UniProtKB - Q5RKV6 (EXOS6_HUMAN)
Exosome complex component MTR3
EXOSC6
Functioni
Caution
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- DNA deamination Source: UniProtKB
- exonucleolytic catabolism of deadenylated mRNA Source: Reactome
- isotype switching Source: UniProtKB
- nuclear mRNA surveillance Source: GO_Central
- nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' Source: GO_Central
- polyadenylation-dependent snoRNA 3'-end processing Source: GO_Central
- positive regulation of isotype switching Source: Ensembl
- regulation of mRNA stability Source: Reactome
- RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
- rRNA catabolic process Source: GO_Central
- rRNA processing Source: Reactome
- U4 snRNA 3'-end processing Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Biological process | rRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q5RKV6 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SIGNORi | Q5RKV6 |
Names & Taxonomyi
Protein namesi | Recommended name: Exosome complex component MTR3Alternative name(s): Exosome component 6 mRNA transport regulator 3 homolog Short name: hMtr3 p11 |
Gene namesi | Name:EXOSC6 Synonyms:MTR3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19055, EXOSC6 |
MIMi | 606490, gene |
neXtProti | NX_Q5RKV6 |
VEuPathDBi | HostDB:ENSG00000223496.2 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear exosome (RNase complex) Source: GO_Central
- nucleolus Source: GO_Central
- nucleoplasm Source: Reactome
Other locations
- cytoplasmic exosome (RNase complex) Source: GO_Central
- exosome (RNase complex) Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Exosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 118460 |
OpenTargetsi | ENSG00000223496 |
PharmGKBi | PA134932096 |
Miscellaneous databases
Pharosi | Q5RKV6, Tbio |
Genetic variation databases
BioMutai | EXOSC6 |
DMDMi | 74736141 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287478 | 1 – 272 | Exosome complex component MTR3Add BLAST | 272 |
Proteomic databases
EPDi | Q5RKV6 |
jPOSTi | Q5RKV6 |
MassIVEi | Q5RKV6 |
MaxQBi | Q5RKV6 |
PaxDbi | Q5RKV6 |
PeptideAtlasi | Q5RKV6 |
PRIDEi | Q5RKV6 |
ProteomicsDBi | 63753 |
TopDownProteomicsi | Q5RKV6 |
PTM databases
iPTMneti | Q5RKV6 |
PhosphoSitePlusi | Q5RKV6 |
SwissPalmi | Q5RKV6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000223496, Expressed in buccal mucosa cell and 221 other tissues |
Genevisiblei | Q5RKV6, HS |
Organism-specific databases
HPAi | ENSG00000223496, Low tissue specificity |
Interactioni
Subunit structurei
Component of the RNA exosome complex (PubMed:29906447). Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 125608, 82 interactors |
ComplexPortali | CPX-476, Nuclear exosome complex, DIS3-EXOSC10 variant CPX-591, Nucleolar exosome complex, EXOSC10 variant CPX-592, Cytoplasmic exosome complex, DIS3L variant CPX-593, Exosome complex, DIS3 variant CPX-600, Cytoplasmic exosome complex, DIS3L-EXOSC10 variant |
CORUMi | Q5RKV6 |
DIPi | DIP-61038N |
IntActi | Q5RKV6, 27 interactors |
MINTi | Q5RKV6 |
STRINGi | 9606.ENSP00000398597 |
Miscellaneous databases
RNActi | Q5RKV6, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q5RKV6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5RKV6 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1068, Eukaryota |
GeneTreei | ENSGT00940000153348 |
HOGENOMi | CLU_063514_1_3_1 |
InParanoidi | Q5RKV6 |
OMAi | RCGLVSQ |
OrthoDBi | 1101132at2759 |
PhylomeDBi | Q5RKV6 |
TreeFami | TF323886 |
Family and domain databases
Gene3Di | 3.30.230.70, 1 hit |
InterProi | View protein in InterPro IPR001247, ExoRNase_PH_dom1 IPR036345, ExoRNase_PH_dom2_sf IPR027408, PNPase/RNase_PH_dom_sf IPR020568, Ribosomal_S5_D2-typ_fold |
Pfami | View protein in Pfam PF01138, RNase_PH, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55666, SSF55666, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPGDHRRIRG PEESQPPQLY AADEEEAPGT RDPTRLRPVY ARAGLLSQAK
60 70 80 90 100
GSAYLEAGGT KVLCAVSGPR QAEGGERGGG PAGAGGEAPA ALRGRLLCDF
110 120 130 140 150
RRAPFAGRRR RAPPGGCEER ELALALQEAL EPAVRLGRYP RAQLEVSALL
160 170 180 190 200
LEDGGSALAA ALTAAALALA DAGVEMYDLV VGCGLSLAPG PAPTWLLDPT
210 220 230 240 250
RLEEERAAAG LTVALMPVLN QVAGLLGSGE GGLTESWAEA VRLGLEGCQR
260 270
LYPVLQQSLV RAARRRGAAA QP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009060 Genomic DNA No translation available. BC052252 mRNA Translation: AAH52252.1 |
CCDSi | CCDS10887.1 |
RefSeqi | NP_478126.1, NM_058219.2 |
Genome annotation databases
Ensembli | ENST00000435634; ENSP00000398597; ENSG00000223496 |
GeneIDi | 118460 |
KEGGi | hsa:118460 |
UCSCi | uc002eym.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009060 Genomic DNA No translation available. BC052252 mRNA Translation: AAH52252.1 |
CCDSi | CCDS10887.1 |
RefSeqi | NP_478126.1, NM_058219.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2NN6 | X-ray | 3.35 | F | 1-272 | [»] | |
6D6Q | electron microscopy | 3.45 | F | 1-272 | [»] | |
6D6R | electron microscopy | 3.45 | F | 1-272 | [»] | |
6H25 | electron microscopy | 3.80 | F | 1-272 | [»] | |
SMRi | Q5RKV6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125608, 82 interactors |
ComplexPortali | CPX-476, Nuclear exosome complex, DIS3-EXOSC10 variant CPX-591, Nucleolar exosome complex, EXOSC10 variant CPX-592, Cytoplasmic exosome complex, DIS3L variant CPX-593, Exosome complex, DIS3 variant CPX-600, Cytoplasmic exosome complex, DIS3L-EXOSC10 variant |
CORUMi | Q5RKV6 |
DIPi | DIP-61038N |
IntActi | Q5RKV6, 27 interactors |
MINTi | Q5RKV6 |
STRINGi | 9606.ENSP00000398597 |
PTM databases
iPTMneti | Q5RKV6 |
PhosphoSitePlusi | Q5RKV6 |
SwissPalmi | Q5RKV6 |
Genetic variation databases
BioMutai | EXOSC6 |
DMDMi | 74736141 |
Proteomic databases
EPDi | Q5RKV6 |
jPOSTi | Q5RKV6 |
MassIVEi | Q5RKV6 |
MaxQBi | Q5RKV6 |
PaxDbi | Q5RKV6 |
PeptideAtlasi | Q5RKV6 |
PRIDEi | Q5RKV6 |
ProteomicsDBi | 63753 |
TopDownProteomicsi | Q5RKV6 |
Protocols and materials databases
Antibodypediai | 29956, 98 antibodies |
Genome annotation databases
Ensembli | ENST00000435634; ENSP00000398597; ENSG00000223496 |
GeneIDi | 118460 |
KEGGi | hsa:118460 |
UCSCi | uc002eym.2, human |
Organism-specific databases
CTDi | 118460 |
DisGeNETi | 118460 |
GeneCardsi | EXOSC6 |
HGNCi | HGNC:19055, EXOSC6 |
HPAi | ENSG00000223496, Low tissue specificity |
MIMi | 606490, gene |
neXtProti | NX_Q5RKV6 |
OpenTargetsi | ENSG00000223496 |
PharmGKBi | PA134932096 |
VEuPathDBi | HostDB:ENSG00000223496.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1068, Eukaryota |
GeneTreei | ENSGT00940000153348 |
HOGENOMi | CLU_063514_1_3_1 |
InParanoidi | Q5RKV6 |
OMAi | RCGLVSQ |
OrthoDBi | 1101132at2759 |
PhylomeDBi | Q5RKV6 |
TreeFami | TF323886 |
Enzyme and pathway databases
PathwayCommonsi | Q5RKV6 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SIGNORi | Q5RKV6 |
Miscellaneous databases
BioGRID-ORCSi | 118460, 755 hits in 1002 CRISPR screens |
ChiTaRSi | EXOSC6, human |
EvolutionaryTracei | Q5RKV6 |
GenomeRNAii | 118460 |
Pharosi | Q5RKV6, Tbio |
PROi | PR:Q5RKV6 |
RNActi | Q5RKV6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000223496, Expressed in buccal mucosa cell and 221 other tissues |
Genevisiblei | Q5RKV6, HS |
Family and domain databases
Gene3Di | 3.30.230.70, 1 hit |
InterProi | View protein in InterPro IPR001247, ExoRNase_PH_dom1 IPR036345, ExoRNase_PH_dom2_sf IPR027408, PNPase/RNase_PH_dom_sf IPR020568, Ribosomal_S5_D2-typ_fold |
Pfami | View protein in Pfam PF01138, RNase_PH, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55666, SSF55666, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EXOS6_HUMAN | |
Accessioni | Q5RKV6Primary (citable) accession number: Q5RKV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families