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Protein

Class A basic helix-loop-helix protein 9

Gene

Bhlha9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Class A basic helix-loop-helix protein 9
Short name:
bHLHa9
Alternative name(s):
Class B basic helix-loop-helix factor 42
Short name:
bHLHf42
Gene namesi
Name:Bhlha9
Synonyms:Bhlhf42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444198 Bhlha9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003413781 – 231Class A basic helix-loop-helix protein 9Add BLAST231

Proteomic databases

PaxDbiQ5RJB0
PRIDEiQ5RJB0

PTM databases

PhosphoSitePlusiQ5RJB0

Expressioni

Developmental stagei

At 10.5 dpc, expressed in forelimb and hindlimb buds, in the distal mesenchyme below the apical ectodermal ridge. At 11.5 dpc, expression is restricted to the subridge mesenchymal layer, as well as in the dorsal and ventral regions of the developing limbs.1 Publication

Gene expression databases

BgeeiENSMUSG00000044243 Expressed in 29 organ(s), highest expression level in female reproductive organ
GenevisibleiQ5RJB0 MM

Interactioni

Subunit structurei

Heterodimer. Efficient DNA binding requires dimerization with another bHLH protein. Interacts with TCF3, TCF4, and TCF12.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050516

Structurei

3D structure databases

ProteinModelPortaliQ5RJB0
SMRiQ5RJB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 113bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiENOG410J0X0 Eukaryota
ENOG4112APN LUCA
GeneTreeiENSGT00390000002453
HOGENOMiHOG000095226
InParanoidiQ5RJB0
OMAiLECHGQA
OrthoDBiEOG091G0MBA
PhylomeDBiQ5RJB0
TreeFamiTF337642

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RJB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRGTPGLGL GGLNRAEDFV EDLGRSCSEA GRNFGVLRRS SLDEAEEAAG
60 70 80 90 100
RKRERPTRSK ARRMAANVRE RKRILDYNEA FNALRRALQH DLGGKRLSKI
110 120 130 140 150
ATLRRAIHRI TALSLVLRAS PAPRWPCGHL ECHGQAAQGS STGNSSFSVP
160 170 180 190 200
RSAPSPIAPS LTRRDIASPL VPPTPRCASC SPHSHLGRPR VMAEVPNLAQ
210 220 230
TSGGNWRQCP GAPPVRPVSW RWGSGLGYQH S
Length:231
Mass (Da):25,115
Last modified:February 20, 2007 - v1
Checksum:iD25ACC159CF730D1
GO

Sequence cautioni

The sequence AAH48728 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC31704 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66A → G in BAC31704 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX000359 Genomic DNA No translation available.
BC048728 mRNA Translation: AAH48728.1 Different initiation.
AK043927 mRNA Translation: BAC31704.1 Different initiation.
CCDSiCCDS25068.2
RefSeqiNP_796156.3, NM_177182.4
UniGeneiMm.131585

Genome annotation databases

EnsembliENSMUST00000056184; ENSMUSP00000050516; ENSMUSG00000044243
GeneIDi320522
KEGGimmu:320522
UCSCiuc007kfx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX000359 Genomic DNA No translation available.
BC048728 mRNA Translation: AAH48728.1 Different initiation.
AK043927 mRNA Translation: BAC31704.1 Different initiation.
CCDSiCCDS25068.2
RefSeqiNP_796156.3, NM_177182.4
UniGeneiMm.131585

3D structure databases

ProteinModelPortaliQ5RJB0
SMRiQ5RJB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050516

PTM databases

PhosphoSitePlusiQ5RJB0

Proteomic databases

PaxDbiQ5RJB0
PRIDEiQ5RJB0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056184; ENSMUSP00000050516; ENSMUSG00000044243
GeneIDi320522
KEGGimmu:320522
UCSCiuc007kfx.1 mouse

Organism-specific databases

CTDi727857
MGIiMGI:2444198 Bhlha9

Phylogenomic databases

eggNOGiENOG410J0X0 Eukaryota
ENOG4112APN LUCA
GeneTreeiENSGT00390000002453
HOGENOMiHOG000095226
InParanoidiQ5RJB0
OMAiLECHGQA
OrthoDBiEOG091G0MBA
PhylomeDBiQ5RJB0
TreeFamiTF337642

Miscellaneous databases

PROiPR:Q5RJB0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044243 Expressed in 29 organ(s), highest expression level in female reproductive organ
GenevisibleiQ5RJB0 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBHA09_MOUSE
AccessioniPrimary (citable) accession number: Q5RJB0
Secondary accession number(s): Q80ZL8, Q8BLP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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