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Protein

Succinate dehydrogenase assembly factor 2, mitochondrial

Gene

Sdhaf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase assembly factor 2, mitochondrialUniRule annotation
Short name:
SDH assembly factor 2UniRule annotation
Short name:
SDHAF2UniRule annotation
Gene namesi
Name:Sdhaf2UniRule annotation
Synonyms:Pgl2UniRule annotation, Sdh5UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309216 Sdhaf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000029436028 – 164Succinate dehydrogenase assembly factor 2, mitochondrialAdd BLAST137

Proteomic databases

PaxDbiQ5RJQ7
PRIDEiQ5RJQ7

PTM databases

PhosphoSitePlusiQ5RJQ7

Expressioni

Gene expression databases

BgeeiENSRNOG00000020646
GenevisibleiQ5RJQ7 RN

Interactioni

Subunit structurei

Interacts with SDHA within the SDH catalytic dimer.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028028

Structurei

3D structure databases

ProteinModelPortaliQ5RJQ7
SMRiQ5RJQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDHAF2 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3326 Eukaryota
COG2938 LUCA
GeneTreeiENSGT00390000001149
HOGENOMiHOG000230636
InParanoidiQ5RJQ7
KOiK18168
OMAiIYYWATD
OrthoDBiEOG091G0VSZ
PhylomeDBiQ5RJQ7
TreeFamiTF300175

Family and domain databases

Gene3Di1.10.150.250, 1 hit
HAMAPiMF_03057 SDHAF2, 1 hit
InterProiView protein in InterPro
IPR005631 SDH
IPR036714 SDH_sf
IPR028882 SDHAF2
PfamiView protein in Pfam
PF03937 Sdh5, 1 hit
SUPFAMiSSF109910 SSF109910, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RJQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVTLIPTL ARVLSKHSLL SPLLSVTSFR RFYRGDSPTD SQKDMIEIPL
60 70 80 90 100
PPWQERTDES IETKRARLLY ESRKRGMLEN CILLSLFAKE YLHNMTEKQL
110 120 130 140 150
NLYDRLINEP SNDWDIYYWA TEAKPAPEIF ENEVMELLRE FTKNKNKEQR
160
LRAPDLEYLF EKPR
Length:164
Mass (Da):19,524
Last modified:December 21, 2004 - v1
Checksum:i9CBE582352281AA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086542 mRNA Translation: AAH86542.1
RefSeqiNP_001008372.1, NM_001008371.1
UniGeneiRn.228653

Genome annotation databases

EnsembliENSRNOT00000028028; ENSRNOP00000028028; ENSRNOG00000020646
GeneIDi361726
KEGGirno:361726
UCSCiRGD:1309216 rat

Similar proteinsi

Entry informationi

Entry nameiSDHF2_RAT
AccessioniPrimary (citable) accession number: Q5RJQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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