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Protein

Keratinocyte-associated protein 2

Gene

Krtcap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Biological processi

Enzyme and pathway databases

UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte-associated protein 2
Short name:
KCP-2
Gene namesi
Name:Krtcap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913309 Krtcap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5LumenalSequence analysis5
Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Topological domaini24 – 34CytoplasmicSequence analysisAdd BLAST11
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 75LumenalSequence analysisAdd BLAST20
Transmembranei76 – 108HelicalSequence analysisAdd BLAST33
Topological domaini109 – 136CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269931 – 136Keratinocyte-associated protein 2Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5RL79
MaxQBiQ5RL79
PaxDbiQ5RL79
PeptideAtlasiQ5RL79
PRIDEiQ5RL79

PTM databases

iPTMnetiQ5RL79
PhosphoSitePlusiQ5RL79

Expressioni

Gene expression databases

BgeeiENSMUSG00000042747
CleanExiMM_KRTCAP2
ExpressionAtlasiQ5RL79 baseline and differential
GenevisibleiQ5RL79 MM

Interactioni

Subunit structurei

Accessory component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130372

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 136Prevents secretion from ERBy similarity4

Sequence similaritiesi

Belongs to the KRTCAP2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4615 Eukaryota
ENOG4111ZNW LUCA
GeneTreeiENSGT00390000003552
HOGENOMiHOG000006286
InParanoidiQ5RL79
OMAiLTCVSNA
OrthoDBiEOG091G0RKT
PhylomeDBiQ5RL79
TreeFamiTF324347

Family and domain databases

InterProiView protein in InterPro
IPR018614 KRTCAP2
PANTHERiPTHR32001 PTHR32001, 1 hit
PfamiView protein in Pfam
PF09775 Keratin_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RL79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGTGTSLA LSSLLSLLLF AGMQIYSRQL ASTEWLTIQG GLLGSGLFVF
60 70 80 90 100
SLTAFNNLEN LVFGKGFQAK IFPEILLCLL LALFASGLIH RVCVTTCFIF
110 120 130
SMVGLYYINK ISSTLYQATA PVLTPAKITG KGKKRN
Length:136
Mass (Da):14,675
Last modified:April 14, 2009 - v2
Checksum:i7DC7FC2CBECB22EE
GO

Sequence cautioni

The sequence AAH43030 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002479 mRNA Translation: BAB22132.1
AK003310 mRNA Translation: BAB22707.1
BC031492 mRNA Translation: AAH31492.1
BC043030 mRNA Translation: AAH43030.1 Different initiation.
CCDSiCCDS50960.1
RefSeqiNP_079603.1, NM_025327.3
UniGeneiMm.177991

Genome annotation databases

EnsembliENSMUST00000040888; ENSMUSP00000043540; ENSMUSG00000042747
GeneIDi66059
KEGGimmu:66059
UCSCiuc008pyl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKTAP2_MOUSE
AccessioniPrimary (citable) accession number: Q5RL79
Secondary accession number(s): Q9CQK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: April 14, 2009
Last modified: September 27, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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