UniProtKB - Q5RJ54 (ZSC26_MOUSE)
Protein
Zinc finger and SCAN domain-containing protein 26
Gene
Zscan26
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 220 – 242 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 26Alternative name(s): Zinc finger protein 187 |
Gene namesi | Name:Zscan26 Synonyms:Zfp187, Znf187 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3531417, Zscan26 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307314 | 1 – 466 | Zinc finger and SCAN domain-containing protein 26Add BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 21 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q5RJ54 |
PaxDbi | Q5RJ54 |
PeptideAtlasi | Q5RJ54 |
PRIDEi | Q5RJ54 |
PTM databases
iPTMneti | Q5RJ54 |
PhosphoSitePlusi | Q5RJ54 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022228, Expressed in retina and 306 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 240783, 2 interactors |
IntActi | Q5RJ54, 1 interactor |
STRINGi | 10090.ENSMUSP00000106111 |
Miscellaneous databases
RNActi | Q5RJ54, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 124 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 220 – 242 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162298 |
HOGENOMi | CLU_002678_49_2_1 |
InParanoidi | Q5RJ54 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5RJ54 |
TreeFami | TF338304 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5RJ54-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALALIHPSK RAYSLAPLNL KEELQGFKVQ GDRKGVGQEP LCKQFRQLRY
60 70 80 90 100
EESTGPREVL RRLRELCRQW LRPETHSKEQ ILELLVLEQF LTILPRDLQV
110 120 130 140 150
QVLEHHPETG EELVGILEDL QLDRGKAGEQ KDSAQRSRPT VLVGEPAPRR
160 170 180 190 200
EAREQPGCAL PQKPEERGKE TRSENGNLIA GTDSCGRMES SCTMTEPIEA
210 220 230 240 250
QCEDLSLKKN PAMPKEKTNS QCLETKERLV QNSGLIEHDR AHTGEMSWES
260 270 280 290 300
VGSQSSVAAD HQEISKDKGH PCQECGKVFQ RSSHLIRHQK IHLGEKPYQC
310 320 330 340 350
KECGKVFSQN AGLLEHLRIH TGEKPYLCIH CGKNFRRSSH LNRHQKIHSQ
360 370 380 390 400
DEPRECKECG KTFSRALLLT HHQRVHGRSK RHHCNECGKA FSLTSDLIRH
410 420 430 440 450
HRIHTGEKPF KCNVCQKAFR LNSHLDQHVR IHNEEKPYKC SECNEAFRQK
460
SGLFQHQRHH HKSKLA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WJ31 | F8WJ31_MOUSE | Zinc finger and SCAN domain-contain... | Zscan26 Zfp187 | 340 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028703 | 1 – 245 | Missing in isoform 2. 1 PublicationAdd BLAST | 245 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX001068 Genomic DNA No translation available. BC068174 mRNA Translation: AAH68174.1 BY139219 mRNA No translation available. |
CCDSi | CCDS84009.1 [Q5RJ54-1] |
RefSeqi | NP_001013808.2, NM_001013786.3 NP_001334420.1, NM_001347491.1 [Q5RJ54-1] XP_011242620.1, XM_011244318.2 |
Genome annotation databases
Ensembli | ENSMUST00000110485; ENSMUSP00000106111; ENSMUSG00000022228 [Q5RJ54-1] |
GeneIDi | 432731 |
KEGGi | mmu:432731 |
UCSCi | uc007pql.2, mouse [Q5RJ54-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX001068 Genomic DNA No translation available. BC068174 mRNA Translation: AAH68174.1 BY139219 mRNA No translation available. |
CCDSi | CCDS84009.1 [Q5RJ54-1] |
RefSeqi | NP_001013808.2, NM_001013786.3 NP_001334420.1, NM_001347491.1 [Q5RJ54-1] XP_011242620.1, XM_011244318.2 |
3D structure databases
SMRi | Q5RJ54 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 240783, 2 interactors |
IntActi | Q5RJ54, 1 interactor |
STRINGi | 10090.ENSMUSP00000106111 |
PTM databases
iPTMneti | Q5RJ54 |
PhosphoSitePlusi | Q5RJ54 |
Proteomic databases
jPOSTi | Q5RJ54 |
PaxDbi | Q5RJ54 |
PeptideAtlasi | Q5RJ54 |
PRIDEi | Q5RJ54 |
Protocols and materials databases
Antibodypediai | 6168, 187 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000110485; ENSMUSP00000106111; ENSMUSG00000022228 [Q5RJ54-1] |
GeneIDi | 432731 |
KEGGi | mmu:432731 |
UCSCi | uc007pql.2, mouse [Q5RJ54-1] |
Organism-specific databases
CTDi | 7741 |
MGIi | MGI:3531417, Zscan26 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162298 |
HOGENOMi | CLU_002678_49_2_1 |
InParanoidi | Q5RJ54 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5RJ54 |
TreeFami | TF338304 |
Miscellaneous databases
BioGRID-ORCSi | 432731, 0 hits in 13 CRISPR screens |
PROi | PR:Q5RJ54 |
RNActi | Q5RJ54, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022228, Expressed in retina and 306 other tissues |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSC26_MOUSE | |
Accessioni | Q5RJ54Primary (citable) accession number: Q5RJ54 Secondary accession number(s): Q6NVD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot