UniProtKB - Q5RHP9 (ERIC3_HUMAN)
Protein
Glutamate-rich protein 3
Gene
ERICH3
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate-rich protein 3 |
Gene namesi | Name:ERICH3 Synonyms:C1orf173 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000178965.13 |
HGNCi | HGNC:25346, ERICH3 |
neXtProti | NX_Q5RHP9 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 127254 |
OpenTargetsi | ENSG00000178965 |
PharmGKBi | PA142672422 |
Miscellaneous databases
Pharosi | Q5RHP9, Tdark |
Polymorphism and mutation databases
BioMutai | ERICH3 |
DMDMi | 74743374 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304972 | 1 – 1530 | Glutamate-rich protein 3Add BLAST | 1530 |
Proteomic databases
jPOSTi | Q5RHP9 |
MassIVEi | Q5RHP9 |
PaxDbi | Q5RHP9 |
PeptideAtlasi | Q5RHP9 |
PRIDEi | Q5RHP9 |
ProteomicsDBi | 63735 [Q5RHP9-1] 63736 [Q5RHP9-2] 63737 [Q5RHP9-3] |
PTM databases
iPTMneti | Q5RHP9 |
PhosphoSitePlusi | Q5RHP9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000178965, Expressed in bronchial epithelial cell and 135 other tissues |
ExpressionAtlasi | Q5RHP9, baseline and differential |
Genevisiblei | Q5RHP9, HS |
Organism-specific databases
HPAi | ENSG00000178965, Tissue enhanced (brain, fallopian tube, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126046, 3 interactors |
IntActi | Q5RHP9, 7 interactors |
STRINGi | 9606.ENSP00000322609 |
Miscellaneous databases
RNActi | Q5RHP9, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 254 – 259 | Poly-Arg | 6 | |
Compositional biasi | 415 – 1489 | Glu-richAdd BLAST | 1075 |
Phylogenomic databases
eggNOGi | ENOG502QVG1, Eukaryota |
GeneTreei | ENSGT00530000064485 |
HOGENOMi | CLU_004102_0_0_1 |
InParanoidi | Q5RHP9 |
OMAi | EAPQHRD |
OrthoDBi | 213114at2759 |
PhylomeDBi | Q5RHP9 |
TreeFami | TF331348 |
Family and domain databases
InterProi | View protein in InterPro IPR027962, DUF4590 |
PANTHERi | PTHR23034, PTHR23034, 1 hit |
Pfami | View protein in Pfam PF15257, DUF4590, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5RHP9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSHSHPAGLL AAYNSLMDKH LAGYFNNTRI RRHLLRSGLI TRSGRILSEK
60 70 80 90 100
EYKLNMMKRD HQKYIRECLA QAIFHKVLDM ERYHQLEIKK KLETLARKER
110 120 130 140 150
IQRFKGEHTR RSVENNMPIL SPHPPVGPKS NRGHSVLVDE GHSSPLALTA
160 170 180 190 200
PRPYTAPGNM QPPIRLQPLP SNPAVETVPK VTSRSRSKTS LLENEALFPI
210 220 230 240 250
GGKKAVMKFR NSIGNSQRMN SYQLPNINSY MMPIPPPLPP TGKITRENRS
260 270 280 290 300
ETWRRRRFRP TTAPNGLEPL LTKDSRRIHK TSLHSNAAIT MIYLGKNVHL
310 320 330 340 350
SSDNPDFRDE IKVYQQHCGG ENLCVYKGKL LEKETFQFIS KRHHGFPFSL
360 370 380 390 400
TFFLNGMQVN RLSSCCEYKH RKGSRLGGKR GYFGFVCVER SSPCYKCIIA
410 420 430 440 450
MGLDKKPSLP KSRKEKSTEK GEELKKAEGK VRKEREYVIP KRNEIKENKT
460 470 480 490 500
SVSAKFSAQE IKTGLKEVVT AVEEMTSKGK PGQEVLEDDQ ENTLKYEYEE
510 520 530 540 550
DFEVDEEKQG EKSNEEGQAD VQMNGIPQSP LDDKKDNLDP EKESETSSQK
560 570 580 590 600
APDARDNVKD ENDGCSESEL EEDKQDMKTA SSTSSRSHPY SSDSEDESAV
610 620 630 640 650
GDREAHTDSS TDESARRSSS QELSENDKPR KSHLPIEESL EIEIEDQEIT
660 670 680 690 700
KADVETKPMP IDESFENVLK EGTEKGTQEI AEGLSEKSGK HVSAEEKEKD
710 720 730 740 750
KSKLWEESTA QVKDKKAGLP GLEEGGKDSL PLAYVLALGA PTMNFMVDET
760 770 780 790 800
AAINSNKESQ QLVQKTYTLE KKEAMEEDEA PQHRDADIVQ GKGEAALWGE
810 820 830 840 850
