UniProtKB - Q5RIA9 (CBWD5_HUMAN)
Protein
COBW domain-containing protein 5
Gene
CBWD5
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 49 – 56 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 110 – 114 | ATPSequence analysis | 5 | |
Nucleotide bindingi | 203 – 206 | ATPSequence analysis | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q5RIA9 |
Names & Taxonomyi
Protein namesi | Recommended name: COBW domain-containing protein 5Alternative name(s): Cobalamin synthase W domain-containing protein 5 |
Gene namesi | Name:CBWD5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24584, CBWD5 |
neXtProti | NX_Q5RIA9 |
VEuPathDBi | HostDB:ENSG00000147996.16 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000147996 |
Miscellaneous databases
Pharosi | Q5RIA9, Tdark |
Genetic variation databases
BioMutai | CBWD5 |
DMDMi | 74743388 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317239 | 1 – 395 | COBW domain-containing protein 5Add BLAST | 395 |
Proteomic databases
jPOSTi | Q5RIA9 |
MassIVEi | Q5RIA9 |
MaxQBi | Q5RIA9 |
PeptideAtlasi | Q5RIA9 |
PRIDEi | Q5RIA9 |
ProteomicsDBi | 63743 [Q5RIA9-1] 63744 [Q5RIA9-2] 63745 [Q5RIA9-3] |
PTM databases
iPTMneti | Q5RIA9 |
PhosphoSitePlusi | Q5RIA9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147996, Expressed in caudate nucleus and 115 other tissues |
ExpressionAtlasi | Q5RIA9, baseline and differential |
Genevisiblei | Q5RIA9, HS |
Organism-specific databases
HPAi | ENSG00000147996, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128658, 5 interactors |
IntActi | Q5RIA9, 2 interactors |
Miscellaneous databases
RNActi | Q5RIA9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 274 – 377 | CobW C-terminalAdd BLAST | 104 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00640000091523 |
HOGENOMi | CLU_017452_0_1_1 |
InParanoidi | Q5RIA9 |
OMAi | HDCHDHH |
OrthoDBi | 1144889at2759 |
PhylomeDBi | Q5RIA9 |
TreeFami | TF332679 |
Family and domain databases
Gene3Di | 3.30.1220.10, 1 hit |
InterProi | View protein in InterPro IPR011629, Cbl_biosynth_CobW-like_C IPR036627, CobW-likC_sf IPR003495, CobW/HypB/UreG_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF02492, cobW, 1 hit PF07683, CobW_C, 1 hit |
SMARTi | View protein in SMART SM00833, CobW_C, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5RIA9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVTSMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII
210 220 230 240 250
LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | D → Y in BC082271 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067710 | 147 | T → A1 PublicationCorresponds to variant dbSNP:rs1411096827Ensembl. | 1 | |
Natural variantiVAR_067711 | 288 | E → D. Corresponds to variant dbSNP:rs1168844980Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033808 | 1 – 291 | Missing in isoform 2. 1 PublicationAdd BLAST | 291 | |
Alternative sequenceiVSP_040475 | 192 – 220 | Missing in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_040476 | 236 – 254 | Missing in isoform 3. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097639 mRNA No translation available. BX284632 Genomic DNA No translation available. BC082271 mRNA No translation available. |
CCDSi | CCDS75841.1 [Q5RIA9-3] CCDS83367.1 [Q5RIA9-1] |
RefSeqi | NP_001317597.1, NM_001330668.1 [Q5RIA9-1] |
Genome annotation databases
Ensembli | ENST00000377395; ENSP00000366612; ENSG00000147996 [Q5RIA9-3] ENST00000382405; ENSP00000371842; ENSG00000147996 [Q5RIA9-1] |
GeneIDi | 220869 |
KEGGi | hsa:220869 |
UCSCi | uc004aga.6, human [Q5RIA9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097639 mRNA No translation available. BX284632 Genomic DNA No translation available. BC082271 mRNA No translation available. |
CCDSi | CCDS75841.1 [Q5RIA9-3] CCDS83367.1 [Q5RIA9-1] |
RefSeqi | NP_001317597.1, NM_001330668.1 [Q5RIA9-1] |
3D structure databases
SMRi | Q5RIA9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128658, 5 interactors |
IntActi | Q5RIA9, 2 interactors |
PTM databases
iPTMneti | Q5RIA9 |
PhosphoSitePlusi | Q5RIA9 |
Genetic variation databases
BioMutai | CBWD5 |
DMDMi | 74743388 |
Proteomic databases
jPOSTi | Q5RIA9 |
MassIVEi | Q5RIA9 |
MaxQBi | Q5RIA9 |
PeptideAtlasi | Q5RIA9 |
PRIDEi | Q5RIA9 |
ProteomicsDBi | 63743 [Q5RIA9-1] 63744 [Q5RIA9-2] 63745 [Q5RIA9-3] |
Protocols and materials databases
Antibodypediai | 54586, 13 antibodies |
Genome annotation databases
Ensembli | ENST00000377395; ENSP00000366612; ENSG00000147996 [Q5RIA9-3] ENST00000382405; ENSP00000371842; ENSG00000147996 [Q5RIA9-1] |
GeneIDi | 220869 |
KEGGi | hsa:220869 |
UCSCi | uc004aga.6, human [Q5RIA9-1] |
Organism-specific databases
CTDi | 220869 |
GeneCardsi | CBWD5 |
HGNCi | HGNC:24584, CBWD5 |
HPAi | ENSG00000147996, Low tissue specificity |
neXtProti | NX_Q5RIA9 |
OpenTargetsi | ENSG00000147996 |
VEuPathDBi | HostDB:ENSG00000147996.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00640000091523 |
HOGENOMi | CLU_017452_0_1_1 |
InParanoidi | Q5RIA9 |
OMAi | HDCHDHH |
OrthoDBi | 1144889at2759 |
PhylomeDBi | Q5RIA9 |
TreeFami | TF332679 |
Enzyme and pathway databases
PathwayCommonsi | Q5RIA9 |
Miscellaneous databases
BioGRID-ORCSi | 220869, 251 hits in 548 CRISPR screens |
ChiTaRSi | CBWD5, human |
GenomeRNAii | 220869 |
Pharosi | Q5RIA9, Tdark |
PROi | PR:Q5RIA9 |
RNActi | Q5RIA9, protein |
Gene expression databases
Bgeei | ENSG00000147996, Expressed in caudate nucleus and 115 other tissues |
ExpressionAtlasi | Q5RIA9, baseline and differential |
Genevisiblei | Q5RIA9, HS |
Family and domain databases
Gene3Di | 3.30.1220.10, 1 hit |
InterProi | View protein in InterPro IPR011629, Cbl_biosynth_CobW-like_C IPR036627, CobW-likC_sf IPR003495, CobW/HypB/UreG_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF02492, cobW, 1 hit PF07683, CobW_C, 1 hit |
SMARTi | View protein in SMART SM00833, CobW_C, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CBWD5_HUMAN | |
Accessioni | Q5RIA9Primary (citable) accession number: Q5RIA9 Secondary accession number(s): Q8N7U8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families