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Protein

Ribosome maturation protein SBDS

Gene

Sbds

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome maturation protein SBDS
Alternative name(s):
Shwachman-Bodian-Diamond syndrome protein homolog
Gene namesi
Name:Sbds
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1311043 Sbds

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003047332 – 250Ribosome maturation protein SBDSAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei238PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RK30
PRIDEiQ5RK30

PTM databases

iPTMnetiQ5RK30
PhosphoSitePlusiQ5RK30

Expressioni

Gene expression databases

BgeeiENSRNOG00000000888
GenevisibleiQ5RK30 RN

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7. Found in a complex consisting of 60S ribosomal subunit, SBDS and EFL1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001190

Structurei

3D structure databases

ProteinModelPortaliQ5RK30
SMRiQ5RK30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDO1/SBDS family.Curated

Phylogenomic databases

eggNOGiKOG2917 Eukaryota
COG1500 LUCA
GeneTreeiENSGT00390000008135
HOGENOMiHOG000216685
HOVERGENiHBG039762
InParanoidiQ5RK30
KOiK14574
OMAiAVNPQMD
OrthoDBiEOG091G0GOU
PhylomeDBiQ5RK30
TreeFamiTF300881

Family and domain databases

Gene3Di1.10.10.900, 1 hit
3.30.1250.10, 1 hit
InterProiView protein in InterPro
IPR018978 Ribosome_mat_SBDS_C
IPR018023 Ribosome_mat_SBDS_CS
IPR019783 Ribosome_mat_SBDS_N
IPR036786 Ribosome_mat_SBDS_N_sf
IPR002140 Sdo1/SBDS
IPR039100 Sdo1/SBDS-like
IPR037188 Sdo1/SBDS_central_sf
PANTHERiPTHR10927 PTHR10927, 1 hit
PTHR10927:SF1 PTHR10927:SF1, 1 hit
PfamiView protein in Pfam
PF01172 SBDS, 1 hit
PF09377 SBDS_C, 1 hit
SUPFAMiSSF109728 SSF109728, 1 hit
SSF89895 SSF89895, 1 hit
TIGRFAMsiTIGR00291 RNA_SBDS, 1 hit
PROSITEiView protein in PROSITE
PS01267 UPF0023, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RK30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFTPTNQI RLTNVAVVRM KRGGKRFEIA CYKNKVVGWR SGVEKDLDEV
60 70 80 90 100
LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER
110 120 130 140 150
HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKPNKST
160 170 180 190 200
KQQALEVIKQ LKEKMKIERA HMRLRFLLPV NEGKKLKEKL KPLMKVVESE
210 220 230 240 250
DYSQQLEIVC LIDPGCFREI DELIKKETKG KGSLEVLSLK DVEEGDEKFE
Length:250
Mass (Da):28,752
Last modified:December 21, 2004 - v1
Checksum:i31339F6BB478740A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086335 mRNA Translation: AAH86335.1
RefSeqiNP_001008290.1, NM_001008289.1
UniGeneiRn.107123

Genome annotation databases

EnsembliENSRNOT00000001190; ENSRNOP00000001190; ENSRNOG00000000888
GeneIDi288615
KEGGirno:288615

Similar proteinsi

Entry informationi

Entry nameiSBDS_RAT
AccessioniPrimary (citable) accession number: Q5RK30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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