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Protein

Protein SMG7

Gene

Smg7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SMG7
Alternative name(s):
EST1-like protein C
SMG-7 homolog
Gene namesi
Name:Smg7
Synonyms:Est1c, Kiaa0250
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2682334 Smg7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000763252 – 1138Protein SMG7Add BLAST1137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei519PhosphoserineBy similarity1
Modified residuei575PhosphothreonineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei848PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RJH6
PeptideAtlasiQ5RJH6
PRIDEiQ5RJH6

PTM databases

iPTMnetiQ5RJH6
PhosphoSitePlusiQ5RJH6

Miscellaneous databases

PMAP-CutDBiQ5RJH6

Expressioni

Gene expression databases

BgeeiENSMUSG00000042772 Expressed in 243 organ(s), highest expression level in skin of back
GenevisibleiQ5RJH6 MM

Interactioni

Subunit structurei

Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041241

Structurei

3D structure databases

ProteinModelPortaliQ5RJH6
SMRiQ5RJH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati152 – 185TPR 1Add BLAST34
Repeati187 – 219TPR 2Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi599 – 794Gln/Pro-richAdd BLAST196
Compositional biasi923 – 1016Ser-richAdd BLAST94

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410INQX Eukaryota
ENOG410XQ61 LUCA
GeneTreeiENSGT00560000077120
HOGENOMiHOG000049052
HOVERGENiHBG056330
InParanoidiQ5RJH6
KOiK14409
OMAiMVTFKEN
OrthoDBiEOG091G04DJ
PhylomeDBiQ5RJH6
TreeFamiTF327119

Family and domain databases

InterProiView protein in InterPro
IPR018834 DNA/RNA-bd_Est1-type
IPR019458 EST1
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF10374 EST1, 1 hit
PF10373 EST1_DNA_bind, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5RJH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLQSAQYLR QAEVLKAEMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY
60 70 80 90 100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG
110 120 130 140 150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHSSTIV KPQSSSCSYI
160 170 180 190 200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG
210 220 230 240 250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEL KTKWGVSDFI
260 270 280 290 300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI
310 320 330 340 350
NLFQLHHLRD FSNETEQHSY SQDEQLCWTQ LLALFMSFLG ILCKCPLQND
360 370 380 390 400
SQESNNAYPL PAVKVSMDWL RLRPRVFQEA VVDERQYIWP WLISLLNSFH
410 420 430 440 450
PREDDLSNTN ATPLPEEFEL QGFLALRPSF RNLDFSKGHQ GITGDKEGQQ
460 470 480 490 500
RRIRQQRLIS IGKWIADNQP RLIQCENEVG KLLFITEIPE LILEDPSEAK
510 520 530 540 550
ENLILQETSV VESLATDGSP GLKSVLSTGR NPSNSCDSGE KPVVTFKENI
560 570 580 590 600
KPREVNQGRS FPPKEVKSQT ELRKTPVSEA RKTPVTQTPS QTSNSQFIPI
610 620 630 640 650
HHPGAFPPLP SRPGFPPPTY VIPPPVAFSM GSGYTFPAGV SVPGTFLQST
660 670 680 690 700
AHSPAGNQVQ AGKQSHIPYS QQRPSGPGPM NQGPQQSQPP SQPPLTSLPA
710 720 730 740 750
QPTAQSTSQL QVQALAQQQQ SPTKVIPALG KSPPHHSGFQ QYQQADASKQ
760 770 780 790 800
LWNPPQVQSP LGKIMPVKQS YYLQTQDPIK LFEPSLQPPV IQQQPLEKKM
810 820 830 840 850
KPFPMEPYNH NPSEVKVPEF YWDSSYSMAD NRAVMAQQPN MDRRSKRSPG
860 870 880 890 900
VFRPEQDPVP RMPFEDPKSS PLLPPDLLKS LAALEEEEEL IFSNPPDLYP
910 920 930 940 950
ALLGPLASLP GRSLFKSLLE KPSELMSHSS SFLSLTGFSV NQERYPNSSM
960 970 980 990 1000
FNEVYGKNLT TSSKAELNPS VASQETSLYS LFEGTPWSPS LPASSDHSTP
1010 1020 1030 1040 1050
ASQSPHSSNP SSLPSSPPTH NHNSAPFSNF GPIGTPDNRD RRPADRWKTD
1060 1070 1080 1090 1100
KPAMGGFGVD YLSATSSSES SWHQASTPSG TWTGHGPSME DSSAVLMESL
1110 1120 1130
KSIWSSSMMH PGPSALEQLL MQQKQKQQRG QGAMNPPH
Length:1,138
Mass (Da):126,841
Last modified:December 21, 2004 - v1
Checksum:i330576E241E35AD4
GO
Isoform 2 (identifier: Q5RJH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MSLQSAQYL → MRTENLKSEEHLKSSNI

Show »
Length:1,146
Mass (Da):127,817
Checksum:i462775EB9EC356F4
GO
Isoform 3 (identifier: Q5RJH6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     566-566: V → VRRDCSKGVTVTQEDGQKDSSKRRAETKRCTLGKLQETGKQSVAVQV
     866-915: Missing.

