UniProtKB - Q5RJH3 (CAD12_MOUSE)
Protein
Cadherin-12
Gene
Cdh12
Organism
Mus musculus (Mouse)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).By similarity
GO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
GO - Biological processi
- adherens junction organization Source: GO_Central
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cell-cell junction assembly Source: GO_Central
- cell morphogenesis Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- multicellular organism development Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-12 |
Gene namesi | Name:Cdh12 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109503, Cdh12 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- catenin complex Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 55 – 609 | ExtracellularSequence analysisAdd BLAST | 555 | |
Transmembranei | 610 – 637 | HelicalSequence analysisAdd BLAST | 28 | |
Topological domaini | 638 – 794 | CytoplasmicSequence analysisAdd BLAST | 157 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000320094 | 24 – 54 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000320095 | 55 – 794 | Cadherin-12Add BLAST | 740 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 456 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 537 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 545 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 787 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q5RJH3 |
PRIDEi | Q5RJH3 |
PTM databases
GlyConnecti | 2165, 2 N-Linked glycans (1 site) |
GlyGeni | Q5RJH3, 4 sites |
iPTMneti | Q5RJH3 |
PhosphoSitePlusi | Q5RJH3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040452, Expressed in cortical layer V and 49 other tissues |
Interactioni
GO - Molecular functioni
- cadherin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000074632 |
Miscellaneous databases
RNActi | Q5RJH3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 160 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 161 – 269 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 270 – 384 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 385 – 487 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 488 – 609 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 122 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000154187 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | Q5RJH3 |
OMAi | WGPRFKI |
OrthoDBi | 173598at2759 |
PhylomeDBi | Q5RJH3 |
TreeFami | TF329887 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5RJH3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTRNSLYLL LWILFDGGLL TPLQPQPQQT LATEPKENVI HLSGRRSHFQ
60 70 80 90 100
RVKRGWVWNQ FFVLEEYMGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT
110 120 130 140 150
VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV
160 170 180 190 200
QDINDNEPKF LDGPYVASVP EMSPVGAYVL QVKATDADDP TYGNSARVVY
210 220 230 240 250
SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA
260 270 280 290 300
GTTVVNITLT DVNDNPPRFP KSIFHLKVPE SSPVGSAIGR IRAVDPDFGK
310 320 330 340 350
NAEIEYNIVP GDGGNLFDIV TDEDTQEGII KLKKPLDFET KKAYTFKVEA
360 370 380 390 400
SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG
410 420 430 440 450
TIIGAVTAQD LDVGSSAVRY FIDWKSDGES YFTIDGTEGT IATNELLDRE
460 470 480 490 500
NMAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN
510 520 530 540 550
AKPGQIIQIV GAVDRDLSPA GQQFSFRLAP EAVIKPNFTV HDFRNNTAGI
560 570 580 590 600
ETRRNGYSRR QQELYFLPIV IEDSSYPVQS STNTMTIRVC RCDSDGTILS
610 620 630 640 650
CNVEAIFLPV GLSTGALIAI LLCMVILLAI VVLYVALRRQ RKKDTLMTSK
660 670 680 690 700
EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL
710 720 730 740 750
SRQRPQVEDN TDIRDFIHRR LQENDADPAA PPYDSLATYA YEGNGSVAES
760 770 780 790
LSSIDSLTTE ADQDYDYLSD WGPRFKVLAD MFGEEESYNP DNVT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC086655 mRNA Translation: AAH86655.1 |
CCDSi | CCDS27396.1 |
RefSeqi | NP_001008420.1, NM_001008420.2 XP_011243643.1, XM_011245341.2 XP_011243644.1, XM_011245342.2 XP_011243645.1, XM_011245343.2 XP_011243646.1, XM_011245344.2 XP_011243647.1, XM_011245345.2 XP_011243649.1, XM_011245347.2 XP_017172034.1, XM_017316545.1 XP_017172035.1, XM_017316546.1 |
Genome annotation databases
Ensembli | ENSMUST00000075132; ENSMUSP00000074632; ENSMUSG00000040452 ENSMUST00000227496; ENSMUSP00000153750; ENSMUSG00000040452 |
GeneIDi | 215654 |
KEGGi | mmu:215654 |
UCSCi | uc007vip.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC086655 mRNA Translation: AAH86655.1 |
CCDSi | CCDS27396.1 |
RefSeqi | NP_001008420.1, NM_001008420.2 XP_011243643.1, XM_011245341.2 XP_011243644.1, XM_011245342.2 XP_011243645.1, XM_011245343.2 XP_011243646.1, XM_011245344.2 XP_011243647.1, XM_011245345.2 XP_011243649.1, XM_011245347.2 XP_017172034.1, XM_017316545.1 XP_017172035.1, XM_017316546.1 |
3D structure databases
SMRi | Q5RJH3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000074632 |
PTM databases
GlyConnecti | 2165, 2 N-Linked glycans (1 site) |
GlyGeni | Q5RJH3, 4 sites |
iPTMneti | Q5RJH3 |
PhosphoSitePlusi | Q5RJH3 |
Proteomic databases
PaxDbi | Q5RJH3 |
PRIDEi | Q5RJH3 |
Protocols and materials databases
Antibodypediai | 22634, 274 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000075132; ENSMUSP00000074632; ENSMUSG00000040452 ENSMUST00000227496; ENSMUSP00000153750; ENSMUSG00000040452 |
GeneIDi | 215654 |
KEGGi | mmu:215654 |
UCSCi | uc007vip.1, mouse |
Organism-specific databases
CTDi | 1010 |
MGIi | MGI:109503, Cdh12 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000154187 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | Q5RJH3 |
OMAi | WGPRFKI |
OrthoDBi | 173598at2759 |
PhylomeDBi | Q5RJH3 |
TreeFami | TF329887 |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Miscellaneous databases
BioGRID-ORCSi | 215654, 0 hits in 17 CRISPR screens |
ChiTaRSi | Cdh12, mouse |
PROi | PR:Q5RJH3 |
RNActi | Q5RJH3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040452, Expressed in cortical layer V and 49 other tissues |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAD12_MOUSE | |
Accessioni | Q5RJH3Primary (citable) accession number: Q5RJH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot