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Entry version 136 (12 Aug 2020)
Sequence version 2 (04 Jan 2005)
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Protein

Aldehyde oxidase 2

Gene

Aox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Cannot use hypoxanthine as substrate.1 Publication

Miscellaneous

AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi48Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi53Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi56Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi78Iron-sulfur 1 (2Fe-2S)By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117MolybdopterinBy similarity1
Metal bindingi118Iron-sulfur 2 (2Fe-2S)By similarity1
Metal bindingi121Iron-sulfur 2 (2Fe-2S)By similarity1
Metal bindingi153Iron-sulfur 2 (2Fe-2S)By similarity1
Metal bindingi155Iron-sulfur 2 (2Fe-2S)By similarity1
Binding sitei155MolybdopterinBy similarity1
Binding sitei347FAD; via amide nitrogenBy similarity1
Binding sitei356FADBy similarity1
Binding sitei360FADBy similarity1
Binding sitei369FADBy similarity1
Binding sitei413FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei1209MolybdopterinBy similarity1
Binding sitei1274Molybdopterin; via carbonyl oxygenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1276Proton acceptor; for azaheterocycle hydroxylase activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi266 – 273FADBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.2.3.1, 3474

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldehyde oxidase 2 (EC:1.2.3.1)
Alternative name(s):
Aldehyde oxidase homolog 3
Azaheterocycle hydroxylase 2 (EC:1.17.3.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aox2
Synonyms:Aoh3, Aox3l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3529596, Aox2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004252451 – 1345Aldehyde oxidase 2Add BLAST1345

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SGK3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SGK3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SGK3

PeptideAtlas

More...
PeptideAtlasi
Q5SGK3

PRoteomics IDEntifications database

More...
PRIDEi
Q5SGK3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SGK3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SGK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in olfactory mucosa epithelium (at protein level). Detected in skin.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079554, Expressed in nose and 30 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229391, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000110006

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5SGK3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 962Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST88
Domaini238 – 423FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST186

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni812 – 813Molybdopterin bindingBy similarity2
Regioni1094 – 1097Molybdopterin bindingBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0430, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001681_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SGK3

KEGG Orthology (KO)

More...
KOi
K00157

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCIHISE

Database of Orthologous Groups

More...
OrthoDBi
48717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SGK3

TreeFam database of animal gene trees

More...
TreeFami
TF353036

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00207, fer2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002888, 2Fe-2S-bd
IPR036884, 2Fe-2S-bd_dom_sf
IPR036010, 2Fe-2S_ferredoxin-like_sf
IPR001041, 2Fe-2S_ferredoxin-type
IPR006058, 2Fe2S_fd_BS
IPR000674, Ald_Oxase/Xan_DH_a/b
IPR036856, Ald_Oxase/Xan_DH_a/b_sf
IPR016208, Ald_Oxase/xanthine_DH
IPR014313, Aldehyde_oxidase
IPR008274, AldOxase/xan_DH_Mopterin-bd
IPR037165, AldOxase/xan_DH_Mopterin-bd_sf
IPR005107, CO_DH_flav_C
IPR036683, CO_DH_flav_C_dom_sf
IPR016166, FAD-bd_PCMH
IPR036318, FAD-bd_PCMH-like_sf
IPR002346, Mopterin_DH_FAD-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01315, Ald_Xan_dh_C, 1 hit
PF02738, Ald_Xan_dh_C2, 1 hit
PF03450, CO_deh_flav_C, 1 hit
PF00941, FAD_binding_5, 1 hit
PF00111, Fer2, 1 hit
PF01799, Fer2_2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000127, Xanthine_DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01008, Ald_Xan_dh_C, 1 hit
SM01092, CO_deh_flav_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47741, SSF47741, 1 hit
SSF54292, SSF54292, 1 hit
SSF54665, SSF54665, 1 hit
SSF55447, SSF55447, 1 hit
SSF56003, SSF56003, 1 hit
SSF56176, SSF56176, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02969, mam_aldehyde_ox, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00197, 2FE2S_FER_1, 1 hit
PS51085, 2FE2S_FER_2, 1 hit
PS51387, FAD_PCMH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5SGK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCPAQISDD LEFFVNGRKV TEKNVDPEVT LLAFLRKNLC LTGTKDACGT
60 70 80 90 100
GGCGACTVMV SQHDPVCKKT RHFSVMACLV PLCSLHGAAV TTVEGVGSIK
110 120 130 140 150
TRLHPVQERI AKSHGTQCGF CTPGMVMSIY TLLRNHPQPS EEQLMEALGG
160 170 180 190 200
NLCRCTGYRP ILESGRTFCM EPDGCPQKGT GQCCLDQKES DSSGSKSDIC
210 220 230 240 250
TKLFVKDEFQ PLDPTQELIF PPELLRMAEN PEKQTLTFYG ERITWIAPGT
260 270 280 290 300
LQELLVLKAK YPEAPLISGN TALGPAMKSQ GHFYPVLLSP ARIPDLRMVT
310 320 330 340 350
KTSGGLTIGA CCSLAQVKDI LAESISELPQ EKTQTYRALL KHLRSLAGQQ
360 370 380 390 400
IRNMASLGGH VISRHCYSDL NPILSVGNTT LNLLSEEGPR QIPLSGHFLA
410 420 430 440 450
GLASADLKPE EILGSVYIPH SQKREFVSAF RQAQCHQNAL PDVNAGMRVL
460 470 480 490 500
FREGTDVIEE LSIAYGGVGP TTVSAQRSCQ QLLGRRWNAL MLDEACRLLL
510 520 530 540 550
DEVSLPGSAL GGKVEFRRTL IVSLFFKFYL EVLQELKADQ KLPPESTDSQ
560 570 580 590 600
RYPEIADRFL SSLGDFQVTL PRGVQTYQRV DSHQPLQDPV GRPIMHLSGL
610 620 630 640 650
KHATGEAVFC DDIPRVDKEL FMALVTSTRA HARIISIDSS EVLDLPGVVD
660 670 680 690 700
VITAEDIPGN NGEEDDKLLA VDKVLCVGQV ICAVVAETDV QAKRATEKIK
710 720 730 740 750
ITYEDLKPVI FTIEDAIKHN SFLCPEKKLE QGNIEEAFEN VDQVAEGTVH
760 770 780 790 800
VGGQEHFYME TQRVLVIPKT EDKELDMYVS TQDPAHVQKT VSSTLNIPIS
810 820 830 840 850
RITCHVKRVG GGFGGKVGRP AVFGAIAAVG AVKTGHPIRL VLDREDDMLI
860 870 880 890 900
TGGRHPLFAK YKVGFMNSGR IKALDIECYI NGGCTLDDSE LVTEFLVLKL
910 920 930 940 950
ENAYKIRNLR LRGRACMTNL PSNTAFRGFG FPQGALVTES CITAVAAKCG
960 970 980 990 1000
LPPEKIREKN MYKTVDKTIY KQAFNPDPLI RCWNECLDKS SFHIRRTRVD
1010 1020 1030 1040 1050
EFNKKSYWKK RGIAIVPMKF SVGFAATSYH QAAALVHIYT DGSVLVAHGG
1060 1070 1080 1090 1100
NELGQGIHTK MLQVASRELK IPLSYLHICE TSTTTVPNTI ATAASVGADV
1110 1120 1130 1140 1150
NGRAVQNACQ ILLKRLEPVI KKNPEGTWRD WIEAAFEKRI SLSATGYFRG
1160 1170 1180 1190 1200
YKAFMDWEKG EGDPFPYYVY GAACSEVEID CLTGAHKKIR TDIVMDACCS
1210 1220 1230 1240 1250
LNPAIDIGQI EGAFIQGMGL YTTEELLYSP EGVLYSRSPD KYKIPTVTDV
1260 1270 1280 1290 1300
PEQFNVSLLP SSQTPLTLYS SKGLGESGMF LGSSVFFAIV DAVAAARRQR
1310 1320 1330 1340
DIAEDFTVKS PATPEWVRMA CADRFTDMIP RDDPKTFKPW SIPIA
Length:1,345
Mass (Da):147,913
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D3FA441A3F6F92C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202K → E in AAI50827 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY187018 mRNA Translation: AAO38750.2
AY665589 mRNA Translation: AAV68256.1
AC121091 Genomic DNA No translation available.
AC163498 Genomic DNA No translation available.
BC150826 mRNA Translation: AAI50827.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35576.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008419.1, NM_001008419.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000114366; ENSMUSP00000110006; ENSMUSG00000079554

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
213043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:213043

UCSC genome browser

More...
UCSCi
uc007bbp.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY187018 mRNA Translation: AAO38750.2
AY665589 mRNA Translation: AAV68256.1
AC121091 Genomic DNA No translation available.
AC163498 Genomic DNA No translation available.
BC150826 mRNA Translation: AAI50827.1
CCDSiCCDS35576.1
RefSeqiNP_001008419.1, NM_001008419.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi229391, 1 interactor
STRINGi10090.ENSMUSP00000110006

PTM databases

iPTMnetiQ5SGK3
PhosphoSitePlusiQ5SGK3

Proteomic databases

jPOSTiQ5SGK3
MaxQBiQ5SGK3
PaxDbiQ5SGK3
PeptideAtlasiQ5SGK3
PRIDEiQ5SGK3

Genome annotation databases

EnsembliENSMUST00000114366; ENSMUSP00000110006; ENSMUSG00000079554
GeneIDi213043
KEGGimmu:213043
UCSCiuc007bbp.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
213043
MGIiMGI:3529596, Aox2

Phylogenomic databases

eggNOGiKOG0430, Eukaryota
GeneTreeiENSGT00950000183114
HOGENOMiCLU_001681_1_2_1
InParanoidiQ5SGK3
KOiK00157
OMAiSCIHISE
OrthoDBi48717at2759
PhylomeDBiQ5SGK3
TreeFamiTF353036

Enzyme and pathway databases

BRENDAi1.2.3.1, 3474

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
213043, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Aox2, mouse

Protein Ontology

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PROi
PR:Q5SGK3
RNActiQ5SGK3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000079554, Expressed in nose and 30 other tissues

Family and domain databases

CDDicd00207, fer2, 1 hit
InterProiView protein in InterPro
IPR002888, 2Fe-2S-bd
IPR036884, 2Fe-2S-bd_dom_sf
IPR036010, 2Fe-2S_ferredoxin-like_sf
IPR001041, 2Fe-2S_ferredoxin-type
IPR006058, 2Fe2S_fd_BS
IPR000674, Ald_Oxase/Xan_DH_a/b
IPR036856, Ald_Oxase/Xan_DH_a/b_sf
IPR016208, Ald_Oxase/xanthine_DH
IPR014313, Aldehyde_oxidase
IPR008274, AldOxase/xan_DH_Mopterin-bd
IPR037165, AldOxase/xan_DH_Mopterin-bd_sf
IPR005107, CO_DH_flav_C
IPR036683, CO_DH_flav_C_dom_sf
IPR016166, FAD-bd_PCMH
IPR036318, FAD-bd_PCMH-like_sf
IPR002346, Mopterin_DH_FAD-bd
PfamiView protein in Pfam
PF01315, Ald_Xan_dh_C, 1 hit
PF02738, Ald_Xan_dh_C2, 1 hit
PF03450, CO_deh_flav_C, 1 hit
PF00941, FAD_binding_5, 1 hit
PF00111, Fer2, 1 hit
PF01799, Fer2_2, 1 hit
PIRSFiPIRSF000127, Xanthine_DH, 1 hit
SMARTiView protein in SMART
SM01008, Ald_Xan_dh_C, 1 hit
SM01092, CO_deh_flav_C, 1 hit
SUPFAMiSSF47741, SSF47741, 1 hit
SSF54292, SSF54292, 1 hit
SSF54665, SSF54665, 1 hit
SSF55447, SSF55447, 1 hit
SSF56003, SSF56003, 1 hit
SSF56176, SSF56176, 1 hit
TIGRFAMsiTIGR02969, mam_aldehyde_ox, 1 hit
PROSITEiView protein in PROSITE
PS00197, 2FE2S_FER_1, 1 hit
PS51085, 2FE2S_FER_2, 1 hit
PS51387, FAD_PCMH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAOXB_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SGK3
Secondary accession number(s): B9EKC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: January 4, 2005
Last modified: August 12, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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