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UniProtKB - Q5RKN9 (Q5RKN9_MOUSE)
Protein
F-actin-capping protein subunit alpha
Gene
Capza1
Organism
Mus musculus (Mouse)
Status
Functioni
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- barbed-end actin filament capping Source: UniProtKB-UniRule
Keywordsi
Molecular function | Actin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit alphaUniRule annotation |
Gene namesi | Name:Capza1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106227, Capza1 |
VEuPathDBi | HostDB:ENSMUSG00000070372 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Structurei
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183119 |
Family and domain databases
Gene3Di | 3.30.1140.60, 1 hit 3.90.1150.210, 1 hit |
InterProi | View protein in InterPro IPR002189, CapZ_alpha IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR042489, CapZ_alpha_1 IPR017865, F-actin_cap_asu_CS |
PANTHERi | PTHR10653, PTHR10653, 1 hit |
Pfami | View protein in Pfam PF01267, F-actin_cap_A, 1 hit |
PRINTSi | PR00191, FACTINCAPA |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00748, F_ACTIN_CAPPING_A_1, 1 hit PS00749, F_ACTIN_CAPPING_A_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5RKN9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADFEDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA
60 70 80 90 100
AHAFAQYNMD QFTPVKIEGY DDQVLITEHG DLGNSRFLDP RNQISFKFDH
110 120 130 140 150
LRKEASDPQP EDVDGGLKSW RESCDSALRA YVKDHYSNGF CTVYAKTIDG
160 170 180 190 200
QQTIIACIES HQFQPKNFWN GRWRSEWKFT ITPPSAQVVG VLKIQVHYYE
210 220 230 240 250
DGNVQLVSHK DVQDSVTVSN EIQTTKEFIK IIESAENEYQ TAISENYQTM
260 270 280
SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP47753 | CAZA1_MOUSE | F-actin-capping protein subunit alp... | Capza1 Cappa1 | 286 | Annotation score: | ||
A0A0G2JE27 | A0A0G2JE27_MOUSE | F-actin-capping protein subunit alp... | Capza1 | 112 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC085506 mRNA Translation: AAH85506.1 AK147049 mRNA Translation: BAE27635.1 AK149602 mRNA Translation: BAE28985.1 AK152364 mRNA Translation: BAE31154.1 AK163418 mRNA Translation: BAE37341.1 AK166964 mRNA Translation: BAE39147.1 AK167193 mRNA Translation: BAE39323.1 AK168916 mRNA Translation: BAE40729.1 AK169806 mRNA Translation: BAE41380.1 |
RefSeqi | NP_033927.2, NM_009797.2 |
Genome annotation databases
Ensembli | ENSMUST00000094028; ENSMUSP00000102381; ENSMUSG00000070372 |
GeneIDi | 12340 |
UCSCi | uc008quq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC085506 mRNA Translation: AAH85506.1 AK147049 mRNA Translation: BAE27635.1 AK149602 mRNA Translation: BAE28985.1 AK152364 mRNA Translation: BAE31154.1 AK163418 mRNA Translation: BAE37341.1 AK166964 mRNA Translation: BAE39147.1 AK167193 mRNA Translation: BAE39323.1 AK168916 mRNA Translation: BAE40729.1 AK169806 mRNA Translation: BAE41380.1 |
RefSeqi | NP_033927.2, NM_009797.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 344668 |
Genome annotation databases
Ensembli | ENSMUST00000094028; ENSMUSP00000102381; ENSMUSG00000070372 |
GeneIDi | 12340 |
UCSCi | uc008quq.2, mouse |
Organism-specific databases
CTDi | 829 |
MGIi | MGI:106227, Capza1 |
VEuPathDBi | HostDB:ENSMUSG00000070372 |
Phylogenomic databases
GeneTreei | ENSGT00950000183119 |
Miscellaneous databases
BioGRID-ORCSi | 12340, 2 hits in 63 CRISPR screens |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.30.1140.60, 1 hit 3.90.1150.210, 1 hit |
InterProi | View protein in InterPro IPR002189, CapZ_alpha IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR042489, CapZ_alpha_1 IPR017865, F-actin_cap_asu_CS |
PANTHERi | PTHR10653, PTHR10653, 1 hit |
Pfami | View protein in Pfam PF01267, F-actin_cap_A, 1 hit |
PRINTSi | PR00191, FACTINCAPA |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00748, F_ACTIN_CAPPING_A_1, 1 hit PS00749, F_ACTIN_CAPPING_A_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5RKN9_MOUSE | |
Accessioni | Q5RKN9Primary (citable) accession number: Q5RKN9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | January 19, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |