Cdh12

Functionⁱ

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).By similarity

GO - Molecular functionⁱ

cadherin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytoskeletal protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adherens junction organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell-cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell-cell adhesion mediated by cadherin
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell-cell junction assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
homophilic cell adhesion via plasma membrane adhesion molecules
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-418990 Adherens junctions interactions

Reactomeⁱ

R-MMU-418990 Adherens junctions interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cadherin-12
Gene namesⁱ	Name:Cdh12
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:109503 Cdh12

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	55 – 609	ExtracellularSequence analysisAdd BLAST	555
Transmembraneⁱ	610 – 637	HelicalSequence analysisAdd BLAST	28
Topological domainⁱ	638 – 794	CytoplasmicSequence analysisAdd BLAST	157

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST	23
PropeptideⁱPRO_0000320094	24 – 54	Sequence analysisAdd BLAST	31
ChainⁱPRO_0000320095	55 – 794	Cadherin-12Add BLAST	740

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	256	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	456	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	537	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	545	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	787	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q5RJH3
PRIDEⁱ	Q5RJH3

PTM databases

iPTMnetⁱ	Q5RJH3
PhosphoSitePlusⁱ	Q5RJH3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000040452 Expressed in 36 organ(s), highest expression level in cortical layer V
CleanExⁱ	MM_CDH12

Interactionⁱ

GO - Molecular functionⁱ

cadherin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytoskeletal protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000074632

STRINGⁱ

10090.ENSMUSP00000074632

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5RJH3
SMRⁱ	Q5RJH3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	55 – 160	Cadherin 1PROSITE-ProRule annotationAdd BLAST	106
Domainⁱ	161 – 269	Cadherin 2PROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	270 – 384	Cadherin 3PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	385 – 487	Cadherin 4PROSITE-ProRule annotationAdd BLAST	103
Domainⁱ	488 – 609	Cadherin 5PROSITE-ProRule annotationAdd BLAST	122

Domainⁱ

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118954
HOGENOMⁱ	HOG000231252
HOVERGENⁱ	HBG005217
InParanoidⁱ	Q5RJH3
KEGG Orthology (KO) More...KOⁱ	K06804
OMAⁱ	EMSPVGA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G023E
PhylomeDBⁱ	Q5RJH3
TreeFamⁱ	TF329887

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR039808 Cadherin IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
PANTHERⁱ	PTHR24027 PTHR24027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 2 hits PS50268 CADHERIN_2, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q5RJH3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLTRNSLYLL LWILFDGGLL TPLQPQPQQT LATEPKENVI HLSGRRSHFQ 
        60         70         80         90        100
RVKRGWVWNQ FFVLEEYMGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT 
       110        120        130        140        150
VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV 
       160        170        180        190        200
QDINDNEPKF LDGPYVASVP EMSPVGAYVL QVKATDADDP TYGNSARVVY 
       210        220        230        240        250
SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA 
       260        270        280        290        300
GTTVVNITLT DVNDNPPRFP KSIFHLKVPE SSPVGSAIGR IRAVDPDFGK 
       310        320        330        340        350
NAEIEYNIVP GDGGNLFDIV TDEDTQEGII KLKKPLDFET KKAYTFKVEA 
       360        370        380        390        400
SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG 
       410        420        430        440        450
TIIGAVTAQD LDVGSSAVRY FIDWKSDGES YFTIDGTEGT IATNELLDRE 
       460        470        480        490        500
NMAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN 
       510        520        530        540        550
AKPGQIIQIV GAVDRDLSPA GQQFSFRLAP EAVIKPNFTV HDFRNNTAGI 
       560        570        580        590        600
ETRRNGYSRR QQELYFLPIV IEDSSYPVQS STNTMTIRVC RCDSDGTILS 
       610        620        630        640        650
CNVEAIFLPV GLSTGALIAI LLCMVILLAI VVLYVALRRQ RKKDTLMTSK 
       660        670        680        690        700
EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL 
       710        720        730        740        750
SRQRPQVEDN TDIRDFIHRR LQENDADPAA PPYDSLATYA YEGNGSVAES 
       760        770        780        790 
LSSIDSLTTE ADQDYDYLSD WGPRFKVLAD MFGEEESYNP DNVT

Length:794

Mass (Da):88,468

Last modified:December 21, 2004 - v1

Checksum:ⁱ963DE4B1CB3088DF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC086655 mRNA Translation: AAH86655.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27396.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001008420.1, NM_001008420.2 XP_011243643.1, XM_011245341.2 XP_011243644.1, XM_011245342.2 XP_011243645.1, XM_011245343.2 XP_011243646.1, XM_011245344.2 XP_011243647.1, XM_011245345.2 XP_011243649.1, XM_011245347.2 XP_017172034.1, XM_017316545.1 XP_017172035.1, XM_017316546.1
UniGeneⁱ	Mm.300909

Genome annotation databases

Ensemblⁱ	ENSMUST00000075132; ENSMUSP00000074632; ENSMUSG00000040452 ENSMUST00000227496; ENSMUSP00000153750; ENSMUSG00000040452
GeneIDⁱ	215654
KEGGⁱ	mmu:215654
UCSC genome browser More...UCSCⁱ	uc007vip.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5RJH3	Cadherin-12		HUMAN		794	UniRef90_P55289
Cadherin 12		FICAL		795
CDH12 isoform 1		PANTR		794
Uncharacterized protein		RHIBE		464
Cadherin-12 preproprotein		CALJA		794
+134

Protein	Similar proteins		Species	Score	Length	Source
Q5RJH3	Cadherin-9		MOUSE		786	UniRef50_P70407
Cadherin-9		HUMAN		789
Cadherin-20		RAT		801
Cadherin-6		BOVIN		790
Cadherin-6		CHICK		790
+2952

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC086655 mRNA Translation: AAH86655.1
CCDSⁱ	CCDS27396.1
RefSeqⁱ	NP_001008420.1, NM_001008420.2 XP_011243643.1, XM_011245341.2 XP_011243644.1, XM_011245342.2 XP_011243645.1, XM_011245343.2 XP_011243646.1, XM_011245344.2 XP_011243647.1, XM_011245345.2 XP_011243649.1, XM_011245347.2 XP_017172034.1, XM_017316545.1 XP_017172035.1, XM_017316546.1
UniGeneⁱ	Mm.300909

3D structure databases

ProteinModelPortalⁱ	Q5RJH3
SMRⁱ	Q5RJH3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000074632

STRINGⁱ

10090.ENSMUSP00000074632

PTM databases

iPTMnetⁱ	Q5RJH3
PhosphoSitePlusⁱ	Q5RJH3

Proteomic databases

PaxDbⁱ	Q5RJH3
PRIDEⁱ	Q5RJH3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000075132; ENSMUSP00000074632; ENSMUSG00000040452 ENSMUST00000227496; ENSMUSP00000153750; ENSMUSG00000040452
GeneIDⁱ	215654
KEGGⁱ	mmu:215654
UCSCⁱ	uc007vip.1 mouse

Organism-specific databases

CTDⁱ	1010
MGIⁱ	MGI:109503 Cdh12

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
GeneTreeⁱ	ENSGT00760000118954
HOGENOMⁱ	HOG000231252
HOVERGENⁱ	HBG005217
InParanoidⁱ	Q5RJH3
KOⁱ	K06804
OMAⁱ	EMSPVGA
OrthoDBⁱ	EOG091G023E
PhylomeDBⁱ	Q5RJH3
TreeFamⁱ	TF329887

Enzyme and pathway databases

Reactomeⁱ	R-MMU-418990 Adherens junctions interactions

Reactomeⁱ

R-MMU-418990 Adherens junctions interactions

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q5RJH3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040452 Expressed in 36 organ(s), highest expression level in cortical layer V
CleanExⁱ	MM_CDH12

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR039808 Cadherin IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
PANTHERⁱ	PTHR24027 PTHR24027, 1 hit
Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 2 hits PS50268 CADHERIN_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAD12_MOUSE
Accessionⁱ	Q5RJH3Primary (citable) accession number: Q5RJH3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5RJH3 (CAD12_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cadherin-12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