AGAVHEAPLR AWKPTAEQPE LAEEFTEKRE IPPGIERGAE GAAEAEGVRR
860 870 880 890 900
LGEGGSDPIG QAAAKDAVGL SKDEAPEKQA LMLTVLETDK AASEGEQGLE
910 920 930 940 950
KAVLANEAAA LNLEHLHEVA ALREAATSEE GEAEGGVAVS DVGESEEEAS
960 970 980 990 1000
IDLEDTGPME DTASKREDGS EEAILGGEEP AKERKEVMRT ETRLSPFTGE
1010 1020 1030 1040 1050
AEASRMQVSE GSPEEGSLAK EAFLCKEDVE GEEMVTEAEA NREDDRKEIL
1060 1070 1080 1090 1100
PKELDLARER RKAERPKTSL RKTDSEREEV TRANALKDED AFKEEQKLKA
1110 1120 1130 1140 1150
EEGETETEVR AEEETKAPPN EMGSDAENEA PVEASELSDN PGLLGEDSLK
1160 1170 1180 1190 1200
ETVVPIFEAT PGFEKSLENI TALRKEGGGE RLSEARDTEH KDREELSSRE
1210 1220 1230 1240 1250
NRALKEGHRQ DGEGALAAPE AEPAGKVQAP EGLIPATGQA EELAAKDHDS
1260 1270 1280 1290 1300
CAGLEGRAEG QGGVDVVLRT QEAVAEEDPI MAEKFREEAV DEDPEEEEDK
1310 1320 1330 1340 1350
ECTLETEAMQ DRNSEGDGDM EGEGNTQKNE GMGGGRVVAV EVLHGGGETA
1360 1370 1380 1390 1400
ETAAEEREVL AGSETAEEKT IANKASSFSD VAEEETWHQQ DELVGKTAAA
1410 1420 1430 1440 1450
GKVVVEELAR SGEEVPAAEE MTVTYTTEAG VGTPGALERK TSGLGQEQEE
1460 1470 1480 1490 1500
GSEGQEAATG SGDGRQETGA AEKFRLGLSR EGERELSPES LQAMATLPVK
1510 1520 1530
PDFTETREKQ QHMVQGESET ADVSPNNVQV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GMY5 | R4GMY5_HUMAN | Glutamate-rich protein 3 | ERICH3 | 110 | Annotation score: |
Sequence cautioni
The sequence BAC86994 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1101 | E → G in BAC86994 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1177 | Missing in CAD39076 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035131 | 264 | P → A1 PublicationCorresponds to variant dbSNP:rs11210490Ensembl. | 1 | |
Natural variantiVAR_035132 | 555 | R → H. Corresponds to variant dbSNP:rs696698Ensembl. | 1 | |
Natural variantiVAR_035133 | 636 | I → V. Corresponds to variant dbSNP:rs17095653Ensembl. | 1 | |
Natural variantiVAR_035134 | 691 | H → R. Corresponds to variant dbSNP:rs2305549Ensembl. | 1 | |
Natural variantiVAR_035135 | 1056 | L → V. Corresponds to variant dbSNP:rs11580409Ensembl. | 1 | |
Natural variantiVAR_035136 | 1528 | V → M1 PublicationCorresponds to variant dbSNP:rs9326116Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028159 | 1 – 742 | Missing in isoform 2. 1 PublicationAdd BLAST | 742 | |
Alternative sequenceiVSP_028160 | 1 – 197 | Missing in isoform 3. 1 PublicationAdd BLAST | 197 | |
Alternative sequenceiVSP_028161 | 198 – 201 | FPIG → MLAK in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_028162 | 728 – 730 | DSL → YGR in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_028163 | 731 – 1530 | Missing in isoform 3. 1 PublicationAdd BLAST | 800 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL834414 mRNA Translation: CAD39076.1 CR749349 mRNA Translation: CAH18202.1 AC096950 Genomic DNA No translation available. BX470253 Genomic DNA No translation available. BC073916 mRNA Translation: AAH73916.1 AK127470 mRNA Translation: BAC86994.1 Sequence problems. |
CCDSi | CCDS30755.1 [Q5RHP9-1] |
RefSeqi | NP_001002912.4, NM_001002912.4 [Q5RHP9-1] XP_016855763.1, XM_017000274.1 [Q5RHP9-1] XP_016855767.1, XM_017000278.1 [Q5RHP9-2] XP_016855768.1, XM_017000279.1 [Q5RHP9-2] XP_016855769.1, XM_017000280.1 [Q5RHP9-2] XP_016855770.1, XM_017000281.1 [Q5RHP9-2] XP_016855771.1, XM_017000282.1 [Q5RHP9-2] XP_016855772.1, XM_017000283.1 [Q5RHP9-2] XP_016855773.1, XM_017000284.1 [Q5RHP9-2] XP_016855774.1, XM_017000285.1 [Q5RHP9-2] |
