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Protein

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

Abcb8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi489 – 496ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1369007 Mitochondrial ABC transporters

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 8, mitochondrial
Gene namesi
Name:Abcb8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1307655 Abcb8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei127 – 147HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei178 – 198HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei278 – 298HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei365 – 385HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionBy similarityAdd BLAST38
ChainiPRO_000035623539 – 714ATP-binding cassette sub-family B member 8, mitochondrialAdd BLAST676

Proteomic databases

PaxDbiQ5RKI8
PRIDEiQ5RKI8

PTM databases

iPTMnetiQ5RKI8
PhosphoSitePlusiQ5RKI8

Expressioni

Tissue specificityi

Strong expression is found in the heart, brain and testis. In the testis, expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes). Also expressed in the lung, liver, intestine and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000008557
ExpressionAtlasiQ5RKI8 baseline and differential
GenevisibleiQ5RKI8 RN

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

CORUMiQ5RKI8
STRINGi10116.ENSRNOP00000012222

Structurei

3D structure databases

ProteinModelPortaliQ5RKI8
SMRiQ5RKI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 419ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST290
Domaini454 – 691ABC transporterPROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
HOVERGENiHBG008358
InParanoidiQ5RKI8
KOiK05655
OMAiAWGTYLV
PhylomeDBiQ5RKI8
TreeFamiTF105196

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RKI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVHLFRVGI RGGPVPRWSL QSLRFQTFSA ARSSDDQFSS CLLRAVAQLR
60 70 80 90 100
SQLRAHLPRS PPASHRSTSA WCWVGGTLVV PAVLWQHPRF CLIALCEAKG
110 120 130 140 150
SPPAQPTRAR ELRFKWKLFW HFLHPHLLAL GLAIVLALGA ALVNVQIPLL
160 170 180 190 200
LGQLVEIVAK YTREHVGSFV SESRRLSIQL LLLYGVQGLL TFGYLVLLSH
210 220 230 240 250
MGERMAMDMR KALFSSLLRQ DIAFFDAKKT GQLVSRLTTD VQEFKSSFKL
260 270 280 290 300
VISQGLRSST QVIGSLMTLS ILSPRLTLML AVVTPALMGV GTLMGSGLRK
310 320 330 340 350
LSRQCQEQIA RATGVADEAL GSVRTVRAFA MEKREEERYQ AELESCCCKA
360 370 380 390 400
EELGRGIALF QGLSNIAFNC MVLGTLFIGG SLVAGQQLKG GDLMSFLVAS
410 420 430 440 450
QTVQRSMASL SVLFGQVVRG LSAGARVFEY MSLSPVIPLT GGYSIPSKDL
460 470 480 490 500
RGSITFQNVS FSYPCRPGFN VLKNFTLKLP PGKIVALVGQ SGGGKTTVAS
510 520 530 540 550
LLERFYDPTA GVVTLDGHDL RTLDPSWLRG QVIGFISQEP VLFATTIMEN
560 570 580 590 600
IRFGKLDASD EEVYTAARKA NAHEFISSFP DGYSTVVGER GTTLSGGQKQ
610 620 630 640 650
RLAIARALIK RPTVLILDEA TSALDAESER IVQEALDRAS AGRTVLVIAH
660 670 680 690 700
RLSTVRAAHS IIVMANGQVC EAGTHEELLQ KGGLYAELIR RQALDASLPS
710
APPAEKPEDH RSCQ
Length:714
Mass (Da):77,770
Last modified:December 21, 2004 - v1
Checksum:iA77B4362C41C9C5C
GO

Sequence cautioni

The sequence ABB71108 differs from that shown. Reason: Frameshift at positions 397, 399 and 406.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti540P → T in ABB71108 (PubMed:16390497).Curated1
Sequence conflicti578S → C in ABB71108 (PubMed:16390497).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ233644 mRNA Translation: ABB71108.1 Frameshift.
CH474020 Genomic DNA Translation: EDL99373.1
BC085781 mRNA Translation: AAH85781.1
RefSeqiNP_001007797.1, NM_001007796.1
UniGeneiRn.79339

Genome annotation databases

EnsembliENSRNOT00000089817; ENSRNOP00000071952; ENSRNOG00000008557
GeneIDi362302
KEGGirno:362302

Similar proteinsi

Entry informationi

Entry nameiABCB8_RAT
AccessioniPrimary (citable) accession number: Q5RKI8
Secondary accession number(s): Q0QVT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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