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Protein

Acyl-CoA-binding domain-containing protein 6

Gene

Acbd6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95Acyl-CoABy similarity1
Binding sitei114Acyl-CoABy similarity1

GO - Molecular functioni

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 6
Gene namesi
Name:Acbd6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1305030 Acbd6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328811 – 282Acyl-CoA-binding domain-containing protein 6Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei106PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5RJK8
PRIDEiQ5RJK8

PTM databases

iPTMnetiQ5RJK8
PhosphoSitePlusiQ5RJK8

Expressioni

Gene expression databases

BgeeiENSRNOG00000003550 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ5RJK8 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004772

Structurei

3D structure databases

ProteinModelPortaliQ5RJK8
SMRiQ5RJK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 127ACBPROSITE-ProRule annotationAdd BLAST86
Repeati191 – 220ANK 1Add BLAST30
Repeati224 – 253ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 73Acyl-CoA bindingBy similarity5

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000241133
HOVERGENiHBG080775
InParanoidiQ5RJK8
OMAiQYRADIN
OrthoDBiEOG091G0NXJ
PhylomeDBiQ5RJK8
TreeFamiTF329102

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR00689 ACOABINDINGP
PR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF47027 SSF47027, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS51228 ACB_2, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q5RJK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPFLPAGA TTGDSGGELS SGDDSGDLES FQTPEAEATR SLAELFEKAA
60 70 80 90 100
AHVQGLVQVA SREQLLYLYA RYKQVKVGNC NIPKPNFFDF EGKQKWEAWK
110 120 130 140 150
ALGDSSPSQA MQEYIAAVKK LDPGWNPQVS EKKGKEGSSG FGGPVVSSLY
160 170 180 190 200
HEETIREEDK NIFDYCRENN IDHITKAIKS KTVDVNMTDE EGRALLHWAC
210 220 230 240 250
DRGHKELVKV LLQCEAGINC QDNEGQTALH YAAACEFSDI VELLLQSGAD
260 270 280
PTLRDQDGCL PEEVTGCKAV SLVLQLHRAG KA
Length:282
Mass (Da):30,810
Last modified:December 21, 2004 - v1
Checksum:i67486B4E629C02A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086598 mRNA Translation: AAH86598.1
RefSeqiNP_001011906.1, NM_001011906.1
UniGeneiRn.27349

Genome annotation databases

EnsembliENSRNOT00000004772; ENSRNOP00000004772; ENSRNOG00000003550
GeneIDi289125
KEGGirno:289125
UCSCiRGD:1305030 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086598 mRNA Translation: AAH86598.1
RefSeqiNP_001011906.1, NM_001011906.1
UniGeneiRn.27349

3D structure databases

ProteinModelPortaliQ5RJK8
SMRiQ5RJK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004772

PTM databases

iPTMnetiQ5RJK8
PhosphoSitePlusiQ5RJK8

Proteomic databases

PaxDbiQ5RJK8
PRIDEiQ5RJK8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004772; ENSRNOP00000004772; ENSRNOG00000003550
GeneIDi289125
KEGGirno:289125
UCSCiRGD:1305030 rat

Organism-specific databases

CTDi84320
RGDi1305030 Acbd6

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000241133
HOVERGENiHBG080775
InParanoidiQ5RJK8
OMAiQYRADIN
OrthoDBiEOG091G0NXJ
PhylomeDBiQ5RJK8
TreeFamiTF329102

Enzyme and pathway databases

ReactomeiR-RNO-77289 Mitochondrial Fatty Acid Beta-Oxidation

Miscellaneous databases

PROiPR:Q5RJK8

Gene expression databases

BgeeiENSRNOG00000003550 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ5RJK8 RN

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR00689 ACOABINDINGP
PR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF47027 SSF47027, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS51228 ACB_2, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiACBD6_RAT
AccessioniPrimary (citable) accession number: Q5RJK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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