Genome annotation databases
Ensembli | ENST00000326665; ENSP00000322609; ENSG00000178965 [Q5RHP9-1] ENST00000420661; ENSP00000398581; ENSG00000178965 [Q5RHP9-3] |
GeneIDi | 127254 |
KEGGi | hsa:127254 |
UCSCi | uc001dgg.3, human [Q5RHP9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL834414 mRNA Translation: CAD39076.1 CR749349 mRNA Translation: CAH18202.1 AC096950 Genomic DNA No translation available. BX470253 Genomic DNA No translation available. BC073916 mRNA Translation: AAH73916.1 AK127470 mRNA Translation: BAC86994.1 Sequence problems. |
CCDSi | CCDS30755.1 [Q5RHP9-1] |
RefSeqi | NP_001002912.4, NM_001002912.4 [Q5RHP9-1] XP_016855763.1, XM_017000274.1 [Q5RHP9-1] XP_016855767.1, XM_017000278.1 [Q5RHP9-2] XP_016855768.1, XM_017000279.1 [Q5RHP9-2] XP_016855769.1, XM_017000280.1 [Q5RHP9-2] XP_016855770.1, XM_017000281.1 [Q5RHP9-2] XP_016855771.1, XM_017000282.1 [Q5RHP9-2] XP_016855772.1, XM_017000283.1 [Q5RHP9-2] XP_016855773.1, XM_017000284.1 [Q5RHP9-2] XP_016855774.1, XM_017000285.1 [Q5RHP9-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126046, 3 interactors |
IntActi | Q5RHP9, 7 interactors |
STRINGi | 9606.ENSP00000322609 |
PTM databases
iPTMneti | Q5RHP9 |
PhosphoSitePlusi | Q5RHP9 |
Polymorphism and mutation databases
BioMutai | ERICH3 |
DMDMi | 74743374 |
Proteomic databases
jPOSTi | Q5RHP9 |
MassIVEi | Q5RHP9 |
PaxDbi | Q5RHP9 |
PeptideAtlasi | Q5RHP9 |
PRIDEi | Q5RHP9 |
ProteomicsDBi | 63735 [Q5RHP9-1] 63736 [Q5RHP9-2] 63737 [Q5RHP9-3] |
Protocols and materials databases
Antibodypediai | 49494, 49 antibodies |
Genome annotation databases
Ensembli | ENST00000326665; ENSP00000322609; ENSG00000178965 [Q5RHP9-1] ENST00000420661; ENSP00000398581; ENSG00000178965 [Q5RHP9-3] |
GeneIDi | 127254 |
KEGGi | hsa:127254 |
UCSCi | uc001dgg.3, human [Q5RHP9-1] |
Organism-specific databases
CTDi | 127254 |
DisGeNETi | 127254 |
EuPathDBi | HostDB:ENSG00000178965.13 |
GeneCardsi | ERICH3 |
HGNCi | HGNC:25346, ERICH3 |
HPAi | ENSG00000178965, Tissue enhanced (brain, fallopian tube, testis) |
neXtProti | NX_Q5RHP9 |
OpenTargetsi | ENSG00000178965 |
PharmGKBi | PA142672422 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVG1, Eukaryota |
GeneTreei | ENSGT00530000064485 |
HOGENOMi | CLU_004102_0_0_1 |
InParanoidi | Q5RHP9 |
OMAi | EAPQHRD |
OrthoDBi | 213114at2759 |
PhylomeDBi | Q5RHP9 |
TreeFami | TF331348 |
Enzyme and pathway databases
PathwayCommonsi | Q5RHP9 |
Miscellaneous databases
BioGRID-ORCSi | 127254, 4 hits in 830 CRISPR screens |
ChiTaRSi | ERICH3, human |
GenomeRNAii | 127254 |
Pharosi | Q5RHP9, Tdark |
PROi | PR:Q5RHP9 |
RNActi | Q5RHP9, protein |
Gene expression databases
Bgeei | ENSG00000178965, Expressed in bronchial epithelial cell and 135 other tissues |
ExpressionAtlasi | Q5RHP9, baseline and differential |
Genevisiblei | Q5RHP9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027962, DUF4590 |
PANTHERi | PTHR23034, PTHR23034, 1 hit |
Pfami | View protein in Pfam PF15257, DUF4590, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERIC3_HUMAN | |
Accessioni | Q5RHP9Primary (citable) accession number: Q5RHP9 Secondary accession number(s): Q68DL8 Q8ND41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations