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Entry version 93 (07 Oct 2020)
Sequence version 2 (10 Jul 2007)
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Protein

Protein broad-minded

Gene

tbc1d32

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for high-level Shh responses in the developing neural tube. Together with cdk20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.1 Publication

Caution

The Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg and Gln in the catalytic finger motifs.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein broad-minded
Alternative name(s):
TBC1 domain family member 32
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tbc1d32
Synonyms:bromi
ORF Names:si:dkey-233p4.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-061106-5, tbc1d32

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Fish are viable during embryogenesis and early larval stages, but exhibit curvature of the body axis and hydrocephalus, and curled cilia in distal kidney tubules.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003600321 – 1298Protein broad-mindedAdd BLAST1298

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5RHR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000041734, Expressed in testis and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5RHR6, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cdk20, which promotes cdk20 stability and function.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000122813

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1171 – 1283Rab-GAP TBCAdd BLAST113

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR93, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153528

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_260246_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5RHR6

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCVQYLE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5RHR6

TreeFam database of animal gene trees

More...
TreeFami
TF329092

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032735, BROMI
IPR035969, Rab-GTPase_TBC_sf
IPR039156, UPF0183/BROMI

The PANTHER Classification System

More...
PANTHERi
PTHR13465, PTHR13465, 1 hit
PTHR13465:SF3, PTHR13465:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14961, BROMI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923, SSF47923, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5RHR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQFSTEDEA ELQTLLRKLL KSVKDRISGA PSVECAEEIL LHLEETDKNF
60 70 80 90 100
HNYEFVKYLR EYVESSLGAV IEVETENFTK GEGHAVGSGQ DTLVHAVTKN
110 120 130 140 150
TRESTQYKQM MQTLKQTMMM VVESLINKFE EDQMKREEMD RKIQHQQSIS
160 170 180 190 200
QYADNCSDSD SSFNQSYAFI KHEQLQVIAE KLDPGRPREV RWEALQSLCH
210 220 230 240 250
APPSDVLSCE SWTGLRRNLS TALTDPDPEL SDKVLQFFAK TFSSSPLNVT
260 270 280 290 300
KDIYASIGNT KTLEAHFLYH KLSFPSGTTS IDANRPDMAR LLKQMRLMND
310 320 330 340 350
FQKEVTTFWI RHPEKYMEEI IENTLSLLAL HSEQGMSSPG SEKSLEPIHL
360 370 380 390 400
ISLLDIKATW FKKWMHGYYS RTVVLRLLER KYKSLIVNAL QQCIYYFDSC
410 420 430 440 450
DALSEETLEM IHSLEHQQIG PAGRTLYTSK ELEFVYFVHS LCVLGRLVMY
460 470 480 490 500
TNGRKFFPIK VKKRRDPVTL TDLVVILINI MYQHPKPSCG ETALADTMSP
510 520 530 540 550
TNLVMEVLRT LCDRTECAVE CLYQIPVIET LLAPLITLLT GKLPKLNSME
560 570 580 590 600
SALTHTADTL ARIATTERGL SLLLYDRNLV SAEGESISAA HLIVQFTQKL
610 620 630 640 650
LAKELQVENS SSMSGAFIFV CRQMYNTCEG LQVLRPYSLH ECIAQAWRTT
660 670 680 690 700
SSMSERVPTP VPGAPPALAS QELQSVVAWE EMLLDNLLNF AATPKGLLLL
710 720 730 740 750
QQTGAINECV TYMFSRFTKK LQVSRCEKFG YGVMVTQVAT TAPGIVALQS
760 770 780 790 800
SGFVQTIVVE LWSALECGRE DVRVVHPKST PMDPIDRSCL KSFLSLVNLL
810 820 830 840 850
SSPHAVWELL GHRALPNKTE YNLREMATSV LDLMDRLIII NSDAKIHSLF
860 870 880 890 900
NYEQSHTFGL RLLSVLCCNL DSFLLLESQY KLTDLLLQGQ RDNVTEPPSG
910 920 930 940 950
EGEFIIDGLS VERNHILVRI CAVGGPSERK LPPRALQKGN DPYPWPMVST
960 970 980 990 1000
YPLPKYYIFD VPKILRTKQE SEIGAFLTSS KETERDASWM DDCRRQFCKI
1010 1020 1030 1040 1050
MATKSNTLTG YVLADLLEMV VLHLSSSSND CFFPPAEYKV VDNSVKTRSL
1060 1070 1080 1090 1100
SSVEQLGVEI SLRYGKFLKL LREDSEQDLC LLLKHCQEFL SQQRVKVTSE
1110 1120 1130 1140 1150
LCGYPGHDWF ASTVFLLMHG DVGRSLSLLL RFSRLLPSAF LWPPRLHSSV
1160 1170 1180 1190 1200
HLPIEIAQSA IHPIYSCTAH YVEMLLKAEV PLVFSAFRMS GFTPSQICVQ
1210 1220 1230 1240 1250
WLGQCFWNYL DWPEICQYVT TCVIMGPDYQ VYMCVSALRH LQQDILQHTQ
1260 1270 1280 1290
TQDLQVFLKE EPIQGFRVSN YLEYMEGLER SYRSMVLSDM RSILPRSS
Length:1,298
Mass (Da):147,547
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47F87FA4895B33C8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX470129, BX470071, CT955964 Genomic DNA Translation: CAI11664.2
BX470071, BX470129, CT955964 Genomic DNA Translation: CAI20996.2
CT955964, BX470071, BX470129 Genomic DNA Translation: CAN88284.1

NCBI Reference Sequences

More...
RefSeqi
NP_001093493.1, NM_001100023.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000061168; ENSDARP00000061167; ENSDARG00000041734
ENSDART00000144401; ENSDARP00000122813; ENSDARG00000041734

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
566474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:566474

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470129, BX470071, CT955964 Genomic DNA Translation: CAI11664.2
BX470071, BX470129, CT955964 Genomic DNA Translation: CAI20996.2
CT955964, BX470071, BX470129 Genomic DNA Translation: CAN88284.1
RefSeqiNP_001093493.1, NM_001100023.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122813

Proteomic databases

PaxDbiQ5RHR6

Genome annotation databases

EnsembliENSDART00000061168; ENSDARP00000061167; ENSDARG00000041734
ENSDART00000144401; ENSDARP00000122813; ENSDARG00000041734
GeneIDi566474
KEGGidre:566474

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221322
ZFINiZDB-GENE-061106-5, tbc1d32

Phylogenomic databases

eggNOGiENOG502QR93, Eukaryota
GeneTreeiENSGT00940000153528
HOGENOMiCLU_260246_0_0_1
InParanoidiQ5RHR6
OMAiQCVQYLE
PhylomeDBiQ5RHR6
TreeFamiTF329092

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5RHR6

Gene expression databases

BgeeiENSDARG00000041734, Expressed in testis and 20 other tissues
ExpressionAtlasiQ5RHR6, baseline

Family and domain databases

InterProiView protein in InterPro
IPR032735, BROMI
IPR035969, Rab-GTPase_TBC_sf
IPR039156, UPF0183/BROMI
PANTHERiPTHR13465, PTHR13465, 1 hit
PTHR13465:SF3, PTHR13465:SF3, 1 hit
PfamiView protein in Pfam
PF14961, BROMI, 1 hit
SUPFAMiSSF47923, SSF47923, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBROMI_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5RHR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 10, 2007
Last modified: October 7, 2020
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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