UniProtKB - Q5S006 (LRRK2_MOUSE)
Leucine-rich repeat serine/threonine-protein kinase 2
Lrrk2
Functioni
Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:30398148, PubMed:29212815).
Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:30398148, PubMed:29212815, PubMed:29125462).
Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:30398148, PubMed:29212815).
Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (By similarity).
Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (By similarity).
Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148).
Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity).
Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity).
Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882).
Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (By similarity).
The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (By similarity).
Phosphorylates PRDX3 (By similarity).
By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718).
Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (By similarity).
In addition, has GTPase activity via its Roc domain which regulates LRKK2 kinase activity (By similarity).
By similarity6 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1906 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 1994 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1341 – 1348 | GTPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1885 – 1893 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 2098 – 2121 | GTPPROSITE-ProRule annotationAdd BLAST | 24 | |
Nucleotide bindingi | 2295 – 2298 | GTPPROSITE-ProRule annotation | 4 |
GO - Molecular functioni
- actin binding Source: MGI
- ATP binding Source: UniProtKB-KW
- beta-catenin destruction complex binding Source: ParkinsonsUK-UCL
- clathrin binding Source: MGI
- GTPase activator activity Source: MGI
- GTPase activity Source: MGI
- GTP binding Source: MGI
- GTP-dependent protein kinase activity Source: MGI
- identical protein binding Source: IntAct
- JUN kinase kinase kinase activity Source: Ensembl
- kinase activity Source: UniProtKB
- magnesium ion binding Source: MGI
- MAP kinase kinase kinase activity Source: MGI
- peroxidase inhibitor activity Source: MGI
- protein-containing complex binding Source: ParkinsonsUK-UCL
- protein homodimerization activity Source: MGI
- protein kinase A binding Source: ParkinsonsUK-UCL
- protein kinase activity Source: MGI
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: MGI
- protein serine/threonine phosphatase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- signaling receptor complex adaptor activity Source: ParkinsonsUK-UCL
- small GTPase binding Source: BHF-UCL
- SNARE binding Source: MGI
- syntaxin-1 binding Source: MGI
- transmembrane transporter binding Source: MGI
- tubulin binding Source: MGI
GO - Biological processi
- autophagy Source: UniProtKB-KW
- calcium-mediated signaling Source: MGI
- cellular protein localization Source: ParkinsonsUK-UCL
- cellular response to dopamine Source: MGI
- cellular response to manganese ion Source: MGI
- cellular response to organic cyclic compound Source: GO_Central
- cellular response to oxidative stress Source: MGI
- cellular response to starvation Source: MGI
- determination of adult lifespan Source: MGI
- endocytosis Source: MGI
- endoplasmic reticulum organization Source: UniProtKB
- excitatory postsynaptic potential Source: ParkinsonsUK-UCL
- exploration behavior Source: MGI
- Golgi organization Source: MGI
- GTP metabolic process Source: MGI
- intracellular distribution of mitochondria Source: MGI
- intracellular signal transduction Source: ParkinsonsUK-UCL
- JNK cascade Source: MGI
- locomotory exploration behavior Source: ParkinsonsUK-UCL
- lysosome organization Source: MGI
- MAPK cascade Source: MGI
- mitochondrion localization Source: MGI
- mitochondrion organization Source: MGI
- negative regulation of autophagosome assembly Source: MGI
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
- negative regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCL
- negative regulation of GTPase activity Source: MGI
- negative regulation of hydrogen peroxide-induced cell death Source: MGI
- negative regulation of macroautophagy Source: MGI
- negative regulation of neuron death Source: MGI
- negative regulation of neuron projection development Source: MGI
- negative regulation of protein binding Source: MGI
- negative regulation of protein phosphorylation Source: ParkinsonsUK-UCL
- negative regulation of protein processing Source: MGI
- negative regulation of protein targeting to mitochondrion Source: MGI
- negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation Source: MGI
- neuromuscular junction development Source: MGI
- neuron death Source: MGI
- neuron projection arborization Source: MGI
- neuron projection morphogenesis Source: UniProtKB
- olfactory bulb development Source: MGI
- peptidyl-serine phosphorylation Source: MGI
- peptidyl-threonine phosphorylation Source: MGI
- phosphorylation Source: MGI
- positive regulation of autophagy Source: BHF-UCL
- positive regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of dopamine receptor signaling pathway Source: MGI
- positive regulation of histone deacetylase activity Source: MGI
- positive regulation of MAP kinase activity Source: MGI
- positive regulation of microglial cell activation Source: MGI
- positive regulation of nitric-oxide synthase biosynthetic process Source: MGI
- positive regulation of programmed cell death Source: MGI
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
- positive regulation of protein autoubiquitination Source: MGI
- positive regulation of protein binding Source: MGI
- positive regulation of protein kinase activity Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of protein ubiquitination Source: MGI
- positive regulation of synaptic vesicle endocytosis Source: MGI
- positive regulation of tumor necrosis factor production Source: MGI
- protein autophosphorylation Source: MGI
- protein import into nucleus Source: MGI
- protein localization to endoplasmic reticulum exit site Source: UniProtKB
- protein phosphorylation Source: MGI
- reactive oxygen species metabolic process Source: MGI
- regulation of autophagy Source: MGI
- regulation of branching morphogenesis of a nerve Source: MGI
- regulation of CAMKK-AMPK signaling cascade Source: MGI
- regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- regulation of dendritic spine morphogenesis Source: ParkinsonsUK-UCL
- regulation of dopamine receptor signaling pathway Source: ParkinsonsUK-UCL
- regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
- regulation of gene expression Source: MGI
- regulation of kidney size Source: BHF-UCL
- regulation of locomotion Source: MGI
- regulation of lysosomal lumen pH Source: MGI
- regulation of membrane potential Source: MGI
- regulation of mitochondrial depolarization Source: MGI
- regulation of neuroblast proliferation Source: MGI
- regulation of neuron death Source: MGI
- regulation of neuron maturation Source: MGI
- regulation of protein kinase A signaling Source: ParkinsonsUK-UCL
- regulation of protein stability Source: MGI
- regulation of retrograde transport, endosome to Golgi Source: MGI
- regulation of synaptic transmission, glutamatergic Source: ParkinsonsUK-UCL
- regulation of synaptic vesicle endocytosis Source: SynGO
- regulation of synaptic vesicle exocytosis Source: MGI
- regulation of synaptic vesicle transport Source: ParkinsonsUK-UCL
- response to oxidative stress Source: MGI
- signal transduction Source: GO_Central
- spermatogenesis Source: Ensembl
- striatum development Source: Ensembl
- synaptic vesicle recycling Source: ParkinsonsUK-UCL
- tangential migration from the subventricular zone to the olfactory bulb Source: MGI
- Wnt signalosome assembly Source: MGI
Keywordsi
Molecular function | GTPase activation, Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Autophagy, Differentiation |
Ligand | ATP-binding, GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-8857538, PTK6 promotes HIF1A stabilization |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Lrrk2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913975, Lrrk2 |
VEuPathDBi | HostDB:ENSMUSG00000036273 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication; Peripheral membrane protein 1 Publication
Endosome
- Endosome 1 Publication
Lysosome
- Lysosome 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Peripheral membrane protein 2 Publications
Golgi apparatus
- Golgi apparatus membrane 2 Publications; Peripheral membrane protein 2 Publications
Other locations
- Cytoplasmic vesicle By similarity
- Perikaryon By similarity
- axon By similarity
- dendrite By similarity
- synaptic vesicle membrane 1 Publication
Note: Colocalized with RAB29 along tubular structures emerging from Golgi apparatus (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882).By similarity1 Publication
Cytosol
- cytosol Source: MGI
- presynaptic cytosol Source: SynGO
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum exit site Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Endosome
- endosome Source: UniProtKB
- multivesicular body, internal vesicle Source: MGI
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
- trans-Golgi network Source: MGI
Lysosome
- autolysosome Source: MGI
- lysosome Source: UniProtKB
Mitochondrion
- cytoplasmic side of mitochondrial outer membrane Source: MGI
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial matrix Source: UniProtKB
- mitochondrial membrane Source: MGI
- mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: MGI
Plasma Membrane
- caveola neck Source: MGI
- plasma membrane Source: MGI
Other locations
- amphisome Source: MGI
- axon Source: UniProtKB
- cytoplasm Source: MGI
- cytoplasmic vesicle Source: UniProtKB
- dendrite Source: ParkinsonsUK-UCL
- dendrite cytoplasm Source: MGI
- glutamatergic synapse Source: SynGO
- Golgi-associated vesicle Source: MGI
- growth cone Source: MGI
- inclusion body Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: MGI
- membrane raft Source: MGI
- microvillus Source: MGI
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- perikaryon Source: UniProtKB
- postsynapse Source: GOC
- ribonucleoprotein complex Source: MGI
- synapse Source: MGI
- synaptic vesicle Source: MGI
- synaptic vesicle membrane Source: UniProtKB-SubCell
- terminal bouton Source: ParkinsonsUK-UCL
- Wnt signalosome Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion outer membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1441 | R → C: Impaired ability to recruit SEC61A and SEC31A to endoplasmic reticulum exit sites. Impaired ability to regulate ER to Golgi vesicle-mediated transport. 1 Publication | 1 | |
Mutagenesisi | 1441 | R → G: Increases kinase activity. Reduces primary ciliogenesis. Causes fragmentation of the trans-Golgi network. 3 Publications | 1 | |
Mutagenesisi | 2016 | A → T: Does not affect kinase activity and decreases sensitivity towards small molecule kinase inhibitors. 1 Publication | 1 | |
Mutagenesisi | 2019 | G → S: Increases kinase activity. Causes loss of dopaminergic neurons in the substantia nigra of 20-month old mice due to increased phosphorylation of APP. Reduces primary ciliogenesis. 3 Publications | 1 |
Chemistry databases
ChEMBLi | CHEMBL2010622 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086239 | 1 – 2527 | Leucine-rich repeat serine/threonine-protein kinase 2Add BLAST | 2527 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 910 | PhosphoserineBy similarity | 1 | |
Modified residuei | 935 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 955 | PhosphoserineBy similarity | 1 | |
Modified residuei | 973 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1292 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1444 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q5S006 |
MaxQBi | Q5S006 |
PaxDbi | Q5S006 |
PeptideAtlasi | Q5S006 |
PRIDEi | Q5S006 |
ProteomicsDBi | 292371 |
PTM databases
iPTMneti | Q5S006 |
PhosphoSitePlusi | Q5S006 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000036273, Expressed in granulocyte and 206 other tissues |
Genevisiblei | Q5S006, MM |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with PRKN, PRDX3 and TPCN2 (By similarity).
Interacts with VPS35 and RAB29 (PubMed:23395371).
Interacts (via ROC domain) with SEC16A (PubMed:25201882).
Interacts with APP; interaction promotes phosphorylation of 'Thr-743' of APP (PubMed:28720718).
Interacts with MAPT (By similarity).
Interacts with RAB8A, RAB10, and RAB12 (By similarity).
Interacts with YWHAG; this interaction is dependent on phosphorylation of Ser-910 and either Ser-935 or Ser-1444 (By similarity).
Interacts with SFN; this interaction is dependent on phosphorylation of Ser-910 and/or Ser-935 (By similarity).
By similarity3 PublicationsBinary interactionsi
Q5S006
GO - Molecular functioni
- actin binding Source: MGI
- clathrin binding Source: MGI
- identical protein binding Source: IntAct
- protein homodimerization activity Source: MGI
- protein kinase A binding Source: ParkinsonsUK-UCL
- small GTPase binding Source: BHF-UCL
- SNARE binding Source: MGI
- syntaxin-1 binding Source: MGI
- transmembrane transporter binding Source: MGI
- tubulin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 211674, 41 interactors |
DIPi | DIP-58648N |
IntActi | Q5S006, 76 interactors |
STRINGi | 10090.ENSMUSP00000052584 |
Miscellaneous databases
RNActi | Q5S006, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 983 – 1004 | LRR 1Add BLAST | 22 | |
Repeati | 1012 – 1033 | LRR 2Add BLAST | 22 | |
Repeati | 1036 – 1057 | LRR 3Add BLAST | 22 | |
Repeati | 1059 – 1080 | LRR 4Add BLAST | 22 | |
Repeati | 1084 – 1105 | LRR 5Add BLAST | 22 | |
Repeati | 1108 – 1129 | LRR 6Add BLAST | 22 | |
Repeati | 1130 – 1151 | LRR 7Add BLAST | 22 | |
Repeati | 1174 – 1195 | LRR 8Add BLAST | 22 | |
Repeati | 1197 – 1218 | LRR 9Add BLAST | 22 | |
Repeati | 1221 – 1242 | LRR 10Add BLAST | 22 | |
Repeati | 1246 – 1267 | LRR 11Add BLAST | 22 | |
Repeati | 1269 – 1291 | LRR 12Add BLAST | 23 | |
Domaini | 1328 – 1511 | RocPROSITE-ProRule annotationAdd BLAST | 184 | |
Domaini | 1879 – 2146 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 268 | |
Repeati | 2139 – 2183 | WD 1Add BLAST | 45 | |
Repeati | 2188 – 2228 | WD 2Add BLAST | 41 | |
Repeati | 2233 – 2276 | WD 3Add BLAST | 44 | |
Repeati | 2281 – 2327 | WD 4Add BLAST | 47 | |
Repeati | 2333 – 2377 | WD 5Add BLAST | 45 | |
Repeati | 2402 – 2438 | WD 6Add BLAST | 37 | |
Repeati | 2443 – 2497 | WD 7Add BLAST | 55 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 957 – 979 | DisorderedSequence analysisAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 9 – 33 | Sequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 958 – 979 | Polar residuesSequence analysisAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Leucine-rich repeat, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0192, Eukaryota KOG0619, Eukaryota |
GeneTreei | ENSGT00940000158267 |
HOGENOMi | CLU_000815_0_0_1 |
InParanoidi | Q5S006 |
OMAi | HASELYI |
OrthoDBi | 14978at2759 |
PhylomeDBi | Q5S006 |
TreeFami | TF313679 |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits 1.25.40.20, 1 hit 2.130.10.10, 1 hit 3.40.50.300, 1 hit 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold IPR032171, COR IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR025875, Leu-rich_rpt_4 IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR027417, P-loop_NTPase IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR020859, ROC_dom IPR008271, Ser/Thr_kinase_AS IPR005225, Small_GTP-bd_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF16095, COR, 1 hit PF12799, LRR_4, 1 hit PF13855, LRR_8, 2 hits PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF48403, SSF48403, 1 hit SSF50978, SSF50978, 1 hit SSF52540, SSF52540, 1 hit SSF56112, SSF56112, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 11 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51424, ROC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MASGACQGCE EEEEEEALKK LIVRLNNVQE GKQIETLLQL LEDMLVFTYS
60 70 80 90 100
DRASKLFEDK NFHVPLLIVL DSYMRVASVQ QAGWSLLCKL IEVCPGTLQS
110 120 130 140 150
LIGPQDIGND WEVLGIHRLI LKMLTVHHAN VNLSIVGLKA LDLLLDSGKL
160 170 180 190 200
TLLILDEECD IFLLIFDAMH RYSANDEVQK LGCKALHVLF ERVSEEQLTE
210 220 230 240 250
FVENKDYTIL LSTFGSFRRD KEIVYHVLCC LHSLAVTCSN VEVLMSGNVR
260 270 280 290 300
CYNLVVEAMK AFPTNENIQE VSCSLFQKLT LGNFFNILVL NEVHVFVVKA
310 320 330 340 350
VRQYPENAAL QISALSCLAL LTETIFLNQD LEERSETQEQ SEEEDSEKLF
360 370 380 390 400
WLEPCYKALV RHRKDKHVQE AACWALNNLL MYQNSLHEKI GDEDGQFPAH
410 420 430 440 450
REVMLSMLMH SSSKDVFQAA AHALSTLLEQ NVNFRKILLA KGVYLNVLEL
460 470 480 490 500
MQKHAHAPEV AESGCKMLSH LFEGSNPSLD TMAAVVPKIL TVMKAHGTSL
510 520 530 540 550
SVQLEALRAI LHFVVPGLLE ESREDSQCRP NVLRKQCFRT DIHKLVLVAL
560 570 580 590 600
NRFIGNPGIQ KCGLKVISSL AHLPDATETL SLQGAVDSVL HTLQMYPDDQ
610 620 630 640 650
EIQCLGLHLM GCLMTKKNFC IGTGHLLAKI LASTLQRFKD VAEVQTTGLQ
660 670 680 690 700
TTLSILELSV SFSKLLVHYS FDVVIFHQMS SSVVEQKDEQ FLNLCCKCFA
710 720 730 740 750
KVAVDDELKN TMLERACDQN NSIMVECLLL LGADANQVKG ATSLIYQVCE
760 770 780 790 800
KESSPKLVEL LLNGGCREQD VRKALTVSIQ KGDSQVISLL LRKLALDLAN
810 820 830 840 850
NSICLGGFGI GKIDPSWLGP LFPDKSSNLR KQTNTGSVLA RKVLRYQMRN
860 870 880 890 900
TLQEGVASGS DGKFSEDALA KFGEWTFIPD SSMDSVFGQS DDLDSEGSES
910 920 930 940 950
SFLVKRKSNS ISVGEVYRDL ALQRCSPNAQ RHSNSLGPVF DHEDLLRRKR
960 970 980 990 1000
KILSSDESLR SSRLPSHMRQ SDSSSSLASE REHITSLDLS ANELKDIDAL
1010 1020 1030 1040 1050
SQKCCLSSHL EHLTKLELHQ NSLTSFPQQL CETLKCLIHL DLHSNKFTSF
1060 1070 1080 1090 1100
PSFVLKMPRI TNLDASRNDI GPTVVLDPAM KCPSLKQLNL SYNQLSSIPE
1110 1120 1130 1140 1150
NLAQVVEKLE QLLLEGNKIS GICSPLSLKE LKILNLSKNH IPSLPGDFLE
1160 1170 1180 1190 1200
ACSKVESFSA RMNFLAAMPA LPSSITSLKL SQNSFTCIPE AIFSLPHLRS
1210 1220 1230 1240 1250
LDMSHNNIEC LPGPAHWKSL NLRELIFSKN QISTLDFSEN PHVWSRVEKL
1260 1270 1280 1290 1300
HLSHNKLKEI PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD
1310 1320 1330 1340 1350
GLHLNFDFKH VGCKAKDIIR FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL
1360 1370 1380 1390 1400
LQQLMKMKKP ELGMQGATVG IDVRDWSIQI RGKRRKDLVL NVWDFAGREE
1410 1420 1430 1440 1450
FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA RASSSPVILV
1460 1470 1480 1490 1500
GTHLDVSDEK QRKACISKIT KELLNKRGFP TIRDYHFVNA TEESDALAKL
1510 1520 1530 1540 1550
RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKA VPTEFPVINR
1560 1570 1580 1590 1600
KHLLQLVNEH QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP
1610 1620 1630 1640 1650
KWLCKVMAQI LTVKVDGCLK HPKGIISRRD VEKFLSKKKR FPKNYMMQYF
1660 1670 1680 1690 1700
KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF
1710 1720 1730 1740 1750
PMGFWSRLIN RLLEISPFML SGRERALRPN RMYWRQGIYL NWSPEAYCLV
1760 1770 1780 1790 1800
GSEVLDNRPE SFLKITVPSC RKGCILLGRV VDHIDSLMEE WFPGLLEIDI
1810 1820 1830 1840 1850
CGEGETLLKK WALYSFNDGE EHQKILLDEL MKKAEEGDLL INPDQPRLTI
1860 1870 1880 1890 1900
PISQIAPDLI LADLPRNIML NNDELEFEEA PEFLLGDGSF GSVYRAAYEG
1910 1920 1930 1940 1950
EEVAVKIFNK HTSLRLLRQE LVVLCHLHHP SLISLLAAGI RPRMLVMELA
1960 1970 1980 1990 2000
SKGSLDRLLQ QDKASLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV
2010 2020 2030 2040 2050
LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA PEVARGNVIY
2060 2070 2080 2090 2100
NQQADVYSFG LLLHDIWTTG SRIMEGLRFP NEFDELAIQG KLPDPVKEYG
2110 2120 2130 2140 2150
CAPWPMVEKL ITKCLKENPQ ERPTSAQVFD ILNSAELICL MRHILIPKNI
2160 2170 2180 2190 2200
IVECMVATNL NSKSATLWLG CGNTEKGQLS LFDLNTERYS YEEVADSRIL
2210 2220 2230 2240 2250
CLALVHLAAE KESWVVCGTQ SGALLVINVE EETKRHTLEK MTDSVTCLHC
2260 2270 2280 2290 2300
NSLAKQSKQS NFLLVGTADG NLMIFEDKAV KCKGAAPLKT LHIGDVSTPL
2310 2320 2330 2340 2350
MCLSESLNSS ERHITWGGCG TKVFSFSNDF TIQKLIETKT NQLFSYAAFS
2360 2370 2380 2390 2400
DSNIIALAVD TALYIAKKNS PVVEVWDKKT EKLCELIDCV HFLKEVMVKL
2410 2420 2430 2440 2450
NKESKHQLSY SGRVKALCLQ KNTALWIGTG GGHILLLDLS TRRVIRTIHN
2460 2470 2480 2490 2500
FCDSVRAMAT AQLGSLKNVM LVLGYKRKST EGIQEQKEIQ SCLSIWDLNL
2510 2520
PHEVQNLEKH IEVRTELADK MRKTSVE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 343 | E → K in BAC35052 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 777 | V → I in AAV63976 (PubMed:15541309).Curated | 1 | |
Sequence conflicti | 863 | K → N in AAV63976 (PubMed:15541309).Curated | 1 | |
Sequence conflicti | 925 | C → Y in AAV63976 (PubMed:15541309).Curated | 1 | |
Sequence conflicti | 1705 – 1707 | WSR → GQD in BAC28700 (PubMed:16141072).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY792512 mRNA Translation: AAV63976.1 AC099704 Genomic DNA No translation available. AC158752 Genomic DNA No translation available. AK052591 mRNA Translation: BAC35052.1 AK034413 mRNA Translation: BAC28700.1 BC034074 mRNA Translation: AAH34074.1 BC035949 mRNA Translation: AAH35949.1 |
CCDSi | CCDS37180.1 |
RefSeqi | NP_080006.3, NM_025730.3 |
Genome annotation databases
Ensembli | ENSMUST00000060642; ENSMUSP00000052584; ENSMUSG00000036273 |
GeneIDi | 66725 |
KEGGi | mmu:66725 |
UCSCi | uc007xhz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY792512 mRNA Translation: AAV63976.1 AC099704 Genomic DNA No translation available. AC158752 Genomic DNA No translation available. AK052591 mRNA Translation: BAC35052.1 AK034413 mRNA Translation: BAC28700.1 BC034074 mRNA Translation: AAH34074.1 BC035949 mRNA Translation: AAH35949.1 |
CCDSi | CCDS37180.1 |
RefSeqi | NP_080006.3, NM_025730.3 |
3D structure databases
SMRi | Q5S006 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211674, 41 interactors |
DIPi | DIP-58648N |
IntActi | Q5S006, 76 interactors |
STRINGi | 10090.ENSMUSP00000052584 |
Chemistry databases
ChEMBLi | CHEMBL2010622 |
PTM databases
iPTMneti | Q5S006 |
PhosphoSitePlusi | Q5S006 |
Proteomic databases
jPOSTi | Q5S006 |
MaxQBi | Q5S006 |
PaxDbi | Q5S006 |
PeptideAtlasi | Q5S006 |
PRIDEi | Q5S006 |
ProteomicsDBi | 292371 |
Protocols and materials databases
ABCDi | Q5S006, 1 sequenced antibody |
Antibodypediai | 2109, 899 antibodies from 46 providers |
DNASUi | 66725 |
Genome annotation databases
Ensembli | ENSMUST00000060642; ENSMUSP00000052584; ENSMUSG00000036273 |
GeneIDi | 66725 |
KEGGi | mmu:66725 |
UCSCi | uc007xhz.1, mouse |
Organism-specific databases
CTDi | 120892 |
MGIi | MGI:1913975, Lrrk2 |
VEuPathDBi | HostDB:ENSMUSG00000036273 |
Phylogenomic databases
eggNOGi | KOG0192, Eukaryota KOG0619, Eukaryota |
GeneTreei | ENSGT00940000158267 |
HOGENOMi | CLU_000815_0_0_1 |
InParanoidi | Q5S006 |
OMAi | HASELYI |
OrthoDBi | 14978at2759 |
PhylomeDBi | Q5S006 |
TreeFami | TF313679 |
Enzyme and pathway databases
Reactomei | R-MMU-8857538, PTK6 promotes HIF1A stabilization |
Miscellaneous databases
BioGRID-ORCSi | 66725, 3 hits in 65 CRISPR screens |
ChiTaRSi | Lrrk2, mouse |
PROi | PR:Q5S006 |
RNActi | Q5S006, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036273, Expressed in granulocyte and 206 other tissues |
Genevisiblei | Q5S006, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits 1.25.40.20, 1 hit 2.130.10.10, 1 hit 3.40.50.300, 1 hit 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold IPR032171, COR IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR025875, Leu-rich_rpt_4 IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR027417, P-loop_NTPase IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR020859, ROC_dom IPR008271, Ser/Thr_kinase_AS IPR005225, Small_GTP-bd_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF16095, COR, 1 hit PF12799, LRR_4, 1 hit PF13855, LRR_8, 2 hits PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF48403, SSF48403, 1 hit SSF50978, SSF50978, 1 hit SSF52540, SSF52540, 1 hit SSF56112, SSF56112, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 11 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51424, ROC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LRRK2_MOUSE | |
Accessioni | Q5S006Primary (citable) accession number: Q5S006 Secondary accession number(s): E9QNJ2 Q8K062 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families