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Protein

WD repeat-containing protein 1

Gene

Wdr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Gene namesi
Name:Wdr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1305789 Wdr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713651 – 606WD repeat-containing protein 1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei238PhosphotyrosineBy similarity1
Modified residuei480N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RKI0
PRIDEiQ5RKI0

2D gel databases

World-2DPAGEi0004:Q5RKI0

PTM databases

iPTMnetiQ5RKI0
PhosphoSitePlusiQ5RKI0
SwissPalmiQ5RKI0

Expressioni

Gene expression databases

BgeeiENSRNOG00000028498 Expressed in 9 organ(s), highest expression level in colon
GenevisibleiQ5RKI0 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi262322, 3 interactors
STRINGi10116.ENSRNOP00000024012

Structurei

3D structure databases

ProteinModelPortaliQ5RKI0
SMRiQ5RKI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 45WD 1Add BLAST42
Repeati48 – 87WD 2Add BLAST40
Repeati93 – 135WD 3Add BLAST43
Repeati138 – 176WD 4Add BLAST39
Repeati180 – 218WD 5Add BLAST39
Repeati224 – 263WD 6Add BLAST40
Repeati270 – 306WD 7Add BLAST37
Repeati311 – 351WD 8Add BLAST41
Repeati358 – 408WD 9Add BLAST51
Repeati432 – 474WD 10Add BLAST43
Repeati480 – 518WD 11Add BLAST39
Repeati523 – 561WD 12Add BLAST39
Repeati566 – 604WD 13Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318 Eukaryota
ENOG410XQN1 LUCA
GeneTreeiENSGT00390000009416
HOGENOMiHOG000162559
HOVERGENiHBG000780
InParanoidiQ5RKI0
OMAiDGHINYW
OrthoDBiEOG091G03SZ
PhylomeDBiQ5RKI0
TreeFamiTF300821

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50974 SSF50974, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RKI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KILGGDPKGD NFLYTNGKCV ILRNIDNPAV
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHILKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDTGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQNRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIFIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVNVNSVVS TFPMGSNVLD QQLGCLWQKD HLLSISLSGY
310 320 330 340 350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFS GKGHTNQVSR MTVDESGQLV SCSMDDTVRY TNLTLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY TVVVCIGQIV LLKDQKKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AVGGSDGNVR VYSILGATLK DEGKLLEAKG PVTDLAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETKVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,181
Last modified:January 23, 2007 - v3
Checksum:i9A3A08A7235EE993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY986483 mRNA Translation: AAX94056.1
BC085864 mRNA Translation: AAH85864.1
RefSeqiNP_001014157.1, NM_001014135.1
UniGeneiRn.3168

Genome annotation databases

EnsembliENSRNOT00000024012; ENSRNOP00000024012; ENSRNOG00000028498
GeneIDi360950
KEGGirno:360950

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY986483 mRNA Translation: AAX94056.1
BC085864 mRNA Translation: AAH85864.1
RefSeqiNP_001014157.1, NM_001014135.1
UniGeneiRn.3168

3D structure databases

ProteinModelPortaliQ5RKI0
SMRiQ5RKI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262322, 3 interactors
STRINGi10116.ENSRNOP00000024012

PTM databases

iPTMnetiQ5RKI0
PhosphoSitePlusiQ5RKI0
SwissPalmiQ5RKI0

2D gel databases

World-2DPAGEi0004:Q5RKI0

Proteomic databases

PaxDbiQ5RKI0
PRIDEiQ5RKI0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024012; ENSRNOP00000024012; ENSRNOG00000028498
GeneIDi360950
KEGGirno:360950

Organism-specific databases

CTDi9948
RGDi1305789 Wdr1

Phylogenomic databases

eggNOGiKOG0318 Eukaryota
ENOG410XQN1 LUCA
GeneTreeiENSGT00390000009416
HOGENOMiHOG000162559
HOVERGENiHBG000780
InParanoidiQ5RKI0
OMAiDGHINYW
OrthoDBiEOG091G03SZ
PhylomeDBiQ5RKI0
TreeFamiTF300821

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation

Miscellaneous databases

PROiPR:Q5RKI0

Gene expression databases

BgeeiENSRNOG00000028498 Expressed in 9 organ(s), highest expression level in colon
GenevisibleiQ5RKI0 RN

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50974 SSF50974, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR1_RAT
AccessioniPrimary (citable) accession number: Q5RKI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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