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Protein

Protein phosphatase 1L

Gene

PPM1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi128Manganese 1By similarity1
Metal bindingi128Manganese 2By similarity1
Metal bindingi129Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi302Manganese 2By similarity1
Metal bindingi342Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.1.3.16 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1660661 Sphingolipid de novo biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5SGD2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1L (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 1-like
Protein phosphatase 2C isoform epsilon
Short name:
PP2C-epsilon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPM1L
Synonyms:PP2CE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163590.13

Human Gene Nomenclature Database

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HGNCi
HGNC:16381 PPM1L

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611931 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SGD2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 42HelicalSequence analysisAdd BLAST17
Topological domaini43 – 360CytoplasmicSequence analysisAdd BLAST318

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151742

Open Targets

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OpenTargetsi
ENSG00000163590

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134871016

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPM1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743437

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000577541 – 360Protein phosphatase 1LAdd BLAST360

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5SGD2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SGD2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SGD2

PeptideAtlas

More...
PeptideAtlasi
Q5SGD2

PRoteomics IDEntifications database

More...
PRIDEi
Q5SGD2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63756
63757 [Q5SGD2-2]
63758 [Q5SGD2-3]
63759 [Q5SGD2-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q5SGD2-1 [Q5SGD2-1]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q5SGD2

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SGD2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SGD2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163590 Expressed in 199 organ(s), highest expression level in layer of synovial tissue

CleanEx database of gene expression profiles

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CleanExi
HS_PPM1L

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5SGD2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019891
HPA019953

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5.By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127400, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417659

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5SGD2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5SGD2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 351PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST260

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0698 Eukaryota
COG0631 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233896

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079483

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5SGD2

KEGG Orthology (KO)

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KOi
K17506

Identification of Orthologs from Complete Genome Data

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OMAi
VCDEAIR

Database of Orthologous Groups

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OrthoDBi
EOG091G05ME

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5SGD2

TreeFam database of animal gene trees

More...
TreeFami
TF332888

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00143 PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom

The PANTHER Classification System

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PANTHERi
PTHR13832 PTHR13832, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00481 PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81606 SSF81606, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SGD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK
60 70 80 90 100
SSRDAVKMVK GKVAEIMQND RLGGLDVLEA EFSKTWEFKN HNVAVYSIQG
110 120 130 140 150
RRDHMEDRFE VLTDLANKTH PSIFGIFDGH GGETAAEYVK SRLPEALKQH
160 170 180 190 200
LQDYEKDKEN SVLSYQTILE QQILSIDREM LEKLTVSYDE AGTTCLIALL
210 220 230 240 250
SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK RIKRAGGFIS
260 270 280 290 300
FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA
310 320 330 340 350
SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK
360
FRNSSKTEEQ
Length:360
Mass (Da):41,053
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08212E7BA32AFE2B
GO
Isoform 2 (identifier: Q5SGD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.

Show »
Length:181
Mass (Da):20,324
Checksum:i74F07366F3C3FB4B
GO
Isoform 3 (identifier: Q5SGD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     128-133: DGHGGE → MPAFST

Show »
Length:233
Mass (Da):26,363
Checksum:i5522C3B41C506168
GO
Isoform 4 (identifier: Q5SGD2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-194: GTT → VTF
     195-360: Missing.

Show »
Length:194
Mass (Da):22,475
Checksum:iBD4465CB810BCBB9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050622262A → S. Corresponds to variant dbSNP:rs13326359Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0169271 – 179Missing in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_0375521 – 127Missing in isoform 3. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_037553128 – 133DGHGGE → MPAFST in isoform 3. 1 Publication6
Alternative sequenceiVSP_037554192 – 194GTT → VTF in isoform 4. 1 Publication3
Alternative sequenceiVSP_037555195 – 360Missing in isoform 4. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY337264 mRNA Translation: AAR00269.1
AK055115 mRNA Translation: BAB70856.1
BC104885 mRNA Translation: AAI04886.1
BC104887 mRNA Translation: AAI04888.1
BC110801 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33886.1 [Q5SGD2-1]
CCDS82868.1 [Q5SGD2-3]
CCDS82869.1 [Q5SGD2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001304840.1, NM_001317911.1 [Q5SGD2-3]
NP_001304841.1, NM_001317912.1 [Q5SGD2-2]
NP_640338.2, NM_139245.3 [Q5SGD2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.389027
Hs.592572
Hs.701353

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295839; ENSP00000295839; ENSG00000163590 [Q5SGD2-3]
ENST00000464260; ENSP00000420746; ENSG00000163590 [Q5SGD2-2]
ENST00000497343; ENSP00000420354; ENSG00000163590 [Q5SGD2-4]
ENST00000498165; ENSP00000417659; ENSG00000163590 [Q5SGD2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
151742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151742

UCSC genome browser

More...
UCSCi
uc003fds.4 human [Q5SGD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337264 mRNA Translation: AAR00269.1
AK055115 mRNA Translation: BAB70856.1
BC104885 mRNA Translation: AAI04886.1
BC104887 mRNA Translation: AAI04888.1
BC110801 mRNA No translation available.
CCDSiCCDS33886.1 [Q5SGD2-1]
CCDS82868.1 [Q5SGD2-3]
CCDS82869.1 [Q5SGD2-2]
RefSeqiNP_001304840.1, NM_001317911.1 [Q5SGD2-3]
NP_001304841.1, NM_001317912.1 [Q5SGD2-2]
NP_640338.2, NM_139245.3 [Q5SGD2-1]
UniGeneiHs.389027
Hs.592572
Hs.701353

3D structure databases

ProteinModelPortaliQ5SGD2
SMRiQ5SGD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127400, 7 interactors
STRINGi9606.ENSP00000417659

PTM databases

DEPODiQ5SGD2
iPTMnetiQ5SGD2
PhosphoSitePlusiQ5SGD2

Polymorphism and mutation databases

BioMutaiPPM1L
DMDMi74743437

Proteomic databases

EPDiQ5SGD2
MaxQBiQ5SGD2
PaxDbiQ5SGD2
PeptideAtlasiQ5SGD2
PRIDEiQ5SGD2
ProteomicsDBi63756
63757 [Q5SGD2-2]
63758 [Q5SGD2-3]
63759 [Q5SGD2-4]
TopDownProteomicsiQ5SGD2-1 [Q5SGD2-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
151742
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295839; ENSP00000295839; ENSG00000163590 [Q5SGD2-3]
ENST00000464260; ENSP00000420746; ENSG00000163590 [Q5SGD2-2]
ENST00000497343; ENSP00000420354; ENSG00000163590 [Q5SGD2-4]
ENST00000498165; ENSP00000417659; ENSG00000163590 [Q5SGD2-1]
GeneIDi151742
KEGGihsa:151742
UCSCiuc003fds.4 human [Q5SGD2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
151742
DisGeNETi151742
EuPathDBiHostDB:ENSG00000163590.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPM1L
HGNCiHGNC:16381 PPM1L
HPAiHPA019891
HPA019953
MIMi611931 gene
neXtProtiNX_Q5SGD2
OpenTargetsiENSG00000163590
PharmGKBiPA134871016

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00940000157030
HOGENOMiHOG000233896
HOVERGENiHBG079483
InParanoidiQ5SGD2
KOiK17506
OMAiVCDEAIR
OrthoDBiEOG091G05ME
PhylomeDBiQ5SGD2
TreeFamiTF332888

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis
SIGNORiQ5SGD2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPM1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
151742

Protein Ontology

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PROi
PR:Q5SGD2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163590 Expressed in 199 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_PPM1L
GenevisibleiQ5SGD2 HS

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPM1L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SGD2
Secondary accession number(s): Q2M3J2, Q96NM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 21, 2004
Last modified: December 5, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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