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Entry version 92 (07 Apr 2021)
Sequence version 1 (21 Dec 2004)
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Protein

Protein MCM10 homolog

Gene

mcm10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA replication
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-176187, Activation of ATR in response to replication stress
R-DRE-68962, Activation of the pre-replicative complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MCM10 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mcm10
ORF Names:si:ch211-206k18.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041210-42, mcm10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002783221 – 833Protein MCM10 homologAdd BLAST833

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5RHY1

PRoteomics IDEntifications database

More...
PRIDEi
Q5RHY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000045815, Expressed in mature ovarian follicle and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5RHY1, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000067338

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5RHY1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 122N-terminal domainBy similarityAdd BLAST122
Regioni202 – 360OB-fold domainBy similarityAdd BLAST159
Regioni361 – 386Zinc finger-like 1Add BLAST26
Regioni741 – 760Zinc finger-like 2By similarityAdd BLAST20
Regioni774 – 794Zinc finger-like 3By similarityAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili70 – 108Sequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.By similarity
The N-terminal domain mediates homodimerization.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCM10 family.Curated

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3056, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007134

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014680_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5RHY1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIERGDL

Database of Orthologous Groups

More...
OrthoDBi
758449at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5RHY1

TreeFam database of animal gene trees

More...
TreeFami
TF313330

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040184, Mcm10
IPR015411, Rep_factor_Mcm10_C
IPR015408, Znf_Mcm10/DnaG

The PANTHER Classification System

More...
PANTHERi
PTHR13454, PTHR13454, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09332, Mcm10, 1 hit
PF09329, zf-primase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01280, Mcm10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5RHY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEEENLDML LSLFAESEGQ DLESPAAEEG EDNLDDLFDE DDDGEQYIEP
60 70 80 90 100
EEAEEEKEEE EEEVSPGKSS SSDLNKSKED LEAELKLMQE KMQKLQQQLE
110 120 130 140 150
ASQKTTPAQN KPAVQRQSTK SLTSPQAGVK TTPPTVRDSD GSPSNITAKL
160 170 180 190 200
KNKQRTAHQP KAASSERQIP IGQSTNQPQP MRDGAKVNSM LKSPPLIKTP
210 220 230 240 250
PTVRQPTPRL PVNQEVAVEK FSGLRLRKPR LSSIDIEQKM ASRKLIRLSQ
260 270 280 290 300
LPDRLARDNL EDSDWVTFAV IINKITPQSK NNGKTFSIWK LNDLHNLEVN
310 320 330 340 350
VSLFLFGSVH TDLWKTDTGT VIGILNPNPM KNKEGSNELS LTVDHPQKVL
360 370 380 390 400
IIGEAMDFGT CKAKKKNGDS CTQLVNLYEC QFCQYHVKAQ YKKMSSKRAE
410 420 430 440 450
LQSSFTGSAP GKGRGRGSLK ERLCQSDFHY GGMSSLACAP SMSAPQPKKQ
460 470 480 490 500
PTIQSALASI PTKKLVLNSG QVSGCSDDFR GLMSMPTPGA LNIKRHLGQS
510 520 530 540 550
KSSAVAGSSV QSVSASDLLK QQKEQHQQRM MARKKRAEEI QKRVLQSGGA
560 570 580 590 600
PVASSRPNVS RGPLLSPKAA SEGPKGSGSS LSGPAVPTLG RGFSEGEDIV
610 620 630 640 650
FDMSPPSSKS LSATKLAAVR KLQAKGSVIV KEDPNAVKRK RANSGDITGR
660 670 680 690 700
VERNIVKAKV TDENSASEEE EPAMKKRREQ LEYIQSEEFQ RILNAKSSNS
710 720 730 740 750
WMMGEIEERA MQEYFEPLVQ KEKMEEKMKS IREMKCRAVT CKTCKYTHFK
760 770 780 790 800
PADRCVEEKH DYHWHDAVKR FFKCPCGQRK ICLARMPHGA CSHCGLFKWE
810 820 830
RDGMLKEKKG PKIGGELLMP RGEEQPKFLN SLK
Length:833
Mass (Da):92,439
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0E7700B2FE8B2C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX323869 Genomic DNA Translation: CAI11761.1

NCBI Reference Sequences

More...
RefSeqi
NP_001019984.1, NM_001024813.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000067339; ENSDARP00000067338; ENSDARG00000045815

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
553396

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:553396

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323869 Genomic DNA Translation: CAI11761.1
RefSeqiNP_001019984.1, NM_001024813.1

3D structure databases

SMRiQ5RHY1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067338

Proteomic databases

PaxDbiQ5RHY1
PRIDEiQ5RHY1

Genome annotation databases

EnsembliENSDART00000067339; ENSDARP00000067338; ENSDARG00000045815
GeneIDi553396
KEGGidre:553396

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55388
ZFINiZDB-GENE-041210-42, mcm10

Phylogenomic databases

eggNOGiKOG3056, Eukaryota
GeneTreeiENSGT00390000007134
HOGENOMiCLU_014680_0_0_1
InParanoidiQ5RHY1
OMAiHIERGDL
OrthoDBi758449at2759
PhylomeDBiQ5RHY1
TreeFamiTF313330

Enzyme and pathway databases

ReactomeiR-DRE-176187, Activation of ATR in response to replication stress
R-DRE-68962, Activation of the pre-replicative complex

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5RHY1

Gene expression databases

BgeeiENSDARG00000045815, Expressed in mature ovarian follicle and 23 other tissues
ExpressionAtlasiQ5RHY1, baseline

Family and domain databases

InterProiView protein in InterPro
IPR040184, Mcm10
IPR015411, Rep_factor_Mcm10_C
IPR015408, Znf_Mcm10/DnaG
PANTHERiPTHR13454, PTHR13454, 1 hit
PfamiView protein in Pfam
PF09332, Mcm10, 1 hit
PF09329, zf-primase, 1 hit
SMARTiView protein in SMART
SM01280, Mcm10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCM10_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5RHY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 21, 2004
Last modified: April 7, 2021
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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