Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-12

Gene

Cdh12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).By similarity

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-12
Gene namesi
Name:Cdh12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109503 Cdh12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini55 – 609ExtracellularSequence analysisAdd BLAST555
Transmembranei610 – 637HelicalSequence analysisAdd BLAST28
Topological domaini638 – 794CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000032009424 – 54Sequence analysisAdd BLAST31
ChainiPRO_000032009555 – 794Cadherin-12Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei787PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5RJH3
PRIDEiQ5RJH3

PTM databases

iPTMnetiQ5RJH3
PhosphoSitePlusiQ5RJH3

Expressioni

Gene expression databases

BgeeiENSMUSG00000040452 Expressed in 36 organ(s), highest expression level in cortical layer V
CleanExiMM_CDH12

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074632

Structurei

3D structure databases

ProteinModelPortaliQ5RJH3
SMRiQ5RJH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 160Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini161 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini270 – 384Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini385 – 487Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini488 – 609Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ5RJH3
KOiK06804
OMAiEMSPVGA
OrthoDBiEOG091G023E
PhylomeDBiQ5RJH3
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RJH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTRNSLYLL LWILFDGGLL TPLQPQPQQT LATEPKENVI HLSGRRSHFQ
60 70 80 90 100
RVKRGWVWNQ FFVLEEYMGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT
110 120 130 140 150
VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV
160 170 180 190 200
QDINDNEPKF LDGPYVASVP EMSPVGAYVL QVKATDADDP TYGNSARVVY
210 220 230 240 250
SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA
260 270 280 290 300
GTTVVNITLT DVNDNPPRFP KSIFHLKVPE SSPVGSAIGR IRAVDPDFGK
310 320 330 340 350
NAEIEYNIVP GDGGNLFDIV TDEDTQEGII KLKKPLDFET KKAYTFKVEA
360 370 380 390 400
SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG
410 420 430 440 450
TIIGAVTAQD LDVGSSAVRY FIDWKSDGES YFTIDGTEGT IATNELLDRE
460 470 480 490 500
NMAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN
510 520 530 540 550
AKPGQIIQIV GAVDRDLSPA GQQFSFRLAP EAVIKPNFTV HDFRNNTAGI
560 570 580 590 600
ETRRNGYSRR QQELYFLPIV IEDSSYPVQS STNTMTIRVC RCDSDGTILS
610 620 630 640 650
CNVEAIFLPV GLSTGALIAI LLCMVILLAI VVLYVALRRQ RKKDTLMTSK
660 670 680 690 700
EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL
710 720 730 740 750
SRQRPQVEDN TDIRDFIHRR LQENDADPAA PPYDSLATYA YEGNGSVAES
760 770 780 790
LSSIDSLTTE ADQDYDYLSD WGPRFKVLAD MFGEEESYNP DNVT
Length:794
Mass (Da):88,468
Last modified:December 21, 2004 - v1
Checksum:i963DE4B1CB3088DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086655 mRNA Translation: AAH86655.1
CCDSiCCDS27396.1
RefSeqiNP_001008420.1, NM_001008420.2
XP_011243643.1, XM_011245341.2
XP_011243644.1, XM_011245342.2
XP_011243645.1, XM_011245343.2
XP_011243646.1, XM_011245344.2
XP_011243647.1, XM_011245345.2
XP_011243649.1, XM_011245347.2
XP_017172034.1, XM_017316545.1
XP_017172035.1, XM_017316546.1
UniGeneiMm.300909

Genome annotation databases

EnsembliENSMUST00000075132; ENSMUSP00000074632; ENSMUSG00000040452
ENSMUST00000227496; ENSMUSP00000153750; ENSMUSG00000040452
GeneIDi215654
KEGGimmu:215654
UCSCiuc007vip.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086655 mRNA Translation: AAH86655.1
CCDSiCCDS27396.1
RefSeqiNP_001008420.1, NM_001008420.2
XP_011243643.1, XM_011245341.2
XP_011243644.1, XM_011245342.2
XP_011243645.1, XM_011245343.2
XP_011243646.1, XM_011245344.2
XP_011243647.1, XM_011245345.2
XP_011243649.1, XM_011245347.2
XP_017172034.1, XM_017316545.1
XP_017172035.1, XM_017316546.1
UniGeneiMm.300909

3D structure databases

ProteinModelPortaliQ5RJH3
SMRiQ5RJH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074632

PTM databases

iPTMnetiQ5RJH3
PhosphoSitePlusiQ5RJH3

Proteomic databases

PaxDbiQ5RJH3
PRIDEiQ5RJH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075132; ENSMUSP00000074632; ENSMUSG00000040452
ENSMUST00000227496; ENSMUSP00000153750; ENSMUSG00000040452
GeneIDi215654
KEGGimmu:215654
UCSCiuc007vip.1 mouse

Organism-specific databases

CTDi1010
MGIiMGI:109503 Cdh12

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ5RJH3
KOiK06804
OMAiEMSPVGA
OrthoDBiEOG091G023E
PhylomeDBiQ5RJH3
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Miscellaneous databases

PROiPR:Q5RJH3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040452 Expressed in 36 organ(s), highest expression level in cortical layer V
CleanExiMM_CDH12

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD12_MOUSE
AccessioniPrimary (citable) accession number: Q5RJH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again