UniProtKB - Q5SDR3 (BMI1_CHICK)
Protein
Polycomb complex protein BMI-1
Gene
BMI1
Organism
Gallus gallus (Chicken)
Status
Functioni
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 18 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- promoter-specific chromatin binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- ubiquitin-protein transferase activator activity Source: Ensembl
- zinc ion binding Source: UniProtKB
GO - Biological processi
- brain development Source: Ensembl
- chromatin silencing Source: GO_Central
- DNA methylation Source: Ensembl
- embryonic skeletal system morphogenesis Source: Ensembl
- histone acetylation Source: Ensembl
- histone H2A-K119 monoubiquitination Source: UniProtKB
- humoral immune response Source: Ensembl
- negative regulation of apoptotic signaling pathway Source: Ensembl
- negative regulation of gene expression, epigenetic Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of B cell proliferation Source: Ensembl
- positive regulation of immature T cell proliferation in thymus Source: Ensembl
- positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
- regulation of adaxial/abaxial pattern formation Source: Ensembl
- rostrocaudal neural tube patterning Source: Ensembl
- somatic stem cell division Source: Ensembl
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-GGA-2559580, Oxidative Stress Induced Senescence R-GGA-3108214, SUMOylation of DNA damage response and repair proteins R-GGA-3899300, SUMOylation of transcription cofactors R-GGA-4551638, SUMOylation of chromatin organization proteins R-GGA-4570464, SUMOylation of RNA binding proteins R-GGA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-GGA-8943724, Regulation of PTEN gene transcription R-GGA-8953750, Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: Polycomb complex protein BMI-1Alternative name(s): Polycomb group RING finger protein 4 |
Gene namesi | Name:BMI1 Synonyms:PCGF4 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
- PcG protein complex Source: UniProtKB
- PRC1 complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
- heterochromatin Source: Ensembl
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000296629 | 1 – 326 | Polycomb complex protein BMI-1Add BLAST | 326 |
Expressioni
Developmental stagei
During early nervous system development, robust expression was observed in the open neural plate and later in the dorsal neural tube and much of the brain. Also present in the developing heart primordia and the sensory placodes.1 Publication
Gene expression databases
Bgeei | ENSGALG00000026623, Expressed in female gonad and 14 other tissues |
Interactioni
Subunit structurei
Component of a PRC1-like complex.
By similarityProtein-protein interaction databases
STRINGi | 9031.ENSGALP00000041259 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 182 | Interaction with PHC2By similarityAdd BLAST | 21 | |
Regioni | 164 – 228 | Interaction with E4F1By similarityAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 81 – 95 | Nuclear localization signalSequence analysisAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 251 – 326 | Pro/Ser-richAdd BLAST | 76 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 18 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2660, Eukaryota |
GeneTreei | ENSGT00940000156042 |
HOGENOMi | CLU_046427_0_0_1 |
InParanoidi | Q5SDR3 |
OMAi | HLICALC |
OrthoDBi | 1344247at2759 |
PhylomeDBi | Q5SDR3 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443, RAWUL IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF16207, RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5SDR3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS
60 70 80 90 100
KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA
110 120 130 140 150
HPSADAANGS NEDRGEVADE DKRIITDDEI ISLSIEFFDQ NRLERKGNKE
160 170 180 190 200
KEKSKEEVND KRYLRCPAAM TVMHLRKFLR SKMDIPNTFQ IDVMYEEEPL
210 220 230 240 250
KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKIGHQR EGLSNSGELE
260 270 280 290 300
SDSGSDKASS PAGGLPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSSSP
310 320
GSNHQSSFTN RARKSSINGS SATSSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY616032 mRNA Translation: AAU25821.1 |
RefSeqi | NP_001007989.1, NM_001007988.1 |
Genome annotation databases
Ensembli | ENSGALT00000047281; ENSGALP00000051910; ENSGALG00000041267 |
GeneIDi | 493647 |
KEGGi | gga:493647 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY616032 mRNA Translation: AAU25821.1 |
RefSeqi | NP_001007989.1, NM_001007988.1 |
3D structure databases
SMRi | Q5SDR3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000041259 |
Genome annotation databases
Ensembli | ENSGALT00000047281; ENSGALP00000051910; ENSGALG00000041267 |
GeneIDi | 493647 |
KEGGi | gga:493647 |
Organism-specific databases
CTDi | 648 |
Phylogenomic databases
eggNOGi | KOG2660, Eukaryota |
GeneTreei | ENSGT00940000156042 |
HOGENOMi | CLU_046427_0_0_1 |
InParanoidi | Q5SDR3 |
OMAi | HLICALC |
OrthoDBi | 1344247at2759 |
PhylomeDBi | Q5SDR3 |
Enzyme and pathway databases
Reactomei | R-GGA-2559580, Oxidative Stress Induced Senescence R-GGA-3108214, SUMOylation of DNA damage response and repair proteins R-GGA-3899300, SUMOylation of transcription cofactors R-GGA-4551638, SUMOylation of chromatin organization proteins R-GGA-4570464, SUMOylation of RNA binding proteins R-GGA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-GGA-8943724, Regulation of PTEN gene transcription R-GGA-8953750, Transcriptional Regulation by E2F6 |
Miscellaneous databases
PROi | PR:Q5SDR3 |
Gene expression databases
Bgeei | ENSGALG00000026623, Expressed in female gonad and 14 other tissues |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443, RAWUL IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF16207, RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMI1_CHICK | |
Accessioni | Q5SDR3Primary (citable) accession number: Q5SDR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |