UniProtKB - Q5S1U1 (HSPB1_PIG)
Protein
Heat shock protein beta-1
Gene
HSPB1
Organism
Sus scrofa (Pig)
Status
Functioni
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.By similarity
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein folding chaperone Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- anterograde axonal protein transport Source: UniProtKB
- chaperone-mediated protein folding Source: UniProtKB
- regulation of protein phosphorylation Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Enzyme and pathway databases
Reactomei | R-SSC-4420097, VEGFA-VEGFR2 Pathway R-SSC-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-SSC-5687128, MAPK6/MAPK4 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein beta-1Short name: HspB1 Alternative name(s): Heat shock 27 kDa protein Short name: HSP 27 |
Gene namesi | Name:HSPB1 Synonyms:HSP27 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- spindle By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Note: Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.By similarity
Cytoskeleton
- spindle Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon cytoplasm Source: GOC
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125929 | 1 – 207 | Heat shock protein beta-1Add BLAST | 207 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 15 | Phosphoserine; by MAPKAPK2 and MAPKAPK3By similarity | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 80 | Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity | 1 | |
Modified residuei | 84 | Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity | 1 | |
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 88 | PhosphoserineBy similarity | 1 | |
Modified residuei | 100 | PhosphoserineBy similarity | 1 | |
Modified residuei | 125 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 176 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 178 | PhosphoserineBy similarity | 1 | |
Modified residuei | 201 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated upon exposure to protein kinase C activators and heat shock. Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement.By similarity
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | Q5S1U1 |
PeptideAtlasi | Q5S1U1 |
PRIDEi | Q5S1U1 |
PTM databases
iPTMneti | Q5S1U1 |
Expressioni
Gene expression databases
Bgeei | ENSSSCG00000024482, Expressed in heart and 38 other tissues |
ExpressionAtlasi | Q5S1U1, baseline and differential |
Genevisiblei | Q5S1U1, SS |
Interactioni
Subunit structurei
Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin.
Interacts with TGFB1I1.
Interacts with CRYAB.
Interacts with HSPB8.
Interacts with HSPBAP1.
By similarityGO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000008216 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 186 | sHSPPROSITE-ProRule annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 207 | Interaction with TGFB1I1By similarityAdd BLAST | 136 |
Sequence similaritiesi
Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
HOGENOMi | CLU_095001_0_0_1 |
InParanoidi | Q5S1U1 |
OMAi | EEWAQWF |
OrthoDBi | 1187096at2759 |
TreeFami | TF105049 |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5S1U1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTERRVPFSL LRSPSWDPFR DWYPAHSRLF DQAFGLPRLP EEWSQWLSHS
60 70 80 90 100
GWPGYVRPLP PPAIEGPAAV AAPAYSRLLS RQLSSGVSEI QQTADRWRVS
110 120 130 140 150
LDVNHFAPEE LTVKTKDGVV EITGKHEERQ DEHGFISRCF TRKYTLPPGV
160 170 180 190 200
DPTQVSSSLS PEGTLSVEAP LPKPATQSAE ITIPVTFEAR AQLGGTEAGK
SEKPGTK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY789513 mRNA Translation: AAV54182.1 |
RefSeqi | NP_001007519.1, NM_001007518.1 |
Genome annotation databases
GeneIDi | 493184 |
KEGGi | ssc:493184 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY789513 mRNA Translation: AAV54182.1 |
RefSeqi | NP_001007519.1, NM_001007518.1 |
3D structure databases
SMRi | Q5S1U1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000008216 |
PTM databases
iPTMneti | Q5S1U1 |
Proteomic databases
PaxDbi | Q5S1U1 |
PeptideAtlasi | Q5S1U1 |
PRIDEi | Q5S1U1 |
Genome annotation databases
GeneIDi | 493184 |
KEGGi | ssc:493184 |
Organism-specific databases
CTDi | 3315 |
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
HOGENOMi | CLU_095001_0_0_1 |
InParanoidi | Q5S1U1 |
OMAi | EEWAQWF |
OrthoDBi | 1187096at2759 |
TreeFami | TF105049 |
Enzyme and pathway databases
Reactomei | R-SSC-4420097, VEGFA-VEGFR2 Pathway R-SSC-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-SSC-5687128, MAPK6/MAPK4 signaling |
Miscellaneous databases
ChiTaRSi | HSPB1, pig |
Gene expression databases
Bgeei | ENSSSCG00000024482, Expressed in heart and 38 other tissues |
ExpressionAtlasi | Q5S1U1, baseline and differential |
Genevisiblei | Q5S1U1, SS |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSPB1_PIG | |
Accessioni | Q5S1U1Primary (citable) accession number: Q5S1U1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families