Show »
Length:1,134
Mass (Da):126,563
Checksum:i7F2A9BC1BE152A66
GO

Sequence cautioni

The sequence BAC97911 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti552P → S in BAC97911 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0165771 – 9MSLQSAQYL → MRTENLKSEEHLKSSNI in isoform 2. 1 Publication9
Alternative sequenceiVSP_016578566V → VRRDCSKGVTVTQEDGQKDS SKRRAETKRCTLGKLQETGK QSVAVQV in isoform 3. 1 Publication1
Alternative sequenceiVSP_016579866 – 915Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129101 mRNA Translation: BAC97911.1 Different initiation.
BC082789 mRNA Translation: AAH82789.1
BC086651 mRNA Translation: AAH86651.1
CCDSiCCDS35740.1 [Q5RJH6-3]
CCDS48394.1 [Q5RJH6-2]
CCDS48395.1 [Q5RJH6-1]
RefSeqiNP_001005507.1, NM_001005507.2 [Q5RJH6-3]
NP_001153728.1, NM_001160256.1 [Q5RJH6-1]
NP_001153729.1, NM_001160257.1 [Q5RJH6-2]
XP_006529515.1, XM_006529452.3
UniGeneiMm.270775

Genome annotation databases

EnsembliENSMUST00000043560; ENSMUSP00000041241; ENSMUSG00000042772 [Q5RJH6-2]
ENSMUST00000073441; ENSMUSP00000073144; ENSMUSG00000042772 [Q5RJH6-3]
ENSMUST00000111836; ENSMUSP00000107467; ENSMUSG00000042772 [Q5RJH6-1]
GeneIDi226517
KEGGimmu:226517
UCSCiuc007czn.1 mouse [Q5RJH6-2]
uc007czo.2 mouse [Q5RJH6-3]
uc007czp.2 mouse [Q5RJH6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129101 mRNA Translation: BAC97911.1 Different initiation.
BC082789 mRNA Translation: AAH82789.1
BC086651 mRNA Translation: AAH86651.1
CCDSiCCDS35740.1 [Q5RJH6-3]
CCDS48394.1 [Q5RJH6-2]
CCDS48395.1 [Q5RJH6-1]
RefSeqiNP_001005507.1, NM_001005507.2 [Q5RJH6-3]
NP_001153728.1, NM_001160256.1 [Q5RJH6-1]
NP_001153729.1, NM_001160257.1 [Q5RJH6-2]
XP_006529515.1, XM_006529452.3
UniGeneiMm.270775

3D structure databases

ProteinModelPortaliQ5RJH6
SMRiQ5RJH6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041241

PTM databases

iPTMnetiQ5RJH6
PhosphoSitePlusiQ5RJH6

Proteomic databases

PaxDbiQ5RJH6
PeptideAtlasiQ5RJH6
PRIDEiQ5RJH6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043560; ENSMUSP00000041241; ENSMUSG00000042772 [Q5RJH6-2]
ENSMUST00000073441; ENSMUSP00000073144; ENSMUSG00000042772 [Q5RJH6-3]
ENSMUST00000111836; ENSMUSP00000107467; ENSMUSG00000042772 [Q5RJH6-1]
GeneIDi226517
KEGGimmu:226517
UCSCiuc007czn.1 mouse [Q5RJH6-2]
uc007czo.2 mouse [Q5RJH6-3]
uc007czp.2 mouse [Q5RJH6-1]

Organism-specific databases

CTDi9887
MGIiMGI:2682334 Smg7
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410INQX Eukaryota
ENOG410XQ61 LUCA
GeneTreeiENSGT00560000077120
HOGENOMiHOG000049052
HOVERGENiHBG056330
InParanoidiQ5RJH6
KOiK14409
OMAiMVTFKEN
OrthoDBiEOG091G04DJ
PhylomeDBiQ5RJH6
TreeFamiTF327119

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

PMAP-CutDBiQ5RJH6
PROiPR:Q5RJH6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042772 Expressed in 243 organ(s), highest expression level in skin of back
GenevisibleiQ5RJH6 MM

Family and domain databases

InterProiView protein in InterPro
IPR018834 DNA/RNA-bd_Est1-type
IPR019458 EST1
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF10374 EST1, 1 hit
PF10373 EST1_DNA_bind, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMG7_MOUSE
AccessioniPrimary (citable) accession number: Q5RJH6
Secondary accession number(s): Q63ZW5, Q6ZQF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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