8)

Entry version 93 (02 Dec 2020)
Sequence version 1 (21 Dec 2004)
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Protein

CinA-like protein

Gene

TTHA1820

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei76ATPCombined sources1
Binding sitei210ATP; via carbonyl oxygenCombined sources1
Binding sitei296Nicotinate mononucleotideCombined sources1
Binding sitei377Nicotinate mononucleotideCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 22AMPCombined sources3
Nucleotide bindingi20 – 22ATPCombined sources3
Nucleotide bindingi69 – 71ATPCombined sources3
Nucleotide bindingi152 – 156ATPCombined sources5
Nucleotide bindingi152 – 153AMPCombined sources2
Nucleotide bindingi269 – 270Nicotinate mononucleotideCombined sources2
Nucleotide bindingi284 – 286Nicotinate mononucleotideCombined sources3
Nucleotide bindingi340 – 346Nicotinate mononucleotideCombined sources7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingCombined sources, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CinA-like proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:TTHA1820Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri300852 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000532 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		300852.55773202

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5SHB0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 172MoCF_biosynthInterPro annotationAdd BLAST168

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CinA family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1058, Bacteria
COG1546, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030805_9_3_0

Identification of Orthologs from Complete Genome Data

More...OMAi		PGVPYEM

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5SHB0

Family and domain databases

Conserved Domains Database

More...CDDi		cd00885, cinA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.980.10, 1 hit
3.90.950.20, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00226_B, CinA_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036653, CinA-like_C
IPR008136, CinA_C
IPR041424, CinA_KH
IPR008135, Competence-induced_CinA
IPR036425, MoaB/Mog-like_dom_sf
IPR001453, MoaB/Mog_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02464, CinA, 1 hit
PF18146, CinA_KH, 1 hit
PF00994, MoCF_biosynth, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006728, CinA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00852, MoCF_biosynth, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF142433, SSF142433, 1 hit
SSF53218, SSF53218, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00200, cinA_nterm, 1 hit
TIGR00199, PncC_domain, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5SHB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERAEILGVG TELLYGETLD TNTAEIARSL KPYALKVERT LRVADEVAPL 
        60         70         80         90        100
AREVEEAFAR ARLVVLSGGL GPTPDDVTRE AVALALGEPL ELDEAVLGEI 
       110        120        130        140        150
EAFFRARGRA MPEANRKQAM RIPSATWLKN PRGTAPGWWV RKGGKDLVLL 
       160        170        180        190        200
PGPPPEWRPM WQEVLPRLGL PRRPYAERVL KTWGIGESEI VERLGPLFVR 
       210        220        230        240        250
GEEVEVGTYP KVHGVEVVVR GREDRVAELA ERIKKKLLKE VWGEGEMTLA 
       260        270        280        290        300
EAVKRRMERE GATLSTMESL TGGLLGAEIT RVPGASRFYL GGVVSYSVGA 
       310        320        330        340        350
KARFGVPQDL LSRTVSAETA RAMAEAARSL FGSTYALATT GVAGPDPLEG 
       360        370        380        390 
EPPGTVYVAL AGPTGAEVRR YRFPGDRETV RLRSVYAALA LLVT
Length:394
Mass (Da):42,915
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06E883848FBB7806
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71643.1

NCBI Reference Sequences

More...RefSeqi		WP_011228938.1, NC_006461.1
YP_145086.1, NC_006461.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		BAD71643; BAD71643; BAD71643

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3168504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ttj:TTHA1820

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|300852.9.peg.1791

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71643.1
RefSeqiWP_011228938.1, NC_006461.1
YP_145086.1, NC_006461.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CT8X-ray2.16A/B1-394[»]
4CT9X-ray2.14A/B1-394[»]
4CTAX-ray2.21A/B1-394[»]
4UOCX-ray2.46A/B1-394[»]
4UUWX-ray1.98A/B1-394[»]
4UUXX-ray1.99A/B1-394[»]
SMRiQ5SHB0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi300852.55773202

Genome annotation databases

EnsemblBacteriaiBAD71643; BAD71643; BAD71643
GeneIDi3168504
KEGGittj:TTHA1820
PATRICifig|300852.9.peg.1791

Phylogenomic databases

eggNOGiCOG1058, Bacteria
COG1546, Bacteria
HOGENOMiCLU_030805_9_3_0
OMAiPGVPYEM
PhylomeDBiQ5SHB0

Family and domain databases

CDDicd00885, cinA, 1 hit
Gene3Di3.40.980.10, 1 hit
3.90.950.20, 1 hit
HAMAPiMF_00226_B, CinA_B, 1 hit
InterProiView protein in InterPro
IPR036653, CinA-like_C
IPR008136, CinA_C
IPR041424, CinA_KH
IPR008135, Competence-induced_CinA
IPR036425, MoaB/Mog-like_dom_sf
IPR001453, MoaB/Mog_dom
PfamiView protein in Pfam
PF02464, CinA, 1 hit
PF18146, CinA_KH, 1 hit
PF00994, MoCF_biosynth, 1 hit
PIRSFiPIRSF006728, CinA, 1 hit
SMARTiView protein in SMART
SM00852, MoCF_biosynth, 1 hit
SUPFAMiSSF142433, SSF142433, 1 hit
SSF53218, SSF53218, 1 hit
TIGRFAMsiTIGR00200, cinA_nterm, 1 hit
TIGR00199, PncC_domain, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5SHB0_THET8
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SHB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: December 2, 2020
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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