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Protein

pre-rRNA processing protein FTSJ3

Gene

Ftsj3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylnucleoside.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei58S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei76S-adenosyl-L-methionineUniRule annotation1
Binding sitei92S-adenosyl-L-methionineUniRule annotation1
Binding sitei117S-adenosyl-L-methionineUniRule annotation1
Active sitei157Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRibosome biogenesis, rRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
pre-rRNA processing protein FTSJ3UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
2'-O-ribose RNA methyltransferase SPB1 homologUniRule annotation
Protein ftsJ homolog 3UniRule annotation
Putative rRNA methyltransferase 3UniRule annotation
Gene namesi
Name:Ftsj3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1307110 Ftsj3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001555801 – 829pre-rRNA processing protein FTSJ3Add BLAST829

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333PhosphoserineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei389CitrullineBy similarity1
Modified residuei531PhosphoserineCombined sources1
Modified residuei544PhosphoserineBy similarity1
Cross-linki570Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei575PhosphoserineBy similarity1
Cross-linki626Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki642Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei659PhosphoserineBy similarity1
Cross-linki661Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei671PhosphoserineBy similarity1
Cross-linki693Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei766CitrullineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5RJT2
PRIDEiQ5RJT2

PTM databases

iPTMnetiQ5RJT2
PhosphoSitePlusiQ5RJT2

Expressioni

Gene expression databases

BgeeiENSRNOG00000009857
GenevisibleiQ5RJT2 RN

Interactioni

Subunit structurei

Interacts with NIP7.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013295

Structurei

3D structure databases

ProteinModelPortaliQ5RJT2
SMRiQ5RJT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili722 – 760UniRule annotationAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi337 – 379Glu-richAdd BLAST43

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1098 Eukaryota
COG0293 LUCA
GeneTreeiENSGT00550000075004
HOGENOMiHOG000176256
HOVERGENiHBG075246
InParanoidiQ5RJT2
KOiK14857
OMAiWFVQEEK
OrthoDBiEOG091G03NZ
PhylomeDBiQ5RJT2
TreeFamiTF106102

Family and domain databases

HAMAPiMF_01547 RNA_methyltr_E, 1 hit
MF_03163 RNA_methyltr_E_SPB1, 1 hit
InterProiView protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR012920 rRNA_MeTfrase_Spb1_C
IPR024576 rRNA_MeTfrase_Spb1_DUF3381
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
IPR028589 Spb1
PfamiView protein in Pfam
PF11861 DUF3381, 1 hit
PF01728 FtsJ, 1 hit
PF07780 Spb1_C, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RJT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKGKVGKS RRDKFYHLAK ETGYRSRSAF KLIQLNRRFQ FLQKARALLD
60 70 80 90 100
LCAAPGGWLQ VAAKFMPVSS LIVGVDLVPI KPLPNVVTLQ EDITTERCRQ
110 120 130 140 150
ALRKELKTWK VDVVLNDGAP NVGASWVHDA YSQAHLTLMA LRLACDFLAR
160 170 180 190 200
GGCFITKVFR SRDYQPLLWI FQQLFHRVQA TKPQASRHES AEIFVVCQGF
210 220 230 240 250
LAPDKVDAKF FDPKFAFKEV EVQAKTVTEL VTKKKPKAEG YAEGDLTLYH
260 270 280 290 300
RTSVTDFLRA ANPVDFLSKA SEISIDDKEL AQHPATTEDI RACCQDIKVL
310 320 330 340 350
GRKELRSLLN WRTKLRRYVA KKLKEQAKAL DISLSSEEEG DEEESAAETK
360 370 380 390 400
QASEEEEERE EEEQLNRTLA EMKAQEVAEL KRKKKKLLRE QRKQRERVEL
410 420 430 440 450
KMDLPGVSIA DEGETGMFSL RTIRGQQLLE EVTQGDMNAA DTFLSDLPRD
460 470 480 490 500
DIYVSDAEDD DDTSLESDLD PEELAGVRTH SDQKEQKSLQ FAQVDDSKEE
510 520 530 540 550
EGENPLLVPL EEKAVLQEEQ ASLWFSKDGF SGIDDDADEA LEISQAQLLY
560 570 580 590 600
KSRQKEQQPT DPPPPPTNLK TEKKSSQCQN EVPKETEAIT DTGGEDRDSS
610 620 630 640 650
DSDSSSSEDE DDWKVSRGKK RSRGSKADED GFEVVPIEDP VKYRILDPEG
660 670 680 690 700
LALGAVIASS KKAKRDLIDN SFNRYAFNEE EEELPEWFVQ EEKQHRIRQL
710 720 730 740 750
PLDKKEVEHY RKRWREINAR PIKKVAEAKA RKKRRMLKKL EQTKKKAEAV
760 770 780 790 800
VNTVDISERE KVAQLRSLYK KAGLGKEKRQ VTYVVAKKGV GRKVRRPAGV
810 820
RGHFKVVDSR MKKDQRAQRK EQKRNHRRK
Length:829
Mass (Da):94,767
Last modified:December 21, 2004 - v1
Checksum:i00CF7A6D13B1B40F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086512 mRNA Translation: AAH86512.1
RefSeqiNP_001012014.1, NM_001012014.1
UniGeneiRn.47509

Genome annotation databases

EnsembliENSRNOT00000013295; ENSRNOP00000013295; ENSRNOG00000009857
GeneIDi303608
KEGGirno:303608
UCSCiRGD:1307110 rat

Similar proteinsi

Entry informationi

Entry nameiSPB1_RAT
AccessioniPrimary (citable) accession number: Q5RJT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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