UniProtKB - Q5RL73 (RBM48_HUMAN)
Protein
RNA-binding protein 48
Gene
RBM48
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q5RL73 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein 48 |
Gene namesi | Name:RBM48 Synonyms:C7orf64 ORF Names:HSPC304 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21785, RBM48 |
neXtProti | NX_Q5RL73 |
VEuPathDBi | HostDB:ENSG00000127993.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84060 |
OpenTargetsi | ENSG00000127993 |
PharmGKBi | PA164717383 |
Miscellaneous databases
Pharosi | Q5RL73, Tdark |
Genetic variation databases
BioMutai | RBM48 |
DMDMi | 74736145 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321514 | 1 – 367 | RNA-binding protein 48Add BLAST | 367 |
Proteomic databases
EPDi | Q5RL73 |
MassIVEi | Q5RL73 |
MaxQBi | Q5RL73 |
PaxDbi | Q5RL73 |
PeptideAtlasi | Q5RL73 |
PRIDEi | Q5RL73 |
ProteomicsDBi | 63754 [Q5RL73-1] |
PTM databases
iPTMneti | Q5RL73 |
PhosphoSitePlusi | Q5RL73 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127993, Expressed in medial globus pallidus and 218 other tissues |
ExpressionAtlasi | Q5RL73, baseline and differential |
Genevisiblei | Q5RL73, HS |
Organism-specific databases
HPAi | ENSG00000127993, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ5RL73
Protein-protein interaction databases
BioGRIDi | 123855, 72 interactors |
IntActi | Q5RL73, 72 interactors |
MINTi | Q5RL73 |
STRINGi | 9606.ENSP00000265732 |
Miscellaneous databases
RNActi | Q5RL73, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 124 | RRMAdd BLAST | 79 |
Sequence similaritiesi
Belongs to the RBM48 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QSNB, Eukaryota |
GeneTreei | ENSGT00390000004541 |
HOGENOMi | CLU_065720_0_0_1 |
InParanoidi | Q5RL73 |
OMAi | KATNQRD |
OrthoDBi | 1117000at2759 |
PhylomeDBi | Q5RL73 |
TreeFami | TF328457 |
Family and domain databases
CDDi | cd12442, RRM_RBM48, 1 hit |
InterProi | View protein in InterPro IPR035979, RBD_domain_sf IPR039599, RBM48 IPR034264, RBM48_RRM |
PANTHERi | PTHR20957, PTHR20957, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5RL73-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSGGELGS LFDHHVQRAV CDTRAKYREG RRPRAVKVYT INLESQYLLI
60 70 80 90 100
QGVPAVGVMK ELVERFALYG AIEQYNALDE YPAEDFTEVY LIKFMNLQSA
110 120 130 140 150
RTAKRKMDEQ SFFGGLLHVC YAPEFETVEE TRKKLQMRKA YVVKTTENKD
160 170 180 190 200
HYVTKKKLVT EHKDTEDFRQ DFHSEMSGFC KAALNTSAGN SNPYLPYSCE
210 220 230 240 250
LPLCYFSSKC MCSSGGPVDR APDSSKDGRN HHKTMGHYNH NDSLRKTQIN
260 270 280 290 300
SLKNSVACPG AQKAITSSEA VDRFMPRTTQ LQERKRRRED DRKLGTFLQT
310 320 330 340 350
NPTGNEIMIG PLLPDISKVD MHDDSLNTTA NLIRHKLKEV ISSVPKPPED
360
KPEDVHTSHP LKQRRRI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J787 | C9J787_HUMAN | RNA-binding protein 48 | RBM48 | 91 | Annotation score: |
Sequence cautioni
The sequence AAH33561 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB70806 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB66554 differs from that shown. Reason: Frameshift.Curated
The sequence CAI45942 differs from that shown. Reason: Erroneous translation. The protein sequence does not correspond to the translation of the nucleic acid sequence.Curated
The sequence EAL24148 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | L → P in CAB66554 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 229 | R → K in BAB70806 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 359 | H → R in BAB70806 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056683 | 341 – 367 | ISSVP…QRRRI → RLFLKNYSKTRFGYRIKWRI ICGNNSTVIFFHFLVF in isoform 2. 1 PublicationAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136619 mRNA Translation: CAB66554.1 Frameshift. CR933641 mRNA Translation: CAI45942.1 Sequence problems. AK054777 mRNA Translation: BAB70806.1 Different initiation. AK294812 mRNA Translation: BAH11891.1 AC005156 Genomic DNA No translation available. AC007566 Genomic DNA No translation available. CH471091 Genomic DNA Translation: EAW76839.1 CH236949 Genomic DNA Translation: EAL24148.1 Sequence problems. BC033561 mRNA Translation: AAH33561.1 Different initiation. BC044570 mRNA Translation: AAH44570.1 BC104865 mRNA Translation: AAI04866.1 BC104867 mRNA Translation: AAI04868.1 BC143576 mRNA Translation: AAI43577.1 |
CCDSi | CCDS43615.1 [Q5RL73-1] |
RefSeqi | NP_115496.2, NM_032120.3 [Q5RL73-1] XP_005250693.1, XM_005250636.4 [Q5RL73-2] |
Genome annotation databases
Ensembli | ENST00000265732; ENSP00000265732; ENSG00000127993 [Q5RL73-1] ENST00000481551; ENSP00000419242; ENSG00000127993 [Q5RL73-2] |
GeneIDi | 84060 |
KEGGi | hsa:84060 |
UCSCi | uc003ulz.4, human [Q5RL73-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136619 mRNA Translation: CAB66554.1 Frameshift. CR933641 mRNA Translation: CAI45942.1 Sequence problems. AK054777 mRNA Translation: BAB70806.1 Different initiation. AK294812 mRNA Translation: BAH11891.1 AC005156 Genomic DNA No translation available. AC007566 Genomic DNA No translation available. CH471091 Genomic DNA Translation: EAW76839.1 CH236949 Genomic DNA Translation: EAL24148.1 Sequence problems. BC033561 mRNA Translation: AAH33561.1 Different initiation. BC044570 mRNA Translation: AAH44570.1 BC104865 mRNA Translation: AAI04866.1 BC104867 mRNA Translation: AAI04868.1 BC143576 mRNA Translation: AAI43577.1 |
CCDSi | CCDS43615.1 [Q5RL73-1] |
RefSeqi | NP_115496.2, NM_032120.3 [Q5RL73-1] XP_005250693.1, XM_005250636.4 [Q5RL73-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123855, 72 interactors |
IntActi | Q5RL73, 72 interactors |
MINTi | Q5RL73 |
STRINGi | 9606.ENSP00000265732 |
PTM databases
iPTMneti | Q5RL73 |
PhosphoSitePlusi | Q5RL73 |
Genetic variation databases
BioMutai | RBM48 |
DMDMi | 74736145 |
Proteomic databases
EPDi | Q5RL73 |
MassIVEi | Q5RL73 |
MaxQBi | Q5RL73 |
PaxDbi | Q5RL73 |
PeptideAtlasi | Q5RL73 |
PRIDEi | Q5RL73 |
ProteomicsDBi | 63754 [Q5RL73-1] |
Protocols and materials databases
Antibodypediai | 8703, 127 antibodies |
Genome annotation databases
Ensembli | ENST00000265732; ENSP00000265732; ENSG00000127993 [Q5RL73-1] ENST00000481551; ENSP00000419242; ENSG00000127993 [Q5RL73-2] |
GeneIDi | 84060 |
KEGGi | hsa:84060 |
UCSCi | uc003ulz.4, human [Q5RL73-1] |
Organism-specific databases
CTDi | 84060 |
DisGeNETi | 84060 |
GeneCardsi | RBM48 |
HGNCi | HGNC:21785, RBM48 |
HPAi | ENSG00000127993, Low tissue specificity |
neXtProti | NX_Q5RL73 |
OpenTargetsi | ENSG00000127993 |
PharmGKBi | PA164717383 |
VEuPathDBi | HostDB:ENSG00000127993.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSNB, Eukaryota |
GeneTreei | ENSGT00390000004541 |
HOGENOMi | CLU_065720_0_0_1 |
InParanoidi | Q5RL73 |
OMAi | KATNQRD |
OrthoDBi | 1117000at2759 |
PhylomeDBi | Q5RL73 |
TreeFami | TF328457 |
Enzyme and pathway databases
PathwayCommonsi | Q5RL73 |
Miscellaneous databases
BioGRID-ORCSi | 84060, 487 hits in 1006 CRISPR screens |
ChiTaRSi | RBM48, human |
GenomeRNAii | 84060 |
Pharosi | Q5RL73, Tdark |
PROi | PR:Q5RL73 |
RNActi | Q5RL73, protein |
Gene expression databases
Bgeei | ENSG00000127993, Expressed in medial globus pallidus and 218 other tissues |
ExpressionAtlasi | Q5RL73, baseline and differential |
Genevisiblei | Q5RL73, HS |
Family and domain databases
CDDi | cd12442, RRM_RBM48, 1 hit |
InterProi | View protein in InterPro IPR035979, RBD_domain_sf IPR039599, RBM48 IPR034264, RBM48_RRM |
PANTHERi | PTHR20957, PTHR20957, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM48_HUMAN | |
Accessioni | Q5RL73Primary (citable) accession number: Q5RL73 Secondary accession number(s): B7Z2K5 Q9H0V7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families