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Protein
Submitted name:

Heterogeneous nuclear ribonucleoprotein U

Gene

HNRNPU

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Heterogeneous nuclear ribonucleoprotein UImported
Gene namesi
Name:HNRNPUImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000153187.16
HGNCiHGNC:5048 HNRNPU

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153187

PTM / Processingi

Proteomic databases

EPDiQ5RI18
PeptideAtlasiQ5RI18
PRIDEiQ5RI18

Expressioni

Gene expression databases

BgeeiENSG00000153187 Expressed in 240 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5RI18 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ5RI18, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ5RI18
SMRiQ5RI18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili429 – 452Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IR1W Eukaryota
ENOG410Y1WQ LUCA
GeneTreeiENSGT00390000020210
HOGENOMiHOG000213843

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR026745 hnRNP_U
IPR027417 P-loop_NTPase
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PANTHERiPTHR12381:SF11 PTHR12381:SF11, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All

Q5RI18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLVCVLGDG KTEQKGGDKK RGVKRPREDH GRGYFEYIEE NKYSRAKSPQ
60 70 80 90 100
PPVEEEDEHF DDTVVCLDTY NCDLHFKISR DRLSASSLTM ESFAFLWAGG
110 120 130 140 150
RASYGVSKGK VCFEMKVTEK IPVRHLYTKD IDIHEVRIGW SLTTSGMLLG
160 170 180 190 200
EEEFSYGYSL KGIKTCNCET EDYGEKFDEN DVITCFANFE SDEVELSYAK
210 220 230 240 250
NGQDLGVAFK ISKEVLAGRP LFPHVLCHNC AVEFNFGQKE KPYFPIPEEY
260 270 280 290 300
TFIQNVPLED RVRGPKGPEE KKDCEVVMMI GLPGAGKTTW VTKHAAENPG
310 320 330 340 350
KYNILGTNTI MDKMMVAGFK KQMADTGKLN TLLQRAPQCL GKFIEIAARK
360 370 380 390 400
KRNFILDQTN VSAAAQRRKM CLFAGFQRKA VVVCPKDEDY KQRTQKKAEV
410 420 430 440 450
EGKDLPEHAV LKMKGNFTLP EVAECFDEIT YVELQKEEAQ KLLEQYKEES
460 470 480 490 500
KKALPPEKKQ NTGSKKSNKN KSGKNQFNRG GGHRGRGGFN MRGGNFRGGA
510 520 530 540 550
PGNRGGYNRR GNMPQRGGGG GGSGGIGYPY PRAPVFPGRG SYSNRGNYNR
560 570 580 590 600
GGMPNRGNYN QNFRGRGNNR GYKNQSQGYN QWQQGQFWGQ KPWSQHYHQG

YY
Length:602
Mass (Da):67,825
Last modified:June 7, 2017 - v9
Checksum:iF84A9AFFB5E866D8
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q00839HNRPU_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU C1orf199, HNRPU, SAFA, U21.1
825Annotation score:
A0A1W2PP22A0A1W2PP22_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
181Annotation score:
A0A1X7SBS1A0A1X7SBS1_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
744Annotation score:
A0A1W2PPS1A0A1W2PPS1_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
804Annotation score:
A0A1W2PP35A0A1W2PP35_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
728Annotation score:
A0A1W2PP34A0A1W2PP34_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
546Annotation score:
A0A1W2PPL4A0A1W2PPL4_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
547Annotation score:
A0A1W2PPH7A0A1W2PPH7_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
549Annotation score:
A0A1W2PQL0A0A1W2PQL0_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
527Annotation score:
A0A1W2PQD4A0A1W2PQD4_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPU
327Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323046 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000440865; ENSP00000410728; ENSG00000153187
UCSCiuc057qxa.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323046 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5RI18
SMRiQ5RI18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5RI18, 1 interactor

Proteomic databases

EPDiQ5RI18
PeptideAtlasiQ5RI18
PRIDEiQ5RI18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000440865; ENSP00000410728; ENSG00000153187
UCSCiuc057qxa.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000153187.16
HGNCiHGNC:5048 HNRNPU
OpenTargetsiENSG00000153187
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR1W Eukaryota
ENOG410Y1WQ LUCA
GeneTreeiENSGT00390000020210
HOGENOMiHOG000213843

Miscellaneous databases

ChiTaRSiHNRNPU human

Gene expression databases

BgeeiENSG00000153187 Expressed in 240 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5RI18 baseline and differential

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR026745 hnRNP_U
IPR027417 P-loop_NTPase
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PANTHERiPTHR12381:SF11 PTHR12381:SF11, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5RI18_HUMAN
AccessioniPrimary (citable) accession number: Q5RI18
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: June 7, 2017
Last modified: September 12, 2018
This is version 105 of the entry and version 9 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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